ES2895904T3 - Tetrahidroindazoles y usos médicos de los mismos - Google Patents
Tetrahidroindazoles y usos médicos de los mismos Download PDFInfo
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- ES2895904T3 ES2895904T3 ES16805882T ES16805882T ES2895904T3 ES 2895904 T3 ES2895904 T3 ES 2895904T3 ES 16805882 T ES16805882 T ES 16805882T ES 16805882 T ES16805882 T ES 16805882T ES 2895904 T3 ES2895904 T3 ES 2895904T3
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- 0 *C(C(C(CCC1)=O)C1=O)=O Chemical compound *C(C(C(CCC1)=O)C1=O)=O 0.000 description 3
- SGRYWJUDZMLGAX-HOYKHHGWSA-N CC(C)(C)[S@](N[C@](C)(CCC1)c2c1[n](-c(cccc1)c1F)nc2)=O Chemical compound CC(C)(C)[S@](N[C@](C)(CCC1)c2c1[n](-c(cccc1)c1F)nc2)=O SGRYWJUDZMLGAX-HOYKHHGWSA-N 0.000 description 1
- YOYFVMSDZKBLAU-UHFFFAOYSA-N CC(C)OC(c1cccc(-[n]2ncc3c2CCCC3N[SH-](C(C)(C)C)=O)c1)=O Chemical compound CC(C)OC(c1cccc(-[n]2ncc3c2CCCC3N[SH-](C(C)(C)C)=O)c1)=O YOYFVMSDZKBLAU-UHFFFAOYSA-N 0.000 description 1
- LCFJQMKZCFGWOZ-MRXNPFEDSA-N CC(C=CCC1)=C1[n]1ncc2c1CCC[C@H]2NC(c1cccnc1O)=O Chemical compound CC(C=CCC1)=C1[n]1ncc2c1CCC[C@H]2NC(c1cccnc1O)=O LCFJQMKZCFGWOZ-MRXNPFEDSA-N 0.000 description 1
- USUMAAZJCOVPIN-UHFFFAOYSA-N CN(C)C=C(C(CCC1)=O)C1=O Chemical compound CN(C)C=C(C(CCC1)=O)C1=O USUMAAZJCOVPIN-UHFFFAOYSA-N 0.000 description 1
- QCYACHGROOAKHF-QGZVFWFLSA-N Cc(cc1)cc(-[n]2ncc3c2CCC[C@H]3NC(c2c(CCCC3)c3n[o]2)=O)c1F Chemical compound Cc(cc1)cc(-[n]2ncc3c2CCC[C@H]3NC(c2c(CCCC3)c3n[o]2)=O)c1F QCYACHGROOAKHF-QGZVFWFLSA-N 0.000 description 1
- YGSJZVRLIIXNRX-OAQYLSRUSA-N Cc1c(C(N[C@H](CCC2)C(C=N)=C2Nc2ccccc2C)=O)[o]c2ccccc12 Chemical compound Cc1c(C(N[C@H](CCC2)C(C=N)=C2Nc2ccccc2C)=O)[o]c2ccccc12 YGSJZVRLIIXNRX-OAQYLSRUSA-N 0.000 description 1
- GHWBABJHJHGNBS-MRXNPFEDSA-N Cc1cc(C(N[C@H](CCC2)c3c2[n](-c(cccc2)c2F)nc3)=O)ncc1 Chemical compound Cc1cc(C(N[C@H](CCC2)c3c2[n](-c(cccc2)c2F)nc3)=O)ncc1 GHWBABJHJHGNBS-MRXNPFEDSA-N 0.000 description 1
- ATSPWCIHZDYOGH-LJQANCHMSA-N Cc1ccc(C(N[C@H](CCC2)C(C=N)=C2Nc2c(C)cccc2)=O)nc1 Chemical compound Cc1ccc(C(N[C@H](CCC2)C(C=N)=C2Nc2c(C)cccc2)=O)nc1 ATSPWCIHZDYOGH-LJQANCHMSA-N 0.000 description 1
- SAPZGQLXLNCWPH-UHFFFAOYSA-N Cc1cccc(-[n]2ncc3c2CCCC3=O)c1C Chemical compound Cc1cccc(-[n]2ncc3c2CCCC3=O)c1C SAPZGQLXLNCWPH-UHFFFAOYSA-N 0.000 description 1
- AYOGEJHUSBPCPA-UHFFFAOYSA-N Cc1cccc(-[n]2ncc3c2CCCC3N)c1 Chemical compound Cc1cccc(-[n]2ncc3c2CCCC3N)c1 AYOGEJHUSBPCPA-UHFFFAOYSA-N 0.000 description 1
- ULKFONVJDNWZBF-UHFFFAOYSA-O N=CC(C(CCC1)NC(c2ccccn2)=O)=C1[NH2+]c1ccccc1F Chemical compound N=CC(C(CCC1)NC(c2ccccn2)=O)=C1[NH2+]c1ccccc1F ULKFONVJDNWZBF-UHFFFAOYSA-O 0.000 description 1
