ES2959692T3 - Cerdulatinib y venetoclax para tratar linfoma no Hodgkin - Google Patents
Cerdulatinib y venetoclax para tratar linfoma no Hodgkin Download PDFInfo
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- ES2959692T3 ES2959692T3 ES16819235T ES16819235T ES2959692T3 ES 2959692 T3 ES2959692 T3 ES 2959692T3 ES 16819235 T ES16819235 T ES 16819235T ES 16819235 T ES16819235 T ES 16819235T ES 2959692 T3 ES2959692 T3 ES 2959692T3
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- Prior art keywords
- cerdulatinib
- pharmaceutically acceptable
- acceptable salt
- venetoclax
- patient
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201562263582P | 2015-12-04 | 2015-12-04 | |
| US201662342727P | 2016-05-27 | 2016-05-27 | |
| US201662342755P | 2016-05-27 | 2016-05-27 | |
| US201662371145P | 2016-08-04 | 2016-08-04 | |
| PCT/US2016/064824 WO2017096303A2 (en) | 2015-12-04 | 2016-12-02 | Cerdulatinib for treating hematological cancers |
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| ES2959692T3 true ES2959692T3 (es) | 2024-02-27 |
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| JP (1) | JP6944936B2 (https=) |
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| AU (1) | AU2016363005A1 (https=) |
| CA (1) | CA2950640A1 (https=) |
| ES (1) | ES2959692T3 (https=) |
| WO (1) | WO2017096303A2 (https=) |
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| JP7258462B2 (ja) | 2015-05-29 | 2023-04-17 | ポートラ ファーマシューティカルズ， エルエルシー | Ｂ細胞悪性腫瘍の治療のためのセルデュラチニブ |
| JP6833816B2 (ja) | 2015-08-12 | 2021-02-24 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ） |
| SG11202005781WA (en) * | 2018-01-09 | 2020-07-29 | Dermavant Sciences GmbH | Cerdulatinib-containing topical skin pharmaceutical compositions and uses thereof |
| CA3098012A1 (en) * | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Methods for treating lymphoma |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| TWI805751B (zh) | 2018-05-04 | 2023-06-21 | 美商普托拉製藥有限公司 | 賽度替尼(cerdulatinib)之合成 |
| PH12021551936A1 (en) * | 2019-02-15 | 2022-05-23 | Janssen Biotech Inc | Combination therapy for treatment of b-cell malignancies |
| US20230181581A1 (en) * | 2020-05-26 | 2023-06-15 | Alexion Pharmaceuticals, Inc. | Circulating b cell subpopulations in indolent b cell lymphoma |
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| EP1054004B1 (en) | 1997-12-15 | 2008-07-16 | Astellas Pharma Inc. | Novel pyrimidine-5-carboxamide derivatives |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1518855B1 (en) | 2002-06-28 | 2011-10-26 | Astellas Pharma Inc. | Diaminopyrimidinecarboxa mide derivative |
| WO2008009458A1 (en) | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| HRP20161310T1 (hr) | 2008-04-16 | 2016-12-02 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pirimidin-5-il-karboksamidi kao inhibitori syk ili jak kinaza |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8367689B2 (en) | 2009-05-06 | 2013-02-05 | Portola Pharmaceuticals, Inc. | Inhibitors of JAK |
| WO2010138588A2 (en) | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP2507227B1 (en) | 2009-12-01 | 2014-10-08 | Rigel Pharmaceuticals, Inc. | Tetrazolones as protein kinase c inhibitors and uses thereof |
| US9357229B2 (en) | 2010-07-28 | 2016-05-31 | Qualcomm Incorporated | Coding motion vectors in video coding |
| EP2621489A1 (en) | 2010-09-30 | 2013-08-07 | Portola Pharmaceuticals, Inc. | Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine |
| PT2643322T (pt) | 2010-11-23 | 2017-11-13 | Abbvie Inc | Sais e formas cristalinas de um agente indutor de apoptose |
| EP2741747A1 (en) | 2011-08-10 | 2014-06-18 | Novartis Pharma AG | JAK P13K/mTOR COMBINATION THERAPY |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| TW201427664A (zh) | 2012-11-02 | 2014-07-16 | Pharmacyclics Inc | Ｔｅｃ家族激酶抑制劑佐劑療法 |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| JP7258462B2 (ja) | 2015-05-29 | 2023-04-17 | ポートラ ファーマシューティカルズ， エルエルシー | Ｂ細胞悪性腫瘍の治療のためのセルデュラチニブ |
| JP6833816B2 (ja) | 2015-08-12 | 2021-02-24 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 骨髄腫を治療するためのセルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ） |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
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| US10736895B2 (en) | 2020-08-11 |
| US11446300B2 (en) | 2022-09-20 |
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| EP3383396B1 (en) | 2023-07-12 |
| WO2017096303A3 (en) | 2017-08-03 |
| CN108367006B (zh) | 2021-12-31 |
| WO2017096303A2 (en) | 2017-06-08 |
| US20180353506A1 (en) | 2018-12-13 |
| JP6944936B2 (ja) | 2021-10-06 |
| CN108367006A (zh) | 2018-08-03 |
| JP2018535996A (ja) | 2018-12-06 |
| AU2016363005A1 (en) | 2018-07-05 |
| CA2950640A1 (en) | 2017-06-04 |
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