ES2956109T3 - Analizador - Google Patents
Analizador Download PDFInfo
- Publication number
- ES2956109T3 ES2956109T3 ES19710787T ES19710787T ES2956109T3 ES 2956109 T3 ES2956109 T3 ES 2956109T3 ES 19710787 T ES19710787 T ES 19710787T ES 19710787 T ES19710787 T ES 19710787T ES 2956109 T3 ES2956109 T3 ES 2956109T3
- Authority
- ES
- Spain
- Prior art keywords
- light
- sample
- detector
- excitation
- dichroic mirror
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000005284 excitation Effects 0.000 claims abstract description 129
- 238000002835 absorbance Methods 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 29
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 5
- 229910052710 silicon Inorganic materials 0.000 claims description 5
- 239000010703 silicon Substances 0.000 claims description 5
- 238000012937 correction Methods 0.000 abstract description 4
- 239000000523 sample Substances 0.000 description 153
- 230000003287 optical effect Effects 0.000 description 25
- 238000003556 assay Methods 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 8
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- 229910052724 xenon Inorganic materials 0.000 description 8
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 239000004593 Epoxy Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 4
- 229910052753 mercury Inorganic materials 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
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- 238000013479 data entry Methods 0.000 description 3
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- 150000004676 glycans Chemical class 0.000 description 3
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- 229910052747 lanthanoid Inorganic materials 0.000 description 3
- 150000002602 lanthanoids Chemical class 0.000 description 3
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- 210000002381 plasma Anatomy 0.000 description 3
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- 102000004196 processed proteins & peptides Human genes 0.000 description 3
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- 238000010998 test method Methods 0.000 description 3
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- 238000013459 approach Methods 0.000 description 2
- BKZJXSDQOIUIIG-UHFFFAOYSA-N argon mercury Chemical compound [Ar].[Hg] BKZJXSDQOIUIIG-UHFFFAOYSA-N 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
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- 239000011230 binding agent Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
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- 239000011538 cleaning material Substances 0.000 description 1
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- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000007620 mathematical function Methods 0.000 description 1
- VSQYNPJPULBZKU-UHFFFAOYSA-N mercury xenon Chemical compound [Xe].[Hg] VSQYNPJPULBZKU-UHFFFAOYSA-N 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 210000000019 nipple aspirate fluid Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 210000005005 sentinel lymph node Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1734—Sequential different kinds of measurements; Combining two or more methods
- G01N2021/1736—Sequential different kinds of measurements; Combining two or more methods with two or more light sources
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1738—Optionally different kinds of measurements; Method being valid for different kinds of measurement
- G01N2021/174—Optionally different kinds of measurements; Method being valid for different kinds of measurement either absorption-reflection or emission-fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6471—Special filters, filter wheel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862631165P | 2018-02-15 | 2018-02-15 | |
| PCT/IB2019/051213 WO2019159109A1 (en) | 2018-02-15 | 2019-02-14 | Analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2956109T3 true ES2956109T3 (es) | 2023-12-13 |
Family
ID=65763686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19710787T Active ES2956109T3 (es) | 2018-02-15 | 2019-02-14 | Analizador |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11119043B2 (https=) |
| EP (1) | EP3752819B1 (https=) |
| JP (1) | JP7206570B2 (https=) |
| ES (1) | ES2956109T3 (https=) |