- WISFCKYUWKDICV-UHFFFAOYSA-O NC(CCC1)C(C=N)=C1[NH2+]c1ccccc1 Chemical compound NC(CCC1)C(C=N)=C1[NH2+]c1ccccc1 WISFCKYUWKDICV-UHFFFAOYSA-O 0.000 description 1
- GTDYESQZZZLIFZ-MRXNPFEDSA-N O=C(c1c(CCCC2)[n]2cn1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 Chemical compound O=C(c1c(CCCC2)[n]2cn1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 GTDYESQZZZLIFZ-MRXNPFEDSA-N 0.000 description 1
- PVCBSHHEKHXODY-UHFFFAOYSA-N O=C(c1c(CCCC2)c2n[o]1)NC(CCC1)c2c1[n](C1=CC=CCC1F)nc2 Chemical compound O=C(c1c(CCCC2)c2n[o]1)NC(CCC1)c2c1[n](C1=CC=CCC1F)nc2 PVCBSHHEKHXODY-UHFFFAOYSA-N 0.000 description 1
- YKFYXPVYBZXGSY-MRXNPFEDSA-N O=C(c1c(CCCC2)c2n[o]1)N[C@H](CCC1)c2c1[n](-c1ccccc1F)nc2 Chemical compound O=C(c1c(CCCC2)c2n[o]1)N[C@H](CCC1)c2c1[n](-c1ccccc1F)nc2 YKFYXPVYBZXGSY-MRXNPFEDSA-N 0.000 description 1
- CPQPLJPWRQGPBK-OAHLLOKOSA-N O=C(c1cc(Br)ccn1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 Chemical compound O=C(c1cc(Br)ccn1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 CPQPLJPWRQGPBK-OAHLLOKOSA-N 0.000 description 1
- MXYMORYXGUMLPQ-UHFFFAOYSA-N O=C(c1ccccn1)NC(CCC1)c2c1[n](-c1ccccc1)nc2 Chemical compound O=C(c1ccccn1)NC(CCC1)c2c1[n](-c1ccccc1)nc2 MXYMORYXGUMLPQ-UHFFFAOYSA-N 0.000 description 1
- SLXPANFOWSUVQY-OAQYLSRUSA-N O=C(c1n[o]c2c1CCCC2)N[C@H](CCC1)c2c1[n](-c1cc(C(N3CCOCC3)=O)ccc1)nc2 Chemical compound O=C(c1n[o]c2c1CCCC2)N[C@H](CCC1)c2c1[n](-c1cc(C(N3CCOCC3)=O)ccc1)nc2 SLXPANFOWSUVQY-OAQYLSRUSA-N 0.000 description 1
- GBIPAUKLXZCHJB-OAHLLOKOSA-N O=C(c1nccc(F)c1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 Chemical compound O=C(c1nccc(F)c1)N[C@H](CCC1)c2c1[n](-c(cccc1)c1F)nc2 GBIPAUKLXZCHJB-OAHLLOKOSA-N 0.000 description 1
- XVXOXEPHMOCNRD-UHFFFAOYSA-N OC(c1n[o]c2c1CCCC2)NC(CCC1)c2c1[n](-c1ccccc1)nc2 Chemical compound OC(c1n[o]c2c1CCCC2)NC(CCC1)c2c1[n](-c1ccccc1)nc2 XVXOXEPHMOCNRD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1551410 | 2015-11-02 | ||
| GBGB1610823.5A GB201610823D0 (en) | 2016-06-21 | 2016-06-21 | Heterocyclic compounds and medical uses |
| PCT/GB2016/053383 WO2017077280A1 (en) | 2015-11-02 | 2016-11-01 | Tetrahydroindazoles and medical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2895904T3 true ES2895904T3 (es) | 2022-02-23 |
Family
ID=57482465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16805882T Active ES2895904T3 (es) | 2015-11-02 | 2016-11-01 | Tetrahidroindazoles y usos médicos de los mismos |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10889564B2 (https=) |
| EP (2) | EP3974424A1 (https=) |
| JP (1) | JP6859358B2 (https=) |
