JP7017247B2 - がんを処置するための組み合わせベクターおよび方法 - Google Patents
がんを処置するための組み合わせベクターおよび方法 Download PDFInfo
- Publication number
- JP7017247B2 JP7017247B2 JP2018547354A JP2018547354A JP7017247B2 JP 7017247 B2 JP7017247 B2 JP 7017247B2 JP 2018547354 A JP2018547354 A JP 2018547354A JP 2018547354 A JP2018547354 A JP 2018547354A JP 7017247 B2 JP7017247 B2 JP 7017247B2
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- small rna
- fdps
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01001—Dimethylallyltranstransferase (2.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022006999A JP2022051775A (ja) | 2016-03-09 | 2022-01-20 | がんを処置するための組み合わせベクターおよび方法 |
| JP2024042163A JP2024069537A (ja) | 2016-03-09 | 2024-03-18 | がんを処置するための組み合わせベクターおよび方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305944P | 2016-03-09 | 2016-03-09 | |
| US62/305,944 | 2016-03-09 | ||
| PCT/US2017/021639 WO2017156311A2 (en) | 2016-03-09 | 2017-03-09 | Combination vectors and methods for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006999A Division JP2022051775A (ja) | 2016-03-09 | 2022-01-20 | がんを処置するための組み合わせベクターおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508045A JP2019508045A (ja) | 2019-03-28 |
| JP2019508045A5 JP2019508045A5 (enExample) | 2020-04-16 |
| JP7017247B2 true JP7017247B2 (ja) | 2022-02-08 |
Family
ID=59789756
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547354A Active JP7017247B2 (ja) | 2016-03-09 | 2017-03-09 | がんを処置するための組み合わせベクターおよび方法 |
| JP2022006999A Ceased JP2022051775A (ja) | 2016-03-09 | 2022-01-20 | がんを処置するための組み合わせベクターおよび方法 |
| JP2024042163A Pending JP2024069537A (ja) | 2016-03-09 | 2024-03-18 | がんを処置するための組み合わせベクターおよび方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006999A Ceased JP2022051775A (ja) | 2016-03-09 | 2022-01-20 | がんを処置するための組み合わせベクターおよび方法 |
| JP2024042163A Pending JP2024069537A (ja) | 2016-03-09 | 2024-03-18 | がんを処置するための組み合わせベクターおよび方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US10767183B2 (enExample) |
| EP (2) | EP3426777B1 (enExample) |
| JP (3) | JP7017247B2 (enExample) |
| DK (1) | DK3426777T3 (enExample) |
| ES (1) | ES2911448T3 (enExample) |
| WO (1) | WO2017156311A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022051775A (ja) * | 2016-03-09 | 2022-04-01 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | がんを処置するための組み合わせベクターおよび方法 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CA3011529A1 (en) | 2016-01-15 | 2017-07-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta t-cells |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| GB201807945D0 (en) | 2018-05-16 | 2018-06-27 | Ospedale San Raffaele Srl | Vector production |
| WO2020097049A1 (en) | 2018-11-05 | 2020-05-14 | American Gene Technologies International Inc. | Vector system for expressing regulatory rna |
| CN110964727A (zh) * | 2019-12-31 | 2020-04-07 | 深圳市疾病预防控制中心(深圳市卫生检验中心、深圳市预防医学研究所) | 特异抑制c-myc基因表达的shRNA慢病毒表达载体构建方法与应用 |
| AU2023272490A1 (en) * | 2022-05-17 | 2024-12-12 | Umoja Biopharma, Inc. | Manufacturing viral particles |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007527240A (ja) | 2004-03-01 | 2007-09-27 | マサチューセッツ インスティテュート オブ テクノロジー | アレルギー性鼻炎および喘息のためのRNAiベースの治療 |
| US20080293142A1 (en) | 2007-04-19 | 2008-11-27 | The Board Of Regents For Oklahoma State University | Multiple shRNA Expression Vectors and Methods of Construction |
| WO2015017755A1 (en) | 2013-08-02 | 2015-02-05 | The Regents Of The University Of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| JP2015518838A (ja) | 2012-05-23 | 2015-07-06 | ガニメド ファーマシューティカルズ アーゲー | がんを処置するためのクローディン18.2に対する抗体を伴う併用療法 |
| JP2016502404A (ja) | 2012-11-13 | 2016-01-28 | ジャン レットバル | 治療剤の送達方法 |
Family Cites Families (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668255A (en) | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| EP0642582A1 (en) | 1992-05-22 | 1995-03-15 | Dana Farber Cancer Institute | Hybrid siv/hiv-1 viral vectors and monkey model for aids |
