ES2969868T3 - Antagonistas selectivos de P2X3 para su uso en el tratamiento de la tos crónica sin pérdida de la respuesta gustativa - Google Patents
Antagonistas selectivos de P2X3 para su uso en el tratamiento de la tos crónica sin pérdida de la respuesta gustativa Download PDFInfo
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- ES2969868T3 ES2969868T3 ES18860273T ES18860273T ES2969868T3 ES 2969868 T3 ES2969868 T3 ES 2969868T3 ES 18860273 T ES18860273 T ES 18860273T ES 18860273 T ES18860273 T ES 18860273T ES 2969868 T3 ES2969868 T3 ES 2969868T3
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- selective
- antagonist
- patient
- pharmaceutically acceptable
- acceptable salt
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
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- 150000005846 sugar alcohols Chemical class 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
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- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
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- 229960004559 theobromine Drugs 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 125000005985 thienyl[1,3]dithianyl group Chemical group 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Amplifiers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560077P | 2017-09-18 | 2017-09-18 | |
| US15/936,316 US10111883B1 (en) | 2017-09-18 | 2018-03-26 | Selective P2X3 modulators |
| PCT/IB2018/001513 WO2019064079A2 (en) | 2017-09-18 | 2018-09-14 | SELECTIVE MODULATORS OF P2X3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2969868T3 true ES2969868T3 (es) | 2024-05-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18860273T Active ES2969868T3 (es) | 2017-09-18 | 2018-09-14 | Antagonistas selectivos de P2X3 para su uso en el tratamiento de la tos crónica sin pérdida de la respuesta gustativa |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10111883B1 (he) |
| EP (2) | EP3684368B8 (he) |
| JP (1) | JP7242681B2 (he) |
| KR (1) | KR20200092938A (he) |
| CN (1) | CN111601601A (he) |
| AU (1) | AU2018342751B2 (he) |
| CA (1) | CA3076150C (he) |
| ES (1) | ES2969868T3 (he) |
| IL (2) | IL303257A (he) |
| MX (1) | MX2020002968A (he) |
| SG (1) | SG11202002460QA (he) |
| WO (1) | WO2019064079A2 (he) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021005334A2 (pt) * | 2018-10-05 | 2021-06-15 | Shionogi & Co., Ltd. | medicamento para tratamento de tosse crônica |
| CA3115939A1 (en) * | 2018-10-10 | 2020-04-16 | Bellus Health Cough Inc. | Treatment of pruritus with p2x3 antagonists |
| EP3880678A4 (en) | 2018-11-13 | 2022-08-31 | Bellus Health Cough Inc. | CRYSTALLINE FORMS OF A SUBSTITUTED IMIDAZOPYRIDINE COMPOUND AND THEIR USE AS A P2X3 MODULATOR |
| JP2022515879A (ja) * | 2018-12-29 | 2022-02-22 | 武漢朗来科技発展有限公司 | 複素環式化合物、中間体、その製造方法及び応用 本願は、出願日が２０１８年１２月２９日の中国特許出願ｃｎ ２０１８１１６４２３１９、出願日が２０１９年０５月２４日の中国特許出願ｃｎ２０１９１０４４０２１４．３及び出願日が２０１９年１０月２４日の中国特許出願ｃｎ２０１９１１０１６１５８．７に基づいて優先権を主張する。また、上記中国特許出願の全文は本願に援用される。 |
| CN113727716A (zh) * | 2019-02-25 | 2021-11-30 | 贝卢斯医疗咳嗽病公司 | 采用p2x3调节剂的治疗 |
| CN112409331B (zh) * | 2019-08-21 | 2024-02-20 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| CN115413279A (zh) * | 2020-02-14 | 2022-11-29 | 贝卢斯医疗咳嗽病公司 | P2x3调节剂 |
| JP2023523335A (ja) | 2020-04-27 | 2023-06-02 | ツイスト バイオサイエンス コーポレーション | コロナウイルス用の変異体核酸ライブラリー相互参照 |
| CN113754654A (zh) * | 2020-06-05 | 2021-12-07 | 武汉人福创新药物研发中心有限公司 | 咪唑并吡啶类化合物及其用途 |
| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
| EP4169921A4 (en) * | 2020-06-29 | 2024-06-19 | Wuhan LL Science and Technology Development Co., Ltd. | CRYSTAL FORM OF A HETEROCYCLIC COMPOUND, ITS PREPARATION METHOD AND ITS USE |
| CN113912601B (zh) * | 2020-07-10 | 2023-06-06 | 上海拓界生物医药科技有限公司 | 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途 |
