ES2879963T3 - Inhibidores de fibrosis de moléculas pequeñas - Google Patents
Inhibidores de fibrosis de moléculas pequeñas Download PDFInfo
- Publication number
- ES2879963T3 ES2879963T3 ES15867774T ES15867774T ES2879963T3 ES 2879963 T3 ES2879963 T3 ES 2879963T3 ES 15867774 T ES15867774 T ES 15867774T ES 15867774 T ES15867774 T ES 15867774T ES 2879963 T3 ES2879963 T3 ES 2879963T3
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- Prior art keywords
- compound
- formula
- nr13r14
- alkyl
- fibrosis
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US201562117846P | 2015-02-18 | 2015-02-18 | |
| PCT/US2015/064814 WO2016094570A1 (en) | 2014-12-10 | 2015-12-09 | Small molecule inhibitors of fibrosis |
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| US11390613B2 (en) | 2017-08-20 | 2022-07-19 | University Of Connecticut | Azole analogues and methods of use thereof |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2021030174A1 (en) | 2019-08-09 | 2021-02-18 | University Of Connecticut | Truncated itraconazole analogues and methods of use thereof |
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| US4267179A (en) | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4619931A (en) | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| US4791111A (en) | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| CA2176937A1 (en) | 1993-11-19 | 1995-05-26 | Carlton Edwin Ash | Polyketone polymer composition |
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| TW457240B (en) | 1995-04-20 | 2001-10-01 | Janssen Pharmaceutica Nv | Novel triazolones as apolipoprotein-B synthesis inhibitors |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| AU5636900A (en) | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| EP1511490A4 (en) | 2002-05-31 | 2009-03-11 | Transform Pharmaceuticals Inc | NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS |
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| CA2663147A1 (en) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Substituted 2-indolinone as ptk inhibitors containing a zinc binding moiety |
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| WO2010021681A2 (en) | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2011088404A1 (en) | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
| WO2012047762A2 (en) | 2010-10-08 | 2012-04-12 | Amplyx Pharmaceuticals, Inc. | Antifungal agents |
| US9346791B2 (en) | 2011-09-07 | 2016-05-24 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| US10774132B2 (en) | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
| CN105849086B (zh) | 2012-11-24 | 2018-07-31 | 杭州多禧生物科技有限公司 | 亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用 |
| AU2014274830B2 (en) | 2013-06-07 | 2017-11-09 | The California Institute For Biomedical Research | Small molecule inhibitors of fibrosis |
| LT3004106T (lt) | 2013-06-07 | 2018-02-26 | Rhizen Pharmaceuticals S.A. | Dvigubi selektyvūs p13 delta ir gamma kinazės inhibitoriai |
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| JP2017537937A (ja) | 2017-12-21 |
| HK1249361A1 (zh) | 2018-11-02 |
| CN107404878B (zh) | 2021-03-30 |
| WO2016094570A1 (en) | 2016-06-16 |
| EP3250036A4 (en) | 2018-06-27 |
| KR102548066B1 (ko) | 2023-06-26 |
| AU2015360583B2 (en) | 2020-01-23 |
| CA2968874A1 (en) | 2016-06-16 |
| AU2015360583A1 (en) | 2017-06-22 |
| KR20170091154A (ko) | 2017-08-08 |
| US20170362211A1 (en) | 2017-12-21 |
| EP3250036B1 (en) | 2021-05-12 |
| CN107404878A (zh) | 2017-11-28 |
| JP6706023B2 (ja) | 2020-06-03 |
| EP3250036A1 (en) | 2017-12-06 |
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