AU2015256012B2 - VMAT2 inhibitors for the treatment of hyperkinetic movement disorders - Google Patents

VMAT2 inhibitors for the treatment of hyperkinetic movement disorders Download PDF

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Publication number
AU2015256012B2
AU2015256012B2 AU2015256012A AU2015256012A AU2015256012B2 AU 2015256012 B2 AU2015256012 B2 AU 2015256012B2 AU 2015256012 A AU2015256012 A AU 2015256012A AU 2015256012 A AU2015256012 A AU 2015256012A AU 2015256012 B2 AU2015256012 B2 AU 2015256012B2
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Australia
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isoquinolin
dimethoxy
isobutyl
pyrido
ester
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AU2015256012A
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AU2015256012A1 (en
Inventor
Christopher F. O'Brien
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Neurocrine Biosciences Inc
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Neurocrine Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2015256012A 2014-05-06 2015-05-06 VMAT2 inhibitors for the treatment of hyperkinetic movement disorders Active AU2015256012B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989240P 2014-05-06 2014-05-06
US61/989,240 2014-05-06
PCT/US2015/029519 WO2015171802A1 (en) 2014-05-06 2015-05-06 Vmat2 inhibitors for the treatment of hyperkinetic movement disorders

Publications (2)

Publication Number Publication Date
AU2015256012A1 AU2015256012A1 (en) 2016-11-24
AU2015256012B2 true AU2015256012B2 (en) 2020-07-23

Family

ID=53264772

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015256012A Active AU2015256012B2 (en) 2014-05-06 2015-05-06 VMAT2 inhibitors for the treatment of hyperkinetic movement disorders

Country Status (24)

Country Link
US (3) US20170071932A1 (OSRAM)
EP (3) EP3936130B1 (OSRAM)
JP (4) JP6635945B2 (OSRAM)
KR (5) KR20240011255A (OSRAM)
CN (3) CN112741836A (OSRAM)
AU (1) AU2015256012B2 (OSRAM)
CA (1) CA2947736C (OSRAM)
CY (1) CY1125058T1 (OSRAM)
DK (2) DK3139925T3 (OSRAM)
ES (2) ES2976207T3 (OSRAM)
FI (1) FI3936130T3 (OSRAM)
HR (2) HRP20220025T1 (OSRAM)
HU (2) HUE057839T2 (OSRAM)
IL (1) IL248745B (OSRAM)
LT (2) LT3139925T (OSRAM)
MX (1) MX387625B (OSRAM)
NZ (1) NZ725826A (OSRAM)
PL (2) PL3139925T3 (OSRAM)
PT (2) PT3139925T (OSRAM)
RS (2) RS65359B1 (OSRAM)
RU (1) RU2753740C2 (OSRAM)
SI (2) SI3936130T1 (OSRAM)
SM (2) SMT202400199T1 (OSRAM)
WO (1) WO2015171802A1 (OSRAM)

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US10065952B2 (en) * 2015-10-30 2018-09-04 Neurocrine Biosciences, Inc. Valbenazine salts and polymorphs thereof
CN108925135B (zh) 2015-12-23 2025-09-19 纽罗克里生物科学有限公司 制备(S)-(2R,3R,11bR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-基2-氨基-3-甲基丁酸酯二(4-甲基苯磺酸盐)的合成方法
CN109153676B (zh) * 2016-06-29 2021-08-10 苏州科睿思制药有限公司 Nbi-98854的晶型及其制备方法和用途
EP3548027A1 (en) * 2016-12-02 2019-10-09 Neurocrine Biosciences, Inc. Use of valbenazine for treating schizophrenia or schizoaffective disorder
WO2018130345A1 (en) 2017-01-10 2018-07-19 Sandoz Ag Crystalline valbenazine free base
EA202090676A1 (ru) 2017-01-27 2021-10-08 Нейрокрин Байосайенсиз, Инк. Способы введения некоторых vmat2-ингибиторов
EP3585787A1 (en) 2017-02-27 2020-01-01 Sandoz AG Crystalline forms of valbenazine salts
WO2018164996A1 (en) * 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
US20190111035A1 (en) * 2017-04-01 2019-04-18 Adeptio Pharmaceuticals Limited Pharmaceutical compositions
JP7250692B2 (ja) * 2017-04-01 2023-04-03 アデプティオ ファーマシューティカルズ リミテッド 運動障害の治療における使用のためのジヒドロテトラベナジン
GB201705303D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
EP3606529A1 (en) * 2017-04-01 2020-02-12 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine for use in the treatment a movement disorder
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705305D0 (en) * 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
US20200179352A1 (en) * 2017-04-26 2020-06-11 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
IL273300B2 (en) 2017-09-21 2024-06-01 Neurocrine Biosciences Inc High dose valbenazine formulation and related preparations, methods and kits
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
KR20200066661A (ko) * 2017-10-10 2020-06-10 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
CN111343985A (zh) 2017-11-08 2020-06-26 逸达生物科技股份有限公司 二氢丁苯那嗪的酯
CA3086611C (en) 2017-12-26 2023-07-25 Crystal Pharmaceutical (Suzhou) Co., Ltd. A crystalline form of valbenazine ditosylate, processes for preparation thereof and use thereof
TWI832854B (zh) 2018-04-25 2024-02-21 美商神經治療股份有限公司 丁苯那嗪經皮輸送裝置
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
TW202011963A (zh) 2018-06-14 2020-04-01 美商紐羅克里生物科學有限公司 Vmat2抑制劑化合物、組合物及其相關方法
KR20210044817A (ko) 2018-08-15 2021-04-23 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
WO2020070236A1 (en) 2018-10-04 2020-04-09 Adeptio Pharmaceuticals Limited (+)-alpha-dihydrotetrabenazine dosage regimen for treating movement disorders
AU2020270145A1 (en) * 2019-05-09 2021-12-23 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors

