ES2980575T3 - Derivados de 3-(5-metoxi-1-oxoisoindolin-2-il)piperidin-2,6-diona y usos de los mismos - Google Patents

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Publication number

ES2980575T3

ES2980575T3 ES20828350T ES20828350T ES2980575T3 ES 2980575 T3 ES2980575 T3 ES 2980575T3 ES 20828350 T ES20828350 T ES 20828350T ES 20828350 T ES20828350 T ES 20828350T ES 2980575 T3 ES2980575 T3 ES 2980575T3

Authority

ES

Spain

Prior art keywords

piperidin

methoxy

oxoisoindolin

dione

methyl

Prior art date

2019-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• UCRSTLCVZRQISL-UHFFFAOYSA-N 3-(6-methoxy-3-oxo-1h-isoindol-2-yl)piperidine-2,6-dione Chemical class C1C2=CC(OC)=CC=C2C(=O)N1C1CCC(=O)NC1=O UCRSTLCVZRQISL-UHFFFAOYSA-N 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims abstract description 210
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
• 238000011282 treatment Methods 0.000 claims abstract description 22
• 208000034737 hemoglobinopathy Diseases 0.000 claims abstract description 13
• 208000007056 sickle cell anemia Diseases 0.000 claims abstract description 13
• -1 -O-R3d Chemical group 0.000 claims description 216
• 125000000217 alkyl group Chemical group 0.000 claims description 199
• 229910052760 oxygen Inorganic materials 0.000 claims description 113
• 125000005842 heteroatom Chemical group 0.000 claims description 112
• 229910052717 sulfur Inorganic materials 0.000 claims description 111
• 125000003118 aryl group Chemical group 0.000 claims description 102
• 125000000623 heterocyclic group Chemical group 0.000 claims description 98
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 72
• 150000003839 salts Chemical class 0.000 claims description 69
• 229910052799 carbon Inorganic materials 0.000 claims description 63
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 54
• 229910052739 hydrogen Inorganic materials 0.000 claims description 50
• 239000001257 hydrogen Substances 0.000 claims description 50
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 44
• 125000003545 alkoxy group Chemical group 0.000 claims description 43
• KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical compound O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 claims description 41
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 39
• 125000001072 heteroaryl group Chemical group 0.000 claims description 39
• 125000001424 substituent group Chemical group 0.000 claims description 36
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 34
• 229910052757 nitrogen Inorganic materials 0.000 claims description 34
• 125000004574 piperidin-2-yl group Chemical group N1C(CCCC1)* 0.000 claims description 34
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 33
• 125000001188 haloalkyl group Chemical group 0.000 claims description 32
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 29
• 239000012453 solvate Substances 0.000 claims description 28
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 24
• 239000003814 drug Substances 0.000 claims description 22
• 229910052736 halogen Inorganic materials 0.000 claims description 22
• 150000002367 halogens Chemical class 0.000 claims description 22
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 17
• 229940124597 therapeutic agent Drugs 0.000 claims description 16
• SDPLBHSUQMOOOW-UHFFFAOYSA-N 3-[6-[(1-ethyl-3,3-dimethylpiperidin-2-yl)methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1C(C(CCC1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SDPLBHSUQMOOOW-UHFFFAOYSA-N 0.000 claims description 14
• 239000002253 acid Substances 0.000 claims description 14
• TYMLMVVEPPLHIL-VXVMZULRSA-N 3-[6-[1-[(2S)-1-ethylpyrrolidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCC1)C(C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O TYMLMVVEPPLHIL-VXVMZULRSA-N 0.000 claims description 13
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 11
• 208000002903 Thalassemia Diseases 0.000 claims description 11
• 125000000304 alkynyl group Chemical group 0.000 claims description 11
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 10
• 125000004432 carbon atom Chemical group C* 0.000 claims description 10
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 10
• 239000003937 drug carrier Substances 0.000 claims description 9
• 125000002947 alkylene group Chemical group 0.000 claims description 8
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 7
• BIHYTUFIRVEMRZ-BRIWLPCBSA-N 3-[3-oxo-6-[[(2R)-1-[(2-piperazin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=C(C=CC=C1)N1CCNCC1)C1C(NC(CC1)=O)=O BIHYTUFIRVEMRZ-BRIWLPCBSA-N 0.000 claims description 7
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 7
• UESKSUGPZYVRBU-GEPVFLLWSA-N 3-[6-[[(2R)-1-[(1-ethyl-2,3-dihydroindol-7-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1CCC2=CC=CC(=C12)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UESKSUGPZYVRBU-GEPVFLLWSA-N 0.000 claims description 6
• OMKDUTGZJMPVBT-VTBWFHPJSA-N 3-[3-oxo-6-[[(2R)-1-propan-2-ylpiperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O OMKDUTGZJMPVBT-VTBWFHPJSA-N 0.000 claims description 5
• DYXOTQFSMUNDCO-CILPGNKCSA-N 3-[6-[[(2R)-1-(2,3-dihydro-1H-indol-7-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1CCC2=CC=CC(=C12)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DYXOTQFSMUNDCO-CILPGNKCSA-N 0.000 claims description 5
• FJRVKDIBFCTIOT-PPUHSXQSSA-N 3-[6-[[(2R)-1-[(2-methoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 FJRVKDIBFCTIOT-PPUHSXQSSA-N 0.000 claims description 5
• FKCZMEITZWLJEK-UFUCKMQHSA-N 3-[6-[[(2R)-1-[(4-ethyl-2,3-dihydro-1,4-benzoxazin-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1C2=C(OCC1)C=CC=C2CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FKCZMEITZWLJEK-UFUCKMQHSA-N 0.000 claims description 5
• JAESGZSSTORQCB-ITUIMRKVSA-N 3-[6-[[(2R)-1-[(6-fluoropyridin-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=CC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JAESGZSSTORQCB-ITUIMRKVSA-N 0.000 claims description 5
• BPNSWQYAXYFQRP-MBIQTGHCSA-N 3-[6-[[(3S)-4-ethylmorpholin-3-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](COCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O BPNSWQYAXYFQRP-MBIQTGHCSA-N 0.000 claims description 5
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
• DELPKCKGPQRPAM-UHFFFAOYSA-N 3-[6-[(4-ethyl-6,6-dimethylmorpholin-3-yl)methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1C(COC(C1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DELPKCKGPQRPAM-UHFFFAOYSA-N 0.000 claims description 4
• JACXNMQINIRPRG-LCQOSCCDSA-N 3-[6-[[(2R)-1-(1,3-benzodioxol-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1COC2=C1C=CC(=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JACXNMQINIRPRG-LCQOSCCDSA-N 0.000 claims description 4
