ES2911448T3 - Vectores combinados y métodos para el tratamiento del cáncer - Google Patents
Vectores combinados y métodos para el tratamiento del cáncer Download PDFInfo
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- ES2911448T3 ES2911448T3 ES17764128T ES17764128T ES2911448T3 ES 2911448 T3 ES2911448 T3 ES 2911448T3 ES 17764128 T ES17764128 T ES 17764128T ES 17764128 T ES17764128 T ES 17764128T ES 2911448 T3 ES2911448 T3 ES 2911448T3
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- C12Y205/01001—Dimethylallyltranstransferase (2.5.1.1)
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- C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
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| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
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Family Cites Families (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668255A (en) | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| EP0642582A1 (en) | 1992-05-22 | 1995-03-15 | Dana Farber Cancer Institute | Hybrid siv/hiv-1 viral vectors and monkey model for aids |
| DE69322495T2 (de) | 1992-09-30 | 1999-06-02 | Tetra Rex Packaging Systems, Inc., Buffalo Grove, Ill. | Verfahren und vorrichtung zum anbringen eines mundstückes an einem kartonbehälter |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| ES2310924T3 (es) | 1993-07-13 | 2009-01-16 | Centelion | Vectores adenovirales defectivos y utilizacion en terapia genica. |
| EP0932694A2 (en) | 1996-09-11 | 1999-08-04 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Aav4 vector and uses thereof |
| AU8828598A (en) | 1997-08-15 | 1999-03-08 | Rubicon Laboratory, Inc. | Retrovirus and viral vectors |
| AU1124499A (en) | 1997-10-28 | 1999-05-17 | Maxygen, Inc. | Human papillomavirus vectors |
| EP1064393B1 (en) | 1998-03-20 | 2004-12-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for helper-free production of recombinant adeno-associated viruses |
| DE69940521D1 (de) | 1998-10-01 | 2009-04-16 | Univ Southern California | Retrovirales genübertragungssystem und entsprechendes verwendungverfahren |
| US6156514A (en) | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| US6410013B1 (en) | 1999-01-25 | 2002-06-25 | Musc Foundation For Research Development | Viral vectors for use in monitoring HIV drug resistance |
| WO2000072886A1 (en) | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
| WO2001083797A2 (en) | 2000-04-28 | 2001-11-08 | Avigen, Inc. | Polynucleotides for use in recombinant adeno-associated virus virion production |
| EP1282449A2 (en) | 2000-05-12 | 2003-02-12 | The Regents Of The University Of California | Treatment of human papillomavirus (hpv)-infected cells |
| WO2001091802A1 (en) | 2000-05-30 | 2001-12-06 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
| NO314588B1 (no) | 2000-09-04 | 2003-04-14 | Bionor Immuno As | HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| US20030119770A1 (en) | 2001-08-02 | 2003-06-26 | Zhennan Lai | Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors |
| AU2002323270A1 (en) | 2001-08-18 | 2003-03-03 | Myriad Genetics, Inc | Composition and method for treating hiv infection |
| US7737124B2 (en) | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
| AU2002363465A1 (en) | 2001-10-25 | 2003-05-19 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human S | Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 |
| US20070203333A1 (en) | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| EP1495141A4 (en) | 2002-03-20 | 2006-03-22 | Massachusetts Inst Technology | THERAPY OF HIV |
| AU2003237159A1 (en) | 2002-04-30 | 2003-11-17 | University Of Florida | Treatment for phenylketonuria |
| WO2004037847A2 (en) | 2002-05-07 | 2004-05-06 | Chiron Corporation | Hiv envelope-cd4 complexes and hybrids |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| US20040161412A1 (en) | 2002-08-22 | 2004-08-19 | The Cleveland Clinic Foundation | Cell-based VEGF delivery |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| ES2334125T3 (es) | 2002-11-04 | 2010-03-05 | University Of Massachusetts | Interferencia de arn especifico de alelos. |
| AU2003283174A1 (en) | 2002-12-11 | 2004-06-30 | Cytos Biotechnology Ag | Method for protein production |
| WO2004104591A2 (en) | 2003-05-23 | 2004-12-02 | Institut National De La Sante Et De La Recherche Medicale | Improvements to gamma delta t cell-mediated therapy |