| DE69322495T2 (de) | 1992-09-30 | 1999-06-02 | Tetra Rex Packaging Systems, Inc., Buffalo Grove, Ill. | Verfahren und vorrichtung zum anbringen eines mundstückes an einem kartonbehälter |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| ES2310924T3 (es) | 1993-07-13 | 2009-01-16 | Centelion | Vectores adenovirales defectivos y utilizacion en terapia genica. |
| EP0932694A2 (en) | 1996-09-11 | 1999-08-04 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Aav4 vector and uses thereof |
| AU8828598A (en) | 1997-08-15 | 1999-03-08 | Rubicon Laboratory, Inc. | Retrovirus and viral vectors |
| AU1124499A (en) | 1997-10-28 | 1999-05-17 | Maxygen, Inc. | Human papillomavirus vectors |
| EP1064393B1 (en) | 1998-03-20 | 2004-12-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for helper-free production of recombinant adeno-associated viruses |
| DE69940521D1 (de) | 1998-10-01 | 2009-04-16 | Univ Southern California | Retrovirales genübertragungssystem und entsprechendes verwendungverfahren |
| US6156514A (en) | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| US6410013B1 (en) | 1999-01-25 | 2002-06-25 | Musc Foundation For Research Development | Viral vectors for use in monitoring HIV drug resistance |
| WO2000072886A1 (en) | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
| WO2001083797A2 (en) | 2000-04-28 | 2001-11-08 | Avigen, Inc. | Polynucleotides for use in recombinant adeno-associated virus virion production |
| EP1282449A2 (en) | 2000-05-12 | 2003-02-12 | The Regents Of The University Of California | Treatment of human papillomavirus (hpv)-infected cells |
| WO2001091802A1 (en) | 2000-05-30 | 2001-12-06 | Baylor College Of Medicine | Chimeric viral vectors for gene therapy |
| NO314588B1 (no) | 2000-09-04 | 2003-04-14 | Bionor Immuno As | HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| US20030119770A1 (en) | 2001-08-02 | 2003-06-26 | Zhennan Lai | Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors |
| AU2002323270A1 (en) | 2001-08-18 | 2003-03-03 | Myriad Genetics, Inc | Composition and method for treating hiv infection |
| US7737124B2 (en) | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
| AU2002363465A1 (en) | 2001-10-25 | 2003-05-19 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human S | Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 |
| US20070203333A1 (en) | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| EP1495141A4 (en) | 2002-03-20 | 2006-03-22 | Massachusetts Inst Technology | THERAPY OF HIV |
| AU2003237159A1 (en) | 2002-04-30 | 2003-11-17 | University Of Florida | Treatment for phenylketonuria |
| WO2004037847A2 (en) | 2002-05-07 | 2004-05-06 | Chiron Corporation | Hiv envelope-cd4 complexes and hybrids |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| US20040161412A1 (en) | 2002-08-22 | 2004-08-19 | The Cleveland Clinic Foundation | Cell-based VEGF delivery |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| ES2334125T3 (es) | 2002-11-04 | 2010-03-05 | University Of Massachusetts | Interferencia de arn especifico de alelos. |
| AU2003283174A1 (en) | 2002-12-11 | 2004-06-30 | Cytos Biotechnology Ag | Method for protein production |
| WO2004104591A2 (en) | 2003-05-23 | 2004-12-02 | Institut National De La Sante Et De La Recherche Medicale | Improvements to gamma delta t cell-mediated therapy |
| WO2005005644A1 (en) | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| US20050019927A1 (en) | 2003-07-13 | 2005-01-27 | Markus Hildinger | DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER |
| US20050138677A1 (en) | 2003-09-16 | 2005-06-23 | Pfister Herbert J. | Transgenic animal model for the treatment of skin tumors |
