AU2017318333B2 - Treatment of dementia - Google Patents

Treatment of dementia Download PDF

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Publication number
AU2017318333B2
AU2017318333B2 AU2017318333A AU2017318333A AU2017318333B2 AU 2017318333 B2 AU2017318333 B2 AU 2017318333B2 AU 2017318333 A AU2017318333 A AU 2017318333A AU 2017318333 A AU2017318333 A AU 2017318333A AU 2017318333 B2 AU2017318333 B2 AU 2017318333B2
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AU
Australia
Prior art keywords
compound
subject
treatment
brain
neurotransmission
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AU2017318333A
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English (en)
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AU2017318333A1 (en
Inventor
Björn Olaf SCHELTER
John Mervyn David Storey
Claude Michel Wischik
Damon Jude Wischik
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Taurx Therapeutics Management Ltd
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Taurx Therapeutics Man Ltd
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Assigned to TauRx Therapeutics Management Ltd reassignment TauRx Therapeutics Management Ltd Request for Assignment Assignors: WISTA LABORATORIES LTD.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Valve Device For Special Equipments (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
AU2017318333A 2016-09-01 2017-08-25 Treatment of dementia Active AU2017318333B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1614834.8A GB201614834D0 (en) 2016-09-01 2016-09-01 Treatment of dementia
GB1614834.8 2016-09-01
PCT/EP2017/071437 WO2018041739A1 (en) 2016-09-01 2017-08-25 Treatment of dementia

Publications (2)

Publication Number Publication Date
AU2017318333A1 AU2017318333A1 (en) 2019-04-18
AU2017318333B2 true AU2017318333B2 (en) 2023-05-11

Family

ID=57139937

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017318333A Active AU2017318333B2 (en) 2016-09-01 2017-08-25 Treatment of dementia

Country Status (18)

Country Link
US (1) US10842796B2 (OSRAM)
EP (1) EP3506904B1 (OSRAM)
JP (1) JP7066679B2 (OSRAM)
KR (1) KR102559354B1 (OSRAM)
CN (1) CN109890391B (OSRAM)
AU (1) AU2017318333B2 (OSRAM)
CA (1) CA3034625A1 (OSRAM)
DK (1) DK3506904T3 (OSRAM)
ES (1) ES2847929T3 (OSRAM)
GB (1) GB201614834D0 (OSRAM)
HR (1) HRP20210162T1 (OSRAM)
MX (1) MX384442B (OSRAM)
MY (1) MY187564A (OSRAM)
PL (1) PL3506904T3 (OSRAM)
PT (1) PT3506904T (OSRAM)
SG (1) SG11201901125TA (OSRAM)
SI (1) SI3506904T1 (OSRAM)
WO (1) WO2018041739A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143757A (en) 2006-03-29 2011-07-15 Wista Lab Ltd 3,7-diamond-10h-phenothiazine salts and their use
AU2007274057B2 (en) 2006-07-11 2012-12-13 TauRx Therapeutics Management Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
EP3487505B1 (en) 2016-07-25 2023-05-03 WisTa Laboratories Ltd. Administration and dosage of diaminophenothiazines
EP4364801B1 (en) * 2018-07-26 2025-11-12 TauRx Therapeutics Management Ltd. Optimised dosage of diaminophenothiazines in populations
US20210193322A1 (en) 2018-09-05 2021-06-24 Genting Taurx Diagnostic Centre Sdn Bhd Network methods for neurodegenerative diseases
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
CN115916211A (zh) * 2020-05-05 2023-04-04 维斯塔实验室有限公司 用于治疗低氧血症的甲基硫堇鎓化合物
GB202006659D0 (en) * 2020-05-05 2020-06-17 Wista Lab Ltd Therapeutic treatments
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
US20240115579A1 (en) * 2022-09-22 2024-04-11 Galenicum Health S.L.U. Pharmaceutical compositions and manufacturing methods thereof
EP4342451A1 (en) * 2022-09-22 2024-03-27 Galenicum Health SLU Pharmaceutical compositions and manufacturing methods thereof
WO2024178120A2 (en) * 2023-02-21 2024-08-29 Prosetta Biosciences, Inc. Phenothiazinyl compounds and uses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101458A1 (en) * 2002-05-31 2003-12-11 H. Lundbeck A/S A combination of an nmda-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease
WO2007110627A2 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
WO2007110630A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. Thioninium compounds and their use
WO2012107706A1 (en) * 2011-02-11 2012-08-16 Wista Laboratories Ltd. Phenothiazine diaminium salts and their use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
SI2322517T1 (sl) 2004-09-23 2019-06-28 Wista Laboratories Ltd. Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC)
FR2899107B1 (fr) * 2006-03-30 2008-06-13 Neurokin Entpr Unipersonnelle Utilisation de la (s)-roscovitine pour la fabrication d'un medicament
AU2007274057B2 (en) 2006-07-11 2012-12-13 TauRx Therapeutics Management Ltd Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
US9034890B2 (en) * 2006-11-15 2015-05-19 Steven A. Rich Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases
CA2690746C (en) * 2007-06-19 2018-01-02 Wista Laboratories Ltd Phenothizine compounds for treating mild cognitive impairment
SI2954932T1 (sl) 2007-10-03 2019-01-31 Wista Laboratories Ltd. Terapevtska uporaba diaminofenotiazinov
PT2480540T (pt) 2009-09-24 2018-02-16 Wista Lab Ltd Pentahidrato de cloreto de metiltionínio e respetivas preparação e utilização farmacêutica
KR20180094126A (ko) 2009-09-24 2018-08-22 위스타 레보레이토리스 리미티드 결정질 메틸티오니늄 클로라이드（메틸렌 블루） 수화물
CN102936244B (zh) * 2012-12-04 2015-02-04 合肥工业大学 一种他克林-吩噻嗪异二联体类化合物及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101458A1 (en) * 2002-05-31 2003-12-11 H. Lundbeck A/S A combination of an nmda-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease
WO2007110627A2 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
WO2007110630A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. Thioninium compounds and their use
WO2012107706A1 (en) * 2011-02-11 2012-08-16 Wista Laboratories Ltd. Phenothiazine diaminium salts and their use

Also Published As

Publication number Publication date
WO2018041739A1 (en) 2018-03-08
JP2019526571A (ja) 2019-09-19
PL3506904T3 (pl) 2021-07-26
EP3506904B1 (en) 2020-12-09
CA3034625A1 (en) 2018-03-08
EP3506904A1 (en) 2019-07-10
KR102559354B1 (ko) 2023-07-26
MX2019002429A (es) 2019-07-08
US20190192530A1 (en) 2019-06-27
GB201614834D0 (en) 2016-10-19
ES2847929T3 (es) 2021-08-04
CN109890391B (zh) 2023-01-31
MX384442B (es) 2025-03-14
SI3506904T1 (sl) 2021-03-31
KR20190045273A (ko) 2019-05-02
MY187564A (en) 2021-09-30
US10842796B2 (en) 2020-11-24
AU2017318333A1 (en) 2019-04-18
SG11201901125TA (en) 2019-03-28
DK3506904T3 (da) 2021-01-04
PT3506904T (pt) 2021-02-02
CN109890391A (zh) 2019-06-14
JP7066679B2 (ja) 2022-05-13
HRP20210162T1 (hr) 2021-03-19

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: TAURX THERAPEUTICS MANAGEMENT LTD

Free format text: FORMER OWNER(S): WISTA LABORATORIES LTD.