ES2976594T3 - Virus AAV/UPR-plus, proteína de fusión UPR-plus, método de tratamiento genético y su uso en el tratamiento de enfermedades neurodegenerativas, tales como la enfermedad de Parkinson y la enfermedad de Huntington, entre otras - Google Patents
Virus AAV/UPR-plus, proteína de fusión UPR-plus, método de tratamiento genético y su uso en el tratamiento de enfermedades neurodegenerativas, tales como la enfermedad de Parkinson y la enfermedad de Huntington, entre otras Download PDFInfo
- Publication number
- ES2976594T3 ES2976594T3 ES16861172T ES16861172T ES2976594T3 ES 2976594 T3 ES2976594 T3 ES 2976594T3 ES 16861172 T ES16861172 T ES 16861172T ES 16861172 T ES16861172 T ES 16861172T ES 2976594 T3 ES2976594 T3 ES 2976594T3
- Authority
- ES
- Spain
- Prior art keywords
- xbp1s
- sequence
- atf6f
- aav
- atf6
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2015003242A CL2015003242A1 (es) | 2015-11-04 | 2015-11-04 | Virus aav/upr-plus, proteína de fusión upr-plus, método de tratamiento genético y su uso en el tratamiento enfermedades neurodegenerativas, tales como las enfermedades de parkinson y huntington, entre otras. |
| PCT/CL2016/000070 WO2017075729A1 (es) | 2015-11-04 | 2016-11-04 | Virus aav/upr-plus, proteina de fusion upr-plus, metodo de tratamiento genetico y su uso en el tratamiento enfermedades neurodegenerativas, tales como la enfermedad de parkinson y huntington, entre otras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2976594T3 true ES2976594T3 (es) | 2024-08-05 |
Family
ID=58661426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16861172T Active ES2976594T3 (es) | 2015-11-04 | 2016-11-04 | Virus AAV/UPR-plus, proteína de fusión UPR-plus, método de tratamiento genético y su uso en el tratamiento de enfermedades neurodegenerativas, tales como la enfermedad de Parkinson y la enfermedad de Huntington, entre otras |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10889831B2 (enExample) |
| EP (1) | EP3372249B1 (enExample) |
| JP (2) | JP6965254B2 (enExample) |
| AU (1) | AU2016348759B2 (enExample) |
| CL (1) | CL2015003242A1 (enExample) |
| ES (1) | ES2976594T3 (enExample) |
| WO (1) | WO2017075729A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2015003242A1 (es) * | 2015-11-04 | 2016-10-14 | Univ Chile | Virus aav/upr-plus, proteína de fusión upr-plus, método de tratamiento genético y su uso en el tratamiento enfermedades neurodegenerativas, tales como las enfermedades de parkinson y huntington, entre otras. |
| WO2019010551A1 (pt) * | 2017-07-10 | 2019-01-17 | Instituto De Biologia Molecular Do Paraná - Ibmp | Plataforma genética para superexpressão heteróloga associada à seleção de células altamente produtoras de proteínas |
| US20220184175A1 (en) * | 2019-02-01 | 2022-06-16 | Universidad De Chile | Treatment of aging or age-related disorders using xbp1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007500016A (ja) * | 2003-06-11 | 2007-01-11 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 培養においてタンパク質生成を増大させるための方法 |
| ES2356154T3 (es) * | 2003-07-21 | 2011-04-05 | Transgene S.A. | Citoquinas multifuncionales. |
| CA2577073C (en) | 2004-09-02 | 2016-10-11 | Wyeth | Systems and methods for protein production employing polypeptides functional in unfolded protein response pathway |
| CL2014003590A1 (es) * | 2014-12-30 | 2015-07-10 | Univ Chile | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
| US20170059554A1 (en) | 2015-09-02 | 2017-03-02 | R. J. Reynolds Tobacco Company | Method for monitoring use of a tobacco product |
| CL2015003024A1 (es) * | 2015-10-09 | 2016-05-13 | Univ Chile | Método de tratamiento genético utilizando el virus aav-xbp1s/gfp, y su uso en la prevención y tratamiento de la esclerosis lateral amiotrofica. |
| CL2015003242A1 (es) * | 2015-11-04 | 2016-10-14 | Univ Chile | Virus aav/upr-plus, proteína de fusión upr-plus, método de tratamiento genético y su uso en el tratamiento enfermedades neurodegenerativas, tales como las enfermedades de parkinson y huntington, entre otras. |
-
2015
- 2015-11-04 CL CL2015003242A patent/CL2015003242A1/es unknown
-
2016
- 2016-11-04 ES ES16861172T patent/ES2976594T3/es active Active
- 2016-11-04 JP JP2018541460A patent/JP6965254B2/ja active Active
- 2016-11-04 EP EP16861172.1A patent/EP3372249B1/en active Active
- 2016-11-04 US US15/773,723 patent/US10889831B2/en active Active
- 2016-11-04 WO PCT/CL2016/000070 patent/WO2017075729A1/es not_active Ceased
- 2016-11-04 AU AU2016348759A patent/AU2016348759B2/en active Active
-
2020
- 2020-12-01 US US17/109,018 patent/US11795476B2/en active Active
-
2021
- 2021-10-20 JP JP2021171510A patent/JP7357039B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017075729A1 (es) | 2017-05-11 |
| JP2018536432A (ja) | 2018-12-13 |
| EP3372249B1 (en) | 2024-03-27 |
| JP2022031637A (ja) | 2022-02-22 |
| US11795476B2 (en) | 2023-10-24 |
| EP3372249A1 (en) | 2018-09-12 |
| JP6965254B2 (ja) | 2021-11-10 |
| EP3372249A4 (en) | 2019-04-03 |
| JP7357039B2 (ja) | 2023-10-05 |
| CL2015003242A1 (es) | 2016-10-14 |
| US20210079424A1 (en) | 2021-03-18 |
| AU2016348759B2 (en) | 2023-08-03 |
| AU2016348759A1 (en) | 2018-06-14 |
| EP3372249C0 (en) | 2024-03-27 |
| US10889831B2 (en) | 2021-01-12 |
| US20190309324A1 (en) | 2019-10-10 |
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