ES2956471T3 - Tratamientos del angioedema hereditario - Google Patents

Tratamientos del angioedema hereditario Download PDF

Info

Publication number
ES2956471T3
ES2956471T3 ES20734283T ES20734283T ES2956471T3 ES 2956471 T3 ES2956471 T3 ES 2956471T3 ES 20734283 T ES20734283 T ES 20734283T ES 20734283 T ES20734283 T ES 20734283T ES 2956471 T3 ES2956471 T3 ES 2956471T3
Authority
ES
Spain
Prior art keywords
compound
formula
solvate
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20734283T
Other languages
English (en)
Spanish (es)
Inventor
Edward Paul Feener
Sally Louise Marsh
Andreas Maetzel
Michael David Smith
Christopher Martyn Yea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalvista Pharmaceuticals Ltd
Original Assignee
Kalvista Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalvista Pharmaceuticals Ltd filed Critical Kalvista Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2956471T3 publication Critical patent/ES2956471T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
ES20734283T 2019-06-14 2020-06-15 Tratamientos del angioedema hereditario Active ES2956471T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962861725P 2019-06-14 2019-06-14
GBGB1910116.1A GB201910116D0 (en) 2019-07-15 2019-07-15 Treatments of hereditary angioedema
PCT/GB2020/051439 WO2020249977A1 (en) 2019-06-14 2020-06-15 Treatments of hereditary angioedema

Publications (1)

Publication Number Publication Date
ES2956471T3 true ES2956471T3 (es) 2023-12-21

Family

ID=67700145

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20734283T Active ES2956471T3 (es) 2019-06-14 2020-06-15 Tratamientos del angioedema hereditario

Country Status (34)

Country Link
US (1) US20220218680A1 (enExample)
EP (2) EP4282474A3 (enExample)
JP (3) JP7356518B2 (enExample)
KR (1) KR102748728B1 (enExample)
CN (1) CN114126612A (enExample)
AR (1) AR119158A1 (enExample)
AU (1) AU2020293614B2 (enExample)
BR (1) BR112021024664A2 (enExample)
CA (1) CA3142218A1 (enExample)
CL (2) CL2021003244A1 (enExample)
DK (1) DK3982960T3 (enExample)
EA (1) EA202193019A1 (enExample)
ES (1) ES2956471T3 (enExample)
FI (1) FI3982960T3 (enExample)
GB (1) GB201910116D0 (enExample)
HR (1) HRP20230696T1 (enExample)
HU (1) HUE063163T2 (enExample)
IL (1) IL288615A (enExample)
LT (1) LT3982960T (enExample)
MA (1) MA56187B1 (enExample)
MD (1) MD3982960T2 (enExample)
MX (1) MX2021014557A (enExample)
MY (1) MY205687A (enExample)
PH (1) PH12021552966A1 (enExample)
PL (1) PL3982960T3 (enExample)
PT (1) PT3982960T (enExample)
RS (1) RS64412B1 (enExample)
SG (1) SG11202113304YA (enExample)
SI (1) SI3982960T1 (enExample)
SM (1) SMT202300261T1 (enExample)
TW (1) TW202112370A (enExample)
UA (1) UA129869C2 (enExample)
WO (1) WO2020249977A1 (enExample)
ZA (1) ZA202110685B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
GB201910116D0 (en) * 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
CN114206852A (zh) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂
WO2022084693A1 (en) * 2020-10-23 2022-04-28 Kalvista Pharmaceuticals Limited Treatments of angioedema
JP2024505596A (ja) 2021-02-09 2024-02-06 カルビスタ・ファーマシューティカルズ・リミテッド 遺伝性血管性浮腫の治療
CA3255900A1 (en) 2022-04-27 2023-11-02 Kalvista Pharmaceuticals Limited FORMULATIONS OF A PLASMA KALLICEREIN INHIBITOR
CN116003386B (zh) * 2022-11-20 2024-03-26 药康众拓(北京)医药科技有限公司 一种氘代n-苄基吡啶酮吡唑甲酰胺类化合物、药物组合物和用途
WO2025172693A1 (en) 2024-02-13 2025-08-21 Kalvista Pharmaceuticals Limited Oral sebetralstat for the treatment of an attack of hereditary angioedema
WO2025172692A1 (en) 2024-02-13 2025-08-21 Kalvista Pharmaceuticals Limited Oral sebetralstat for the treatment of an attack of hereditary angioedema