• ZWWBQSFKZVVTCB-MIJJZIGMSA-N 3-[6-[[(2R)-1-[[2-(4-ethylpiperazin-1-yl)-5-fluorophenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1CCN(CC1)C1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C(C=C1)F ZWWBQSFKZVVTCB-MIJJZIGMSA-N 0.000 claims description 4
• QCEFQWDJOQNXBO-IIGOATNISA-N 3-[6-[[(2R)-1-[[2-[4-(oxan-4-ylmethyl)piperazin-1-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=C(C=CC=C1)N1CCN(CC1)CC1CCOCC1)C1C(NC(CC1)=O)=O QCEFQWDJOQNXBO-IIGOATNISA-N 0.000 claims description 4
• HNNZLAMSNVVMEP-ZZTVPSNHSA-N 3-[6-[[(2R)-1-[[4-[4-(cyclopropylmethyl)piperazin-1-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CC1)CN1CCN(CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 HNNZLAMSNVVMEP-ZZTVPSNHSA-N 0.000 claims description 4
• DANAVBYBZFXJOL-UYEDPJPISA-N 3-[6-[[(2R)-1-[[4-[4-(oxan-4-yl)piperazin-1-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=C(C=C1)N1CCN(CC1)C1CCOCC1)C1C(NC(CC1)=O)=O DANAVBYBZFXJOL-UYEDPJPISA-N 0.000 claims description 4
• 150000002431 hydrogen Chemical class 0.000 claims description 4
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 4
• BMCREDWQKWZWEA-LCQOSCCDSA-N 3-[3-oxo-6-[[(2R)-1-[(3-oxo-4H-1,4-benzoxazin-5-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=CC=2OCC(NC=21)=O)C1C(NC(CC1)=O)=O BMCREDWQKWZWEA-LCQOSCCDSA-N 0.000 claims description 3
• YMHQRQIVWNGUMS-RXVAYIKUSA-N 3-[3-oxo-6-[[(2R)-1-[(4-piperidin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=C(C=C1)N1CCCCC1)C1C(NC(CC1)=O)=O YMHQRQIVWNGUMS-RXVAYIKUSA-N 0.000 claims description 3
• AJIPEDQAJXKIBZ-PPUHSXQSSA-N 3-[6-[[(2R)-1-(3,4-dihydro-2H-1,4-benzoxazin-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1C2=C(NCC1)C(=CC=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O AJIPEDQAJXKIBZ-PPUHSXQSSA-N 0.000 claims description 3
• SUXPQVBXIYCGFH-ITUIMRKVSA-N 3-[6-[[(2R)-1-(4,4-difluorocyclohexyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1(CCC(CC1)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)F SUXPQVBXIYCGFH-ITUIMRKVSA-N 0.000 claims description 3
• YKXFDECQQUVBHX-FIQOPJFZSA-N 3-[6-[[(2R)-1-[(3-ethyl-4-piperidin-4-ylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1C1CCNCC1 YKXFDECQQUVBHX-FIQOPJFZSA-N 0.000 claims description 3
• ANMFNLMNPWXDRX-MOFFZIGISA-N 3-[6-[[(2R)-1-[[3-ethyl-4-(1-ethylpiperidin-4-yl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1C1CCN(CC1)CC ANMFNLMNPWXDRX-MOFFZIGISA-N 0.000 claims description 3
• YTTNRAPGRFUDIV-ZZTVPSNHSA-N 3-[6-[[(2R)-1-[[4-[4-(oxetan-3-ylmethyl)piperazin-1-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CC(C1)CN1CCN(CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 YTTNRAPGRFUDIV-ZZTVPSNHSA-N 0.000 claims description 3
• PTYLKMXUIPMTNK-LCQOSCCDSA-N 3-[6-[[(2R)-1-benzoylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)(=O)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O PTYLKMXUIPMTNK-LCQOSCCDSA-N 0.000 claims description 3
• DHFJHVJOMHNTSK-NNJIEVJOSA-N 3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-NNJIEVJOSA-N 0.000 claims description 3
• ZBPIJUXCCIJKSO-RZNDIHJXSA-N 3-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]bicyclo[1.1.1]pentane-1-carbonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC12CC(C1)(C2)C#N)=O)=O ZBPIJUXCCIJKSO-RZNDIHJXSA-N 0.000 claims description 3
• 125000002757 morpholinyl group Chemical group 0.000 claims description 3
• 125000004193 piperazinyl group Chemical group 0.000 claims description 3
• DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims description 3
• 125000003386 piperidinyl group Chemical group 0.000 claims description 3
• FMTAFXCDCOSCLC-UFUCKMQHSA-N 3-[3-oxo-6-[[(2R)-1-(2-phenylmethoxyethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)OCCN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FMTAFXCDCOSCLC-UFUCKMQHSA-N 0.000 claims description 2
• KUXGMLPREIKZQY-CGHJUBPDSA-N 3-[6-[[(2R)-1-[(2,4-dimethoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC(=C1)OC KUXGMLPREIKZQY-CGHJUBPDSA-N 0.000 claims description 2
• LCQBAPGKPOLKAR-DIAVIDTQSA-N 3-[6-[[(2R)-1-[(3,3-difluorocyclobutyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1(CC(C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)F LCQBAPGKPOLKAR-DIAVIDTQSA-N 0.000 claims description 2
• UMADQLRVIMYBRW-VQUJKIMHSA-N 3-[6-[[(2R)-1-[(3-fluoro-1-bicyclo[1.1.1]pentanyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC12CC(C1)(C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UMADQLRVIMYBRW-VQUJKIMHSA-N 0.000 claims description 2
• AQVJZYAJEFHYJN-HWYAHNCWSA-N 3-[6-[[(2R)-1-[(3-fluoro-4-methoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1OC AQVJZYAJEFHYJN-HWYAHNCWSA-N 0.000 claims description 2
• ALSVDULFHBEPDH-BRIWLPCBSA-N 3-[6-[[(2R)-1-[(5-fluoro-2-piperazin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=CC(=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=1)N1CCNCC1 ALSVDULFHBEPDH-BRIWLPCBSA-N 0.000 claims description 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 125000004043 oxo group Chemical group O=* 0.000 claims 8
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
• RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 2
• FXVBPOZXSQBDAF-LZBRWLDZSA-N (3R)-3-[6-[[(1R,3R,4S)-2-ethyl-2-azabicyclo[2.2.1]heptan-3-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H]2CC[C@H]([C@@H]1COC=1C=C3CN(C(C3=CC=1)=O)[C@H]1C(NC(CC1)=O)=O)C2 FXVBPOZXSQBDAF-LZBRWLDZSA-N 0.000 claims 1
• FXVBPOZXSQBDAF-ALQDCCJHSA-N (3R)-3-[6-[[(1S,3S,4R)-2-ethyl-2-azabicyclo[2.2.1]heptan-3-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H]2CC[C@@H]([C@H]1COC=1C=C3CN(C(C3=CC=1)=O)[C@H]1C(NC(CC1)=O)=O)C2 FXVBPOZXSQBDAF-ALQDCCJHSA-N 0.000 claims 1
• JJRMOUOVYXNVIK-RHSMWYFYSA-N (3R)-3-[6-[[(2R)-1-ethyl-4,4-difluoropiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CC(CC1)(F)F)COC=1C=C2CN(C(C2=CC=1)=O)[C@H]1C(NC(CC1)=O)=O JJRMOUOVYXNVIK-RHSMWYFYSA-N 0.000 claims 1
• DHFJHVJOMHNTSK-CRAIPNDOSA-N (3R)-3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)[C@H]1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-CRAIPNDOSA-N 0.000 claims 1
• JJRMOUOVYXNVIK-WMLDXEAASA-N (3R)-3-[6-[[(2S)-1-ethyl-4,4-difluoropiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CC(CC1)(F)F)COC=1C=C2CN(C(C2=CC=1)=O)[C@H]1C(NC(CC1)=O)=O JJRMOUOVYXNVIK-WMLDXEAASA-N 0.000 claims 1
• DHFJHVJOMHNTSK-MAUKXSAKSA-N (3R)-3-[6-[[(2S)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)[C@H]1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-MAUKXSAKSA-N 0.000 claims 1
• JJRMOUOVYXNVIK-PBHICJAKSA-N (3S)-3-[6-[[(2R)-1-ethyl-4,4-difluoropiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CC(CC1)(F)F)COC=1C=C2CN(C(C2=CC=1)=O)[C@@H]1C(NC(CC1)=O)=O JJRMOUOVYXNVIK-PBHICJAKSA-N 0.000 claims 1
• DHFJHVJOMHNTSK-QAPCUYQASA-N (3S)-3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)[C@@H]1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-QAPCUYQASA-N 0.000 claims 1