| US20070275010A1 (en) | 2003-09-18 | 2007-11-29 | Mark Feinberg | Mva Vaccines |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| US20080039413A1 (en) | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| WO2005081911A2 (en) | 2004-02-25 | 2005-09-09 | Dana-Farber Cancer Institute, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HIV INFECTION USING TRIM5α |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| WO2005118802A2 (en) | 2004-06-03 | 2005-12-15 | The Regents Of The University Of California | Targeting pseudotyped retroviral vectors |
| US20080131940A1 (en) | 2004-06-25 | 2008-06-05 | Robert Chiu | Target Cell-Specific Short Interfering Rna and Methods of Use Thereof |
| EP1789447B1 (en) | 2004-08-16 | 2012-04-25 | Immune Disease Institute, Inc. | Method of delivering rna interference and uses thereof |
| US7358361B2 (en) | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| EP1647595A1 (en) | 2004-10-15 | 2006-04-19 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Nucleic acids against viruses, in particular HIV |
| JP2008518591A (ja) | 2004-11-02 | 2008-06-05 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | 複製欠損アデノウイルスベクターの製造のためのアデノウイルスアンプリコンおよびプロデューサー細胞、その製造方法および用途 |
| US7790446B2 (en) | 2005-02-11 | 2010-09-07 | Kosagen Cell Factory Oü | Vectors, cell lines and their use in obtaining extended episomal maintenance replication of hybrid plasmids and expression of gene products |
| EP1858332A4 (en) | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| PL2002003T3 (pl) | 2005-05-27 | 2016-06-30 | Ospedale San Raffaele Srl | Wektor genetyczny zawierający mi-RNA |
| US20070032443A1 (en) | 2005-08-02 | 2007-02-08 | Jaeseob Kim | Therapy for Alzheimer's disease |
| WO2007015122A1 (en) | 2005-08-02 | 2007-02-08 | Genexel, Inc. | Therapy for alzheimer’s disease |
| US20070105835A1 (en) | 2005-11-07 | 2007-05-10 | Kazantsev Aleksey G | Compositions and methods for modulating poly(ADP-ribose) polymerase activity |
| WO2007133674A2 (en) | 2006-05-12 | 2007-11-22 | Lentigen Corporation | Lentiviral vector compositions, methods and applications |
| US8535897B2 (en) | 2006-06-19 | 2013-09-17 | The Trustees Of Columbia University In The City Of New York | Assays for non-apoptotic cell death and uses thereof |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| WO2008008719A2 (en) * | 2006-07-10 | 2008-01-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the myc gene |
| EP1878440A1 (en) | 2006-07-13 | 2008-01-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for increasing the efficiency of therapeutic antibodies using gamma delta cell activator compounds |
| CN101516365A (zh) | 2006-07-26 | 2009-08-26 | 诺瓦提斯公司 | 十一异戊二烯基焦磷酸酯合酶的抑制剂 |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| EP2426142A3 (en) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modified vaccinia virus strains for use in a diagnostic and therapeutic method |
| ES2639568T3 (es) | 2007-01-23 | 2017-10-27 | Janssen Pharmaceutica Nv | Método para diseñar un régimen farmacológico para pacientes infectados con el VIH |
| EP2203460A4 (en) | 2007-04-12 | 2012-03-14 | Univ Illinois | BIPHOSPHONATE COMPOUNDS AND METHODS WITH INCREASED POTENTIAL FOR MULTIPLE OBJECTIVES, INCLUDING FPPS, GGPPS AND DPPS |
| EP2173342A2 (en) | 2007-06-22 | 2010-04-14 | ETH Zurich | Antivirals |
| EP2008656A1 (en) | 2007-06-28 | 2008-12-31 | Bergen Teknologioverforing AS | Compositions for the treatment of hyperphenylalaninemia |
| US8673477B2 (en) | 2008-06-16 | 2014-03-18 | Polyplus Battery Company | High energy density aqueous lithium/air-battery cells |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| EP2090659A1 (en) | 2008-02-14 | 2009-08-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Infectious particle, process for its preparation and use thereof |
| GB0810209D0 (en) | 2008-06-04 | 2008-07-09 | Cambridge Entpr Ltd | Pluripotency associated epigenetic factor |
| US8629334B2 (en) | 2008-07-16 | 2014-01-14 | University Of Florida Research Foundation, Inc. | Viral-based transient-expression vector system for trees |
| WO2010022195A2 (en) | 2008-08-20 | 2010-02-25 | Virxsys Corporation | Non-integrating lenti/adeno-associated virus hybrid vector system |