| CN (1) | CN108349947B (https=) |
| ES (1) | ES2895904T3 (https=) |
| WO (1) | WO2017077280A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2895904T3 (es) | 2015-11-02 | 2022-02-23 | Genase Therapeutics B V | Tetrahidroindazoles y usos médicos de los mismos |
| JP7542538B2 (ja) | 2018-09-18 | 2024-08-30 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体 |
| GB202013558D0 (en) * | 2020-08-28 | 2020-10-14 | Heptares Therapeutics Ltd | GRP52 Modularor compounds |
| CN118946568A (zh) | 2022-01-27 | 2024-11-12 | 格纳赛治疗有限公司 | 用于治疗癌症和病毒感染的四氢吡喃并吡唑衍生物 |
| IL305348B2 (en) * | 2023-08-20 | 2024-08-01 | Selene Therapeutics LTD | DHODH inhibitors penetrate the blood-brain barrier and their uses |
| WO2026062223A1 (en) | 2024-09-20 | 2026-03-26 | Prinses Máxima Centrum Voor Kinderoncologie B.V. | Use of dhodh-inhibitors for the treatment of cmarcb1 -mutant associated cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2651939T1 (sl) | 2010-12-13 | 2015-07-31 | Array Biopharma, Inc. | SUBSTITUIRANE N-(1H-INDAZOL-4-IL)IMIDAZO(1,2-a)PIRIDIN-3-KARBOKSAMIDNE SPOJINE KOT INHIBITORJI RECEPTORSKE TIROZINSKE KINAZE TIPA III |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| LV14476B (lv) | 2011-12-07 | 2012-05-20 | Rīgas Tehniskā Universitāte | Bioloģiski aktīvu 4-acilamino-4,5,6,7-tetrahidroindazolu sintēze |
| EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| ES2895904T3 (es) | 2015-11-02 | 2022-02-23 | Genase Therapeutics B V | Tetrahidroindazoles y usos médicos de los mismos |
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2016
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- 2016-11-01 WO PCT/GB2016/053383 patent/WO2017077280A1/en not_active Ceased
- 2016-11-01 EP EP21203472.2A patent/EP3974424A1/en active Pending
- 2016-11-01 JP JP2018541572A patent/JP6859358B2/ja active Active
- 2016-11-01 EP EP16805882.4A patent/EP3371172B1/en active Active
- 2016-11-01 CN CN201680063929.6A patent/CN108349947B/zh active Active
- 2016-11-01 US US15/772,650 patent/US10889564B2/en active Active
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2021
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| EP3371172B1 (en) | 2021-10-20 |
| US20190152943A1 (en) | 2019-05-23 |
| CN108349947B (zh) | 2021-10-01 |
| WO2017077280A1 (en) | 2017-05-11 |
| US20210230141A1 (en) | 2021-07-29 |
| US10889564B2 (en) | 2021-01-12 |
| EP3371172A1 (en) | 2018-09-12 |
| JP2018532786A (ja) | 2018-11-08 |
| CN108349947A (zh) | 2018-07-31 |
| US11795157B2 (en) | 2023-10-24 |
| EP3974424A1 (en) | 2022-03-30 |
| JP6859358B2 (ja) | 2021-04-14 |
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