ES2855732T3 - Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP - Google Patents
Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP Download PDFInfo
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- ES2855732T3 ES2855732T3 ES17720928T ES17720928T ES2855732T3 ES 2855732 T3 ES2855732 T3 ES 2855732T3 ES 17720928 T ES17720928 T ES 17720928T ES 17720928 T ES17720928 T ES 17720928T ES 2855732 T3 ES2855732 T3 ES 2855732T3
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- alkyl
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- membered
- optionally substituted
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- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
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US201662324071P | 2016-04-18 | 2016-04-18 | |
US201662324081P | 2016-04-18 | 2016-04-18 | |
PCT/US2017/028167 WO2017184624A1 (fr) | 2016-04-18 | 2017-04-18 | Composés et compositions pour traiter des états associés à une activité de nlrp |
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ES17720928T Active ES2855732T3 (es) | 2016-04-18 | 2017-04-18 | Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP |
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ES17722216T Active ES2927777T3 (es) | 2016-04-18 | 2017-04-18 | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP |
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US (3) | US11339136B2 (fr) |
EP (3) | EP3445756B1 (fr) |
JP (2) | JP7050751B2 (fr) |
AU (2) | AU2017254522B2 (fr) |
ES (2) | ES2927777T3 (fr) |
MA (2) | MA44729A (fr) |
WO (2) | WO2017184624A1 (fr) |
Families Citing this family (55)
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AU2017254522B2 (en) | 2016-04-18 | 2021-09-23 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
CR20190356A (es) | 2017-01-23 | 2019-11-20 | Genentech Inc | Compuestos químicos como inhibidores de la actividad de la interleuquina-1 |
WO2018215818A1 (fr) | 2017-05-24 | 2018-11-29 | The University Of Queensland | Nouveaux composés et utilisations |
WO2019008029A1 (fr) * | 2017-07-07 | 2019-01-10 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
PL3661925T3 (pl) | 2017-07-07 | 2022-02-28 | Inflazome Limited | Nowe związki sulfonamidowo karboksyamidowe |
WO2019023147A1 (fr) | 2017-07-24 | 2019-01-31 | IFM Tre, Inc. | Composés et compositions destinés au traitement d'états pathologiques associés à une activité de nlrp |
US11370763B2 (en) | 2017-07-24 | 2022-06-28 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
CN111093773A (zh) | 2017-08-15 | 2020-05-01 | 英夫拉索姆有限公司 | 作为nlrp3抑制剂的磺酰脲和磺酰硫脲 |
US11926600B2 (en) | 2017-08-15 | 2024-03-12 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
US11542255B2 (en) | 2017-08-15 | 2023-01-03 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
WO2019043610A1 (fr) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
RU2020115098A (ru) * | 2017-11-09 | 2021-12-10 | Инфлазоум Лимитед | Соединения новых сульфонамидкарбоксамидов |
GB201803393D0 (en) * | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
GB201803394D0 (en) * | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
WO2019166627A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
WO2019166619A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
US20200407340A1 (en) | 2018-03-02 | 2020-12-31 | Inflazome Limited | Sulfonamide derivates as nlrp3 inhibitors |
GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
CN112533913A (zh) | 2018-05-04 | 2021-03-19 | 英夫拉索姆有限公司 | 新颖化合物 |
EP3817817A1 (fr) * | 2018-07-03 | 2021-05-12 | Novartis AG | Modulateurs de nlrp |
CN113613721A (zh) * | 2018-07-03 | 2021-11-05 | 诺华股份有限公司 | Nlrp调节剂 |
WO2020010118A1 (fr) | 2018-07-03 | 2020-01-09 | Novartis Inflammasome Research, Inc. | Méthodes de traitement ou de sélection d'un traitement pour un sujet résistant à un inhibiteur de tnf à l'aide d'un antagoniste de nlrp3 |
CN112437683A (zh) | 2018-07-20 | 2021-03-02 | 豪夫迈·罗氏有限公司 | 用作白细胞介素-1 活性抑制剂的磺酰脲类化合物 |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
AU2019322546A1 (en) | 2018-08-15 | 2021-03-04 | Inflazome Limited | Novel sulfonamideurea compounds |
WO2020086732A1 (fr) * | 2018-10-24 | 2020-04-30 | Novartis Inflammasome Research, Inc. | Composés et compositions pour traiter des états associés à l'activité des nlrp |
ES2974842T3 (es) * | 2018-11-13 | 2024-07-01 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de nlrp |
CN113166065A (zh) * | 2018-11-13 | 2021-07-23 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
JP2022507505A (ja) * | 2018-11-16 | 2022-01-18 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
SG11202107680PA (en) | 2019-01-14 | 2021-08-30 | Cadila Healthcare Ltd | Novel substituted sulfonylurea derivatives |
GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
CN111848461A (zh) * | 2019-04-29 | 2020-10-30 | 苏州大学 | Nlrp3炎症小体抑制剂及其制备方法和应用 |
CN114007690B (zh) * | 2019-06-17 | 2024-03-01 | 欧拉泰克治疗有限责任公司 | 治疗哮喘的方法 |