| US8871515B2 (en) | 2008-09-17 | 2014-10-28 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| AU2009308707A1 (en) | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | LIGHT targeting molecules and uses thereof |
| WO2010051521A1 (en) | 2008-10-31 | 2010-05-06 | Lentigen Corporation | Cell therapy product for the treatment of hiv infection |
| WO2011071476A2 (en) | 2008-11-14 | 2011-06-16 | Life Technologies Corporation | Compositions and methods for engineering cells |
| EP2191834A1 (en) | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| CA2756670A1 (en) | 2009-03-26 | 2010-09-30 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory rna for disease modification |
| CN102438631A (zh) | 2009-04-09 | 2012-05-02 | 史坦赛特股份有限公司 | 抗hiv干细胞及其用途 |
| KR20120088542A (ko) | 2009-04-13 | 2012-08-08 | 아프세스 게엠베하 & 씨오. 카게 | 종양 치료를 위한 조작된 중간엽 줄기세포 및 이를 사용하는 방법 |
| EP2425001A4 (en) | 2009-04-30 | 2012-11-14 | Univ California | ANTI-HIV COMBINATION VECTORS, TARGETING VECTORS AND METHOD OF USE |
| DK3329772T3 (da) | 2009-07-15 | 2020-01-27 | Calimmune Inc | Dobbeltvektor til inhibering af human immundefektvirus |
| WO2011066578A1 (en) | 2009-11-30 | 2011-06-03 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer |
| CN101805750B (zh) * | 2009-12-29 | 2011-11-30 | 浙江大学 | 法呢基焦磷酸合成酶rna干扰重组慢病毒载体构建及用途 |
| CA2790426A1 (en) | 2010-02-18 | 2011-08-25 | Emory University | Vectors expressing hiv antigens and gm-csf and related methods for generating an immune response |
| WO2011119942A1 (en) | 2010-03-25 | 2011-09-29 | Vistagen Therapeutics, Inc. | Induction of ips cells using transient episomal vectors |
| WO2011133687A2 (en) | 2010-04-20 | 2011-10-27 | President And Fellows Of Harvard College | Methods and compositions for inhibition of beta2-adrenergic receptor degradation |
| AU2011242576B2 (en) | 2010-04-23 | 2016-03-31 | Cold Spring Harbor Laboratory | Novel structurally designed shRNAs |
| CN102946907A (zh) | 2010-05-28 | 2013-02-27 | 牛津生物医学(英国)有限公司 | 慢病毒载体向脑的递送 |
| WO2012020757A1 (ja) | 2010-08-10 | 2012-02-16 | タカラバイオ株式会社 | 細胞集団の製造方法 |
| WO2012048303A2 (en) | 2010-10-07 | 2012-04-12 | Columbia University | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION |
| WO2012061075A2 (en) | 2010-10-25 | 2012-05-10 | The Regents Of The University Of California | Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells |
| EP2643045A4 (en) | 2010-11-23 | 2016-01-13 | Presage Biosciences Inc | THERAPEUTIC PROCESSES AND COMPOSITIONS FOR SOLID FORM DELIVERY |
| JP6091435B2 (ja) | 2011-02-22 | 2017-03-08 | カリフォルニア インスティチュート オブ テクノロジー | アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達 |
| WO2012145624A2 (en) | 2011-04-21 | 2012-10-26 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| CA2850836A1 (en) | 2011-10-15 | 2013-04-18 | Genentech, Inc. | Methods of using scd1 antagonists |
| JP6348064B2 (ja) | 2011-11-22 | 2018-06-27 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | 効率の高いトランスジーン送達のためのウイルスベクター |
| US9745631B2 (en) | 2011-12-20 | 2017-08-29 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
| CN107982548A (zh) | 2012-02-07 | 2018-05-04 | 全球生物疗法有限公司 | 核酸输送的区室化方法及其组合物和应用 |
| WO2013182662A1 (en) | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Vaccine |
| WO2014016817A2 (en) | 2012-07-17 | 2014-01-30 | Universite De Geneve | Nucleic acids for down-regulation of gene expression |
| EP2900835B1 (en) | 2012-09-27 | 2025-04-30 | Population Bio, Inc. | Method for screening and treating developmental disorders |
| AU2013355327A1 (en) | 2012-12-05 | 2015-06-11 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of metabolic disorders |
| US9642921B2 (en) | 2012-12-20 | 2017-05-09 | Tocagen Inc. | Cancer combination therapy and recombinant vectors |
| WO2014117050A2 (en) | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| CN103184224A (zh) | 2013-04-03 | 2013-07-03 | 衡阳师范学院 | 一种抗艾滋病病毒感染的三联miRNA及构建方法 |