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9019558D0 (en) 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
SE9301911D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptide derivatives
US5589467A (en) 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
GB0205527D0 (en) 2002-03-08 2002-04-24 Ferring Bv Inhibitors
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
JP5322935B2 (ja) 2006-07-31 2013-10-23 アクティベサイト ファーマシューティカルズ インコーポレイティッド 血漿カリクレインの阻害薬
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
JP2013121919A (ja) 2010-03-25 2013-06-20 Astellas Pharma Inc 血漿カリクレイン阻害剤
WO2012004678A2 (en) 2010-07-07 2012-01-12 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors
WO2012009009A2 (en) 2010-07-14 2012-01-19 Addex Pharma S.A. Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
US9290485B2 (en) 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
ES2626968T3 (es) 2013-05-23 2017-07-26 Kalvista Pharmaceuticals Limited Derivados heterocíclicos
EP2815749A1 (en) * 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
EP2886107A1 (en) * 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201721515D0 (en) * 2017-12-21 2018-02-07 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibtor
GB201910116D0 (en) * 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema

Also Published As

Publication number Publication date
MA56187A (fr) 2022-04-20
PH12021552966A1 (en) 2022-07-25
EA202193019A1 (ru) 2022-03-24
IL288615A (en) 2022-02-01
LT3982960T (lt) 2023-08-25
DK3982960T3 (da) 2023-08-21
HRP20230696T1 (hr) 2023-10-13
UA129869C2 (uk) 2025-08-27
RS64412B1 (sr) 2023-09-29
WO2020249977A1 (en) 2020-12-17
MX2021014557A (es) 2022-01-11
CN114126612A (zh) 2022-03-01
ZA202110685B (en) 2024-06-26
AU2020293614B2 (en) 2024-08-15
KR102748728B1 (ko) 2024-12-30
JP2023166406A (ja) 2023-11-21
FI3982960T3 (fi) 2023-08-29
TW202112370A (zh) 2021-04-01
NZ782935A (en) 2025-02-28
EP3982960A1 (en) 2022-04-20
US20220218680A1 (en) 2022-07-14
BR112021024664A2 (pt) 2022-05-31
GB201910116D0 (en) 2019-08-28
CA3142218A1 (en) 2020-12-17
SG11202113304YA (en) 2021-12-30
SMT202300261T1 (it) 2023-09-06
KR20220024220A (ko) 2022-03-03
MA56187B1 (fr) 2023-09-27
PL3982960T3 (pl) 2024-01-15
JP7356518B2 (ja) 2023-10-04
MD3982960T2 (ro) 2023-12-31
JP2022536287A (ja) 2022-08-15
MY205687A (en) 2024-11-06
EP4282474A3 (en) 2024-02-14
JP2025124716A (ja) 2025-08-26
JP7688078B2 (ja) 2025-06-03
CL2023000639A1 (es) 2023-10-30
CL2021003244A1 (es) 2022-09-30
SI3982960T1 (sl) 2023-10-30
AU2020293614A1 (en) 2022-01-27
EP3982960B1 (en) 2023-06-28
EP4282474A2 (en) 2023-11-29
AR119158A1 (es) 2021-12-01
PT3982960T (pt) 2023-09-26
HUE063163T2 (hu) 2023-12-28

Similar Documents

Publication Publication Date Title
ES2956471T3 (es) Tratamientos del angioedema hereditario
JP7640474B2 (ja) 血管性浮腫の治療
US20240122909A1 (en) Treatments of hereditary angioedema
US20230381162A1 (en) Treatments of angioedema
ES2991820T3 (es) Formulaciones de un inhibidor de la calicreína plasmática
HK40101443A (en) Treatments of hereditary angioedema
HK40070596B (en) Treatments of hereditary angioedema
HK40070596A (en) Treatments of hereditary angioedema
EA048676B1 (ru) Лечение наследственного ангионевротического отека
WO2024180100A1 (en) New solid form of a plasma kallikrein inhibitor
JP2022069377A (ja) 血管性浮腫の処置
WO2025172692A1 (en) Oral sebetralstat for the treatment of an attack of hereditary angioedema
WO2025172693A1 (en) Oral sebetralstat for the treatment of an attack of hereditary angioedema