ES2962824T3 - Anticuerpos contra FcRn y procedimientos de uso de los mismos - Google Patents
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- ES2962824T3 ES2962824T3 ES16744204T ES16744204T ES2962824T3 ES 2962824 T3 ES2962824 T3 ES 2962824T3 ES 16744204 T ES16744204 T ES 16744204T ES 16744204 T ES16744204 T ES 16744204T ES 2962824 T3 ES2962824 T3 ES 2962824T3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Immunology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562110071P | 2015-01-30 | 2015-01-30 | |
| US201562258082P | 2015-11-20 | 2015-11-20 | |
| PCT/US2016/015720 WO2016123521A2 (en) | 2015-01-30 | 2016-01-29 | Fcrn antibodies and methods of use thereof |
Publications (1)
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| ES2962824T3 true ES2962824T3 (es) | 2024-03-21 |
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| ES16744204T Active ES2962824T3 (es) | 2015-01-30 | 2016-01-29 | Anticuerpos contra FcRn y procedimientos de uso de los mismos |
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| AU (2) | AU2016211280B2 (enExample) |
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| ES (1) | ES2962824T3 (enExample) |
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| HR (1) | HRP20231399T1 (enExample) |
| HU (1) | HUE063778T2 (enExample) |
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| LT (1) | LT3250610T (enExample) |
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| PT (1) | PT3250610T (enExample) |
| RS (1) | RS64768B1 (enExample) |
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| SI (1) | SI3250610T1 (enExample) |
| SM (1) | SMT202300365T1 (enExample) |
| WO (1) | WO2016123521A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG11201605203UA (en) | 2013-12-24 | 2016-07-28 | Argen X N V | Fcrn antagonists and methods of use |
| RU2714153C2 (ru) * | 2014-06-12 | 2020-02-12 | Ф. Хоффманн-Ля Рош Аг | СПОСОБ ОТБОРА АНТИТЕЛ С МОДИФИЦИРОВАННЫМ ВЗАИМОДЕЙСТВИЕМ С FcRn |
| CN118562003A (zh) | 2015-01-30 | 2024-08-30 | 动量制药公司 | Fcrn抗体及其使用方法 |
| DK3491025T3 (da) * | 2016-07-29 | 2024-01-15 | Momenta Pharmaceuticals Inc | Fcrn-antistoffer og anvendelsesmetoder heraf |
| EP3638305A1 (en) * | 2017-06-15 | 2020-04-22 | UCB Biopharma SRL | Method for the treatment of immune thrombocytopenia |
| EP3720877A1 (en) | 2017-12-08 | 2020-10-14 | Argenx BVBA | Use of fcrn antagonists for treatment of generalized myasthenia gravis |
| AU2018386193B2 (en) * | 2017-12-13 | 2025-04-24 | Momenta Pharmaceuticals, Inc. | FcRn antibodies and methods of use thereof |
| AU2019283673B2 (en) | 2018-06-08 | 2023-12-07 | argenx BV | Compositions and methods for treating immune thrombocytopenia |
| EP3823978A4 (en) * | 2018-07-20 | 2022-12-14 | Momenta Pharmaceuticals, Inc. | Fcrn antibody compositions |
| SG11202100420UA (en) * | 2018-07-20 | 2021-02-25 | Momenta Pharmaceuticals Inc | Compositions of fcrn antibodies and methods of use thereof |
| CN113646051A (zh) | 2018-10-16 | 2021-11-12 | Ucb生物制药有限责任公司 | 重症肌无力的治疗方法 |
| MX2021014756A (es) | 2019-06-07 | 2022-01-18 | Argenx Bvba | Formulaciones farmaceuticas de inhibidores de fcrn adecuadas para administracion subcutanea. |
| CN114630678A (zh) * | 2019-08-01 | 2022-06-14 | 詹森生物科技公司 | FcRn抗体及其使用方法 |
| MX2022005862A (es) * | 2019-11-19 | 2022-06-23 | Immunovant Sciences Gmbh | Metodos de tratamiento de anemia hemolitica autoinmune caliente mediante el uso de anticuerpos anti-fcrn. |
| CN115836086A (zh) | 2020-01-08 | 2023-03-21 | 阿尔金克斯有限公司 | 治疗天疱疮病症的方法 |
| IL302516A (en) * | 2020-11-06 | 2023-07-01 | Janssen Biotech Inc | FCRN antibodies and methods of using them |
| WO2022166900A1 (en) * | 2021-02-02 | 2022-08-11 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric fcrn |
| WO2023016538A1 (en) * | 2021-08-13 | 2023-02-16 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing fcrn and uses thereof |