| EP2999797B1 (en) | 2013-05-21 | 2018-07-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Isoforms of gata6 and nkx2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy |
| JP2016520316A (ja) | 2013-06-03 | 2016-07-14 | テラベクティ | MHCクラスI、MHCクラスIIまたはβ2ミクログロブリン上流プロモーター配列を含有するレンチウイルスベクター |
| WO2015042308A2 (en) | 2013-09-18 | 2015-03-26 | City Of Hope | Rna-based hiv inhibitors |
| WO2015061491A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| CN113699159A (zh) | 2014-03-28 | 2021-11-26 | 明尼苏达大学评议会 | 涉及经工程改造的cd16的多肽、细胞和方法 |
| US11400115B2 (en) | 2014-04-23 | 2022-08-02 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| SI3689899T1 (sl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | MND promotor kimeričnih antigenskih receptorjev |
| DK3546585T3 (da) | 2014-04-25 | 2025-11-03 | Genethon | Nukleinsyrer med en modificeret intron til brug i behandlingen af hyperbilirubinæmi |
| US20160060707A1 (en) * | 2014-08-29 | 2016-03-03 | Immunomedics, Inc. | Identification of Cancer Genes by In-Vivo Fusion of Human Cancer Cells and Animal Cells |
| DK3197472T3 (da) | 2014-09-22 | 2021-10-18 | Tanea Medical Ab | Rekombinante phe-frie proteiner til anvendelse i behandlingen af phenylketonuri |
| CA2964173A1 (en) * | 2014-10-10 | 2016-04-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting cd47 |
| US10968451B2 (en) | 2014-10-14 | 2021-04-06 | Texas Tech University System | Multiplexed shRNAs and uses thereof |
| WO2016069716A1 (en) | 2014-10-30 | 2016-05-06 | The Scripps Research Institute | Compositions and methods comprising tyrosyl-trna synthetases and resveratrol compounds |
| GB201509202D0 (en) | 2015-05-28 | 2015-07-15 | Ge Healthcare Bio Sciences Ab | Semi-static cell culture |
| US20180161455A1 (en) | 2015-06-10 | 2018-06-14 | American Gene Technologies International, Inc. | Non-integrating viral delivery system and methods of use therof |
| EP3319631A4 (en) | 2015-07-08 | 2019-01-09 | American Gene Technologies International Inc. | HIV PREMUNICATION AND IMMUNOTHERAPY |
| US11028369B2 (en) | 2015-08-13 | 2021-06-08 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced extended pluripotent stem cells, method of making and using |
| CN105112370B (zh) | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| JP7059179B2 (ja) | 2015-10-20 | 2022-04-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
| US11389546B2 (en) | 2015-12-09 | 2022-07-19 | Modernatx, Inc. | Heterologous UTR sequences for enhanced mRNA expression |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CA3011529A1 (en) | 2016-01-15 | 2017-07-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta t-cells |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| SG11201807223UA (en) | 2016-03-23 | 2018-09-27 | Univ Columbia | CANCER TREATMENT BASED ON DELIVERY OF OLIGOES VIA GAP JUNCTIONS FROM HUMAN MESENCHYMAL STEM CELLS (hMSC) |
| US20190117799A1 (en) | 2016-04-01 | 2019-04-25 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| IL300730A (en) | 2016-07-08 | 2023-04-01 | American Gene Tech Int Inc | Pre-HIV vaccine and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| WO2018126112A1 (en) | 2016-12-30 | 2018-07-05 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating phenylketonuria |
| AU2018205388A1 (en) | 2017-01-09 | 2019-07-18 | American Gene Technologies International Inc. | HIV immunotherapy with no pre-immunization step |
| CA3053008A1 (en) | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation with heterobifunctional compounds |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| US20200181645A1 (en) | 2017-06-16 | 2020-06-11 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| CA3077355A1 (en) | 2017-10-02 | 2019-04-11 | American Gene Technologies International Inc. | Vectors with promoter and enhancer combinations for treating phenylketonuria |
| WO2019136273A1 (en) | 2018-01-05 | 2019-07-11 | NantBio Inc. | Reprogrammed t cell-like nk cells |