• JJRMOUOVYXNVIK-YOEHRIQHSA-N (3S)-3-[6-[[(2S)-1-ethyl-4,4-difluoropiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CC(CC1)(F)F)COC=1C=C2CN(C(C2=CC=1)=O)[C@@H]1C(NC(CC1)=O)=O JJRMOUOVYXNVIK-YOEHRIQHSA-N 0.000 claims 1
• DHFJHVJOMHNTSK-YJBOKZPZSA-N (3S)-3-[6-[[(2S)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)[C@@H]1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-YJBOKZPZSA-N 0.000 claims 1
• 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
• NIFKWUSOZDUTDG-LJQANCHMSA-N 1-[6-[[(2R)-1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1SC(=C(N=1)C)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)N1C(CCCC1=O)=O NIFKWUSOZDUTDG-LJQANCHMSA-N 0.000 claims 1
• JHYJISPZAQABLX-CILPGNKCSA-N 2-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]benzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC1=C(C#N)C=CC=C1)=O)=O JHYJISPZAQABLX-CILPGNKCSA-N 0.000 claims 1
• FVRZJVVQUUGASD-CILPGNKCSA-N 2-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC=1N=C2N(C=CC(=C2)C#N)C=1)=O)=O FVRZJVVQUUGASD-CILPGNKCSA-N 0.000 claims 1
• JHYJISPZAQABLX-XEGCMXMBSA-N 2-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]benzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC1=C(C#N)C=CC=C1)=O)=O JHYJISPZAQABLX-XEGCMXMBSA-N 0.000 claims 1
• FVRZJVVQUUGASD-XEGCMXMBSA-N 2-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC=1N=C2N(C=CC(=C2)C#N)C=1)=O)=O FVRZJVVQUUGASD-XEGCMXMBSA-N 0.000 claims 1
• ZYMYGKSXEPSVDE-HXBUSHRASA-N 2-chloro-5-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]benzenesulfonamide Chemical compound ClC1=C(C=C(C=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)S(=O)(=O)N ZYMYGKSXEPSVDE-HXBUSHRASA-N 0.000 claims 1
• VHPLOIFUSZRJDE-DIAVIDTQSA-N 3-[3-oxo-6-[[(2R)-1-(1H-pyrazol-4-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1N=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VHPLOIFUSZRJDE-DIAVIDTQSA-N 0.000 claims 1
• CRFOMUFNRNZPKX-HWYAHNCWSA-N 3-[3-oxo-6-[[(2R)-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=CC=2C1=NC=CC=2CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O CRFOMUFNRNZPKX-HWYAHNCWSA-N 0.000 claims 1
• ZFMKKDUTSHFYHN-LCQOSCCDSA-N 3-[3-oxo-6-[[(2R)-1-(pyridin-4-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=NC=C1)C1C(NC(CC1)=O)=O ZFMKKDUTSHFYHN-LCQOSCCDSA-N 0.000 claims 1
• ZJZOVLUULBTWFK-ITUIMRKVSA-N 3-[3-oxo-6-[[(2R)-1-(pyrimidin-5-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C=NC=NC=1)C1C(NC(CC1)=O)=O ZJZOVLUULBTWFK-ITUIMRKVSA-N 0.000 claims 1
• XYFJBKNHRMBHES-FPSALIRRSA-N 3-[3-oxo-6-[[(2R)-1-(quinolin-2-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=NC2=CC=CC=C2C=C1)C1C(NC(CC1)=O)=O XYFJBKNHRMBHES-FPSALIRRSA-N 0.000 claims 1
• UMFPGJIATAXVLK-FPSALIRRSA-N 3-[3-oxo-6-[[(2R)-1-(quinolin-3-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C=NC2=CC=CC=C2C=1)C1C(NC(CC1)=O)=O UMFPGJIATAXVLK-FPSALIRRSA-N 0.000 claims 1
• BTYROQKKGVVMHL-UFUCKMQHSA-N 3-[3-oxo-6-[[(2R)-1-[(1-propan-2-ylpiperidin-4-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)N1CCC(CC1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O BTYROQKKGVVMHL-UFUCKMQHSA-N 0.000 claims 1
• ZRLRSWANVKEUAW-PPUHSXQSSA-N 3-[3-oxo-6-[[(2R)-1-[(1-pyrazin-2-ylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C=NN(C=1)C1=NC=CN=C1)C1C(NC(CC1)=O)=O ZRLRSWANVKEUAW-PPUHSXQSSA-N 0.000 claims 1
• GMXAAUDZSDVKKE-ITUIMRKVSA-N 3-[3-oxo-6-[[(2R)-1-[(2-oxo-1H-pyridin-3-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C(NC=CC=1)=O)C1C(NC(CC1)=O)=O GMXAAUDZSDVKKE-ITUIMRKVSA-N 0.000 claims 1
• TZIAYOODDGXKQP-RIBGEGAISA-N 3-[3-oxo-6-[[(2R)-1-[(2-piperidin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=C(C=CC=C1)N1CCCCC1)C1C(NC(CC1)=O)=O TZIAYOODDGXKQP-RIBGEGAISA-N 0.000 claims 1
• ZQCBTOUKKHXNOO-PLEWWHCXSA-N 3-[3-oxo-6-[[(2R)-1-[(3,4,5-trifluorophenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC(=C(C(=C1)F)F)F)C1C(NC(CC1)=O)=O ZQCBTOUKKHXNOO-PLEWWHCXSA-N 0.000 claims 1
• DAWUVGGYQOCDCW-DXDQHDRFSA-N 3-[3-oxo-6-[[(2R)-1-[(3-pyrrolidin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC(=CC=C1)N1CCCC1)C1C(NC(CC1)=O)=O DAWUVGGYQOCDCW-DXDQHDRFSA-N 0.000 claims 1
• XNCKRDWTFZAIIE-UFUCKMQHSA-N 3-[3-oxo-6-[[(2R)-1-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C=NC(=CC=1)N1CCCC1)C1C(NC(CC1)=O)=O XNCKRDWTFZAIIE-UFUCKMQHSA-N 0.000 claims 1
• BPKOGLWJADSAAD-XXTRANHVSA-N 3-[3-oxo-6-[[(2R)-1-[[(3R)-oxolan-3-yl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)C[C@@H]1COCC1)C1C(NC(CC1)=O)=O BPKOGLWJADSAAD-XXTRANHVSA-N 0.000 claims 1
• BPKOGLWJADSAAD-NOORDXFBSA-N 3-[3-oxo-6-[[(2R)-1-[[(3S)-oxolan-3-yl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)C[C@H]1COCC1)C1C(NC(CC1)=O)=O BPKOGLWJADSAAD-NOORDXFBSA-N 0.000 claims 1
• LSZDASRNKBCGTE-GEPVFLLWSA-N 3-[3-oxo-6-[[(2R)-1-[[2-(1,2,4-triazol-1-ylmethyl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(N=CN=C1)CC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 LSZDASRNKBCGTE-GEPVFLLWSA-N 0.000 claims 1
• HFKRYPXYGCFGQU-DXDQHDRFSA-N 3-[3-oxo-6-[[(2R)-1-[[3-(pyrazol-1-ylmethyl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(N=CC=C1)CC=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 HFKRYPXYGCFGQU-DXDQHDRFSA-N 0.000 claims 1
• CZWIYIOIRCBBPC-DXDQHDRFSA-N 3-[3-oxo-6-[[(2R)-1-[[4-(pyrrolidine-1-carbonyl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=C(C=C1)C(=O)N1CCCC1)C1C(NC(CC1)=O)=O CZWIYIOIRCBBPC-DXDQHDRFSA-N 0.000 claims 1
• QNBVQSXGXRNJFK-UFUCKMQHSA-N 3-[3-oxo-6-[[(2R)-1-[[4-(triazol-2-yl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N=1N(N=CC=1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 QNBVQSXGXRNJFK-UFUCKMQHSA-N 0.000 claims 1
• WYTMEFPYBUQSFN-HWYAHNCWSA-N 3-[3-oxo-6-[[(2R)-1-[[4-(trifluoromethoxy)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1=CC=C(C=C1)OC(F)(F)F)C1C(NC(CC1)=O)=O WYTMEFPYBUQSFN-HWYAHNCWSA-N 0.000 claims 1
• DOLRNPOPCBRBGR-AJZOCDQUSA-N 3-[3-oxo-6-[[(2S)-1-(1-phenyl-1,2,4-triazole-3-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)C(=O)C1=NN(C=N1)C1=CC=CC=C1)C1C(NC(CC1)=O)=O DOLRNPOPCBRBGR-AJZOCDQUSA-N 0.000 claims 1
• VHPLOIFUSZRJDE-DIMJTDRSSA-N 3-[3-oxo-6-[[(2S)-1-(1H-pyrazol-4-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1N=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VHPLOIFUSZRJDE-DIMJTDRSSA-N 0.000 claims 1
• CRFOMUFNRNZPKX-HSTJUUNISA-N 3-[3-oxo-6-[[(2S)-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=CC=2C1=NC=CC=2CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O CRFOMUFNRNZPKX-HSTJUUNISA-N 0.000 claims 1
• JWHLQEIZKZFTKY-YDNXMHBPSA-N 3-[3-oxo-6-[[(2S)-1-(2-piperidin-1-yl-1,3-thiazole-5-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)C(=O)C1=CN=C(S1)N1CCCCC1)C1C(NC(CC1)=O)=O JWHLQEIZKZFTKY-YDNXMHBPSA-N 0.000 claims 1
• CEBHOCCORFEPFO-PBVYKCSPSA-N 3-[3-oxo-6-[[(2S)-1-(3-propan-2-yl-1,2-oxazole-5-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)C1=NOC(=C1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O CEBHOCCORFEPFO-PBVYKCSPSA-N 0.000 claims 1