| WO2005005644A1 (en) | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| US20050019927A1 (en) | 2003-07-13 | 2005-01-27 | Markus Hildinger | DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER |
| US20050138677A1 (en) | 2003-09-16 | 2005-06-23 | Pfister Herbert J. | Transgenic animal model for the treatment of skin tumors |
| US20070275010A1 (en) | 2003-09-18 | 2007-11-29 | Mark Feinberg | Mva Vaccines |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| US20080039413A1 (en) | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| WO2005081911A2 (en) | 2004-02-25 | 2005-09-09 | Dana-Farber Cancer Institute, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HIV INFECTION USING TRIM5α |
| WO2005085443A2 (en) * | 2004-03-01 | 2005-09-15 | Massachusetts Institute Of Technology | Rnai-based therapeutics for allergic rhinitis and asthma |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| WO2005118802A2 (en) | 2004-06-03 | 2005-12-15 | The Regents Of The University Of California | Targeting pseudotyped retroviral vectors |
| US20080131940A1 (en) | 2004-06-25 | 2008-06-05 | Robert Chiu | Target Cell-Specific Short Interfering Rna and Methods of Use Thereof |
| EP1789447B1 (en) | 2004-08-16 | 2012-04-25 | Immune Disease Institute, Inc. | Method of delivering rna interference and uses thereof |
| US7358361B2 (en) | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| EP1647595A1 (en) | 2004-10-15 | 2006-04-19 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Nucleic acids against viruses, in particular HIV |
| JP2008518591A (ja) | 2004-11-02 | 2008-06-05 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | 複製欠損アデノウイルスベクターの製造のためのアデノウイルスアンプリコンおよびプロデューサー細胞、その製造方法および用途 |
| US7790446B2 (en) | 2005-02-11 | 2010-09-07 | Kosagen Cell Factory Oü | Vectors, cell lines and their use in obtaining extended episomal maintenance replication of hybrid plasmids and expression of gene products |
| EP1858332A4 (en) | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| PL2002003T3 (pl) | 2005-05-27 | 2016-06-30 | Ospedale San Raffaele Srl | Wektor genetyczny zawierający mi-RNA |
| US20070032443A1 (en) | 2005-08-02 | 2007-02-08 | Jaeseob Kim | Therapy for Alzheimer's disease |
| WO2007015122A1 (en) | 2005-08-02 | 2007-02-08 | Genexel, Inc. | Therapy for alzheimer’s disease |
| US20070105835A1 (en) | 2005-11-07 | 2007-05-10 | Kazantsev Aleksey G | Compositions and methods for modulating poly(ADP-ribose) polymerase activity |
| WO2007133674A2 (en) | 2006-05-12 | 2007-11-22 | Lentigen Corporation | Lentiviral vector compositions, methods and applications |
| US8535897B2 (en) | 2006-06-19 | 2013-09-17 | The Trustees Of Columbia University In The City Of New York | Assays for non-apoptotic cell death and uses thereof |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| WO2008008719A2 (en) * | 2006-07-10 | 2008-01-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the myc gene |
| EP1878440A1 (en) | 2006-07-13 | 2008-01-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for increasing the efficiency of therapeutic antibodies using gamma delta cell activator compounds |
| CN101516365A (zh) | 2006-07-26 | 2009-08-26 | 诺瓦提斯公司 | 十一异戊二烯基焦磷酸酯合酶的抑制剂 |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| EP2426142A3 (en) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modified vaccinia virus strains for use in a diagnostic and therapeutic method |
| ES2639568T3 (es) | 2007-01-23 | 2017-10-27 | Janssen Pharmaceutica Nv | Método para diseñar un régimen farmacológico para pacientes infectados con el VIH |
| EP2203460A4 (en) | 2007-04-12 | 2012-03-14 | Univ Illinois | BIPHOSPHONATE COMPOUNDS AND METHODS WITH INCREASED POTENTIAL FOR MULTIPLE OBJECTIVES, INCLUDING FPPS, GGPPS AND DPPS |
| US20080293142A1 (en) * | 2007-04-19 | 2008-11-27 | The Board Of Regents For Oklahoma State University | Multiple shRNA Expression Vectors and Methods of Construction |
| EP2173342A2 (en) | 2007-06-22 | 2010-04-14 | ETH Zurich | Antivirals |
| EP2008656A1 (en) | 2007-06-28 | 2008-12-31 | Bergen Teknologioverforing AS | Compositions for the treatment of hyperphenylalaninemia |
| US8673477B2 (en) | 2008-06-16 | 2014-03-18 | Polyplus Battery Company | High energy density aqueous lithium/air-battery cells |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| EP2090659A1 (en) | 2008-02-14 | 2009-08-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Infectious particle, process for its preparation and use thereof |
