ES2904911T3 - Anticuerpos anti-receptor P2X7 y fragmentos de los mismos - Google Patents

Anticuerpos anti-receptor P2X7 y fragmentos de los mismos Download PDF

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Publication number
ES2904911T3
ES2904911T3 ES18175591T ES18175591T ES2904911T3 ES 2904911 T3 ES2904911 T3 ES 2904911T3 ES 18175591 T ES18175591 T ES 18175591T ES 18175591 T ES18175591 T ES 18175591T ES 2904911 T3 ES2904911 T3 ES 2904911T3
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ES
Spain
Prior art keywords
sequence
seq
antibody
binding site
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18175591T
Other languages
English (en)
Spanish (es)
Inventor
Julian Alexander Barden
Neil Brewis
Philip Jones
Steven Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosceptre Aust Pty Ltd
Biosceptre Pty Ltd
Original Assignee
Biosceptre Aust Pty Ltd
Biosceptre Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009903928A external-priority patent/AU2009903928A0/en
Application filed by Biosceptre Aust Pty Ltd, Biosceptre Pty Ltd filed Critical Biosceptre Aust Pty Ltd
Application granted granted Critical
Publication of ES2904911T3 publication Critical patent/ES2904911T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES18175591T 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos Active ES2904911T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2009903928A AU2009903928A0 (en) 2009-08-20 Anti P2X7 receptor antibodies and fragments thereof

Publications (1)

Publication Number Publication Date
ES2904911T3 true ES2904911T3 (es) 2022-04-06

Family

ID=43606479

Family Applications (3)

Application Number Title Priority Date Filing Date
ES10809371.7T Active ES2557456T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
ES18175591T Active ES2904911T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
ES15178381T Active ES2704711T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES10809371.7T Active ES2557456T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15178381T Active ES2704711T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Country Status (5)

Country Link
US (6) US9127059B2 (enExample)
EP (3) EP3395832B1 (enExample)
JP (3) JP5936067B2 (enExample)
ES (3) ES2557456T3 (enExample)
WO (1) WO2011020155A1 (enExample)

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BRPI0915367B8 (pt) 2008-07-04 2021-05-25 Biosceptre International Ltd peptídeo anti-p2x7
ES2557456T3 (es) 2009-08-20 2016-01-26 Biosceptre (Aust) Pty Ltd Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
JP5992831B2 (ja) 2009-12-24 2016-09-14 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 非機能性オリゴマーp2x7受容体に対する抗体
US9562094B2 (en) 2010-09-10 2017-02-07 Biosceptre (Aust) Pty Ltd Companion animal treatments
CA2840251C (en) 2011-07-01 2023-09-12 Biosceptre International Limited Combination therapy of diseases that are associated with non-functional p2x7 receptor expression
AU2016240410B2 (en) * 2015-04-02 2021-09-16 Biosceptre (Aust) Pty Ltd Pain treatment
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GB201522541D0 (en) * 2015-12-21 2016-02-03 Inst Research In Biomedicine Compositions
WO2018071959A1 (en) * 2016-10-21 2018-04-26 Biosceptre (Uk) Limited Cytotoxic particles
FR3084365B1 (fr) * 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
CN110054691B (zh) * 2019-05-09 2021-09-07 潍坊医学院 一种抗人p2rx7单克隆抗体的杂交瘤细胞系
BR112022000142A2 (pt) * 2019-07-26 2022-04-12 Biosceptre Aust Pty Ltd Métodos de tratamento
CN111234016B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的全人源单克隆抗体及应用
CN111171149B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的人源化单链抗体及其应用
US20250281611A1 (en) * 2021-03-11 2025-09-11 Biosceptre ( Aust ) Pty Ltd Novel cell therapy system
MX2023015028A (es) * 2021-09-01 2024-02-16 Biosceptre Aust Pty Ltd Nuevos aglutinantes del p2x7 disfuncional.
WO2025042968A1 (en) * 2023-08-22 2025-02-27 Integral Molecular, Inc. Compositions and methods related to chicken recombinant heavy-chain only antibodies

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Also Published As

Publication number Publication date
JP2016136949A (ja) 2016-08-04
US20250084161A1 (en) 2025-03-13
US20220315652A1 (en) 2022-10-06
US10988532B2 (en) 2021-04-27
US20120282278A1 (en) 2012-11-08
JP6417016B2 (ja) 2018-10-31
US20170327576A1 (en) 2017-11-16
EP2467404A4 (en) 2013-01-23
JP6224141B2 (ja) 2017-11-01
US9127059B2 (en) 2015-09-08
WO2011020155A1 (en) 2011-02-24
EP2467404B1 (en) 2015-09-30
US20190040129A1 (en) 2019-02-07
EP2966090A1 (en) 2016-01-13
HK1168365A1 (en) 2012-12-28
EP3395832A1 (en) 2018-10-31
ES2704711T3 (es) 2019-03-19
US10053508B2 (en) 2018-08-21
US12129295B2 (en) 2024-10-29
JP2013502204A (ja) 2013-01-24
EP2966090B1 (en) 2018-10-10
US20150266969A1 (en) 2015-09-24
US9688771B2 (en) 2017-06-27
EP3395832B1 (en) 2021-11-24
JP2018023396A (ja) 2018-02-15
EP2467404A1 (en) 2012-06-27
ES2557456T3 (es) 2016-01-26
JP5936067B2 (ja) 2016-06-15

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