ES2841305T3 - Implantes que usan ondas ultrasónicas para estimular un tejido - Google Patents
Implantes que usan ondas ultrasónicas para estimular un tejido Download PDFInfo
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- ES2841305T3 ES2841305T3 ES17743117T ES17743117T ES2841305T3 ES 2841305 T3 ES2841305 T3 ES 2841305T3 ES 17743117 T ES17743117 T ES 17743117T ES 17743117 T ES17743117 T ES 17743117T ES 2841305 T3 ES2841305 T3 ES 2841305T3
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3581105B1 (en) | 2010-05-08 | 2022-08-31 | The Regents of the University of California | Apparatus for early detection of ulcers by scanning of subepidermal moisture |
| US12465324B2 (en) | 2015-02-12 | 2025-11-11 | Foundry Innovation & Research 1, Ltd. | Patient fluid management systems and methods employing integrated fluid status sensing |
| WO2018031714A1 (en) | 2016-08-11 | 2018-02-15 | Foundry Innovation & Research 1, Ltd. | Systems and methods for patient fluid management |
| CA3059988C (en) | 2015-04-24 | 2023-03-07 | Bruin Biometrics, Llc | Apparatus and methods for determining damaged tissue using sub-epidermal moisture measurements |
| US11043988B2 (en) | 2016-03-15 | 2021-06-22 | Verily Life Sciences LLP | Systems for providing wireless power to deep implanted devices |
| EP3481285B1 (en) | 2016-07-07 | 2020-09-30 | The Regents of The University of California | Implants using ultrasonic waves for stimulating tissue |
| US10758127B2 (en) * | 2016-07-25 | 2020-09-01 | Sarah Kathryn Patch | Systems and methods for radiation beam range verification using sonic measurements |
| US11047979B2 (en) * | 2016-07-27 | 2021-06-29 | Sound Technology Inc. | Ultrasound transducer array |
| US11701018B2 (en) | 2016-08-11 | 2023-07-18 | Foundry Innovation & Research 1, Ltd. | Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore |
| US11206992B2 (en) | 2016-08-11 | 2021-12-28 | Foundry Innovation & Research 1, Ltd. | Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore |
| US11309744B2 (en) * | 2016-09-11 | 2022-04-19 | Verily Life Sciences Llc | Systems and methods for providing wireless power to deep implanted devices |
| US11937981B2 (en) * | 2016-12-28 | 2024-03-26 | The Trustees Of Columbia University In The City Of New York | Ultrasound phased array patch on flexible CMOS and methods for fabricating thereof |
| CN110419115B (zh) * | 2017-01-10 | 2024-03-19 | 加利福尼亚大学董事会 | 可拉伸超声换能器器件 |
| CA3042093A1 (en) | 2017-02-03 | 2018-08-09 | Bruin Biometrics, Llc | Measurement of tissue viability |
| MX2019004926A (es) | 2017-02-03 | 2019-06-20 | Bruin Biometrics Llc | Medicion del edema. |
| ES3008659T3 (en) | 2017-02-03 | 2025-03-24 | Bbi Medical Innovations Llc | Measurement of susceptibility to diabetic foot ulcers |
| US11083174B2 (en) * | 2017-03-24 | 2021-08-10 | Zalliant, LLC | Communication assembly for monitoring biological data of animals |
| WO2018194616A1 (en) * | 2017-04-20 | 2018-10-25 | Hewlett-Packard Development Company, L.P. | Calibrating communication lines |
| US10747905B2 (en) | 2017-05-11 | 2020-08-18 | Microsoft Technology Licensing, Llc | Enclave ring and pair topologies |
| US10528722B2 (en) | 2017-05-11 | 2020-01-07 | Microsoft Technology Licensing, Llc | Enclave pool shared key |
| US10740455B2 (en) | 2017-05-11 | 2020-08-11 | Microsoft Technology Licensing, Llc | Encave pool management |