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WO2008058261A1 (en) * 2006-11-08 2008-05-15 Neurocrine Biosciences, Inc. Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto
WO2011153157A2 (en) * 2010-06-01 2011-12-08 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
WO2014047167A1 (en) * 2012-09-18 2014-03-27 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2015120317A1 (en) * 2014-02-07 2015-08-13 Neurocrine Biosciences, Inc. Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof

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EP2083744A4 (en) * 2006-11-09 2013-08-28 Univ New York DEGRADED GLASS / ZIRCONIUM / GLASS STRUCTURES FOR DAMAGE-RESISTANT DENTAL AND ORTHOPEDIC CERAMIC PROSTHESES
GB2462611A (en) 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
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JP2013501810A (ja) * 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物

Patent Citations (4)

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WO2008058261A1 (en) * 2006-11-08 2008-05-15 Neurocrine Biosciences, Inc. Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto
WO2011153157A2 (en) * 2010-06-01 2011-12-08 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
WO2014047167A1 (en) * 2012-09-18 2014-03-27 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2015120317A1 (en) * 2014-02-07 2015-08-13 Neurocrine Biosciences, Inc. Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof

Non-Patent Citations (1)

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Publication number Publication date
EP4389227A2 (en) 2024-06-26
DK3139925T3 (da) 2021-12-20
CN112741835A (zh) 2021-05-04
JP2024153782A (ja) 2024-10-29
KR20200133003A (ko) 2020-11-25
US20210196702A1 (en) 2021-07-01
RU2016147523A (ru) 2018-06-08
KR20160147044A (ko) 2016-12-21
SI3139925T1 (sl) 2022-04-29
SMT202400199T1 (it) 2024-07-09
EP3936130A1 (en) 2022-01-12
KR20220140647A (ko) 2022-10-18
EP3936130B1 (en) 2024-02-14
IL248745B (en) 2022-07-01
CN112741836A (zh) 2021-05-04
WO2015171802A1 (en) 2015-11-12
JP2021191799A (ja) 2021-12-16
EP4389227A3 (en) 2024-09-04
HUE066361T2 (hu) 2024-07-28
PT3936130T (pt) 2024-04-17
CY1125058T1 (el) 2023-06-09
RU2753740C2 (ru) 2021-08-23
SMT202200193T1 (it) 2022-07-21
IL248745A0 (en) 2017-01-31
CN106456629A (zh) 2017-02-22
US20170071932A1 (en) 2017-03-16
EP3139925A1 (en) 2017-03-15
EP3139925B1 (en) 2021-12-01
HUE057839T2 (hu) 2022-06-28
CA2947736A1 (en) 2015-11-12
ES2904526T3 (es) 2022-04-05
SI3936130T1 (sl) 2024-05-31
CA2947736C (en) 2023-04-18
NZ725826A (en) 2023-05-26
JP6635945B2 (ja) 2020-01-29
AU2015256012A1 (en) 2016-11-24
DK3936130T3 (da) 2024-03-25
MX2016014429A (es) 2017-04-06
HRP20220025T1 (hr) 2022-04-01
PL3936130T3 (pl) 2024-06-10
RS62782B1 (sr) 2022-01-31
JP2017514850A (ja) 2017-06-08
MX387625B (es) 2025-03-18
KR20250029267A (ko) 2025-03-04
LT3936130T (lt) 2024-04-25
FI3936130T3 (fi) 2024-04-23
ES2976207T3 (es) 2024-07-26
RS65359B1 (sr) 2024-04-30
JP2019218407A (ja) 2019-12-26
HRP20240459T1 (hr) 2024-06-21
US20200101063A1 (en) 2020-04-02
PT3139925T (pt) 2022-01-26
PL3139925T3 (pl) 2022-03-21
KR20240011255A (ko) 2024-01-25
RU2016147523A3 (OSRAM) 2018-12-28
LT3139925T (lt) 2022-01-25

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