| WO2023030501A1 (zh) * | 2021-09-03 | 2023-03-09 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别FcRn的抗体及其应用 |
| CN119013043A (zh) | 2022-05-30 | 2024-11-22 | 韩兀生物制药股份有限公司 | 具有改善的稳定性的抗FcRn抗体或其抗原结合片段 |
| JP2025520431A (ja) | 2022-06-15 | 2025-07-03 | アルジェニクス ビーブイ | Ｆｃｒｎ／抗原結合分子及び使用方法 |
| TW202444412A (zh) | 2023-02-04 | 2024-11-16 | 美商默門塔醫藥公司 | 用於治療胎兒及新生兒溶血性疾病之組成物及方法 |
| TW202527982A (zh) | 2023-09-11 | 2025-07-16 | 美商默門塔醫藥公司 | Fcrn抗體之醫藥組成物 |
| WO2025099576A1 (en) | 2023-11-06 | 2025-05-15 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2025163617A1 (en) | 2024-02-04 | 2025-08-07 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating sjögren's disease |
| WO2025186787A1 (en) | 2024-03-08 | 2025-09-12 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating fetal and neonatal alloimmune thrombocytopenia |
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| WO2003068259A1 (fr) | 2002-02-14 | 2003-08-21 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
| JP2007501847A (ja) * | 2003-08-08 | 2007-02-01 | ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク | 自己／同種免疫状態の治療用抗ＦｃＲｎ抗体 |
| US7662928B2 (en) | 2003-08-08 | 2010-02-16 | The Research Foundation Of State University Of New York | Anti-FcRn antibodies for treatment of auto/allo immune conditions |
| CN101124245A (zh) * | 2003-11-12 | 2008-02-13 | 比奥根艾迪克Ma公司 | 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法 |
| US20090110681A1 (en) | 2005-03-08 | 2009-04-30 | Pfizer, Inc. | Anti-M-CSF Antibody Compositions |
| CA2637929A1 (en) | 2006-01-25 | 2007-08-02 | The Research Foundation Of State University Of New York | Anti-fcrn antibodies for treatement of auto/allo immune conditions |
| CN101421297A (zh) * | 2006-02-17 | 2009-04-29 | 森托尼克斯制药有限公司 | 阻断lgG对FcRn的结合的肽 |
| CA2644405A1 (en) * | 2006-03-13 | 2007-09-20 | Ablynx N.V. | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| SG10201804513WA (en) * | 2008-04-25 | 2018-07-30 | Dyax Corp | Antibodies Against Fcrn And Use Thereof |
| JP5683581B2 (ja) * | 2009-06-30 | 2015-03-11 | リサーチ ディベロップメント ファウンデーション | 免疫グロブリンＦｃポリペプチド |
| CN105622754B (zh) * | 2011-06-02 | 2019-12-27 | 戴埃克斯有限公司 | Fc受体结合蛋白 |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| US20130323242A1 (en) | 2012-06-01 | 2013-12-05 | Ophthotech Corp. | Compositions comprising an anti-pdgf aptamer and a vegf antagonist |
| WO2014099636A1 (en) | 2012-12-18 | 2014-06-26 | Merck Sharp & Dohme Corp. | Liquid formulations for an anti-tnf alpha antibody |
| ES2802274T3 (es) | 2013-05-02 | 2021-01-18 | Momenta Pharmaceuticals Inc | Glicoproteínas sialiladas |
| KR101815265B1 (ko) | 2013-06-20 | 2018-01-04 | 한올바이오파마주식회사 | FcRn 특이적 인간 항체 및 이를 포함하는 자가면역 질환 치료용 조성물 |
| CN118562003A (zh) | 2015-01-30 | 2024-08-30 | 动量制药公司 | Fcrn抗体及其使用方法 |
| MY188761A (en) | 2015-03-09 | 2021-12-29 | Argenx Bvba | Method of reducing serum levels of fc-containing agents using fcrn antagonists |
| WO2016183352A1 (en) | 2015-05-12 | 2016-11-17 | Syntimmune, Inc. | Humanized affinity matured anti-fcrn antibodies |
| DK3491025T3 (da) | 2016-07-29 | 2024-01-15 | Momenta Pharmaceuticals Inc | Fcrn-antistoffer og anvendelsesmetoder heraf |
| EP3720877A1 (en) | 2017-12-08 | 2020-10-14 | Argenx BVBA | Use of fcrn antagonists for treatment of generalized myasthenia gravis |
| AU2018386193B2 (en) | 2017-12-13 | 2025-04-24 | Momenta Pharmaceuticals, Inc. | FcRn antibodies and methods of use thereof |
| SG11202100420UA (en) | 2018-07-20 | 2021-02-25 | Momenta Pharmaceuticals Inc | Compositions of fcrn antibodies and methods of use thereof |
| EP3823978A4 (en) | 2018-07-20 | 2022-12-14 | Momenta Pharmaceuticals, Inc. | Fcrn antibody compositions |
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2016
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2023
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