ES2959811T3 - Construcciones de adenovirus de chimpancé con antígenos de Lyssavirus - Google Patents

Construcciones de adenovirus de chimpancé con antígenos de Lyssavirus Download PDF

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Publication number
ES2959811T3
ES2959811T3 ES17828782T ES17828782T ES2959811T3 ES 2959811 T3 ES2959811 T3 ES 2959811T3 ES 17828782 T ES17828782 T ES 17828782T ES 17828782 T ES17828782 T ES 17828782T ES 2959811 T3 ES2959811 T3 ES 2959811T3
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adenoviral
protein
gene
seq
chad155
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Virginia Ammendola
Stefano Colloca
Alessandra Vitelli
Benjamin Wizel
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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ES17828782T 2016-12-09 2017-12-08 Construcciones de adenovirus de chimpancé con antígenos de Lyssavirus Active ES2959811T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662432033P 2016-12-09 2016-12-09
US201762465378P 2017-03-01 2017-03-01
PCT/IB2017/057759 WO2018104919A1 (en) 2016-12-09 2017-12-08 Chimpanzee adenovirus constructs with lyssavirus antigens

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Publication Number Publication Date
ES2959811T3 true ES2959811T3 (es) 2024-02-28

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US (2) US20220112245A2 (enExample)
EP (1) EP3551644B1 (enExample)
JP (1) JP7118062B2 (enExample)
CN (1) CN110036020A (enExample)
BR (1) BR112019010275A2 (enExample)
CA (1) CA3045976A1 (enExample)
ES (1) ES2959811T3 (enExample)
MX (1) MX2019006722A (enExample)
WO (1) WO2018104919A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
CA3062591A1 (en) 2017-05-08 2018-11-15 Gritstone Oncology, Inc. Alphavirus neoantigen vectors
CN111108203A (zh) * 2017-07-17 2020-05-05 葛兰素史密丝克莱恩生物有限公司 狂犬病病毒抗原构建体
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
KR102077772B1 (ko) * 2018-11-29 2020-02-17 주식회사 바이오앱 광견병 예방용 백신 조성물 및 이의 제조 방법
WO2020121273A1 (en) 2018-12-14 2020-06-18 Glaxosmithkline Biologicals Sa Heterologous prime boost vaccine compositions and methods
MX2021014525A (es) * 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
BR112021025025A2 (pt) * 2019-06-11 2022-02-22 Glaxosmithkline Biologicals Sa Formulações de vacinas de mucosa
US20230234992A1 (en) 2020-06-05 2023-07-27 Glaxosmithkline Biologicals Sa Modified betacoronavirus spike proteins
WO2022077330A1 (zh) * 2020-10-15 2022-04-21 中国科学院深圳先进技术研究院 一种新型g基因及其在高效逆向跨单突触中的应用
CN112210565B (zh) * 2020-10-15 2022-07-29 中国科学院深圳先进技术研究院 一种g基因及其在高效逆向跨单突触中的应用
CN114591922A (zh) * 2022-03-30 2022-06-07 长睿生物技术(成都)有限公司 一种表达狂犬病毒g蛋白的重组黑猩猩源腺病毒及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698202A (en) * 1995-06-05 1997-12-16 The Wistar Institute Of Anatomy & Biology Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier
ES2322043T3 (es) * 2001-06-22 2009-06-16 The Wistar Institute Of Anatomy And Biology Procedimientos de indusccion de una respuesta citotoxica inmune y composiciones de adenovirus de simio recombinante utiles en los mismos.
ES2871907T3 (es) * 2004-01-23 2021-11-02 Msd Italia Srl Portadores de vacuna de adenovirus de chimpancé
EP2220217A2 (en) 2007-11-28 2010-08-25 The Trustees of the University of Pennsylvania Simian subfamily c adenoviruses sadv-40, -31, and-34 and uses thereof
WO2010085984A1 (en) 2009-02-02 2010-08-05 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
MX2011007980A (es) 2009-02-02 2011-08-17 Okairos Ag Secuencias de acido nucleico y aminoacido de adenovirus de simio, vectores que contienen los mismos y usos de las mismas.
WO2012089231A1 (en) 2010-12-30 2012-07-05 Okairòs Ag Paramyxovirus vaccines
JP6091435B2 (ja) 2011-02-22 2017-03-08 カリフォルニア インスティチュート オブ テクノロジー アデノ随伴ウイルス（ａａｖ）ベクターを用いたタンパク質の送達
IN2014DN03005A (enExample) 2011-10-05 2015-05-08 Genvec Inc
JP6757120B2 (ja) 2011-10-05 2020-09-16 ジェンヴェック エルエルシー アーフェンアデノウイルス（ゴリラ）又はアデノウイルスベクター、及び使用方法
CN103987726B (zh) 2011-10-05 2017-10-03 金维克有限公司 猴(大猩猩)腺病毒或腺病毒载体及其使用方法
WO2015119291A1 (ja) * 2014-02-10 2015-08-13 有限会社生物資源研究所 ウイルス様粒子
CN106659777A (zh) * 2014-06-13 2017-05-10 葛兰素史密丝克莱恩生物有限公司 免疫原性组合产品
EA038402B9 (ru) * 2015-06-12 2021-09-22 Глаксосмитклайн Байолоджикалс Са Аденовирусные полинуклеотиды и полипептиды

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