US20220378801A1 (en) | 2019-06-21 | 2022-12-01 | Ac Immune Sa | Novel compounds |
WO2021002887A1 (fr) * | 2019-07-02 | 2021-01-07 | Novartis Inflammasome Research, Inc. | Antagonistes de nlrp3 ciblant l'intestin et leur utilisation en thérapie |
EP3999496A1 (fr) * | 2019-07-17 | 2022-05-25 | Zomagen Biosciences Ltd | Dérivés de n-((1,2,3,5,6,7-hexahydro-s-indacèn-4-yl)carbamoyl)-4,5,6,7-tétrahydrobenzofuran -2-sulfonamide et composés apparentés en tant que modulateurs de nlpr3 pour le traitement de la sclérose en plaques (sep) |
CN114401971A (zh) | 2019-08-16 | 2022-04-26 | 英夫拉索姆有限公司 | 用作nlrp3抑制剂的大环磺酰脲衍生物 |
EP4025565A1 (fr) | 2019-09-06 | 2022-07-13 | Inflazome Limited | Inhibiteurs de nlrp3 |
CN111100042B (zh) * | 2019-11-18 | 2022-05-31 | 苏州诚和医药化学有限公司 | 一种2-甲氧基-5-磺酰胺基苯甲酸的制备方法 |
CN111018750B (zh) * | 2019-12-19 | 2022-05-27 | 苏州诚和医药化学有限公司 | 一种2,3-二甲氧基-5-磺酰胺基苯甲酸的制备新方法 |
US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
US20230121952A1 (en) | 2020-02-18 | 2023-04-20 | Inflazome Limited | Compounds |
EP4121032A1 (fr) | 2020-03-19 | 2023-01-25 | Softhale NV | Procédé de traitement de maladies associées à nlrp3 |
JP7504234B2 (ja) * | 2020-06-11 | 2024-06-21 | シーセン ファーマシューティカル カンパニー リミテッド | ジメチルスルホキシミン誘導体 |
MX2022014709A (es) | 2020-06-19 | 2022-12-16 | Ac Immune Sa | Derivados de dihidrooxazol y tiourea que modulan la ruta del inflamasoma de la proteina 3 que contiene el dominio pirina de la familia del receptor similar al dominio de oligomerizacion de union a nucleotido (nlrp3). |
WO2022023907A1 (fr) | 2020-07-31 | 2022-02-03 | Novartis Ag | Méthodes de sélection et de traitement de patients présentant un risque élevé d'événements cardiaques indésirables majeurs |
WO2022171185A1 (fr) * | 2021-02-10 | 2022-08-18 | 杭州英创医药科技有限公司 | Composé servant d'inhibiteur de nlrp3 |
US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
WO2022237780A1 (fr) * | 2021-05-10 | 2022-11-17 | 成都百裕制药股份有限公司 | Dérivé d'amide et son utilisation |
WO2023098612A1 (fr) * | 2021-12-03 | 2023-06-08 | 南京明德新药研发有限公司 | Forme saline et forme cristalline de dérivé de diméthyl sulfoximine |
WO2023118521A1 (fr) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Composés dérivés de dihydro-oxazol |
US20240034735A1 (en) | 2022-07-14 | 2024-02-01 | Ac Immune Sa | Novel compounds |
US20240101563A1 (en) | 2022-07-28 | 2024-03-28 | Ac Immune Sa | Novel compounds |
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IL98784A0 (en) * | 1990-07-17 | 1992-07-15 | Lilly Co Eli | Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them |
US5169860A (en) | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
CA2110524A1 (fr) | 1992-12-10 | 1994-06-11 | Gerald Burr Grindey | Compositions antitumorales et methodes de traitement |
ES2198598T3 (es) | 1997-01-29 | 2004-02-01 | Pfizer Inc. | Derivados de sulfonilurea y su uso en el control de la actividad de la interleuquina-1. |
EP0987552A3 (fr) | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Protéines de liaison pour diarylsulfonylurée |
AU6464400A (en) | 1999-09-14 | 2001-04-17 | Pfizer Products Inc. | Combination treatment with il-1ra and diaryl sulphonyl urea compounds |
CA2369967A1 (fr) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methodes de traitement de maladies et de troubles relies au facteur nucleaire-kappa b |
WO2003045400A1 (fr) * | 2001-11-30 | 2003-06-05 | Pfizer Products Inc. | Combinaison d'un inhibiteur d'il-1/18 avec un inhibiteur de tnf pour le traitement d'inflammations |
DK200600313A (da) * | 2006-03-03 | 2006-03-13 | Novo Nordisk As | Treating type 2 diabetes or metabolic syndrome with an interleukin 1beta inhibitor or an interleukin 1beta synthesis or release inhibitor |
CN105579433A (zh) | 2013-05-21 | 2016-05-11 | 弗吉尼亚联邦大学 | 用于预防和治疗炎症的Cryopyrin抑制剂 |
EP3888749A1 (fr) | 2015-02-16 | 2021-10-06 | The University of Queensland | Sulfonylurées, composés apparentés, et leur utilisation |
AU2017254522B2 (en) | 2016-04-18 | 2021-09-23 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
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ES2927777T3 (es) | 2022-11-10 |
US11339136B2 (en) | 2022-05-24 |
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EP3445757B1 (fr) | 2020-11-25 |
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MA44729A (fr) | 2021-05-12 |
EP3872070A1 (fr) | 2021-09-01 |
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AU2017254523A1 (en) | 2018-11-01 |
US20190119224A1 (en) | 2019-04-25 |
AU2017254523B2 (en) | 2021-09-02 |
WO2017184623A1 (fr) | 2017-10-26 |
WO2017184624A1 (fr) | 2017-10-26 |
US11760735B2 (en) | 2023-09-19 |
JP2019515952A (ja) | 2019-06-13 |
JP2019518071A (ja) | 2019-06-27 |
MA56008A (fr) | 2022-04-06 |
AU2017254522A1 (en) | 2018-11-01 |
JP7050751B2 (ja) | 2022-04-08 |
EP3445756A1 (fr) | 2019-02-27 |
US11597706B2 (en) | 2023-03-07 |
AU2017254522B2 (en) | 2021-09-23 |
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