ES2847929T3 - Tratamiento de la demencia - Google Patents

Tratamiento de la demencia Download PDF

Info

Publication number
ES2847929T3
ES2847929T3 ES17761842T ES17761842T ES2847929T3 ES 2847929 T3 ES2847929 T3 ES 2847929T3 ES 17761842 T ES17761842 T ES 17761842T ES 17761842 T ES17761842 T ES 17761842T ES 2847929 T3 ES2847929 T3 ES 2847929T3
Authority
ES
Spain
Prior art keywords
compound
subject
treatment
ftld
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17761842T
Other languages
English (en)
Spanish (es)
Inventor
Claude Michel Wischik
Björn Olaf Schelter
Damon Jude Wischik
John Mervyn David Storey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wista Laboratories Ltd
Original Assignee
Wista Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Laboratories Ltd filed Critical Wista Laboratories Ltd
Application granted granted Critical
Publication of ES2847929T3 publication Critical patent/ES2847929T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Valve Device For Special Equipments (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
ES17761842T 2016-09-01 2017-08-25 Tratamiento de la demencia Active ES2847929T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1614834.8A GB201614834D0 (en) 2016-09-01 2016-09-01 Treatment of dementia
PCT/EP2017/071437 WO2018041739A1 (en) 2016-09-01 2017-08-25 Treatment of dementia

Publications (1)

Publication Number Publication Date
ES2847929T3 true ES2847929T3 (es) 2021-08-04

Family

ID=57139937

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17761842T Active ES2847929T3 (es) 2016-09-01 2017-08-25 Tratamiento de la demencia

Country Status (18)

Country Link
US (1) US10842796B2 (OSRAM)
EP (1) EP3506904B1 (OSRAM)
JP (1) JP7066679B2 (OSRAM)
KR (1) KR102559354B1 (OSRAM)
CN (1) CN109890391B (OSRAM)
AU (1) AU2017318333B2 (OSRAM)
CA (1) CA3034625A1 (OSRAM)
DK (1) DK3506904T3 (OSRAM)
ES (1) ES2847929T3 (OSRAM)
GB (1) GB201614834D0 (OSRAM)
HR (1) HRP20210162T1 (OSRAM)
MX (1) MX384442B (OSRAM)
MY (1) MY187564A (OSRAM)
PL (1) PL3506904T3 (OSRAM)
PT (1) PT3506904T (OSRAM)
SG (1) SG11201901125TA (OSRAM)
SI (1) SI3506904T1 (OSRAM)
WO (1) WO2018041739A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143757A (en) 2006-03-29 2011-07-15 Wista Lab Ltd 3,7-diamond-10h-phenothiazine salts and their use
AU2007274057B2 (en) 2006-07-11 2012-12-13 TauRx Therapeutics Management Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
EP3487505B1 (en) 2016-07-25 2023-05-03 WisTa Laboratories Ltd. Administration and dosage of diaminophenothiazines
EP4364801B1 (en) * 2018-07-26 2025-11-12 TauRx Therapeutics Management Ltd. Optimised dosage of diaminophenothiazines in populations
US20210193322A1 (en) 2018-09-05 2021-06-24 Genting Taurx Diagnostic Centre Sdn Bhd Network methods for neurodegenerative diseases
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
CN115916211A (zh) * 2020-05-05 2023-04-04 维斯塔实验室有限公司 用于治疗低氧血症的甲基硫堇鎓化合物
GB202006659D0 (en) * 2020-05-05 2020-06-17 Wista Lab Ltd Therapeutic treatments
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
US20240115579A1 (en) * 2022-09-22 2024-04-11 Galenicum Health S.L.U. Pharmaceutical compositions and manufacturing methods thereof
EP4342451A1 (en) * 2022-09-22 2024-03-27 Galenicum Health SLU Pharmaceutical compositions and manufacturing methods thereof
WO2024178120A2 (en) * 2023-02-21 2024-08-29 Prosetta Biosciences, Inc. Phenothiazinyl compounds and uses