• GBISCWSFISIGEQ-BXXZMZEQSA-N 3-[3-oxo-6-[[(2S)-1-(4-pentylbenzoyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)C(C1=CC=C(C=C1)CCCCC)=O)C1C(NC(CC1)=O)=O GBISCWSFISIGEQ-BXXZMZEQSA-N 0.000 claims 1
• FRANGHYFDPEXLH-PBVYKCSPSA-N 3-[3-oxo-6-[[(2S)-1-(5-propan-2-yl-1,2-oxazole-3-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)C1=CC(=NO1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FRANGHYFDPEXLH-PBVYKCSPSA-N 0.000 claims 1
• YJAJGYJSBTUVHN-LBOXEOMUSA-N 3-[3-oxo-6-[[(2S)-1-(5-propyl-1,2-oxazole-3-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)C(=O)C1=NOC(=C1)CCC)C1C(NC(CC1)=O)=O YJAJGYJSBTUVHN-LBOXEOMUSA-N 0.000 claims 1
• ZJZOVLUULBTWFK-YMXDCFFPSA-N 3-[3-oxo-6-[[(2S)-1-(pyrimidin-5-ylmethyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC=1C=NC=NC=1)C1C(NC(CC1)=O)=O ZJZOVLUULBTWFK-YMXDCFFPSA-N 0.000 claims 1
• ZPWUMMAUGUOKAV-XGLRFROISA-N 3-[3-oxo-6-[[(2S)-1-(quinoxaline-6-carbonyl)piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)C(=O)C=1C=C2N=CC=NC2=CC=1)C1C(NC(CC1)=O)=O ZPWUMMAUGUOKAV-XGLRFROISA-N 0.000 claims 1
• BTYROQKKGVVMHL-XADRRFQNSA-N 3-[3-oxo-6-[[(2S)-1-[(1-propan-2-ylpiperidin-4-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)N1CCC(CC1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O BTYROQKKGVVMHL-XADRRFQNSA-N 0.000 claims 1
• GMXAAUDZSDVKKE-YMXDCFFPSA-N 3-[3-oxo-6-[[(2S)-1-[(2-oxo-1H-pyridin-3-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC=1C(NC=CC=1)=O)C1C(NC(CC1)=O)=O GMXAAUDZSDVKKE-YMXDCFFPSA-N 0.000 claims 1
• YCONEHXSAHPJPB-YMXDCFFPSA-N 3-[3-oxo-6-[[(2S)-1-[(2-oxo-1H-pyridin-4-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound OC1=NC=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O YCONEHXSAHPJPB-YMXDCFFPSA-N 0.000 claims 1
• DAWUVGGYQOCDCW-BXXZMZEQSA-N 3-[3-oxo-6-[[(2S)-1-[(3-pyrrolidin-1-ylphenyl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC1=CC(=CC=C1)N1CCCC1)C1C(NC(CC1)=O)=O DAWUVGGYQOCDCW-BXXZMZEQSA-N 0.000 claims 1
• DTDPMHUJPAMKIL-TYKNXJODSA-N 3-[3-oxo-6-[[(2S)-1-[(5-pyridin-3-yloxy-2H-indazol-3-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC1=NNC2=CC=C(C=C12)OC=1C=NC=CC=1)C1C(NC(CC1)=O)=O DTDPMHUJPAMKIL-TYKNXJODSA-N 0.000 claims 1
• XNCKRDWTFZAIIE-XADRRFQNSA-N 3-[3-oxo-6-[[(2S)-1-[(6-pyrrolidin-1-ylpyridin-3-yl)methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC=1C=NC(=CC=1)N1CCCC1)C1C(NC(CC1)=O)=O XNCKRDWTFZAIIE-XADRRFQNSA-N 0.000 claims 1
• HFKRYPXYGCFGQU-BXXZMZEQSA-N 3-[3-oxo-6-[[(2S)-1-[[3-(pyrazol-1-ylmethyl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(N=CC=C1)CC=1C=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 HFKRYPXYGCFGQU-BXXZMZEQSA-N 0.000 claims 1
• GMSRIMVHZSTKRG-ZZHFZYNASA-N 3-[3-oxo-6-[[(2S)-1-[[4-(2-oxopyrrolidin-1-yl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC1=CC=C(C=C1)N1C(CCC1)=O)C1C(NC(CC1)=O)=O GMSRIMVHZSTKRG-ZZHFZYNASA-N 0.000 claims 1
• CZWIYIOIRCBBPC-BXXZMZEQSA-N 3-[3-oxo-6-[[(2S)-1-[[4-(pyrrolidine-1-carbonyl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC1=CC=C(C=C1)C(=O)N1CCCC1)C1C(NC(CC1)=O)=O CZWIYIOIRCBBPC-BXXZMZEQSA-N 0.000 claims 1
• QNBVQSXGXRNJFK-XADRRFQNSA-N 3-[3-oxo-6-[[(2S)-1-[[4-(triazol-2-yl)phenyl]methyl]piperidin-2-yl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N=1N(N=CC=1)C1=CC=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 QNBVQSXGXRNJFK-XADRRFQNSA-N 0.000 claims 1
• YPOMBOMUPFSHOZ-UHFFFAOYSA-N 3-[6-[(1-ethyl-4-fluoropiperidin-2-yl)methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1C(CC(CC1)F)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O YPOMBOMUPFSHOZ-UHFFFAOYSA-N 0.000 claims 1
• FVZCFUKXGUUDBQ-QSFPRURJSA-N 3-[6-[(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CCCC1)[C@@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FVZCFUKXGUUDBQ-QSFPRURJSA-N 0.000 claims 1
• FVZCFUKXGUUDBQ-FQPPOJKCSA-N 3-[6-[(1R)-1-[(2S)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCCC1)[C@@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FVZCFUKXGUUDBQ-FQPPOJKCSA-N 0.000 claims 1
• TYMLMVVEPPLHIL-GTDUKUAFSA-N 3-[6-[(1R)-1-[(2S)-1-ethylpyrrolidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCC1)[C@@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O TYMLMVVEPPLHIL-GTDUKUAFSA-N 0.000 claims 1
• FVZCFUKXGUUDBQ-BQGOGBDGSA-N 3-[6-[(1S)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](CCCC1)[C@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FVZCFUKXGUUDBQ-BQGOGBDGSA-N 0.000 claims 1
• FVZCFUKXGUUDBQ-ZWSMLAFMSA-N 3-[6-[(1S)-1-[(2S)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCCC1)[C@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FVZCFUKXGUUDBQ-ZWSMLAFMSA-N 0.000 claims 1
• TYMLMVVEPPLHIL-VELWFJCASA-N 3-[6-[(1S)-1-[(2S)-1-ethylpyrrolidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCC1)[C@H](C)OC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O TYMLMVVEPPLHIL-VELWFJCASA-N 0.000 claims 1
• JBUJIHGPJGAYLR-UHFFFAOYSA-N 3-[6-[(4,4-difluoropiperidin-2-yl)methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1(CC(NCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)F JBUJIHGPJGAYLR-UHFFFAOYSA-N 0.000 claims 1
• XDRVDQUOSWKWAT-HWYAHNCWSA-N 3-[6-[[(2R)-1-(1,3-benzoxazol-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1C=NC2=C1C=CC(=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O XDRVDQUOSWKWAT-HWYAHNCWSA-N 0.000 claims 1
• PYWHEFPNMQMKLL-NNJIEVJOSA-N 3-[6-[[(2R)-1-(1,3-oxazole-5-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1C=NC=C1C(=O)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O PYWHEFPNMQMKLL-NNJIEVJOSA-N 0.000 claims 1
• MOKNFZWBPHPCRQ-VTBWFHPJSA-N 3-[6-[[(2R)-1-(1H-imidazol-2-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C(=NC=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O MOKNFZWBPHPCRQ-VTBWFHPJSA-N 0.000 claims 1
• LVAZWCSCNHGDAX-DIAVIDTQSA-N 3-[6-[[(2R)-1-(1H-imidazol-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=NC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O LVAZWCSCNHGDAX-DIAVIDTQSA-N 0.000 claims 1
• MAJCCITUIXXQCM-PPUHSXQSSA-N 3-[6-[[(2R)-1-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1C2=C(OCC1)C(=CC=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O MAJCCITUIXXQCM-PPUHSXQSSA-N 0.000 claims 1
• ABYUWQACCCIQPP-VTBWFHPJSA-N 3-[6-[[(2R)-1-(2-methylpropanoyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C(C)C)(=O)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O ABYUWQACCCIQPP-VTBWFHPJSA-N 0.000 claims 1
• JYTLGMQRBQTPQN-DIAVIDTQSA-N 3-[6-[[(2R)-1-(2-methylpropyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C(C)C)N1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JYTLGMQRBQTPQN-DIAVIDTQSA-N 0.000 claims 1
• LPLSUTHCWQRLRY-PHSANKKPSA-N 3-[6-[[(2R)-1-(3H-benzimidazol-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=NC2=C1C=CC(=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O LPLSUTHCWQRLRY-PHSANKKPSA-N 0.000 claims 1