| US10833858B2 (en) | 2017-05-11 | 2020-11-10 | Microsoft Technology Licensing, Llc | Secure cryptlet tunnel |
| US10664591B2 (en) | 2017-05-11 | 2020-05-26 | Microsoft Technology Licensing, Llc | Enclave pools |
| WO2018220143A1 (en) | 2017-05-31 | 2018-12-06 | Foundry Innovation And Research 1, Ltd | Implantable ultrasonic vascular sensor |
| WO2018220146A1 (en) | 2017-05-31 | 2018-12-06 | Foundry Innovation & Research 1, Ltd. | Implantable sensors for vascular monitoring |
| US10238288B2 (en) * | 2017-06-15 | 2019-03-26 | Microsoft Technology Licensing, Llc | Direct frequency modulating radio-frequency sensors |
| US11641168B2 (en) * | 2017-07-17 | 2023-05-02 | Georgia Tech Research Corporation | Parametric resonator for electrical transduction |
| US11547347B2 (en) * | 2017-10-06 | 2023-01-10 | Massachusetts Institute Of Technology | Flexible piezoelectric devices for gastrointestinal motility sensing |
| EP3562392A4 (en) | 2017-11-16 | 2021-06-09 | Bruin Biometrics, LLC | STRATEGIC TREATMENT OF SULSURES USING SUBEPIDERMAL MOISTURE VALUES |
| GB201800820D0 (en) * | 2018-01-18 | 2018-03-07 | Univ Oslo Hf | Medical implant with wireless communication |
| WO2019147185A1 (en) * | 2018-01-24 | 2019-08-01 | National University Of Singapore | Photodynamic therapy devices, systems and methods |
| WO2019152562A1 (en) * | 2018-02-01 | 2019-08-08 | Electric Power Research Institute, Inc. | Apparatus for measuring strain and methods for making and using same |
| ES2984425T3 (es) | 2018-02-09 | 2024-10-29 | Bruin Biometrics Llc | Detección de daños tisulares |
| DE102018204949A1 (de) * | 2018-03-30 | 2019-10-02 | Bernhard Clasbrummel | Implantat und Verfahren zur Diagnose und/oder Behandlung entzündlicher Gewebezustände |
| US11381834B2 (en) * | 2018-04-02 | 2022-07-05 | Hfi Innovation Inc. | Video processing methods and apparatuses for sub-block motion compensation in video coding systems |
| WO2019204773A1 (en) | 2018-04-19 | 2019-10-24 | Iota Biosciences, Inc. | Implants using ultrasonic communication for neural sensing and stimulation |
| EP3556279B1 (en) | 2018-04-19 | 2024-11-06 | Cochlear Limited | Near infrared light in hearing aid appliances |
| BR112020021286A2 (pt) * | 2018-04-19 | 2021-01-26 | Iota Biosciences, Inc. | implantes usando comunicação ultrassônica para modular a atividade do nervo esplênico |
| KR20210013152A (ko) | 2018-05-24 | 2021-02-03 | 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 | 정전 용량 센서 |
| DE102018209449A1 (de) * | 2018-06-13 | 2019-12-19 | Neuroloop GmbH | Medizinisches Implantat, Anordnung zum Implantieren des medizinischen Implantats sowie Anordnung zum Erfassen eines intrakorporalen Bewegungsmusters mit dem medizinischen Implantat |
| US11266840B2 (en) | 2018-06-27 | 2022-03-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Wireless cardiac pace making |
| US11464964B2 (en) * | 2018-08-03 | 2022-10-11 | Brown University | Neural interrogation platform |
| US11134858B1 (en) | 2018-08-04 | 2021-10-05 | PhonoFlow Medical, LLC | Systems, apparatuses, and methods for locating blood flow turbulence in the cardiovascular system |
| US11167375B2 (en) | 2018-08-10 | 2021-11-09 | The Research Foundation For The State University Of New York | Additive manufacturing processes and additively manufactured products |
| KR20210053915A (ko) | 2018-08-29 | 2021-05-12 | 아이오타 바이오사이언시즈 인코퍼레이티드 | 이식 가능한 폐회로 뉴로모듈레이션 장치, 시스템 및 사용 방법 |
| CN109381786B (zh) * | 2018-09-10 | 2023-10-31 | 清华大学 | 用于检测植入式医疗仪器交叉电脉冲性能的系统 |