| CA3187092A1 (en) * | 2020-08-13 | 2022-02-17 | Wenming Li | Benzimidazole derivatives, preparation method therefor and medical use thereof |
| WO2022161462A1 (zh) * | 2021-01-29 | 2022-08-04 | 上海海雁医药科技有限公司 | 吗啉衍生物及其药物组合物和用途 |
| WO2022258059A1 (zh) * | 2021-06-10 | 2022-12-15 | 武汉朗来科技发展有限公司 | 一种药物组合物、制剂及其制备方法和应用 |
| CN115043836B (zh) * | 2021-08-20 | 2023-07-18 | 苏州璞正医药有限公司 | 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途 |
| US20230218661A1 (en) * | 2022-01-10 | 2023-07-13 | Sensory Cloud, Inc. | Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012011518B8 (pt) * | 2009-11-18 | 2023-01-10 | Astrazeneca Ab | Compostos, composição farmacêutica, kit e usos de um composto |
| RU2656593C2 (ru) * | 2013-01-31 | 2018-06-06 | Неомед Инститьют | Соединения имидазопиридина, полезные при лечении состояния, связанного с активностью p2x3 и/или p2x2/3 |
| AU2014308606B2 (en) * | 2013-08-23 | 2017-08-03 | Afferent Pharmaceuticals Inc. | Diaminopyrimidine P2X3 and P2X 2/3 receptor modulators for treatment of acute, sub-acute or chronic cough |
| HRP20230445T1 (hr) * | 2015-09-29 | 2023-07-21 | Afferent Pharmaceuticals Inc. | Modulatori diaminopirimidin p2x3 i p2x2/3 receptora za primjenu u liječenju kašlja |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| CN116854693A (zh) * | 2016-09-30 | 2023-10-10 | 阿沙纳生物科学公司 | P2x3和/或p2x2/3化合物及方法 |
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2018
- 2018-03-26 US US15/936,316 patent/US10111883B1/en active Active
- 2018-09-14 AU AU2018342751A patent/AU2018342751B2/en active Active
- 2018-09-14 ES ES18860273T patent/ES2969868T3/es active Active
- 2018-09-14 MX MX2020002968A patent/MX2020002968A/es unknown
- 2018-09-14 IL IL303257A patent/IL303257A/he unknown
- 2018-09-14 CN CN201880073147.XA patent/CN111601601A/zh active Pending
- 2018-09-14 KR KR1020207010982A patent/KR20200092938A/ko not_active Application Discontinuation
- 2018-09-14 IL IL273348A patent/IL273348B2/he unknown
- 2018-09-14 EP EP18860273.4A patent/EP3684368B8/en active Active
- 2018-09-14 SG SG11202002460QA patent/SG11202002460QA/en unknown
- 2018-09-14 JP JP2020537064A patent/JP7242681B2/ja active Active
- 2018-09-14 EP EP23219770.7A patent/EP4331669A3/en active Pending
- 2018-09-14 WO PCT/IB2018/001513 patent/WO2019064079A2/en unknown
- 2018-09-14 US US16/647,821 patent/US20200230148A1/en not_active Abandoned
- 2018-09-14 CA CA3076150A patent/CA3076150C/en active Active
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2020
- 2020-11-17 US US16/950,742 patent/US20210069201A1/en not_active Abandoned
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2021
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2022
- 2022-02-11 US US17/669,806 patent/US20220160724A1/en not_active Abandoned
- 2022-09-14 US US17/932,200 patent/US20230248736A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL273348B2 (he) | 2023-11-01 |
| JP2020534355A (ja) | 2020-11-26 |
| US20210322432A1 (en) | 2021-10-21 |
| EP3684368A2 (en) | 2020-07-29 |
| CA3076150A1 (en) | 2019-04-04 |
| AU2018342751B2 (en) | 2023-06-15 |
| EP3684368B1 (en) | 2024-01-03 |
| US20200230148A1 (en) | 2020-07-23 |
| CA3076150C (en) | 2024-01-02 |
| EP4331669A3 (en) | 2024-05-01 |
| EP4331669A2 (en) | 2024-03-06 |
| EP3684368B8 (en) | 2024-02-14 |
| SG11202002460QA (en) | 2020-04-29 |
| US20210069201A1 (en) | 2021-03-11 |
| WO2019064079A2 (en) | 2019-04-04 |
| US10111883B1 (en) | 2018-10-30 |
| JP7242681B2 (ja) | 2023-03-20 |
| CN111601601A (zh) | 2020-08-28 |
| IL273348A (he) | 2020-05-31 |
| EP3684368A4 (en) | 2021-05-26 |
| US20230248736A1 (en) | 2023-08-10 |
| IL273348B1 (he) | 2023-07-01 |
| US20220160724A1 (en) | 2022-05-26 |
| MX2020002968A (es) | 2020-08-17 |
| KR20200092938A (ko) | 2020-08-04 |
| AU2018342751A1 (en) | 2020-04-23 |
| IL303257A (he) | 2023-07-01 |
| WO2019064079A3 (en) | 2019-05-16 |
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