• OZGNPVVQNBHPIP-PPUHSXQSSA-N 3-[6-[[(2R)-1-(cyclohexylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CCCCC1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O OZGNPVVQNBHPIP-PPUHSXQSSA-N 0.000 claims 1
• NUVMWJYBEKEVMQ-DIAVIDTQSA-N 3-[6-[[(2R)-1-(cyclopropylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CC1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O NUVMWJYBEKEVMQ-DIAVIDTQSA-N 0.000 claims 1
• XCKSNQQEABTUEV-PPUHSXQSSA-N 3-[6-[[(2R)-1-(imidazo[1,2-a]pyridin-8-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N=1C=CN2C=1C(=CC=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O XCKSNQQEABTUEV-PPUHSXQSSA-N 0.000 claims 1
• ATYGMXOJZSLCQD-LCQOSCCDSA-N 3-[6-[[(2R)-1-(oxan-4-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC1CCOCC1)C1C(NC(CC1)=O)=O ATYGMXOJZSLCQD-LCQOSCCDSA-N 0.000 claims 1
• HHAPUSYEFJWVCS-DIAVIDTQSA-N 3-[6-[[(2R)-1-(oxetan-3-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CC(C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O HHAPUSYEFJWVCS-DIAVIDTQSA-N 0.000 claims 1
• RVZFXXYFFZMTAZ-GEPVFLLWSA-N 3-[6-[[(2R)-1-[(1-benzylimidazol-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1C(=NC=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RVZFXXYFFZMTAZ-GEPVFLLWSA-N 0.000 claims 1
• WLPOIWLWKGVZBB-QZWVJJBASA-N 3-[6-[[(2R)-1-[(1-benzylpiperidin-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1CCC(CC1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O WLPOIWLWKGVZBB-QZWVJJBASA-N 0.000 claims 1
• NHYSSHVYYHDWTI-DXDQHDRFSA-N 3-[6-[[(2R)-1-[(1-benzylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1N=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O NHYSSHVYYHDWTI-DXDQHDRFSA-N 0.000 claims 1
• RHSPRKSLMMGCDU-GEPVFLLWSA-N 3-[6-[[(2R)-1-[(1-cyclohexylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CCCCC1)N1N=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RHSPRKSLMMGCDU-GEPVFLLWSA-N 0.000 claims 1
• BJXHEYZUCUAELM-LCQOSCCDSA-N 3-[6-[[(2R)-1-[(1-ethylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1N=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O BJXHEYZUCUAELM-LCQOSCCDSA-N 0.000 claims 1
• ZLOGAMSMVMAPIB-GEPVFLLWSA-N 3-[6-[[(2R)-1-[(1-methyl-5-phenylpyrazol-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=C(C=C1C1=CC=CC=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O ZLOGAMSMVMAPIB-GEPVFLLWSA-N 0.000 claims 1
• RUNQXRYKRWBRBM-PHSANKKPSA-N 3-[6-[[(2R)-1-[(1-methylbenzimidazol-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C(=NC2=C1C=CC=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RUNQXRYKRWBRBM-PHSANKKPSA-N 0.000 claims 1
• GYEGKWQXHXNJSW-PHSANKKPSA-N 3-[6-[[(2R)-1-[(1-methylbenzotriazol-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=NC2=C1C=CC(=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O GYEGKWQXHXNJSW-PHSANKKPSA-N 0.000 claims 1
• UECKRCWNHPAJKR-OSMGYRLQSA-N 3-[6-[[(2R)-1-[(1-methylindol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C=CC2=C(C=CC=C12)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UECKRCWNHPAJKR-OSMGYRLQSA-N 0.000 claims 1
• ILXOWOYLHIFRCQ-ITUIMRKVSA-N 3-[6-[[(2R)-1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1(OC2=C(O1)C=CC(=C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)F ILXOWOYLHIFRCQ-ITUIMRKVSA-N 0.000 claims 1
• RCIWXIAPQBNEPE-HWYAHNCWSA-N 3-[6-[[(2R)-1-[(2,4-difluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC(=C1)F RCIWXIAPQBNEPE-HWYAHNCWSA-N 0.000 claims 1
• MRQPQBCONBVJIP-LIXIDFRTSA-N 3-[6-[[(2R)-1-[(2,6-difluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C(=CC=C1)F MRQPQBCONBVJIP-LIXIDFRTSA-N 0.000 claims 1
• NFFGPEAVEQMQFS-HWYAHNCWSA-N 3-[6-[[(2R)-1-[(2-chloro-4-fluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC(=C1)F NFFGPEAVEQMQFS-HWYAHNCWSA-N 0.000 claims 1
• JOTLNMQSDRSCGJ-ZZWBGTBQSA-N 3-[6-[[(2R)-1-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C=1NC(=C(N=1)C)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JOTLNMQSDRSCGJ-ZZWBGTBQSA-N 0.000 claims 1
• GONVTGOXRBKTDB-ITUIMRKVSA-N 3-[6-[[(2R)-1-[(2-fluoropyridin-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=NC=CC=C1CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O GONVTGOXRBKTDB-ITUIMRKVSA-N 0.000 claims 1
• HOOSKBLQUNVSEP-ITUIMRKVSA-N 3-[6-[[(2R)-1-[(2-methyl-1H-imidazol-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1NC(=CN=1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O HOOSKBLQUNVSEP-ITUIMRKVSA-N 0.000 claims 1
• HEFJXIDNYPWIGI-PPUHSXQSSA-N 3-[6-[[(2R)-1-[(2-methylimidazo[1,2-a]pyridin-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N=C2N(C=CC=C2)C=1CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O HEFJXIDNYPWIGI-PPUHSXQSSA-N 0.000 claims 1
• GSGWECDVWNHEEV-BRIWLPCBSA-N 3-[6-[[(2R)-1-[(2-morpholin-4-ylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 GSGWECDVWNHEEV-BRIWLPCBSA-N 0.000 claims 1
• SOCYKQKRZGCGPV-UFUCKMQHSA-N 3-[6-[[(2R)-1-[(2-morpholin-4-ylpyridin-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=NC=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SOCYKQKRZGCGPV-UFUCKMQHSA-N 0.000 claims 1
• DRALMOMZCUYHDP-FKSKYRLFSA-N 3-[6-[[(2R)-1-[(3,4-difluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1F DRALMOMZCUYHDP-FKSKYRLFSA-N 0.000 claims 1
• VDOISWOCFIFGFM-ZZWBGTBQSA-N 3-[6-[[(2R)-1-[(3-fluoro-2-hydroxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C(=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1)O VDOISWOCFIFGFM-ZZWBGTBQSA-N 0.000 claims 1
• MILABUGZFRFKRE-RZNDIHJXSA-N 3-[6-[[(2R)-1-[(3-methoxy-1-bicyclo[1.1.1]pentanyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC12CC(C1)(C2)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O MILABUGZFRFKRE-RZNDIHJXSA-N 0.000 claims 1
• FIFAQFVYYISMHA-CILPGNKCSA-N 3-[6-[[(2R)-1-[(3-methoxy-4-methylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1C FIFAQFVYYISMHA-CILPGNKCSA-N 0.000 claims 1
• VQCZPHVZQMJAFN-OQHSHRKDSA-N 3-[6-[[(2R)-1-[(3-methylimidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C=NC=C1CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VQCZPHVZQMJAFN-OQHSHRKDSA-N 0.000 claims 1
• SNSFCHDKLSOXOY-PPUHSXQSSA-N 3-[6-[[(2R)-1-[(4-fluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 SNSFCHDKLSOXOY-PPUHSXQSSA-N 0.000 claims 1
• XPGCQHPGIKWCSW-HWYAHNCWSA-N 3-[6-[[(2R)-1-[(4-hydroxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound OC1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 XPGCQHPGIKWCSW-HWYAHNCWSA-N 0.000 claims 1
• CRDZSFINOIZXII-DIAVIDTQSA-N 3-[6-[[(2R)-1-[(4-methyl-1,3-thiazol-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N=C(SC=1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O CRDZSFINOIZXII-DIAVIDTQSA-N 0.000 claims 1
• XXDWVEPLIZXTRG-LCQOSCCDSA-N 3-[6-[[(2R)-1-[(4-methyloxan-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1(CCOCC1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O XXDWVEPLIZXTRG-LCQOSCCDSA-N 0.000 claims 1
• VJFBGALUNONBAH-DXDQHDRFSA-N 3-[6-[[(2R)-1-[(4-morpholin-4-ylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 VJFBGALUNONBAH-DXDQHDRFSA-N 0.000 claims 1
