ES2925527T3 - Exosomas derivados de células mesenquimales para tratar trastornos neurológicos - Google Patents

Exosomas derivados de células mesenquimales para tratar trastornos neurológicos Download PDF

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Publication number
ES2925527T3
ES2925527T3 ES17841210T ES17841210T ES2925527T3 ES 2925527 T3 ES2925527 T3 ES 2925527T3 ES 17841210 T ES17841210 T ES 17841210T ES 17841210 T ES17841210 T ES 17841210T ES 2925527 T3 ES2925527 T3 ES 2925527T3
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Prior art keywords
exosomes
msc
btbr
mesenchymal stem
saline
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ES17841210T
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English (en)
Spanish (es)
Inventor
Daniel Offen
Nisim Perets
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Ramot at Tel Aviv University Ltd
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Ramot at Tel Aviv University Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES17841210T 2016-08-14 2017-08-14 Exosomas derivados de células mesenquimales para tratar trastornos neurológicos Active ES2925527T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662374852P 2016-08-14 2016-08-14
PCT/IL2017/050899 WO2018033911A1 (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

Publications (1)

Publication Number Publication Date
ES2925527T3 true ES2925527T3 (es) 2022-10-18

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ID=61196484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17841210T Active ES2925527T3 (es) 2016-08-14 2017-08-14 Exosomas derivados de células mesenquimales para tratar trastornos neurológicos

Country Status (10)

Country Link
US (2) US11129852B2 (cg-RX-API-DMAC7.html)
EP (1) EP3496730B1 (cg-RX-API-DMAC7.html)
JP (1) JP7014449B2 (cg-RX-API-DMAC7.html)
CN (1) CN109843305B (cg-RX-API-DMAC7.html)
AU (1) AU2017311684B2 (cg-RX-API-DMAC7.html)
ES (1) ES2925527T3 (cg-RX-API-DMAC7.html)
IL (1) IL264825B (cg-RX-API-DMAC7.html)
PL (1) PL3496730T3 (cg-RX-API-DMAC7.html)
SG (1) SG11201901272WA (cg-RX-API-DMAC7.html)
WO (1) WO2018033911A1 (cg-RX-API-DMAC7.html)

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EP3990625A4 (en) 2019-06-26 2023-07-19 Technion Research & Development Foundation Limited PRODUCTION OF EXTRACELLULAR VESICLES FROM STEM CELLS
JP6830286B1 (ja) 2020-06-26 2021-02-17 デクソンファーマシューティカルズ株式会社 精巣機能改善剤および精巣機能改善方法
US20230210910A1 (en) 2020-07-17 2023-07-06 Dexon Pharmaceuticals Inc. Method for preventing infection of a healthy person or a healthy animal with a virus that uses ace2 as a receptor, binding inhibitor and medical device
EP4212163A4 (en) 2020-09-08 2024-09-18 Dexon Pharmaceuticals Inc. CYTOKINE STORM INHIBITOR, METHOD FOR USING CYTOKINE STORM INHIBITOR, AND METHOD FOR SCREENING CYTOKINE INHIBITOR
JP6974892B1 (ja) 2021-05-27 2021-12-01 デクソンファーマシューティカルズ株式会社 癌悪液質の改善剤および癌悪液質の改善方法
JP7492757B2 (ja) 2022-03-22 2024-05-30 Ｄｅｘｏｎファーマシューティカルズ株式会社 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法
US20250136992A1 (en) 2022-05-15 2025-05-01 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
CN115006427A (zh) * 2022-05-31 2022-09-06 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在治疗帕金森病中的应用
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WO2023248844A1 (ja) 2022-06-20 2023-12-28 Ｄｅｘｏｎファーマシューティカルズ株式会社 Ｈｍｇｂ１の発現制御剤；急性肺損傷、急性呼吸窮迫症候群または敗血症の予防薬または治療薬、あるいはそれらの改善方法
CN120078807B (zh) * 2025-02-08 2026-03-31 广东省人民医院 改善卵巢功能的MSC-sEVs药物及其制备方法和应用

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Also Published As

Publication number Publication date
EP3496730A1 (en) 2019-06-19
EP3496730B1 (en) 2022-05-25
AU2017311684A2 (en) 2019-03-28
AU2017311684B2 (en) 2023-05-04
SG11201901272WA (en) 2019-03-28
JP7014449B2 (ja) 2022-02-01
AU2017311684A1 (en) 2019-03-07
JP2019524824A (ja) 2019-09-05
IL264825A (cg-RX-API-DMAC7.html) 2019-04-30
EP3496730A4 (en) 2020-05-06
CN109843305B (zh) 2023-03-10
US20210361717A1 (en) 2021-11-25
CN109843305A (zh) 2019-06-04
US20190209621A1 (en) 2019-07-11
WO2018033911A1 (en) 2018-02-22
US11129852B2 (en) 2021-09-28
PL3496730T3 (pl) 2022-09-26
CA3033951A1 (en) 2018-02-22
IL264825B (en) 2022-08-01

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