ES2976207T3 - Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas - Google Patents

Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas Download PDF

Info

Publication number
ES2976207T3
ES2976207T3 ES21178882T ES21178882T ES2976207T3 ES 2976207 T3 ES2976207 T3 ES 2976207T3 ES 21178882 T ES21178882 T ES 21178882T ES 21178882 T ES21178882 T ES 21178882T ES 2976207 T3 ES2976207 T3 ES 2976207T3
Authority
ES
Spain
Prior art keywords
pharmaceutical composition
htbz
use according
treatment
isoquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES21178882T
Other languages
English (en)
Spanish (es)
Inventor
Christopher O'brien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurocrine Biosciences Inc
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of ES2976207T3 publication Critical patent/ES2976207T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES21178882T 2014-05-06 2015-05-06 Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas Active ES2976207T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461989240P 2014-05-06 2014-05-06

Publications (1)

Publication Number Publication Date
ES2976207T3 true ES2976207T3 (es) 2024-07-26

Family

ID=53264772

Family Applications (2)

Application Number Title Priority Date Filing Date
ES21178882T Active ES2976207T3 (es) 2014-05-06 2015-05-06 Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas
ES15724438T Active ES2904526T3 (es) 2014-05-06 2015-05-06 Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15724438T Active ES2904526T3 (es) 2014-05-06 2015-05-06 Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas

Country Status (24)

Country Link
US (3) US20170071932A1 (OSRAM)
EP (3) EP3936130B1 (OSRAM)
JP (4) JP6635945B2 (OSRAM)
KR (5) KR20240011255A (OSRAM)
CN (3) CN112741836A (OSRAM)
AU (1) AU2015256012B2 (OSRAM)
CA (1) CA2947736C (OSRAM)
CY (1) CY1125058T1 (OSRAM)
DK (2) DK3139925T3 (OSRAM)
ES (2) ES2976207T3 (OSRAM)
FI (1) FI3936130T3 (OSRAM)
HR (2) HRP20220025T1 (OSRAM)
HU (2) HUE057839T2 (OSRAM)
IL (1) IL248745B (OSRAM)
LT (2) LT3139925T (OSRAM)
MX (1) MX387625B (OSRAM)
NZ (1) NZ725826A (OSRAM)
PL (2) PL3139925T3 (OSRAM)
PT (2) PT3139925T (OSRAM)
RS (2) RS65359B1 (OSRAM)
RU (1) RU2753740C2 (OSRAM)
SI (2) SI3936130T1 (OSRAM)
SM (2) SMT202400199T1 (OSRAM)
WO (1) WO2015171802A1 (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10065952B2 (en) * 2015-10-30 2018-09-04 Neurocrine Biosciences, Inc. Valbenazine salts and polymorphs thereof
CN108925135B (zh) 2015-12-23 2025-09-19 纽罗克里生物科学有限公司 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法
CN109153676B (zh) * 2016-06-29 2021-08-10 苏州科睿思制药有限公司 Nbi-98854的晶型及其制备方法和用途
EP3548027A1 (en) * 2016-12-02 2019-10-09 Neurocrine Biosciences, Inc. Use of valbenazine for treating schizophrenia or schizoaffective disorder
WO2018130345A1 (en) 2017-01-10 2018-07-19 Sandoz Ag Crystalline valbenazine free base
EA202090676A1 (ru) 2017-01-27 2021-10-08 Нейрокрин Байосайенсиз, Инк. Способы введения некоторых vmat2-ингибиторов
EP3585787A1 (en) 2017-02-27 2020-01-01 Sandoz AG Crystalline forms of valbenazine salts
WO2018164996A1 (en) * 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
US20190111035A1 (en) * 2017-04-01 2019-04-18 Adeptio Pharmaceuticals Limited Pharmaceutical compositions
JP7250692B2 (ja) * 2017-04-01 2023-04-03 アデプティオ ファーマシューティカルズ リミテッド 運動障害の治療における使用のためのジヒドロテトラベナジン
GB201705303D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
EP3606529A1 (en) * 2017-04-01 2020-02-12 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine for use in the treatment a movement disorder
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705305D0 (en) * 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
US20200179352A1 (en) * 2017-04-26 2020-06-11 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
IL273300B2 (en) 2017-09-21 2024-06-01 Neurocrine Biosciences Inc High dose valbenazine formulation and related preparations, methods and kits
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
KR20200066661A (ko) * 2017-10-10 2020-06-10 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
CN111343985A (zh) 2017-11-08 2020-06-26 逸达生物科技股份有限公司 二氢丁苯那嗪的酯
CA3086611C (en) 2017-12-26 2023-07-25 Crystal Pharmaceutical (Suzhou) Co., Ltd. A crystalline form of valbenazine ditosylate, processes for preparation thereof and use thereof
TWI832854B (zh) 2018-04-25 2024-02-21 美商神經治療股份有限公司 丁苯那嗪經皮輸送裝置
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
TW202011963A (zh) 2018-06-14 2020-04-01 美商紐羅克里生物科學有限公司 Vmat2抑制劑化合物、組合物及其相關方法
KR20210044817A (ko) 2018-08-15 2021-04-23 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
WO2020070236A1 (en) 2018-10-04 2020-04-09 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine dosage regimen for treating movement disorders
AU2020270145A1 (en) * 2019-05-09 2021-12-23 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007317242B2 (en) * 2006-11-08 2013-08-01 Neurocrine Biosciences, Inc. Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto
EP2083744A4 (en) * 2006-11-09 2013-08-28 Univ New York DEGRADED GLASS / ZIRCONIUM / GLASS STRUCTURES FOR DAMAGE-RESISTANT DENTAL AND ORTHOPEDIC CERAMIC PROSTHESES
GB2462611A (en) 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
ES2896678T3 (es) 2008-09-18 2022-02-25 Auspex Pharmaceuticals Inc Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2
JP2013501810A (ja) * 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物
JP2013527237A (ja) * 2010-06-01 2013-06-27 オースペックス・ファーマシューティカルズ・インコーポレイテッド ベンゾキノロン系ｖｍａｔ２阻害剤
CA2883641C (en) * 2012-09-18 2021-09-14 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9782398B2 (en) * 2014-02-07 2017-10-10 Neurocrine Biosciences, Inc. Pharmaceutical compositions comprising an antipsychotic drug and a VMAT2 inhibitor and uses thereof

