ES3050660T3 - 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression - Google Patents

3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression

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Publication number
ES3050660T3
ES3050660T3 ES17871446T ES17871446T ES3050660T3 ES 3050660 T3 ES3050660 T3 ES 3050660T3 ES 17871446 T ES17871446 T ES 17871446T ES 17871446 T ES17871446 T ES 17871446T ES 3050660 T3 ES3050660 T3 ES 3050660T3
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Spain
Prior art keywords
phenylpiperazin
decan
azaspiro
oxa
modulators
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Application number
ES17871446T
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English (en)
Spanish (es)
Inventor
Daniel J Canney
Benjamin E Blass
Kevin M Blattner
Douglas A Pippin
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Temple Univ School of Medicine
Praeventix LLC
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Temple Univ School of Medicine
Praeventix LLC
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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ES17871446T 2016-11-15 2017-11-15 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression Active ES3050660T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662422344P 2016-11-15 2016-11-15
PCT/US2017/061677 WO2018093818A1 (en) 2016-11-15 2017-11-15 Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use

Publications (1)

Publication Number Publication Date
ES3050660T3 true ES3050660T3 (en) 2025-12-22

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ES17871446T Active ES3050660T3 (en) 2016-11-15 2017-11-15 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression

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US (4) US10858368B2 (OSRAM)
EP (1) EP3541790B1 (OSRAM)
JP (3) JP7107955B2 (OSRAM)
KR (2) KR102900157B1 (OSRAM)
CN (2) CN110177776B (OSRAM)
AU (3) AU2017361078B2 (OSRAM)
CA (1) CA3043319A1 (OSRAM)
CL (1) CL2019001329A1 (OSRAM)
EA (1) EA201990915A1 (OSRAM)
ES (1) ES3050660T3 (OSRAM)
IL (3) IL309982A (OSRAM)
MX (2) MX394746B (OSRAM)
UA (1) UA125631C2 (OSRAM)
WO (1) WO2018093818A1 (OSRAM)
ZA (1) ZA202105774B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2804545T3 (es) 2013-03-11 2021-02-08 Univ Temple Nuevos moduladores de la actividad del receptor de 5-hidroxitriptamina 7 y su método de uso
EP3200589A4 (en) 2014-09-10 2018-07-25 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
KR102900157B1 (ko) 2016-11-15 2025-12-12 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법
WO2018175188A1 (en) 2017-03-21 2018-09-27 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the sigma-2 receptor and their method of use
JP7365238B2 (ja) 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
MX2020012030A (es) * 2018-05-11 2021-03-29 Univ Temple Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
BR112022009361A2 (pt) * 2019-11-13 2022-08-09 Univ Temple Novas lactonas funcionalizadas como moduladores do receptor 7 de 5- hidroxitriptamina e seu método de uso
AU2020381460A1 (en) * 2019-11-13 2022-06-09 Praeventix, Llc Novel functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and their method of use
TW202328148A (zh) * 2021-09-22 2023-07-16 日商塩野義製藥股份有限公司 具有血清素受體結合活性之螺雜環衍生物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040064499A1 (en) 2002-09-26 2004-04-01 Kasra Kasravi Method and system for active knowledge management
WO2004067703A2 (en) 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists
CA2552681A1 (en) 2004-01-16 2005-07-28 F. Hoffmann-La Roche Ag 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1h-quinazolin-2-one derivatives and the respective 1h-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(d) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-ht) for the treatment of diseases of the central nervous system
NZ565334A (en) 2005-08-04 2010-12-24 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
EP1875899A1 (en) 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Use of 5HT7 receptor agonists for the treatment of pain
WO2009048765A1 (en) 2007-10-12 2009-04-16 Eli Lilly And Company 5-ht7 receptor antagonists
US7902091B2 (en) 2008-08-13 2011-03-08 Varian Semiconductor Equipment Associates, Inc. Cleaving of substrates
US20100069390A1 (en) 2008-09-05 2010-03-18 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (ADHD)
WO2010069390A1 (en) 2008-12-19 2010-06-24 Nokia Siemens Networks Oy Method and device for data processing in an udwdm network and communication system comprising such device
US8637263B1 (en) * 2010-10-14 2014-01-28 Epiomed Therapeutics, Inc. Assay for determination of compounds having anti-emetic activity
WO2012058769A1 (en) 2010-11-03 2012-05-10 Mcmaster University Method of treating mucosal inflammation
WO2013154513A1 (en) * 2012-04-04 2013-10-17 Mi̇lli̇ Savunma Bakanliği The use of 5-ht7 receptor antagonists including some atypical antipsychotics as antipruritic agents
WO2014085413A1 (en) 2012-11-28 2014-06-05 Temple University - Of The Commonwealth System Of Higher Education Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators
ES2804545T3 (es) * 2013-03-11 2021-02-08 Univ Temple Nuevos moduladores de la actividad del receptor de 5-hidroxitriptamina 7 y su método de uso
EP3200589A4 (en) 2014-09-10 2018-07-25 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US20180221365A1 (en) 2015-05-12 2018-08-09 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
KR102900157B1 (ko) 2016-11-15 2025-12-12 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법
WO2018175188A1 (en) 2017-03-21 2018-09-27 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the sigma-2 receptor and their method of use
JP7365238B2 (ja) 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
MX2020012030A (es) 2018-05-11 2021-03-29 Univ Temple Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
BR112022009361A2 (pt) * 2019-11-13 2022-08-09 Univ Temple Novas lactonas funcionalizadas como moduladores do receptor 7 de 5- hidroxitriptamina e seu método de uso

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