| GB0810209D0 (en) | 2008-06-04 | 2008-07-09 | Cambridge Entpr Ltd | Pluripotency associated epigenetic factor |
| US8629334B2 (en) | 2008-07-16 | 2014-01-14 | University Of Florida Research Foundation, Inc. | Viral-based transient-expression vector system for trees |
| WO2010022195A2 (en) | 2008-08-20 | 2010-02-25 | Virxsys Corporation | Non-integrating lenti/adeno-associated virus hybrid vector system |
| US8871515B2 (en) | 2008-09-17 | 2014-10-28 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| AU2009308707A1 (en) | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | LIGHT targeting molecules and uses thereof |
| WO2010051521A1 (en) | 2008-10-31 | 2010-05-06 | Lentigen Corporation | Cell therapy product for the treatment of hiv infection |
| WO2011071476A2 (en) | 2008-11-14 | 2011-06-16 | Life Technologies Corporation | Compositions and methods for engineering cells |
| EP2191834A1 (en) | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| CA2756670A1 (en) | 2009-03-26 | 2010-09-30 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory rna for disease modification |
| CN102438631A (zh) | 2009-04-09 | 2012-05-02 | 史坦赛特股份有限公司 | 抗hiv干细胞及其用途 |
| KR20120088542A (ko) | 2009-04-13 | 2012-08-08 | 아프세스 게엠베하 & 씨오. 카게 | 종양 치료를 위한 조작된 중간엽 줄기세포 및 이를 사용하는 방법 |
| EP2425001A4 (en) | 2009-04-30 | 2012-11-14 | Univ California | ANTI-HIV COMBINATION VECTORS, TARGETING VECTORS AND METHOD OF USE |
| DK3329772T3 (da) | 2009-07-15 | 2020-01-27 | Calimmune Inc | Dobbeltvektor til inhibering af human immundefektvirus |
| WO2011066578A1 (en) | 2009-11-30 | 2011-06-03 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer |
| CN101805750B (zh) * | 2009-12-29 | 2011-11-30 | 浙江大学 | 法呢基焦磷酸合成酶rna干扰重组慢病毒载体构建及用途 |
| CA2790426A1 (en) | 2010-02-18 | 2011-08-25 | Emory University | Vectors expressing hiv antigens and gm-csf and related methods for generating an immune response |
| WO2011119942A1 (en) | 2010-03-25 | 2011-09-29 | Vistagen Therapeutics, Inc. | Induction of ips cells using transient episomal vectors |
| WO2011133687A2 (en) | 2010-04-20 | 2011-10-27 | President And Fellows Of Harvard College | Methods and compositions for inhibition of beta2-adrenergic receptor degradation |
| AU2011242576B2 (en) | 2010-04-23 | 2016-03-31 | Cold Spring Harbor Laboratory | Novel structurally designed shRNAs |
| CN102946907A (zh) | 2010-05-28 | 2013-02-27 | 牛津生物医学(英国)有限公司 | 慢病毒载体向脑的递送 |
| WO2012020757A1 (ja) | 2010-08-10 | 2012-02-16 | タカラバイオ株式会社 | 細胞集団の製造方法 |
| WO2012048303A2 (en) | 2010-10-07 | 2012-04-12 | Columbia University | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION |
| WO2012061075A2 (en) | 2010-10-25 | 2012-05-10 | The Regents Of The University Of California | Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells |
| EP2643045A4 (en) | 2010-11-23 | 2016-01-13 | Presage Biosciences Inc | THERAPEUTIC PROCESSES AND COMPOSITIONS FOR SOLID FORM DELIVERY |
| JP6091435B2 (ja) | 2011-02-22 | 2017-03-08 | カリフォルニア インスティチュート オブ テクノロジー | アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達 |
| WO2012145624A2 (en) | 2011-04-21 | 2012-10-26 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| CA2850836A1 (en) | 2011-10-15 | 2013-04-18 | Genentech, Inc. | Methods of using scd1 antagonists |
| JP6348064B2 (ja) | 2011-11-22 | 2018-06-27 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | 効率の高いトランスジーン送達のためのウイルスベクター |
| US9745631B2 (en) | 2011-12-20 | 2017-08-29 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
| CN107982548A (zh) | 2012-02-07 | 2018-05-04 | 全球生物疗法有限公司 | 核酸输送的区室化方法及其组合物和应用 |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2013182662A1 (en) | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Vaccine |
| WO2014016817A2 (en) | 2012-07-17 | 2014-01-30 | Universite De Geneve | Nucleic acids for down-regulation of gene expression |
| EP2900835B1 (en) | 2012-09-27 | 2025-04-30 | Population Bio, Inc. | Method for screening and treating developmental disorders |
| ES2686129T3 (es) * | 2012-11-13 | 2018-10-16 | Codiak Biosciences, Inc. | Administración de agentes terapéuticos |
| AU2013355327A1 (en) | 2012-12-05 | 2015-06-11 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of metabolic disorders |
| US9642921B2 (en) | 2012-12-20 | 2017-05-09 | Tocagen Inc. | Cancer combination therapy and recombinant vectors |