Also Published As

Publication number Publication date
EP4389227A2 (en) 2024-06-26
DK3139925T3 (da) 2021-12-20
CN112741835A (zh) 2021-05-04
JP2024153782A (ja) 2024-10-29
KR20200133003A (ko) 2020-11-25
US20210196702A1 (en) 2021-07-01
RU2016147523A (ru) 2018-06-08
KR20160147044A (ko) 2016-12-21
SI3139925T1 (sl) 2022-04-29
SMT202400199T1 (it) 2024-07-09
EP3936130A1 (en) 2022-01-12
KR20220140647A (ko) 2022-10-18
EP3936130B1 (en) 2024-02-14
IL248745B (en) 2022-07-01
CN112741836A (zh) 2021-05-04
WO2015171802A1 (en) 2015-11-12
JP2021191799A (ja) 2021-12-16
EP4389227A3 (en) 2024-09-04
HUE066361T2 (hu) 2024-07-28
PT3936130T (pt) 2024-04-17
CY1125058T1 (el) 2023-06-09
RU2753740C2 (ru) 2021-08-23
SMT202200193T1 (it) 2022-07-21
IL248745A0 (en) 2017-01-31
CN106456629A (zh) 2017-02-22
US20170071932A1 (en) 2017-03-16
EP3139925A1 (en) 2017-03-15
EP3139925B1 (en) 2021-12-01
HUE057839T2 (hu) 2022-06-28
CA2947736A1 (en) 2015-11-12
ES2904526T3 (es) 2022-04-05
SI3936130T1 (sl) 2024-05-31
CA2947736C (en) 2023-04-18
NZ725826A (en) 2023-05-26
AU2015256012B2 (en) 2020-07-23
JP6635945B2 (ja) 2020-01-29
AU2015256012A1 (en) 2016-11-24
DK3936130T3 (da) 2024-03-25
MX2016014429A (es) 2017-04-06
HRP20220025T1 (hr) 2022-04-01
PL3936130T3 (pl) 2024-06-10
RS62782B1 (sr) 2022-01-31
JP2017514850A (ja) 2017-06-08
MX387625B (es) 2025-03-18
KR20250029267A (ko) 2025-03-04
LT3936130T (lt) 2024-04-25
FI3936130T3 (fi) 2024-04-23
RS65359B1 (sr) 2024-04-30
JP2019218407A (ja) 2019-12-26
HRP20240459T1 (hr) 2024-06-21
US20200101063A1 (en) 2020-04-02
PT3139925T (pt) 2022-01-26
PL3139925T3 (pl) 2022-03-21
KR20240011255A (ko) 2024-01-25
RU2016147523A3 (OSRAM) 2018-12-28
LT3139925T (lt) 2022-01-25

Similar Documents

Publication Publication Date Title
ES2976207T3 (es) Pauta posológica de valbenazina para el tratamiento de discinesias hipercinéticas
Glazer Extrapyramidal side effects, tardive dyskinesia, and the concept of atypicality
Pigott et al. Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study
US20160166543A1 (en) Stable combination oral liquid formulation of melatonin and an antihistaminic agent
BR112020011345A2 (pt) tratamento com ciclobenzaprina para agitação, psicose e declínio cognitivo na demência e condições neurodegenerativas
ES2822562T3 (es) Composiciones intranasales para el tratamiento de enfermedades y trastornos neurológicos y degenerativos
ES2459877T3 (es) Combinación de nilotinib y clorambucil para el tratamiento de leucemia linfocítica crónica
ES2280602T3 (es) Uso de 2-(5-(4-fluorofenil)-3-piridilmetilaminometil)-cromano y sus sales fisiologicamente aceptables.
ZA200509904B (en) Asenapine for the treatment of schizophrenia in a patient with overweight or predisposition for overweight
HK40111840A (en) Valbenazine dosage regimen for the treatment of hyperkinetic movement disorders
CN107735094A (zh) 胱氨酸‑谷氨酸转运蛋白的抑制剂的新用途
JP7366108B2 (ja) ロキソプロフェン又はその塩及びビタミンｂ１２類を含有する経口用医薬組成物
ES2742888T3 (es) Combinación de brexpiprazol y nalmefeno y su uso para tratar trastornos relacionados con una sustancia
HK40067005B (en) Valbenazine dosage regimen for the treatment of hyperkinetic movement disorders
HK40067005A (en) Valbenazine dosage regimen for the treatment of hyperkinetic movement disorders
Stroup et al. Pharmacological and Somatic Therapies
Karen Ruby Oral pregabalin in aneurysmal subarachnoid haemorrhage patients reduces pain and anaesthetic requirement in the perioperative period
EP2435044A1 (en) Method of treating sleep disorders using the combination of eplivanserin and zolpidem