ES2929576T3 - Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama - Google Patents
Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama Download PDFInfo
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- ES2929576T3 ES2929576T3 ES14851657T ES14851657T ES2929576T3 ES 2929576 T3 ES2929576 T3 ES 2929576T3 ES 14851657 T ES14851657 T ES 14851657T ES 14851657 T ES14851657 T ES 14851657T ES 2929576 T3 ES2929576 T3 ES 2929576T3
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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| CN105939716A (zh) * | 2013-12-03 | 2016-09-14 | 埃斯泰隆制药公司 | 组蛋白脱乙酰基酶抑制剂和免疫调节药物的组合 |
| JP7017309B2 (ja) * | 2013-12-20 | 2022-02-08 | アセチロン ファーマシューティカルズ インコーポレイテッド | 多発性骨髄腫におけるヒストン脱アセチル化酵素６（ｈｄａｃ６）バイオマーカー |
| US9464073B2 (en) * | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| US20150359794A1 (en) | 2014-06-13 | 2015-12-17 | Buck Institute For Research On Aging | Impairment of the large ribosomal subunit protein rpl24 by depletion or acetylation |
| JP6952602B2 (ja) * | 2014-07-07 | 2021-10-20 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ヒストンデアセチラーゼ阻害剤による白血病の治療 |
| EP3204006A4 (en) | 2014-10-08 | 2018-04-04 | Regenacy Pharmaceuticals, LLC | Induction of gata2 by hdac1 and hdac2 inhibitors |
| US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| WO2016090230A1 (en) | 2014-12-05 | 2016-06-09 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds for treating peripheral neuropathy |
| HK1251566A1 (zh) | 2014-12-12 | 2019-02-01 | Regenacy Pharmaceuticals, Llc | 作为hdac1/2抑制剂的呱啶衍生物 |
| JP2019515909A (ja) * | 2016-04-19 | 2019-06-13 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物 |
-
2014
- 2014-10-06 JP JP2016521347A patent/JP6626437B2/ja active Active
- 2014-10-06 ES ES14851657T patent/ES2929576T3/es active Active
- 2014-10-06 US US14/506,889 patent/US9403779B2/en active Active
- 2014-10-06 WO PCT/US2014/059238 patent/WO2015054099A1/en not_active Ceased
- 2014-10-06 EP EP14851657.8A patent/EP3054952B1/en active Active
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2016
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Also Published As
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| JP2016536286A (ja) | 2016-11-24 |
| US10722512B2 (en) | 2020-07-28 |
| US20170020872A1 (en) | 2017-01-26 |
| US9403779B2 (en) | 2016-08-02 |
| JP6626437B2 (ja) | 2019-12-25 |
| EP3054952B1 (en) | 2022-10-26 |
| EP3054952A1 (en) | 2016-08-17 |
| US20150099744A1 (en) | 2015-04-09 |
| WO2015054099A1 (en) | 2015-04-16 |
| EP3054952A4 (en) | 2017-04-12 |
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