ES2912930T3 - Membranas de cromatografía en modo mixto - Google Patents

Membranas de cromatografía en modo mixto Download PDF

Info

Publication number
ES2912930T3
ES2912930T3 ES14756874T ES14756874T ES2912930T3 ES 2912930 T3 ES2912930 T3 ES 2912930T3 ES 14756874 T ES14756874 T ES 14756874T ES 14756874 T ES14756874 T ES 14756874T ES 2912930 T3 ES2912930 T3 ES 2912930T3
Authority
ES
Spain
Prior art keywords
certain embodiments
diacrylate
composite material
dimethacrylate
support member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14756874T
Other languages
English (en)
Spanish (es)
Inventor
Charles Honeyman
Elena Komkova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Millipore Ltd
Original Assignee
Merck Millipore Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Millipore Ltd filed Critical Merck Millipore Ltd
Application granted granted Critical
Publication of ES2912930T3 publication Critical patent/ES2912930T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033Membrane, sheet, cloth, pad, lamellar or mat
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291Gel sorbents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26Cation exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20Anion exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J43/00Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groups; Use of material as amphoteric ion-exchangers; Treatment of material for improving their amphoteric ion-exchange properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00Ion-exchange processes in general; Apparatus therefor
    • B01J47/12Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
ES14756874T 2013-02-26 2014-02-26 Membranas de cromatografía en modo mixto Active ES2912930T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361769330P 2013-02-26 2013-02-26
PCT/US2014/018635 WO2014134147A1 (en) 2013-02-26 2014-02-26 Mixed-mode chromatography membranes

Publications (1)

Publication Number Publication Date
ES2912930T3 true ES2912930T3 (es) 2022-05-30

Family

ID=51387082

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14756874T Active ES2912930T3 (es) 2013-02-26 2014-02-26 Membranas de cromatografía en modo mixto

Country Status (8)

Country Link
US (2) US20140238935A1 (https=)
EP (2) EP2961762B1 (https=)
JP (3) JP6639236B2 (https=)
KR (1) KR102284079B1 (https=)
AU (1) AU2014223583B2 (https=)
CA (1) CA2902180C (https=)
ES (1) ES2912930T3 (https=)
WO (1) WO2014134147A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2912930T3 (es) 2013-02-26 2022-05-30 Merck Millipore Ltd Membranas de cromatografía en modo mixto
US10308678B2 (en) 2014-07-25 2019-06-04 Asahi Kasei Medical Co., Ltd. Cation exchange chromatographic support and method for using same
WO2018047906A1 (ja) * 2016-09-09 2018-03-15 旭化成メディカル株式会社 強カチオン交換クロマトグラフィー担体及びその使用方法
US11446613B2 (en) 2016-09-09 2022-09-20 3M Innovative Properties Company Functionalized copolymers and use thereof
JP2020525445A (ja) * 2017-06-21 2020-08-27 セファロン・インコーポレイテッドCephalon,Incorporated カチオン交換クロマトグラフィーの洗浄緩衝液
JP7018175B2 (ja) * 2017-12-08 2022-02-10 東ソー株式会社 共重合体、基材用表面処理剤および細胞培養基材
EP3826743A4 (en) * 2018-07-25 2022-09-14 Merck Sharp & Dohme Corp. METHODS FOR SEPARATION OF HOST CELL LIPASES FROM A PRODUCTION PROTEIN IN CHROMATOGRAPHIC METHODS
US12485364B2 (en) 2018-08-10 2025-12-02 Clemson University Research Foundation Multi-modal ion-exchange membranes for rapid separations
US11045773B2 (en) 2018-08-31 2021-06-29 Pall Corporation Salt tolerant porous medium
US10737259B2 (en) * 2018-08-31 2020-08-11 Pall Corporation Salt tolerant anion exchange medium
GB201815405D0 (en) * 2018-09-21 2018-11-07 Fujifilm Mfg Europe Bv Membranes suitable for detecting, filtering and/or purifying biomolecules
CN118904316A (zh) 2018-12-12 2024-11-08 唐纳森公司 亲和膜及其制备方法
TWI786468B (zh) * 2019-11-21 2022-12-11 愛爾蘭商默克密理博有限公司 將配體偶合至複合材料的方法
KR102909544B1 (ko) * 2020-06-17 2026-01-09 엔테그리스, 아이엔씨. 이온-교환 멤브레인, 필터 및 방법
CN111909418B (zh) * 2020-08-17 2021-09-03 吉林大学 一种改性聚酰亚胺气凝胶及其制备方法和应用
CN114618455A (zh) * 2020-12-11 2022-06-14 中国科学院大连化学物理研究所 一种多极性官能团包埋的反相色谱固定相及其制备和应用
WO2022140437A1 (en) * 2020-12-22 2022-06-30 California Institute Of Technology Functional composite membranes for chromatography and catalysis
WO2026052759A1 (en) 2024-09-06 2026-03-12 Merck Millipore Ltd. Aav9 affinity ligands
WO2026052761A2 (en) 2024-09-06 2026-03-12 Merck Patent Gmbh Caustic-resistant affinity ligands for chromatography

