ES2890098T3 - Moldeado de láminas y material hemostático - Google Patents
Moldeado de láminas y material hemostático Download PDFInfo
- Publication number
- ES2890098T3 ES2890098T3 ES13791531T ES13791531T ES2890098T3 ES 2890098 T3 ES2890098 T3 ES 2890098T3 ES 13791531 T ES13791531 T ES 13791531T ES 13791531 T ES13791531 T ES 13791531T ES 2890098 T3 ES2890098 T3 ES 2890098T3
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- Spain
- Prior art keywords
- fibrinogen
- thrombin
- sheet product
- formed sheet
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
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- A—HUMAN NECESSITIES
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- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Dispersion Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| JP2012110391 | 2012-05-14 | ||
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| JP2012110393 | 2012-05-14 | ||
| JP2013003273 | 2013-01-11 | ||
| PCT/JP2013/063872 WO2013172472A1 (ja) | 2012-05-14 | 2013-05-13 | シート成形体および止血材 |
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| AR091031A1 (es) * | 2012-05-14 | 2014-12-30 | Teijin Ltd | Producto en planchas y material hemostatico |
| MX384582B (es) * | 2015-11-06 | 2025-03-14 | Ethicon Inc | Agregados celulósicos hemostáticos compactados. |
| EP3427726B1 (en) * | 2016-03-07 | 2023-05-03 | Osaka University | Sustained drug release sheet for treating nerve injury |
| CN106267328B (zh) * | 2016-09-20 | 2019-04-12 | 安徽思维特生物科技有限公司 | 一种聚己内酯-胎牛皮胶原纤维复合止血凝胶的制备方法 |
| BR112019014236A2 (pt) * | 2017-01-23 | 2020-03-17 | Afyx Therapeutics A/S | Método para a fabricação de um produto de duas camadas à base de fibras eletrofiadas |
| KR102029926B1 (ko) * | 2017-12-14 | 2019-10-08 | 금오공과대학교 산학협력단 | 풀루란을 이용한 하이드로젤 지혈제 및 그 제조방법 |
| CA3090405A1 (en) * | 2018-02-15 | 2019-08-22 | Biom'up France SAS | Multi-dimensional hemostatic product and method for producing the same |
| MX2021011420A (es) | 2019-03-20 | 2021-10-13 | Astellas Pharma Inc | Lamina hemostatica portadora de trombina. |
| JP7555981B2 (ja) | 2019-07-12 | 2024-09-25 | ガット テクノロジーズ ビー．ブイ． | 組織接着性シートを調製するための方法 |
| WO2021009013A1 (en) | 2019-07-12 | 2021-01-21 | Gatt Technologies B.V. | Biocompatible, flexible, haemostatic sheet |
| JP7530182B2 (ja) * | 2020-02-06 | 2024-08-07 | 株式会社東芝 | 生体適合部材 |
| US12629445B2 (en) | 2020-03-20 | 2026-05-19 | Bard Peripheral Vascular, Inc. | Reactive hydrogel forming formulations and related methods, including methods of preparation |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| WO2022146917A1 (en) | 2020-12-28 | 2022-07-07 | Davol Inc. | Reactive dry powdered hemostatic materials comprising a protein and a multifunctionalized modified polyethylene glycol based crosslinking agent |
| EP4456935A1 (en) | 2021-12-30 | 2024-11-06 | Baxter International Inc. | Fibrinogen and thrombin solutions for a fibrin sealant and fibrin sealant kit |
| CN117771417A (zh) * | 2022-09-29 | 2024-03-29 | 苏州泽璟生物制药股份有限公司 | 一种含重组人凝血酶的生物可降解止血粉及其制备方法和用途 |
| WO2025144087A1 (ru) * | 2023-12-24 | 2025-07-03 | Олег ЕВСЕЕНКОВ | Гемостатическое средство |
| CN118236562A (zh) * | 2024-03-21 | 2024-06-25 | 额尔德木图 | 一种凝血酶涂层医用弹簧圈的制备方法 |
Family Cites Families (39)
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|---|---|---|---|---|
| DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| SE439078B (sv) | 1984-07-17 | 1985-05-28 | Philips Norden Ab | Anordning vid en avstembar magnetron |
| DE19521324C1 (de) | 1995-06-12 | 1996-10-31 | Immuno Ag | Gewebeklebstoff und Verwendung desselben als Hämostyptikum |
| US5702715A (en) * | 1995-10-27 | 1997-12-30 | Drying Technology | Reinforced biological sealants |
| EP0835667B1 (en) | 1996-03-15 | 2005-11-09 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Spray device for applying tissue adhesive |