| WO (1) | WO2019159109A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3990894A1 (en) | 2019-06-28 | 2022-05-04 | ProciseDx Inc. | Methods for accommodating for sample matrix effects in light measurement assays |
| JP7712365B2 (ja) * | 2021-07-20 | 2025-07-23 | 株式会社日立ハイテク | 分析方法および分析装置 |
| JP2025506770A (ja) * | 2022-02-23 | 2025-03-13 | メソ スケール テクノロジーズ エルエルシー | 光学センサベースのシステムのダイナミックレンジを増加させるための方法及びデバイス |
| CN114923885B (zh) * | 2022-04-13 | 2025-05-16 | 奥谱天成（厦门）光电有限公司 | 一种原位超微量、荧光、浊度多功能液滴测量平台 |
| WO2025089022A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社日立ハイテク | 自動分析装置 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077480B1 (en) * | 1988-08-22 | 1996-07-02 | United Sciences Inc | Transmissometer having solid state light source |
| JPH04138343A (ja) * | 1990-09-28 | 1992-05-12 | Shimadzu Corp | 分光螢光光度計 |
| US6515113B2 (en) | 1999-02-18 | 2003-02-04 | The Regents Of The University Of California | Phthalamide lanthanide complexes for use as luminescent markers |
| WO2000048991A1 (en) | 1999-02-18 | 2000-08-24 | The Regents Of The University Of California | Salicylamide-lanthanide complexes for use as luminescent markers |
| US20050279949A1 (en) | 1999-05-17 | 2005-12-22 | Applera Corporation | Temperature control for light-emitting diode stabilization |
| US7283230B2 (en) * | 1999-09-24 | 2007-10-16 | Cao Group, Inc | Semiconductor forensic light kit |
| WO2001055701A1 (en) * | 2000-01-31 | 2001-08-02 | Board Of Regents, The University Of Texas System | System and method for the analysis of bodily fluids |
| US20060041385A1 (en) * | 2004-08-18 | 2006-02-23 | Bauer Kenneth D | Method of quantitating proteins and genes in cells using a combination of immunohistochemistry and in situ hybridization |
| US7663750B2 (en) * | 2005-06-30 | 2010-02-16 | Applied Biosystems, Llc | Two-dimensional spectral imaging system |
| EP2203735A4 (en) * | 2007-10-29 | 2012-03-21 | Ca Nat Research Council | METHOD AND DEVICE FOR DETECTING PARTICULARLY BONDED FLUOROPHORS IMPEDED BY PARTICULAR CASES |
| US8480856B2 (en) * | 2007-11-19 | 2013-07-09 | Nalco Company | Fluorometric method for monitoring surface additives in a papermaking process |
| WO2011120006A1 (en) * | 2010-03-25 | 2011-09-29 | Auantalife, Inc. A Delaware Corporation | Detection system for droplet-based assays |
| US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
| WO2011064778A2 (en) | 2009-11-30 | 2011-06-03 | Bio-Rad Laboratories Inc. | Bead reader |
| BR112013010096B1 (pt) * | 2010-11-01 | 2020-03-10 | 3M Innovative Properties Company | Método de detecção de uma atividade biológica |
| US9795330B2 (en) * | 2011-12-15 | 2017-10-24 | Given Imaging Ltd. | Device, system and method for in-vivo detection of bleeding in the gastrointestinal tract |
| CN102519881A (zh) | 2011-12-29 | 2012-06-27 | 北京国科华仪科技有限公司 | 适用于吸收光检测和荧光检测的光学检测系统 |
| AT513863B1 (de) | 2013-02-15 | 2014-12-15 | Vwm Gmbh | Verfahren und Vorrichtung zur Bestimmung einer Konzentration einer fluoreszierenden Substanz in einem Medium |
| JP2015017940A (ja) | 2013-07-12 | 2015-01-29 | 株式会社ニコン | 検出方法、検出装置、バイオチップのスクリーニング方法、スクリーニング装置及びバイオチップ |
| US9618450B2 (en) * | 2013-09-27 | 2017-04-11 | Ecolab USA, Inc. | Multi-channel fluorometric sensor and method of using same |
| DK3129350T3 (da) | 2014-04-09 | 2021-11-22 | Lumiphore Inc | Makrocyklusser |
| EP3224597B1 (en) * | 2014-11-25 | 2021-08-18 | Cytiva Sweden AB | Integration of fluorescence detection capability into light absorbance measurement apparatus |
| EP3524962A1 (de) * | 2015-12-09 | 2019-08-14 | Diamontech GmbH | Vorrichtung und verfahren zum analysieren eines stoffs |
-
2019
- 2019-02-14 ES ES19710787T patent/ES2956109T3/es active Active
- 2019-02-14 EP EP19710787.3A patent/EP3752819B1/en active Active
- 2019-02-14 JP JP2020536620A patent/JP7206570B2/ja active Active
- 2019-02-14 WO PCT/IB2019/051213 patent/WO2019159109A1/en not_active Ceased
-
2020
- 2020-03-30 US US16/835,170 patent/US11119043B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3752819A1 (en) | 2020-12-23 |
| JP7206570B2 (ja) | 2023-01-18 |
| EP3752819B1 (en) | 2023-08-09 |
| EP3752819C0 (en) | 2023-08-09 |
| JP2021514051A (ja) | 2021-06-03 |
| WO2019159109A1 (en) | 2019-08-22 |
| US20200225158A1 (en) | 2020-07-16 |
| US11119043B2 (en) | 2021-09-14 |
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