ES2915609T3 - Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería - Google Patents

Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería Download PDF

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Publication number
ES2915609T3
ES2915609T3 ES20180508T ES20180508T ES2915609T3 ES 2915609 T3 ES2915609 T3 ES 2915609T3 ES 20180508 T ES20180508 T ES 20180508T ES 20180508 T ES20180508 T ES 20180508T ES 2915609 T3 ES2915609 T3 ES 2915609T3
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Prior art keywords
human
mouse
light chain
gene segments
gene
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ES20180508T
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English (en)
Spanish (es)
Inventor
Chunguang Guo
Faith Harris
Vera Voronina
John Mcwhirter
Natasha Levenkova
Lynn Macdonald
Naxin Tu
Andrew J Murphy
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES20180508T 2016-11-04 2017-11-03 Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería Active ES2915609T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662417845P 2016-11-04 2016-11-04
US201762567932P 2017-10-04 2017-10-04

Publications (1)

Publication Number Publication Date
ES2915609T3 true ES2915609T3 (es) 2022-06-23

Family

ID=62025924

Family Applications (3)

Application Number Title Priority Date Filing Date
ES20180508T Active ES2915609T3 (es) 2016-11-04 2017-11-03 Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería
ES17863293T Active ES2823305T3 (es) 2016-11-04 2017-11-03 Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería
ES22164751T Active ES3035365T3 (en) 2016-11-04 2017-11-03 Non-human animals having an engineered immunoglobulin lambda light chain locus

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES17863293T Active ES2823305T3 (es) 2016-11-04 2017-11-03 Animales no humanos que tienen un locus de cadena ligera lambda de inmunoglobulina modificado por ingeniería
ES22164751T Active ES3035365T3 (en) 2016-11-04 2017-11-03 Non-human animals having an engineered immunoglobulin lambda light chain locus

Country Status (26)

Country Link
US (2) US10820582B2 (OSRAM)
EP (4) EP3407709B9 (OSRAM)
JP (5) JP6884860B2 (OSRAM)
KR (4) KR20240055863A (OSRAM)
CN (2) CN109996441B (OSRAM)
AU (2) AU2017391167B2 (OSRAM)
BR (1) BR112019008675A2 (OSRAM)
CA (1) CA3038720A1 (OSRAM)
CY (2) CY1123491T1 (OSRAM)
DK (3) DK3766343T3 (OSRAM)
ES (3) ES2915609T3 (OSRAM)
FI (1) FI4082334T3 (OSRAM)
HR (3) HRP20250695T1 (OSRAM)
HU (3) HUE061980T2 (OSRAM)
IL (2) IL308197A (OSRAM)
LT (3) LT4082334T (OSRAM)
MA (2) MA53935A (OSRAM)
MX (2) MX385857B (OSRAM)
PL (3) PL3766343T3 (OSRAM)
PT (3) PT3766343T (OSRAM)
RS (3) RS66884B1 (OSRAM)
RU (2) RU2757665C2 (OSRAM)
SG (2) SG11201903344XA (OSRAM)
SI (3) SI3407709T1 (OSRAM)
SM (3) SMT202000558T1 (OSRAM)
WO (1) WO2018128691A1 (OSRAM)

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DK3766343T3 (da) 2016-11-04 2022-06-20 Regeneron Pharma Ikke-humane dyr med et manipuleret immunoglobulin-lambda-letkædelocus
LT3772927T (lt) 2018-03-24 2025-02-10 Regeneron Pharmaceuticals, Inc. Genetiškai modifikuotos pelės arba žiurkės, skirtos gaminti terapinius antikūnus prieš peptidų- mhc kompleksus, jų gamybos būdai ir panaudojimas
CN116420679B (zh) 2018-03-26 2025-10-03 瑞泽恩制药公司 用于测试治疗剂的人源化啮齿动物
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DK3766343T3 (da) 2016-11-04 2022-06-20 Regeneron Pharma Ikke-humane dyr med et manipuleret immunoglobulin-lambda-letkædelocus

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Publication number Publication date
LT3407709T (lt) 2020-10-12
US20180125043A1 (en) 2018-05-10
IL266282B1 (en) 2023-12-01
SG11201903344XA (en) 2019-05-30
EP4567119A3 (en) 2025-09-24
DK3766343T3 (da) 2022-06-20
MA44091A (fr) 2018-10-24
JP2021090455A (ja) 2021-06-17
SI3407709T1 (sl) 2020-10-30
PL3407709T3 (pl) 2021-01-11
WO2018128691A1 (en) 2018-07-12
MX2019005256A (es) 2019-08-05
PT3766343T (pt) 2022-05-30
EP3766343A1 (en) 2021-01-20
HRP20250695T1 (hr) 2025-08-01
KR102658529B1 (ko) 2024-04-19
RU2019112589A (ru) 2020-12-04
RU2757665C2 (ru) 2021-10-20
ES2823305T3 (es) 2021-05-06
SMT202000558T1 (it) 2020-11-10
CN109996441A (zh) 2019-07-09
IL266282A (en) 2019-06-30
JP2023053400A (ja) 2023-04-12
EP3407709B9 (en) 2021-10-06
US12433264B2 (en) 2025-10-07
DK3407709T3 (da) 2020-08-31
IL308197A (en) 2024-01-01
NZ753456A (en) 2021-08-27
IL266282B2 (en) 2024-04-01
RS66884B1 (sr) 2025-07-31
SI4082334T1 (sl) 2025-06-30
LT3766343T (lt) 2022-06-10
CY1123491T1 (el) 2022-03-24
SMT202500204T1 (it) 2025-07-22
PT3407709T (pt) 2020-08-20
HRP20201403T1 (hr) 2020-11-27
HUE052087T2 (hu) 2021-04-28
KR20240055863A (ko) 2024-04-29
EP4082334B1 (en) 2025-03-26
BR112019008675A2 (pt) 2019-07-09
EP3407709B1 (en) 2020-07-29
CY1125474T1 (el) 2025-05-09
EP3407709A1 (en) 2018-12-05
KR102492433B1 (ko) 2023-01-30
HUE061980T2 (hu) 2023-09-28
PT4082334T (pt) 2025-05-21
FI4082334T3 (fi) 2025-06-10
CN114369157A (zh) 2022-04-19
RS63390B1 (sr) 2022-08-31
KR20210134059A (ko) 2021-11-08
SI3766343T1 (sl) 2022-06-30
JP7386292B2 (ja) 2023-11-24
MA53935A (fr) 2021-12-22
CN109996441B (zh) 2022-02-08
JP6884860B2 (ja) 2021-06-09
KR102319069B1 (ko) 2021-11-01
SG10201913483XA (en) 2020-03-30
JP2025166207A (ja) 2025-11-05
RU2021129958A (ru) 2021-11-02
US10820582B2 (en) 2020-11-03
AU2017391167A1 (en) 2019-05-30
ES3035365T3 (en) 2025-09-02
EP3766343B1 (en) 2022-05-11
PL4082334T3 (pl) 2025-08-11
LT4082334T (lt) 2025-05-26
DK4082334T3 (da) 2025-06-02
HUE071595T2 (hu) 2025-09-28
HRP20220888T1 (hr) 2022-10-28
EP4082334A1 (en) 2022-11-02
PL3766343T3 (pl) 2022-09-26
WO2018128691A8 (en) 2019-02-28
RS60886B1 (sr) 2020-11-30
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