• POBKYGGKMYGFEN-LCQOSCCDSA-N 3-[6-[[(2R)-1-[(5-fluoropyridin-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=CC(=NC=1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O POBKYGGKMYGFEN-LCQOSCCDSA-N 0.000 claims 1
• SJGBEBROFHGYHB-ITUIMRKVSA-N 3-[6-[[(2R)-1-[(5-methyl-1,2-oxazol-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=CC(=NO1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SJGBEBROFHGYHB-ITUIMRKVSA-N 0.000 claims 1
• PJHXVNXZJATIAR-OQHSHRKDSA-N 3-[6-[[(2R)-1-[(5-methyl-1H-imidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N=CNC=1CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O PJHXVNXZJATIAR-OQHSHRKDSA-N 0.000 claims 1
• MMCZOWALTOTBFI-UFUCKMQHSA-N 3-[6-[[(2R)-1-[(6-morpholin-4-ylpyridin-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=CC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O MMCZOWALTOTBFI-UFUCKMQHSA-N 0.000 claims 1
• YMTGQFWTCOLNEK-CILPGNKCSA-N 3-[6-[[(2R)-1-[[1-(2-methylpropyl)pyrazol-4-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C(C)C)N1N=CC(=C1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O YMTGQFWTCOLNEK-CILPGNKCSA-N 0.000 claims 1
• YRXBOUCHJKZGGI-RXVAYIKUSA-N 3-[6-[[(2R)-1-[[2-(2-morpholin-4-ylethoxy)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)CCOC1=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 YRXBOUCHJKZGGI-RXVAYIKUSA-N 0.000 claims 1
• DYJGJHIDYALWDH-LCQOSCCDSA-N 3-[6-[[(2R)-1-[[2-(dimethylamino)pyrimidin-5-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN(C1=NC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C DYJGJHIDYALWDH-LCQOSCCDSA-N 0.000 claims 1
• AIWHAVFIOWAVBF-LCQOSCCDSA-N 3-[6-[[(2R)-1-[[2-(methylamino)pyridin-3-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CNC1=NC=CC=C1CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O AIWHAVFIOWAVBF-LCQOSCCDSA-N 0.000 claims 1
• PANKJKDYXKBQMK-YOWDQXJLSA-N 3-[6-[[(2R)-1-[[2-hydroxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-3a,4,7,7a-tetrahydro-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound OC1=C(CN2[C@H](CCCC2)COC=2CC3CN(C(C3CC=2)=O)C2C(NC(CC2)=O)=O)C=C(C=C1)N1N=NN=C1C(F)(F)F PANKJKDYXKBQMK-YOWDQXJLSA-N 0.000 claims 1
• QQSITFLOASFXCE-DXDQHDRFSA-N 3-[6-[[(2R)-1-[[3-(imidazol-1-ylmethyl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(C=NC=C1)CC=1C=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 QQSITFLOASFXCE-DXDQHDRFSA-N 0.000 claims 1
• IQNNLZIEJWSDLY-DXDQHDRFSA-N 3-[6-[[(2R)-1-[[4-(2-methylimidazol-1-yl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N(C=CN=1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 IQNNLZIEJWSDLY-DXDQHDRFSA-N 0.000 claims 1
• OHTVKPJTQBHWGH-MIJJZIGMSA-N 3-[6-[[(2R)-1-[[4-(2-morpholin-4-ylethoxy)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)CCOC1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 OHTVKPJTQBHWGH-MIJJZIGMSA-N 0.000 claims 1
• CRUSITLXODVELF-RXVAYIKUSA-N 3-[6-[[(2R)-1-[[4-(3,6-dihydro-2H-pyran-4-yl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCC(=CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 CRUSITLXODVELF-RXVAYIKUSA-N 0.000 claims 1
• IBWOHEQNLHWFTD-DXDQHDRFSA-N 3-[6-[[(2R)-1-[[4-(imidazol-1-ylmethyl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1(C=NC=C1)CC1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 IBWOHEQNLHWFTD-DXDQHDRFSA-N 0.000 claims 1
• HKSSETJYCNVPON-NHQUYOMTSA-N 3-[6-[[(2R)-1-[[4-[1-(2-fluoroethyl)piperidin-4-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FCCN1CCC(CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 HKSSETJYCNVPON-NHQUYOMTSA-N 0.000 claims 1
• HPWIZWPOJVZXBW-UYEDPJPISA-N 3-[6-[[(2R)-1-[[4-[1-(oxetan-3-ylmethyl)piperidin-4-yl]phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CC(C1)CN1CCC(CC1)C1=CC=C(CN2[C@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 HPWIZWPOJVZXBW-UYEDPJPISA-N 0.000 claims 1
• NZFOLDYPLUIRHL-GEPVFLLWSA-N 3-[6-[[(2R)-1-[[5-(3-methylphenyl)-1H-pyrazol-4-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@@H]1N(CCCC1)CC=1C(=NNC=1)C=1C=C(C=CC=1)C)C1C(NC(CC1)=O)=O NZFOLDYPLUIRHL-GEPVFLLWSA-N 0.000 claims 1
• NPWNAQYGOZWHSG-XIDOUCRZSA-N 3-[6-[[(2R)-1-[[5-chloro-3-[4-[2-[(dimethylamino)methyl]-3-methylimidazol-4-yl]phenoxy]pyridin-2-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC=1C=C(C(=NC=1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)OC1=CC=C(C=C1)C1=CN=C(N1C)CN(C)C NPWNAQYGOZWHSG-XIDOUCRZSA-N 0.000 claims 1
• DQSKPQCSEHPJNW-UFUCKMQHSA-N 3-[6-[[(2R)-1-[[6-(diethylamino)pyridin-3-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N(C1=CC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)CC DQSKPQCSEHPJNW-UFUCKMQHSA-N 0.000 claims 1
• SDPLBHSUQMOOOW-GGYWPGCISA-N 3-[6-[[(2R)-1-ethyl-3,3-dimethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](C(CCC1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SDPLBHSUQMOOOW-GGYWPGCISA-N 0.000 claims 1
• CPAFYWSGOUQTHY-DIMJTDRSSA-N 3-[6-[[(2S)-1-(1,3-oxazol-4-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1C=NC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O CPAFYWSGOUQTHY-DIMJTDRSSA-N 0.000 claims 1
• MYZBNLFOMAOSRD-BWDMCYIDSA-N 3-[6-[[(2S)-1-(1-methyl-5-phenylpyrazole-3-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=C(C=C1C1=CC=CC=C1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O MYZBNLFOMAOSRD-BWDMCYIDSA-N 0.000 claims 1
• LVAZWCSCNHGDAX-DIMJTDRSSA-N 3-[6-[[(2S)-1-(1H-imidazol-5-ylmethyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound N1C=NC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O LVAZWCSCNHGDAX-DIMJTDRSSA-N 0.000 claims 1
• HFDJCVUCZCTSKX-UCFFOFKASA-N 3-[6-[[(2S)-1-(2-ethyl-1,3-thiazole-5-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C=1SC(=CN=1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O HFDJCVUCZCTSKX-UCFFOFKASA-N 0.000 claims 1
• RHFQNSJCLMFOOJ-HXBUSHRASA-N 3-[6-[[(2S)-1-(2-methyl-5-propan-2-ylpyrazole-3-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)(C)C1=NN(C(=C1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C RHFQNSJCLMFOOJ-HXBUSHRASA-N 0.000 claims 1
• QJWGHZOAWWXJTP-HXBUSHRASA-N 3-[6-[[(2S)-1-(2-morpholin-4-yl-1,3-thiazole-4-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C=1SC=C(N=1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O QJWGHZOAWWXJTP-HXBUSHRASA-N 0.000 claims 1
• UWAWDGBFGOAIFF-PBVYKCSPSA-N 3-[6-[[(2S)-1-(3,5-diethyl-1,2-oxazole-4-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C1=NOC(=C1C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)CC UWAWDGBFGOAIFF-PBVYKCSPSA-N 0.000 claims 1
• MIASMCGMPJAOQF-LBOXEOMUSA-N 3-[6-[[(2S)-1-(3,5-difluoro-4-methoxybenzoyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C(C=1OC)F MIASMCGMPJAOQF-LBOXEOMUSA-N 0.000 claims 1
• IVKXVLXCDZONMP-ZZHFZYNASA-N 3-[6-[[(2S)-1-(3,5-dimethyl-1-phenylpyrazole-4-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=NN(C(=C1C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C)C1=CC=CC=C1 IVKXVLXCDZONMP-ZZHFZYNASA-N 0.000 claims 1
