ES3037292T3 - Preparation of trifarotene and intermediates and polymorphs thereof - Google Patents

Preparation of trifarotene and intermediates and polymorphs thereof

Info

Publication number
ES3037292T3
ES3037292T3 ES20838774T ES20838774T ES3037292T3 ES 3037292 T3 ES3037292 T3 ES 3037292T3 ES 20838774 T ES20838774 T ES 20838774T ES 20838774 T ES20838774 T ES 20838774T ES 3037292 T3 ES3037292 T3 ES 3037292T3
Authority
ES
Spain
Prior art keywords
approximately
substituted
group
formula
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20838774T
Other languages
English (en)
Spanish (es)
Inventor
Ilana Ozer
Yulia Kaftanov
Elliot Simhon
Andrey Dushkin
Dee-Noor Shani Sheffer
Hillel Pizem
Avi Avramoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taro Pharmaceutical Industries Ltd
Original Assignee
Taro Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharmaceutical Industries Ltd filed Critical Taro Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of ES3037292T3 publication Critical patent/ES3037292T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES20838774T 2019-12-11 2020-12-10 Preparation of trifarotene and intermediates and polymorphs thereof Active ES3037292T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962946943P 2019-12-11 2019-12-11
PCT/US2020/064365 WO2021119351A1 (en) 2019-12-11 2020-12-10 Preparation of trifarotene and intermediates and polymorphs thereof

Publications (1)

Publication Number Publication Date
ES3037292T3 true ES3037292T3 (en) 2025-09-30

Family

ID=74141909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20838774T Active ES3037292T3 (en) 2019-12-11 2020-12-10 Preparation of trifarotene and intermediates and polymorphs thereof

Country Status (9)

Country Link
US (2) US11691946B2 (https=)
EP (2) EP4073035B1 (https=)
JP (3) JP7281016B2 (https=)
CN (1) CN114787129B (https=)
AU (2) AU2020402049B2 (https=)
CA (1) CA3161509A1 (https=)
ES (1) ES3037292T3 (https=)
IL (2) IL293800B2 (https=)
WO (1) WO2021119351A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL293800B2 (en) * 2019-12-11 2024-10-01 Taro Pharma Ind Preparation of trifarotene and intermediates and polymorphs thereof
CN117342993A (zh) * 2022-07-05 2024-01-05 石家庄迪斯凯威医药科技有限公司 一种曲法罗汀盐及其药物组合物和用途
CN115745913B (zh) * 2022-09-16 2024-05-24 南京迈诺威医药科技有限公司 曲法罗汀多晶型及其制备方法
JP2026507122A (ja) * 2023-02-28 2026-02-27 タロー・ファーマシューティカル・インダストリーズ・リミテッド トリファロテンを調製する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248869A2 (en) * 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
WO2004083335A2 (en) * 2003-03-21 2004-09-30 University Of Rochester Glassy chiral-nematic liquid crystals and optical devices containing same
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
DK1817301T3 (da) * 2004-11-22 2012-02-27 Lilly Co Eli Forstærkere af glutamat-receptorer
PL1831149T3 (pl) * 2004-12-23 2012-06-29 Galderma Res & Dev Nowe ligandy, które modulują receptory RAR, i ich zastosowanie w medycynie i kosmetyce
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
EP3475312B1 (en) * 2016-06-23 2020-05-27 Galderma S.A. Cyclodextrin-grafted cross-linked hyaluronic acid complexed with active drug substances and uses thereof
IL293800B2 (en) * 2019-12-11 2024-10-01 Taro Pharma Ind Preparation of trifarotene and intermediates and polymorphs thereof

Also Published As

Publication number Publication date
JP2026016786A (ja) 2026-02-03
IL293800A (en) 2022-08-01
JP2022550632A (ja) 2022-12-02
EP4552691A3 (en) 2025-09-10
IL293800B1 (en) 2024-06-01
CA3161509A1 (en) 2021-06-17
WO2021119351A1 (en) 2021-06-17
US20230051259A1 (en) 2023-02-16
CN114787129B (zh) 2025-07-04
AU2023222982B2 (en) 2025-01-02
EP4073035B1 (en) 2025-05-07
NZ788464A (en) 2024-07-05
IL293800B2 (en) 2024-10-01
EP4073035A1 (en) 2022-10-19
US11691946B2 (en) 2023-07-04
IL312356A (en) 2024-06-01
JP7281016B2 (ja) 2023-05-24
JP2023100974A (ja) 2023-07-19
EP4552691A2 (en) 2025-05-14
AU2020402049B2 (en) 2023-06-01
CN114787129A (zh) 2022-07-22
AU2023222982A1 (en) 2023-09-21
US20230278956A1 (en) 2023-09-07
AU2020402049A1 (en) 2022-06-09

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