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991017A (en) * 1973-12-20 1976-11-09 Rohm And Haas Company Ion exchange resins derived from hybrid copolymers
MX3036E (es) * 1974-10-15 1980-03-03 Rohm & Haas Composicion de resina hibrida de intercambio ionico y procedimiento para su obtencion
KR100378500B1 (ko) 1994-07-28 2003-05-22 밀리포어 코포레이션 복합다공성막및형성방법
US5814372A (en) 1995-10-19 1998-09-29 Millipore Corporation Process for forming porous composite membrane
US5647979A (en) * 1996-06-14 1997-07-15 Bio-Rad Laboratories, Inc. One-step preparation of separation media for reversed-phase chromatography
JP2003066157A (ja) * 2001-08-24 2003-03-05 Fujitsu Ten Ltd 車両内人体検出方法
US7073671B2 (en) 2002-06-07 2006-07-11 Millipore Corporation Microporous membrane substrate having caustic stable, low protein binding surface
EP2143482A1 (en) * 2003-02-19 2010-01-13 Natrix Separations Inc. Composite materials comprising supported porous gels
EP2821135A1 (en) * 2004-02-05 2015-01-07 EMD Millipore Corporation Porous adsorptive or chromatographic media
SE0400501D0 (sv) 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
AU2005216847B2 (en) 2004-02-27 2010-04-01 Cytiva Bioprocess R&D Ab A process for the purification of antibodies
US8133840B2 (en) * 2004-06-07 2012-03-13 Natrix Separations Inc. Stable composite material comprising supported porous gels
CA2576221A1 (en) 2004-08-13 2006-02-16 Mcmaster University Composite material comprising a non-crosslinked gel polymer
KR101243601B1 (ko) 2004-10-21 2013-03-20 지이 헬스케어 바이오-사이언시스 에이비 크로마토그래피 리간드
EP2152405B2 (de) * 2007-05-25 2017-04-05 Merck Patent GmbH Mischpfropfpolymere für die kationenaustauschchromatographie
US8710111B2 (en) * 2007-11-09 2014-04-29 3M Innovative Properties Company Porous polymeric resins
US7800382B2 (en) * 2007-12-19 2010-09-21 AEHR Test Ststems System for testing an integrated circuit of a device and its method of use
BRPI0915331A2 (pt) * 2008-06-30 2015-10-27 3M Innovative Properties Co método de formação de uma membrana assimétrica remolhável
CA2736814C (en) * 2008-09-02 2017-02-28 Natrix Separations Inc. Chromatography membranes, devices containing them, and methods of use thereof
AU2008221604B2 (en) * 2008-09-22 2010-04-22 Commonwealth Scientific And Industrial Research Organisation Temperature-responsive polymer particles in protein separation applications
SG169305A1 (en) * 2009-08-26 2011-03-30 Siemens Pte Ltd Ion exchange membranes
KR20170104656A (ko) * 2009-11-13 2017-09-15 나트릭스 세퍼레이션즈, 인코포레이티드 소수성 상호반응 크로마토그래피용 막 및 그의 사용방법
WO2011146179A2 (en) * 2010-05-18 2011-11-24 Abbott Laboratories Apparatus and process of purification of proteins
JP5460651B2 (ja) * 2010-07-28 2014-04-02 ローム アンド ハース カンパニー クロマトグラフィー媒体性能を向上させるグラフト化方法
US20130225701A1 (en) * 2010-07-29 2013-08-29 Emd Millipore Corporation Grafting method to improve chromatography media performance
EP2616169A2 (en) * 2010-09-14 2013-07-24 Natrix Separations Inc. Chromatography membranes for the purification of chiral compounds
ES2912930T3 (es) 2013-02-26 2022-05-30 Merck Millipore Ltd Membranas de cromatografía en modo mixto

Also Published As

Publication number Publication date
KR102284079B1 (ko) 2021-08-02
CA2902180C (en) 2023-08-15
EP4089101A1 (en) 2022-11-16
KR20150123309A (ko) 2015-11-03
AU2014223583A1 (en) 2015-10-15
JP2016510005A (ja) 2016-04-04
US20140238935A1 (en) 2014-08-28
CA2902180A1 (en) 2014-09-04
EP2961762A4 (en) 2016-11-02
AU2014223583B2 (en) 2019-03-28
WO2014134147A1 (en) 2014-09-04
JP2019206002A (ja) 2019-12-05
JP2021184987A (ja) 2021-12-09
US11554361B2 (en) 2023-01-17
JP6639236B2 (ja) 2020-02-05
EP2961762B1 (en) 2022-04-06
US20180353939A1 (en) 2018-12-13
JP7246277B2 (ja) 2023-03-27
EP2961762A1 (en) 2016-01-06

Similar Documents

Publication Publication Date Title
ES2912930T3 (es) Membranas de cromatografía en modo mixto
CA2780095C (en) Hydrophobic interaction chromatography membranes, and methods of use thereof
ES2811137T3 (es) Membranas para cromatografía formadas por reacciones de polimerización clic de tiol-eno o tiol-ino
ES2661237T3 (es) Membrana con grupos sulfónicos para eliminar agregados de proteína
JP7830610B2 (ja) 複合材料に配位子をカップリングするための方法
US20040203149A1 (en) Composite materials comprising supported porous gels
JP2018048162A (ja) フロースルー式での生物製剤からのタンパク質凝集体の除去
US20140273158A1 (en) Chromatography Membranes Stable Under Caustic Conditions
Afeyan Hamilton (CA); Elena N. Komkova, 3.3 A 3.2: St. Fa