• VTMWFVJYJCMHKR-CEABTFRJSA-N 3-[6-[[(2S)-1-(3-fluorobicyclo[1.1.1]pentane-1-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC12CC(C1)(C2)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VTMWFVJYJCMHKR-CEABTFRJSA-N 0.000 claims 1
• DSHVJKCPOXEQCY-LBOXEOMUSA-N 3-[6-[[(2S)-1-(4-chloro-3-iodobenzoyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC1=C(C=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1)I DSHVJKCPOXEQCY-LBOXEOMUSA-N 0.000 claims 1
• BWEHBYOFSZDODI-ALLRNTDFSA-N 3-[6-[[(2S)-1-(4-methoxy-3-phenylmethoxybenzoyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)OC=1C=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1OC BWEHBYOFSZDODI-ALLRNTDFSA-N 0.000 claims 1
• UEFSVAJBKXJPIA-YDNXMHBPSA-N 3-[6-[[(2S)-1-(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazine-7-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C2=C(OCC1)C=C(C=N2)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UEFSVAJBKXJPIA-YDNXMHBPSA-N 0.000 claims 1
• XAJFESAKNSZVNY-XEGCMXMBSA-N 3-[6-[[(2S)-1-(4-methyl-3-phenyl-1H-pyrazole-5-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1C(=NNC=1C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C1=CC=CC=C1 XAJFESAKNSZVNY-XEGCMXMBSA-N 0.000 claims 1
• YQLIAGCDDMFXSR-ZZHFZYNASA-N 3-[6-[[(2S)-1-(4-morpholin-4-ylbenzoyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=CC=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 YQLIAGCDDMFXSR-ZZHFZYNASA-N 0.000 claims 1
• AYJVYAJMGLIWEW-AJZOCDQUSA-N 3-[6-[[(2S)-1-(5-butyl-4-methoxypyrimidine-2-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(CCC)C=1C(=NC(=NC=1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)OC AYJVYAJMGLIWEW-AJZOCDQUSA-N 0.000 claims 1
• SPRBLACRBMXWSO-XNUZUHMRSA-N 3-[6-[[(2S)-1-(7-methoxy-1H-indole-3-carbonyl)piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC=1C=CC=C2C(=CNC=12)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SPRBLACRBMXWSO-XNUZUHMRSA-N 0.000 claims 1
• NHYSSHVYYHDWTI-BXXZMZEQSA-N 3-[6-[[(2S)-1-[(1-benzylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C1=CC=CC=C1)N1N=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O NHYSSHVYYHDWTI-BXXZMZEQSA-N 0.000 claims 1
• RHSPRKSLMMGCDU-ZZHFZYNASA-N 3-[6-[[(2S)-1-[(1-cyclohexylpyrazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CCCCC1)N1N=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RHSPRKSLMMGCDU-ZZHFZYNASA-N 0.000 claims 1
• RUNQXRYKRWBRBM-XGLRFROISA-N 3-[6-[[(2S)-1-[(1-methylbenzimidazol-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C(=NC2=C1C=CC=C2)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RUNQXRYKRWBRBM-XGLRFROISA-N 0.000 claims 1
• GYEGKWQXHXNJSW-XGLRFROISA-N 3-[6-[[(2S)-1-[(1-methylbenzotriazol-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=NC2=C1C=CC(=C2)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O GYEGKWQXHXNJSW-XGLRFROISA-N 0.000 claims 1
• UECKRCWNHPAJKR-GVNKFJBHSA-N 3-[6-[[(2S)-1-[(1-methylindol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C=CC2=C(C=CC=C12)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O UECKRCWNHPAJKR-GVNKFJBHSA-N 0.000 claims 1
• HTXWVOOSOKQJJR-YMXDCFFPSA-N 3-[6-[[(2S)-1-[(2,3-dihydroxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound OC1=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1O HTXWVOOSOKQJJR-YMXDCFFPSA-N 0.000 claims 1
• BMVAGEGCGNOEKH-DIMJTDRSSA-N 3-[6-[[(2S)-1-[(2-aminopyrimidin-5-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound NC1=NC=C(C=N1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O BMVAGEGCGNOEKH-DIMJTDRSSA-N 0.000 claims 1
• PSVPQBGGXPXVHZ-NVHKAFQKSA-N 3-[6-[[(2S)-1-[(2-chloro-6-fluorophenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC1=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C(=CC=C1)F PSVPQBGGXPXVHZ-NVHKAFQKSA-N 0.000 claims 1
• JOTLNMQSDRSCGJ-HXBUSHRASA-N 3-[6-[[(2S)-1-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)C=1NC(=C(N=1)C)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O JOTLNMQSDRSCGJ-HXBUSHRASA-N 0.000 claims 1
• FJRVKDIBFCTIOT-AJZOCDQUSA-N 3-[6-[[(2S)-1-[(2-methoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 FJRVKDIBFCTIOT-AJZOCDQUSA-N 0.000 claims 1
• SOCYKQKRZGCGPV-XADRRFQNSA-N 3-[6-[[(2S)-1-[(2-morpholin-4-ylpyridin-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=NC=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SOCYKQKRZGCGPV-XADRRFQNSA-N 0.000 claims 1
• MZNGJJHPIGRTMW-AJZOCDQUSA-N 3-[6-[[(2S)-1-[(3,4-dimethoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC=1C=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1OC MZNGJJHPIGRTMW-AJZOCDQUSA-N 0.000 claims 1
• DMUBNGJOPXFAFN-HXBUSHRASA-N 3-[6-[[(2S)-1-[(3-chloro-4-hydroxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC=1C=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1O DMUBNGJOPXFAFN-HXBUSHRASA-N 0.000 claims 1
• AQVJZYAJEFHYJN-HSTJUUNISA-N 3-[6-[[(2S)-1-[(3-fluoro-4-methoxyphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC=1C=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1OC AQVJZYAJEFHYJN-HSTJUUNISA-N 0.000 claims 1
• FIFAQFVYYISMHA-XEGCMXMBSA-N 3-[6-[[(2S)-1-[(3-methoxy-4-methylphenyl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC=1C=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1C FIFAQFVYYISMHA-XEGCMXMBSA-N 0.000 claims 1
• VQCZPHVZQMJAFN-PBVYKCSPSA-N 3-[6-[[(2S)-1-[(3-methylimidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1C=NC=C1CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O VQCZPHVZQMJAFN-PBVYKCSPSA-N 0.000 claims 1
• YXKXWAJGKZVKCO-ZZHFZYNASA-N 3-[6-[[(2S)-1-[(5-cyclohexa-1,5-dien-1-yl-1-methylpyrazol-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(=CCCC=C1)C1=CC(=NN1C)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O YXKXWAJGKZVKCO-ZZHFZYNASA-N 0.000 claims 1
• SJGBEBROFHGYHB-YMXDCFFPSA-N 3-[6-[[(2S)-1-[(5-methyl-1,2-oxazol-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC1=CC(=NO1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SJGBEBROFHGYHB-YMXDCFFPSA-N 0.000 claims 1
• PJHXVNXZJATIAR-PBVYKCSPSA-N 3-[6-[[(2S)-1-[(5-methyl-1H-imidazol-4-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N=CNC=1CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O PJHXVNXZJATIAR-PBVYKCSPSA-N 0.000 claims 1
• WEFBHPNLJRGXGS-YDNXMHBPSA-N 3-[6-[[(2S)-1-[(6-methoxypyridin-3-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1=CC=C(C=N1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O WEFBHPNLJRGXGS-YDNXMHBPSA-N 0.000 claims 1
• KBOWLBRUCQCVHW-XADRRFQNSA-N 3-[6-[[(2S)-1-[(6-morpholin-4-ylpyridin-2-yl)methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)C1=CC=CC(=N1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O KBOWLBRUCQCVHW-XADRRFQNSA-N 0.000 claims 1