| ATE439150T1 (de) | 1997-11-17 | 2009-08-15 | Haemacure Corp | Ein hyaluronsäurederivat enthaltende fibrinsiegel-oder fibrinklebmasse |
| US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
| US6056970A (en) * | 1998-05-07 | 2000-05-02 | Genzyme Corporation | Compositions comprising hemostatic compounds and bioabsorbable polymers |
| JP4480270B2 (ja) | 1998-05-19 | 2010-06-16 | ジ・アメリカン・ナショナル・レッド・クロス | 止血サンドウィッチ包帯 |
| PL206194B1 (pl) * | 2001-01-25 | 2010-07-30 | Nycomed Pharma Asnycomed Pharma As | Sposób wytwarzania zawiesiny cząstek fibrynogenu i trombiny, zawiesina zawierająca fibrynogen, trombinę i alkohol oraz sposób powlekania nośnika taką zawiesiną |
| US7135189B2 (en) | 2001-08-23 | 2006-11-14 | Boston Scientific Scimed, Inc. | Compositions and techniques for localized therapy |
| US20030198659A1 (en) * | 2001-10-25 | 2003-10-23 | Hoffmann Michael P. | Fibrous pest control |
| US20040101546A1 (en) * | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
| WO2004032713A2 (en) * | 2002-10-04 | 2004-04-22 | Nanomatrix, Inc. | Sealants for skin and other tissues |
| WO2004043503A1 (ja) * | 2002-11-14 | 2004-05-27 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | トロンビン固定化生体吸収性合成不織布 |
| US20060051340A1 (en) | 2003-01-20 | 2006-03-09 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Hemostatic materials |
| DE602004026561D1 (de) | 2003-02-13 | 2010-05-27 | Teijin Ltd | Poröse faser, poröses fasergebilde und herstellungsverfahren |
| US20070172651A1 (en) | 2004-03-16 | 2007-07-26 | Takanori Miyoshi | Ultrafine polyactic acid fibers and fiber structure, and process for their production |
| JP4526851B2 (ja) | 2004-03-31 | 2010-08-18 | 明彦 谷岡 | 多糖類のナノスケールの繊維および成形体 |
| KR20070026578A (ko) | 2004-05-21 | 2007-03-08 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 조직 봉합제 |
| JP4481994B2 (ja) * | 2004-09-07 | 2010-06-16 | 帝人株式会社 | 生体吸収性多孔体 |
| ES2530989T3 (es) | 2004-10-20 | 2015-03-09 | Ethicon Inc | Hemostático absorbible |
| US20090136651A1 (en) * | 2006-03-28 | 2009-05-28 | Gustavo Larsen | Method of Manufacturing Fibrous Hemostatic Bandages |
| CA2649081A1 (en) | 2006-04-10 | 2007-10-18 | Ethicon, Inc. | A reinforced absorbable multilayered hemostatic wound dressing and method of making |
| US20100254961A1 (en) | 2007-09-05 | 2010-10-07 | Taiyokagaku Co., Ltd. | Water-soluble electrospun sheet |
| WO2009073854A1 (en) * | 2007-12-06 | 2009-06-11 | Nanosys, Inc. | Resorbable nanoenhanced hemostatic structures and bandage materials |
| JP5192254B2 (ja) * | 2008-02-08 | 2013-05-08 | 一般財団法人化学及血清療法研究所 | シート状組織接着剤 |
| WO2009128474A1 (ja) | 2008-04-16 | 2009-10-22 | 財団法人化学及血清療法研究所 | トロンビン固定化生体吸収性シート製剤の製造方法 |
| JP2010069031A (ja) * | 2008-09-19 | 2010-04-02 | Chemo Sero Therapeut Res Inst | シート状フィブリン糊接着剤 |
| WO2010143711A1 (ja) | 2009-06-11 | 2010-12-16 | 一般財団法人化学及血清療法研究所 | 創傷被覆材 |
| EP2477617B1 (en) * | 2009-09-18 | 2018-01-31 | Bioinspire Technologies Inc. | Free-standing biodegradable patch |
| US8349354B2 (en) * | 2009-09-22 | 2013-01-08 | Ethicon, Inc. | Composite layered hemostasis device |
| US8273369B2 (en) * | 2010-05-17 | 2012-09-25 | Ethicon, Inc. | Reinforced absorbable synthetic matrix for hemostatic applications |
| US8329211B2 (en) | 2010-05-17 | 2012-12-11 | Ethicon, Inc. | Reinforced absorbable multi-layered fabric for hemostatic applications |
| JP5889188B2 (ja) * | 2010-07-20 | 2016-03-22 | 一般財団法人化学及血清療法研究所 | 組織接着用シート製剤 |
| US9861590B2 (en) | 2010-10-19 | 2018-01-09 | Covidien Lp | Self-supporting films for delivery of therapeutic agents |
| JP5905590B2 (ja) | 2011-10-26 | 2016-04-20 | エルジー エレクトロニクス インコーポレイティド | 無線通信システムにおける制御チャネルを割り当てる方法及び装置 |
| KR102037555B1 (ko) * | 2012-05-14 | 2019-10-28 | 데이진 가부시키가이샤 | 멸균 조성물 |
| AR091031A1 (es) * | 2012-05-14 | 2014-12-30 | Teijin Ltd | Producto en planchas y material hemostatico |
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2019
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