| WO2014117050A2 (en) | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| CN103184224A (zh) | 2013-04-03 | 2013-07-03 | 衡阳师范学院 | 一种抗艾滋病病毒感染的三联miRNA及构建方法 |
| EP2999797B1 (en) | 2013-05-21 | 2018-07-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Isoforms of gata6 and nkx2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy |
| JP2016520316A (ja) | 2013-06-03 | 2016-07-14 | テラベクティ | MHCクラスI、MHCクラスIIまたはβ2ミクログロブリン上流プロモーター配列を含有するレンチウイルスベクター |
| EP3027755B1 (en) | 2013-08-02 | 2019-10-09 | The Regents of The University of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| WO2015042308A2 (en) | 2013-09-18 | 2015-03-26 | City Of Hope | Rna-based hiv inhibitors |
| WO2015061491A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| CN113699159A (zh) | 2014-03-28 | 2021-11-26 | 明尼苏达大学评议会 | 涉及经工程改造的cd16的多肽、细胞和方法 |
| US11400115B2 (en) | 2014-04-23 | 2022-08-02 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| SI3689899T1 (sl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | MND promotor kimeričnih antigenskih receptorjev |
| DK3546585T3 (da) | 2014-04-25 | 2025-11-03 | Genethon | Nukleinsyrer med en modificeret intron til brug i behandlingen af hyperbilirubinæmi |
| US20160060707A1 (en) * | 2014-08-29 | 2016-03-03 | Immunomedics, Inc. | Identification of Cancer Genes by In-Vivo Fusion of Human Cancer Cells and Animal Cells |
| DK3197472T3 (da) | 2014-09-22 | 2021-10-18 | Tanea Medical Ab | Rekombinante phe-frie proteiner til anvendelse i behandlingen af phenylketonuri |
| CA2964173A1 (en) * | 2014-10-10 | 2016-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting cd47 |
| US10968451B2 (en) | 2014-10-14 | 2021-04-06 | Texas Tech University System | Multiplexed shRNAs and uses thereof |
| WO2016069716A1 (en) | 2014-10-30 | 2016-05-06 | The Scripps Research Institute | Compositions and methods comprising tyrosyl-trna synthetases and resveratrol compounds |
| GB201509202D0 (en) | 2015-05-28 | 2015-07-15 | Ge Healthcare Bio Sciences Ab | Semi-static cell culture |
| US20180161455A1 (en) | 2015-06-10 | 2018-06-14 | American Gene Technologies International, Inc. | Non-integrating viral delivery system and methods of use therof |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| US11028369B2 (en) | 2015-08-13 | 2021-06-08 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced extended pluripotent stem cells, method of making and using |
| CN105112370B (zh) | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| JP7059179B2 (ja) | 2015-10-20 | 2022-04-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
| US11389546B2 (en) | 2015-12-09 | 2022-07-19 | Modernatx, Inc. | Heterologous UTR sequences for enhanced mRNA expression |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CA3011529A1 (en) | 2016-01-15 | 2017-07-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta t-cells |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| SG11201807223UA (en) | 2016-03-23 | 2018-09-27 | Univ Columbia | CANCER TREATMENT BASED ON DELIVERY OF OLIGOES VIA GAP JUNCTIONS FROM HUMAN MESENCHYMAL STEM CELLS (hMSC) |
| US20190117799A1 (en) | 2016-04-01 | 2019-04-25 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| WO2018126112A1 (en) | 2016-12-30 | 2018-07-05 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating phenylketonuria |
| AU2018205388A1 (en) | 2017-01-09 | 2019-07-18 | American Gene Technologies International Inc. | HIV immunotherapy with no pre-immunization step |
| CA3053008A1 (en) | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation with heterobifunctional compounds |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| US20200181645A1 (en) | 2017-06-16 | 2020-06-11 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| CA3077355A1 (en) | 2017-10-02 | 2019-04-11 | American Gene Technologies International Inc. | Vectors with promoter and enhancer combinations for treating phenylketonuria |
| WO2019136273A1 (en) | 2018-01-05 | 2019-07-11 | NantBio Inc. | Reprogrammed t cell-like nk cells |
| JP7447388B2 (ja) | 2018-07-13 | 2024-03-12 | ナンジン レジェンド バイオテック カンパニー,リミテッド | 感染性疾患の治療のための共受容体システム |
| WO2020097049A1 (en) | 2018-11-05 | 2020-05-14 | American Gene Technologies International Inc. | Vector system for expressing regulatory rna |
| CA3137698A1 (en) | 2019-05-31 | 2020-12-03 | Tyler LAHUSEN | Optimized phenylalanine hydroxylase expression |
| CN115551532A (zh) | 2020-03-03 | 2022-12-30 | 美国基因技术国际有限公司 | 在淋巴细胞中按需表达外源性因子以治疗hiv |
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