| JP7447388B2 (ja) | 2018-07-13 | 2024-03-12 | ナンジン レジェンド バイオテック カンパニー,リミテッド | 感染性疾患の治療のための共受容体システム |
| WO2020097049A1 (en) | 2018-11-05 | 2020-05-14 | American Gene Technologies International Inc. | Vector system for expressing regulatory rna |
| CA3137698A1 (en) | 2019-05-31 | 2020-12-03 | Tyler LAHUSEN | Optimized phenylalanine hydroxylase expression |
| CN115551532A (zh) | 2020-03-03 | 2022-12-30 | 美国基因技术国际有限公司 | 在淋巴细胞中按需表达外源性因子以治疗hiv |
-
2017
- 2017-03-09 ES ES17764128T patent/ES2911448T3/es active Active
- 2017-03-09 EP EP17764128.9A patent/EP3426777B1/en active Active
- 2017-03-09 WO PCT/US2017/021639 patent/WO2017156311A2/en not_active Ceased
- 2017-03-09 US US16/083,384 patent/US10767183B2/en active Active
- 2017-03-09 JP JP2018547354A patent/JP7017247B2/ja active Active
- 2017-03-09 DK DK17764128.9T patent/DK3426777T3/da active
- 2017-03-09 EP EP22154806.8A patent/EP4036231A1/en active Pending
-
2020
- 2020-07-30 US US16/943,800 patent/US10975374B2/en active Active
-
2021
- 2021-03-10 US US17/198,017 patent/US11242527B1/en active Active
-
2022
- 2022-01-06 US US17/570,313 patent/US12359203B2/en active Active
- 2022-01-20 JP JP2022006999A patent/JP2022051775A/ja not_active Ceased
-
2024
- 2024-03-18 JP JP2024042163A patent/JP2024069537A/ja active Pending
-
2025
- 2025-06-09 US US19/232,291 patent/US20250376685A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007527240A (ja) | 2004-03-01 | 2007-09-27 | マサチューセッツ インスティテュート オブ テクノロジー | アレルギー性鼻炎および喘息のためのRNAiベースの治療 |
| US20080293142A1 (en) | 2007-04-19 | 2008-11-27 | The Board Of Regents For Oklahoma State University | Multiple shRNA Expression Vectors and Methods of Construction |
| JP2015518838A (ja) | 2012-05-23 | 2015-07-06 | ガニメド ファーマシューティカルズ アーゲー | がんを処置するためのクローディン18.2に対する抗体を伴う併用療法 |
| JP2016502404A (ja) | 2012-11-13 | 2016-01-28 | ジャン レットバル | 治療剤の送達方法 |
| WO2015017755A1 (en) | 2013-08-02 | 2015-02-05 | The Regents Of The University Of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
Non-Patent Citations (2)
| Title |
|---|
| Li, J. et al.,Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by V γ9Vδ2 T cells,The Journal of Immunology,2009年,Vol. 182(12),pp. 8118-8124 |
| Wang, Y. et al.,Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis,Molecular Therapy,2013年,Vol. 21(10),pp. 1919-1929 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022051775A (ja) * | 2016-03-09 | 2022-04-01 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | がんを処置するための組み合わせベクターおよび方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11242527B1 (en) | 2022-02-08 |
| ES2911448T3 (es) | 2022-05-19 |
| JP2019508045A (ja) | 2019-03-28 |
| EP4036231A1 (en) | 2022-08-03 |
| JP2022051775A (ja) | 2022-04-01 |
| WO2017156311A3 (en) | 2017-10-19 |
| EP3426777A4 (en) | 2019-09-11 |
| JP2024069537A (ja) | 2024-05-21 |
| US10975374B2 (en) | 2021-04-13 |
| US20250376685A1 (en) | 2025-12-11 |
| WO2017156311A2 (en) | 2017-09-14 |
| US12359203B2 (en) | 2025-07-15 |
| US20210047644A1 (en) | 2021-02-18 |
| EP3426777B1 (en) | 2022-02-16 |
| US20220251563A1 (en) | 2022-08-11 |
| US10767183B2 (en) | 2020-09-08 |
| EP3426777A2 (en) | 2019-01-16 |
| DK3426777T3 (da) | 2022-04-25 |
| US20190078096A1 (en) | 2019-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7017247B2 (ja) | がんを処置するための組み合わせベクターおよび方法 | |
| JP2023144131A (ja) | ガンマデルタt細胞の活性化のための方法および組成物 | |
| JP2023133396A (ja) | ヒトガンマデルタt細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200306 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200306 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210204 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210216 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210506 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210715 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211221 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220120 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7017247 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |