ES3050660T3 - 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression - Google Patents

3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression

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Publication number
ES3050660T3
ES3050660T3 ES17871446T ES17871446T ES3050660T3 ES 3050660 T3 ES3050660 T3 ES 3050660T3 ES 17871446 T ES17871446 T ES 17871446T ES 17871446 T ES17871446 T ES 17871446T ES 3050660 T3 ES3050660 T3 ES 3050660T3
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Prior art keywords
phenylpiperazin
decan
azaspiro
oxa
modulators
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ES17871446T
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English (en)
Spanish (es)
Inventor
Daniel J Canney
Benjamin E Blass
Kevin M Blattner
Douglas A Pippin
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Temple Univ School of Medicine
Praeventix LLC
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Temple Univ School of Medicine
Praeventix LLC
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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ES17871446T 2016-11-15 2017-11-15 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression Active ES3050660T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662422344P 2016-11-15 2016-11-15
PCT/US2017/061677 WO2018093818A1 (en) 2016-11-15 2017-11-15 Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use

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ES3050660T3 true ES3050660T3 (en) 2025-12-22

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ES17871446T Active ES3050660T3 (en) 2016-11-15 2017-11-15 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression

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US (4) US10858368B2 (enExample)
EP (1) EP3541790B1 (enExample)
JP (3) JP7107955B2 (enExample)
KR (2) KR102590403B1 (enExample)
CN (2) CN110177776B (enExample)
AU (3) AU2017361078B2 (enExample)
CA (1) CA3043319A1 (enExample)
CL (1) CL2019001329A1 (enExample)
EA (1) EA201990915A1 (enExample)
ES (1) ES3050660T3 (enExample)
IL (3) IL291029B2 (enExample)
MX (2) MX394746B (enExample)
UA (1) UA125631C2 (enExample)
WO (1) WO2018093818A1 (enExample)
ZA (1) ZA202105774B (enExample)

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WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
EP3200589A4 (en) 2014-09-10 2018-07-25 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
EP3541790B1 (en) 2016-11-15 2025-09-03 Temple University - Of The Commonwealth System of Higher Education 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
WO2018175188A1 (en) 2017-03-21 2018-09-27 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the sigma-2 receptor and their method of use
JP7365238B2 (ja) * 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
TW202523659A (zh) * 2018-05-11 2025-06-16 美國坦普大學 高等教育聯邦系統 作為5-羥基色胺受體7之調節劑之新穎官能化內醯胺及其使用方法
CN115003675A (zh) * 2019-11-13 2022-09-02 英联邦高等教育系统坦普尔大学 作为5-羟色胺受体7调节剂的新型官能化内酰胺及其使用方法
BR112022009361A2 (pt) * 2019-11-13 2022-08-09 Univ Temple Novas lactonas funcionalizadas como moduladores do receptor 7 de 5- hidroxitriptamina e seu método de uso
TW202328148A (zh) * 2021-09-22 2023-07-16 日商塩野義製藥股份有限公司 具有血清素受體結合活性之螺雜環衍生物

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