ES2557456T3 - Anticuerpos anti-receptor P2X7 y fragmentos de los mismos - Google Patents

Anticuerpos anti-receptor P2X7 y fragmentos de los mismos Download PDF

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Publication number
ES2557456T3
ES2557456T3 ES10809371.7T ES10809371T ES2557456T3 ES 2557456 T3 ES2557456 T3 ES 2557456T3 ES 10809371 T ES10809371 T ES 10809371T ES 2557456 T3 ES2557456 T3 ES 2557456T3
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ES
Spain
Prior art keywords
pep2
seq
antigen binding
sequence
binding site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10809371.7T
Other languages
English (en)
Spanish (es)
Inventor
Julian Alexander Barden
Neil Brewis
Philip Jones
Steven Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosceptre Pty Ltd
Original Assignee
Biosceptre Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009903928A external-priority patent/AU2009903928A0/en
Application filed by Biosceptre Pty Ltd filed Critical Biosceptre Pty Ltd
Application granted granted Critical
Publication of ES2557456T3 publication Critical patent/ES2557456T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10809371.7T 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos Active ES2557456T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009903928 2009-08-20
AU2009903928A AU2009903928A0 (en) 2009-08-20 Anti P2X7 receptor antibodies and fragments thereof
PCT/AU2010/001070 WO2011020155A1 (en) 2009-08-20 2010-08-20 Anti p2x7 receptor antibodies and fragments thereof

Publications (1)

Publication Number Publication Date
ES2557456T3 true ES2557456T3 (es) 2016-01-26

Family

ID=43606479

Family Applications (3)

Application Number Title Priority Date Filing Date
ES15178381T Active ES2704711T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
ES10809371.7T Active ES2557456T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
ES18175591T Active ES2904911T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES15178381T Active ES2704711T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES18175591T Active ES2904911T3 (es) 2009-08-20 2010-08-20 Anticuerpos anti-receptor P2X7 y fragmentos de los mismos

Country Status (5)

Country Link
US (6) US9127059B2 (enExample)
EP (3) EP3395832B1 (enExample)
JP (3) JP5936067B2 (enExample)
ES (3) ES2704711T3 (enExample)
WO (1) WO2011020155A1 (enExample)

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CA2737126C (en) 2007-09-14 2018-05-01 Biosceptre International Limited Novel p2x7 epitopes
BRPI0915367B8 (pt) 2008-07-04 2021-05-25 Biosceptre International Ltd peptídeo anti-p2x7
JP5936067B2 (ja) 2009-08-20 2016-06-15 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 抗p2x7受容体抗体およびその断片
US8835609B2 (en) 2009-12-24 2014-09-16 Biosceptre International Limited Antigen binding sites to non-functional oligomeric P2X7 receptors and methods of use thereof
EP2613808B1 (en) 2010-09-10 2017-11-08 Biosceptre (Aust) Pty Ltd Companion animal cancer treatments with an anti p2x7 antibody
AU2012278921B2 (en) 2011-07-01 2016-11-10 Biosceptre International Limited Combination therapy
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GB201522541D0 (en) * 2015-12-21 2016-02-03 Inst Research In Biomedicine Compositions
EP3528789A4 (en) 2016-10-21 2020-06-24 Biosceptre UK Limited CYTOTOXIC PARTICLES
FR3084365B1 (fr) * 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
CN110054691B (zh) * 2019-05-09 2021-09-07 潍坊医学院 一种抗人p2rx7单克隆抗体的杂交瘤细胞系
CN114173811A (zh) * 2019-07-26 2022-03-11 生物权威(澳大利亚)有限责任公司 P2x7受体靶向治疗
CN111234016B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的全人源单克隆抗体及应用
CN111171149B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的人源化单链抗体及其应用
CA3211323A1 (en) * 2021-03-11 2022-09-15 Patrick Schlegel Novel cell therapy system
US20240376193A1 (en) * 2021-09-01 2024-11-14 Biosceptre (Aust) Pty Ltd Novel dysfunctional p2x7 binders
WO2025042968A1 (en) * 2023-08-22 2025-02-27 Integral Molecular, Inc. Compositions and methods related to chicken recombinant heavy-chain only antibodies

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Also Published As

Publication number Publication date
JP2018023396A (ja) 2018-02-15
US20250084161A1 (en) 2025-03-13
US9127059B2 (en) 2015-09-08
US20190040129A1 (en) 2019-02-07
EP3395832A1 (en) 2018-10-31
EP3395832B1 (en) 2021-11-24
US10988532B2 (en) 2021-04-27
JP5936067B2 (ja) 2016-06-15
US20150266969A1 (en) 2015-09-24
US20220315652A1 (en) 2022-10-06
US10053508B2 (en) 2018-08-21
US12129295B2 (en) 2024-10-29
HK1168365A1 (en) 2012-12-28
US20120282278A1 (en) 2012-11-08
WO2011020155A1 (en) 2011-02-24
EP2467404B1 (en) 2015-09-30
JP2013502204A (ja) 2013-01-24
JP2016136949A (ja) 2016-08-04
ES2904911T3 (es) 2022-04-06
JP6417016B2 (ja) 2018-10-31
ES2704711T3 (es) 2019-03-19
JP6224141B2 (ja) 2017-11-01
EP2966090B1 (en) 2018-10-10
EP2467404A4 (en) 2013-01-23
EP2467404A1 (en) 2012-06-27
US20170327576A1 (en) 2017-11-16
EP2966090A1 (en) 2016-01-13
US9688771B2 (en) 2017-06-27

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