ES2988672T3 - Formas sólidas de ursodesoxicolato de berberina y composiciones y métodos de las mismas - Google Patents
Formas sólidas de ursodesoxicolato de berberina y composiciones y métodos de las mismas Download PDFInfo
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- ES2988672T3 ES2988672T3 ES18798004T ES18798004T ES2988672T3 ES 2988672 T3 ES2988672 T3 ES 2988672T3 ES 18798004 T ES18798004 T ES 18798004T ES 18798004 T ES18798004 T ES 18798004T ES 2988672 T3 ES2988672 T3 ES 2988672T3
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
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- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/CN2018/086461 WO2018205987A1 (en) | 2017-05-12 | 2018-05-11 | Solid forms of berberine ursodeoxycholate and compositions and methods thereof |
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| CN108864077B (zh) * | 2017-05-12 | 2020-05-22 | 深圳君圣泰生物技术有限公司 | 小檗碱有机酸盐的固体形式及其制备方法 |
| CN110954645B (zh) * | 2019-09-09 | 2020-09-29 | 山东琪康生物技术有限公司 | 一种高质量四黄止痢颗粒的检测方法 |
| CN112851660B (zh) * | 2019-11-12 | 2022-03-18 | 广东药科大学 | 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途 |
| KR102636847B1 (ko) * | 2020-09-18 | 2024-02-19 | 경북대학교 산학협력단 | 티아민 유도체를 포함하는 이식편대숙주질환 예방 또는 치료용 약학적 조성물 |
| CN111920777A (zh) * | 2020-09-18 | 2020-11-13 | 四川迪菲特药业有限公司 | 一种盐酸小檗碱片及其制备方法 |
| US20230112845A1 (en) * | 2020-10-23 | 2023-04-13 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| WO2022083713A1 (en) * | 2020-10-23 | 2022-04-28 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| WO2022161468A1 (en) * | 2021-01-28 | 2022-08-04 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating primary sclerosing cholangitis |
| US20230346803A1 (en) * | 2021-01-28 | 2023-11-02 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating primary sclerosing cholangitis |
| WO2023088463A1 (en) * | 2021-11-22 | 2023-05-25 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods of berberine ursodeoxycholate for modulating gut microbiome compositions |
| CN115710263A (zh) * | 2021-12-02 | 2023-02-24 | 山西医科大学 | 小檗碱新盐的晶型及其制备方法 |
| CN114716498B (zh) * | 2022-01-20 | 2024-01-23 | 成都贝诺科成生物科技有限公司 | 一种高稳定性的失碳熊去氧胆酸小檗碱盐晶型及其制备方法 |
| CN115477647A (zh) * | 2022-10-26 | 2022-12-16 | 山西医科大学 | 小檗碱富马酸盐晶型及其制备方法和其组合物与应用 |
| WO2024120452A1 (en) * | 2022-12-07 | 2024-06-13 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for prophylaxis and treatment of covid-19 |
| TW202432104A (zh) * | 2022-12-30 | 2024-08-16 | 大陸商深圳君聖泰生物技術有限公司 | 藥物組合、藥物組合物及其應用 |
| CN120659782A (zh) * | 2023-02-15 | 2025-09-16 | 深圳君圣泰生物技术有限公司 | 小檗碱牛磺熊去氧胆酸盐组合物及其方法 |
| WO2024179570A1 (en) * | 2023-03-01 | 2024-09-06 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for treating severe hypertriglyceridemia |
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| WO2007005644A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| AU2006275702A1 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| CA2616383C (en) | 2005-07-29 | 2015-06-09 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| CN102229636A (zh) * | 2011-04-21 | 2011-11-02 | 东北林业大学 | 小檗碱9位酯键偶合胆酸的新衍生物及其制备方法 |
| US9597337B2 (en) * | 2014-04-04 | 2017-03-21 | North American Biomedical Research Center Usa, Inc. | Berberine-ursodeoxycholic acid conjugate for treating the liver |
| CA2945609C (en) | 2014-07-29 | 2023-05-23 | Shenzhen Hightide Biopharmaceutical, Ltd. | Berberine-ursodeoxycholic salt, method of preparation and application therof |
| CN105693805A (zh) * | 2016-03-15 | 2016-06-22 | 合肥华方医药科技有限公司 | 一种胆酸类小檗碱偶合物的制备及医药用途 |
| CN108864077B (zh) * | 2017-05-12 | 2020-05-22 | 深圳君圣泰生物技术有限公司 | 小檗碱有机酸盐的固体形式及其制备方法 |
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2017
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2018
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| EP3625229B1 (en) | 2024-07-31 |
| EP3625229B9 (en) | 2024-10-09 |
| CN108864077B (zh) | 2020-05-22 |
| EP3625229A4 (en) | 2021-03-03 |
| JP2025183212A (ja) | 2025-12-16 |
| AU2022206685A1 (en) | 2022-08-11 |
| NZ799031A (en) | 2026-02-27 |
| US20210251981A1 (en) | 2021-08-19 |
| AU2022206685B2 (en) | 2024-05-02 |
| CA3062833A1 (en) | 2018-11-15 |
| JP7685314B2 (ja) | 2025-05-29 |
| EP3625229C0 (en) | 2024-07-31 |
| JP2020519654A (ja) | 2020-07-02 |
| NZ759154A (en) | 2024-07-26 |
| EP4234568A2 (en) | 2023-08-30 |
| JP7728295B2 (ja) | 2025-08-22 |
| US20200188387A1 (en) | 2020-06-18 |
| CN108864077A (zh) | 2018-11-23 |
| EA201992607A1 (ru) | 2020-06-29 |
| US10959999B2 (en) | 2021-03-30 |
| KR20250017765A (ko) | 2025-02-04 |
| US20250099456A1 (en) | 2025-03-27 |
| KR102761338B1 (ko) | 2025-02-04 |
| WO2018205987A1 (en) | 2018-11-15 |
| KR20230017930A (ko) | 2023-02-07 |
| EP4234568A3 (en) | 2024-01-03 |
| AU2018264384B2 (en) | 2022-05-19 |
| EP3625229A1 (en) | 2020-03-25 |
| US12138258B2 (en) | 2024-11-12 |
| AU2018264384A1 (en) | 2019-12-12 |
| JP2023104925A (ja) | 2023-07-28 |
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