• IYOHXYKUCYLOKW-BWDMCYIDSA-N 3-[6-[[(2S)-1-[2,5-dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrole-3-carbonyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N(C(=CC=1C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C)C1=NOC(=C1)C IYOHXYKUCYLOKW-BWDMCYIDSA-N 0.000 claims 1
• YAPAPQCQXGTDFX-CHQVSRGASA-N 3-[6-[[(2S)-1-[3-(1-methylpyrazol-3-yl)benzoyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN1N=C(C=C1)C=1C=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1 YAPAPQCQXGTDFX-CHQVSRGASA-N 0.000 claims 1
• PHHDGVAZLABSAH-DQUNLGLBSA-N 3-[6-[[(2S)-1-[3-(4-methoxyphenyl)-1H-pyrazole-5-carbonyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound COC1=CC=C(C=C1)C1=NNC(=C1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O PHHDGVAZLABSAH-DQUNLGLBSA-N 0.000 claims 1
• QZBPOHSSDAEFMX-HXBUSHRASA-N 3-[6-[[(2S)-1-[3-(difluoromethoxy)benzoyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC(OC=1C=C(C(=O)N2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=1)F QZBPOHSSDAEFMX-HXBUSHRASA-N 0.000 claims 1
• RKYBZELKHKGXDL-XNUZUHMRSA-N 3-[6-[[(2S)-1-[5-(2,2-dimethylpropyl)-1,2-oxazole-3-carbonyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C(C)(C)C)C1=CC(=NO1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RKYBZELKHKGXDL-XNUZUHMRSA-N 0.000 claims 1
• FMYGVIHTSYBGRR-DCCUJTHKSA-N 3-[6-[[(2S)-1-[5-(4-fluorophenyl)pyridine-2-carbonyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound FC1=CC=C(C=C1)C=1C=CC(=NC=1)C(=O)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O FMYGVIHTSYBGRR-DCCUJTHKSA-N 0.000 claims 1
• YMTGQFWTCOLNEK-XEGCMXMBSA-N 3-[6-[[(2S)-1-[[1-(2-methylpropyl)pyrazol-4-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C(C)C)N1N=CC(=C1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O YMTGQFWTCOLNEK-XEGCMXMBSA-N 0.000 claims 1
• FEBPJLOVOASMNH-DCCUJTHKSA-N 3-[6-[[(2S)-1-[[1-(benzenesulfonyl)pyrrol-2-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(CC2=CC(=CC=C12)OC[C@H]1N(CCCC1)CC=1N(C=CC=1)S(=O)(=O)C1=CC=CC=C1)C1C(NC(CC1)=O)=O FEBPJLOVOASMNH-DCCUJTHKSA-N 0.000 claims 1
• RNLIYSSTENQXQT-JOMKWTIYSA-N 3-[6-[[(2S)-1-[[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C1(CC=CCC1)CN1CCC(CC1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O RNLIYSSTENQXQT-JOMKWTIYSA-N 0.000 claims 1
• YRXBOUCHJKZGGI-ALLRNTDFSA-N 3-[6-[[(2S)-1-[[2-(2-morpholin-4-ylethoxy)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound O1CCN(CC1)CCOC1=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=CC=C1 YRXBOUCHJKZGGI-ALLRNTDFSA-N 0.000 claims 1
• DYJGJHIDYALWDH-YDNXMHBPSA-N 3-[6-[[(2S)-1-[[2-(dimethylamino)pyrimidin-5-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CN(C1=NC=C(C=N1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)C DYJGJHIDYALWDH-YDNXMHBPSA-N 0.000 claims 1
• AIWHAVFIOWAVBF-YDNXMHBPSA-N 3-[6-[[(2S)-1-[[2-(methylamino)pyridin-3-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CNC1=NC=CC=C1CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O AIWHAVFIOWAVBF-YDNXMHBPSA-N 0.000 claims 1
• IQNNLZIEJWSDLY-BXXZMZEQSA-N 3-[6-[[(2S)-1-[[4-(2-methylimidazol-1-yl)phenyl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound CC=1N(C=CN=1)C1=CC=C(CN2[C@@H](CCCC2)COC=2C=C3CN(C(C3=CC=2)=O)C2C(NC(CC2)=O)=O)C=C1 IQNNLZIEJWSDLY-BXXZMZEQSA-N 0.000 claims 1
• NPWNAQYGOZWHSG-BSXJZHEVSA-N 3-[6-[[(2S)-1-[[5-chloro-3-[4-[2-[(dimethylamino)methyl]-3-methylimidazol-4-yl]phenoxy]pyridin-2-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound ClC=1C=C(C(=NC=1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)OC1=CC=C(C=C1)C1=CN=C(N1C)CN(C)C NPWNAQYGOZWHSG-BSXJZHEVSA-N 0.000 claims 1
• DQSKPQCSEHPJNW-XADRRFQNSA-N 3-[6-[[(2S)-1-[[6-(diethylamino)pyridin-3-yl]methyl]piperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N(C1=CC=C(C=N1)CN1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)CC DQSKPQCSEHPJNW-XADRRFQNSA-N 0.000 claims 1
• SDPLBHSUQMOOOW-MUMRKEEXSA-N 3-[6-[[(2S)-1-ethyl-3,3-dimethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](C(CCC1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O SDPLBHSUQMOOOW-MUMRKEEXSA-N 0.000 claims 1
• DHFJHVJOMHNTSK-BUSXIPJBSA-N 3-[6-[[(2S)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DHFJHVJOMHNTSK-BUSXIPJBSA-N 0.000 claims 1
• DELPKCKGPQRPAM-NNJIEVJOSA-N 3-[6-[[(3R)-4-ethyl-6,6-dimethylmorpholin-3-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@@H](COC(C1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DELPKCKGPQRPAM-NNJIEVJOSA-N 0.000 claims 1
• DELPKCKGPQRPAM-BUSXIPJBSA-N 3-[6-[[(3S)-4-ethyl-6,6-dimethylmorpholin-3-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione Chemical compound C(C)N1[C@H](COC(C1)(C)C)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O DELPKCKGPQRPAM-BUSXIPJBSA-N 0.000 claims 1
• BWDCTAPMXJSRIJ-XEGCMXMBSA-N 3-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]benzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC=1C=C(C#N)C=CC=1)=O)=O BWDCTAPMXJSRIJ-XEGCMXMBSA-N 0.000 claims 1
• ACLRHJNASAXHGG-QZWVJJBASA-N 3-[[3-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]-2-oxopyridin-1-yl]methyl]benzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC=1C(N(C=CC=1)CC=1C=C(C#N)C=CC=1)=O)=O)=O ACLRHJNASAXHGG-QZWVJJBASA-N 0.000 claims 1
• LXMJMCBORFFGIN-CILPGNKCSA-N 4-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]-2-methoxybenzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC1=CC(=C(C#N)C=C1)OC)=O)=O LXMJMCBORFFGIN-CILPGNKCSA-N 0.000 claims 1
• KSXGTOQJCIWSAA-CILPGNKCSA-N 4-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]-3-methoxybenzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC1=C(C=C(C#N)C=C1)OC)=O)=O KSXGTOQJCIWSAA-CILPGNKCSA-N 0.000 claims 1
• KSXGTOQJCIWSAA-XEGCMXMBSA-N 4-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]-3-methoxybenzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC1=C(C=C(C#N)C=C1)OC)=O)=O KSXGTOQJCIWSAA-XEGCMXMBSA-N 0.000 claims 1
• WUCZPZHGVQPYJG-HSTJUUNISA-N 4-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]benzenesulfonamide Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC1=CC=C(C=C1)S(=O)(=O)N)=O)=O WUCZPZHGVQPYJG-HSTJUUNISA-N 0.000 claims 1
• ZUXQMCQRMWMEFO-AJZOCDQUSA-N 4-[[(2S)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]pyridine-2-carbonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@H]1N(CCCC1)CC1=CC(=NC=C1)C#N)=O)=O ZUXQMCQRMWMEFO-AJZOCDQUSA-N 0.000 claims 1
• DLWCAMZRMSGHIX-CILPGNKCSA-N 5-[[(2R)-2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxymethyl]piperidin-1-yl]methyl]-2-methoxybenzonitrile Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)OC[C@@H]1N(CCCC1)CC=1C=CC(=C(C#N)C=1)OC)=O)=O DLWCAMZRMSGHIX-CILPGNKCSA-N 0.000 claims 1
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• WPGGMFMYAJBHJI-DXDQHDRFSA-N C(C)N1CCN(CC1)C1=CC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O Chemical compound C(C)N1CCN(CC1)C1=CC=C(C=N1)CN1[C@H](CCCC1)COC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O WPGGMFMYAJBHJI-DXDQHDRFSA-N 0.000 claims 1
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