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
AU2003227516B2 (en) * 2002-05-31 2008-03-20 H. Lundbeck A/S A combination of an NMDA-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease
SI2322517T1 (sl) 2004-09-23 2019-06-28 Wista Laboratories Ltd. Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
DK2001556T3 (da) * 2006-03-29 2014-11-10 Wista Lab Ltd Thioninium-forbindelser og anvendelse deraf
MY143757A (en) 2006-03-29 2011-07-15 Wista Lab Ltd 3,7-diamond-10h-phenothiazine salts and their use
FR2899107B1 (fr) * 2006-03-30 2008-06-13 Neurokin Entpr Unipersonnelle Utilisation de la (s)-roscovitine pour la fabrication d'un medicament
AU2007274057B2 (en) 2006-07-11 2012-12-13 TauRx Therapeutics Management Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
US9034890B2 (en) * 2006-11-15 2015-05-19 Steven A. Rich Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases
CA2690746C (en) * 2007-06-19 2018-01-02 Wista Laboratories Ltd Phenothizine compounds for treating mild cognitive impairment
SI2954932T1 (sl) 2007-10-03 2019-01-31 Wista Laboratories Ltd. Terapevtska uporaba diaminofenotiazinov
PT2480540T (pt) 2009-09-24 2018-02-16 Wista Lab Ltd Pentahidrato de cloreto de metiltionínio e respetivas preparação e utilização farmacêutica
KR20180094126A (ko) 2009-09-24 2018-08-22 위스타 레보레이토리스 리미티드 결정질 메틸티오니늄 클로라이드(메틸렌 블루) 수화물
SG192666A1 (en) * 2011-02-11 2013-09-30 Wista Lab Ltd Phenothiazine diaminium salts and their use
CN102936244B (zh) * 2012-12-04 2015-02-04 合肥工业大学 一种他克林-吩噻嗪异二联体类化合物及其制备方法

Also Published As

Publication number Publication date
WO2018041739A1 (en) 2018-03-08
JP2019526571A (ja) 2019-09-19
PL3506904T3 (pl) 2021-07-26
AU2017318333B2 (en) 2023-05-11
EP3506904B1 (en) 2020-12-09
CA3034625A1 (en) 2018-03-08
EP3506904A1 (en) 2019-07-10
KR102559354B1 (ko) 2023-07-26
MX2019002429A (es) 2019-07-08
US20190192530A1 (en) 2019-06-27
GB201614834D0 (en) 2016-10-19
CN109890391B (zh) 2023-01-31
MX384442B (es) 2025-03-14
SI3506904T1 (sl) 2021-03-31
KR20190045273A (ko) 2019-05-02
MY187564A (en) 2021-09-30
US10842796B2 (en) 2020-11-24
AU2017318333A1 (en) 2019-04-18
SG11201901125TA (en) 2019-03-28
DK3506904T3 (da) 2021-01-04
PT3506904T (pt) 2021-02-02
CN109890391A (zh) 2019-06-14
JP7066679B2 (ja) 2022-05-13
HRP20210162T1 (hr) 2021-03-19

Similar Documents

Publication Publication Date Title
ES2847929T3 (es) Tratamiento de la demencia
AU2022291420B2 (en) Administration and dosage of diaminophenothiazines
ES2938546T3 (es) Método de tratamiento de la esclerosis lateral amiotrófica con pridopidina
ES2900016T3 (es) Una forma cristalina de un inhibidor de MAGL
AU2018383098B2 (en) Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
ES2886873T3 (es) Composiciones farmacéuticas para mejorar el rendimiento de la memoria
CN114096254A (zh) 作为认知功能的增强剂的白甲锍堇
HK40003690B (en) Treatment of dementia
HK40003690A (en) Treatment of dementia
TW202410901A (zh) 利用含亞甲藍(mt)化合物治療神經退化性疾病
JP2025500088A (ja) Fenm及びアセチルコリンエステラーゼ阻害剤をベースとする新規相乗的組合せ