| WO2020077168A1 (en) * | 2018-10-11 | 2020-04-16 | The Penn State Research Foundation | An implantable dual mode ultrasonic device |
| US10950960B2 (en) | 2018-10-11 | 2021-03-16 | Bruin Biometrics, Llc | Device with disposable element |
| WO2020079596A1 (en) | 2018-10-15 | 2020-04-23 | Mazor Robotics Ltd. | Versatile multi-arm robotic surgical system |
| JP6942687B2 (ja) * | 2018-11-07 | 2021-09-29 | 古河電気工業株式会社 | 医療器具及び医療器具確認システム |
| CA3120288A1 (en) * | 2018-12-06 | 2020-06-11 | Jose M. Carmena | Device networks for modulating neural activity |
| BR112021013075A2 (pt) * | 2019-01-04 | 2021-09-21 | Iota Biosciences, Inc. | Controles de potência para um dispositivo implantável alimentado com o uso de ondas ultrassônicas |
| CN113226455A (zh) | 2019-01-04 | 2021-08-06 | 艾奧塔生物科技公司 | 用于操作可植入设备的基于超声的协议 |
| WO2020151179A1 (en) * | 2019-01-23 | 2020-07-30 | The Hong Kong Polytechnic University | Targeted energy transmission method using one or more ultrasonic transducers on an implantable device |
| US12375925B2 (en) * | 2019-03-12 | 2025-07-29 | Impulse Dynamics Nv | Secure short-range communications link for medical devices |
| US11696713B2 (en) | 2019-03-15 | 2023-07-11 | Arizona Board Of Regents On Behalf Of Arizona State University | Contour electrocorticography (ECoG) array |
| US11428588B2 (en) | 2019-03-28 | 2022-08-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Fully-passive pressure sensors and methods for their use |
| WO2020219202A1 (en) * | 2019-04-25 | 2020-10-29 | Medtronic, Inc. | Implantable ultrasonic device |
| JP7393881B2 (ja) * | 2019-06-17 | 2023-12-07 | 株式会社アイシン | ソナーユニット |
| EP3997776A4 (en) * | 2019-07-10 | 2023-07-12 | Ulink Labs, Inc. | SYSTEMS, DEVICES AND METHODS FOR ESTABLISHING A WIRELESS LINK |
| US20210007602A1 (en) * | 2019-07-12 | 2021-01-14 | Neuralink Corp. | Brain implant with subcutaneous wireless relay and external wearable communication and power device |
| WO2021011902A1 (en) * | 2019-07-17 | 2021-01-21 | NXgenPort, L.L.C. | Implantable venous access port with remote physiological monitoring capabilities |
| CN110368033B (zh) * | 2019-08-30 | 2024-12-31 | 深圳开立生物医疗科技股份有限公司 | 一种血管内超声诊断系统 |
| EP3789125A1 (de) * | 2019-09-03 | 2021-03-10 | BIOTRONIK SE & Co. KG | Implantierbarer ultraschallwandler |
| EP3788948A1 (en) * | 2019-09-04 | 2021-03-10 | Universitat Pompeu Fabra | Implantable electronic sensing system for measuring and monitoring medical parameters |
| CN110801223B (zh) * | 2019-09-30 | 2021-09-14 | 昆明理工大学 | 一种无线脑深部神经接口系统 |
| AU2020366623A1 (en) * | 2019-10-16 | 2022-04-07 | Wyss Center For Bio And Neuro Engineering | Optical transmission for an implantable system |
| MX2022004585A (es) | 2019-10-17 | 2022-07-27 | Iota Biosciences Inc | Manguito de nervio helicoidal y dispositivos implantables relacionados. |
| KR20220082063A (ko) * | 2019-10-17 | 2022-06-16 | 아이오타 바이오사이언시즈 인코퍼레이티드 | 암 환자에서 면역 시스템 활동을 조정하고 암을 치료하기 위한 장치 및 방법 |
| CN119745450A (zh) * | 2019-11-11 | 2025-04-04 | 新加坡国立大学 | 无线触发装置 |
| CN110769610A (zh) * | 2019-11-27 | 2020-02-07 | 华中科技大学 | 一种表皮电子器件和多模态表皮电子传感器的制备方法 |
| US20210196989A1 (en) * | 2019-12-13 | 2021-07-01 | Northeastern University | Implantable Bio-Heating System Based on Piezoelectric Micromachined Ultrasonic Transducers |
| US11320453B2 (en) * | 2019-12-30 | 2022-05-03 | Texas Instruments Incorporated | Aging compensation of a ferroelectric piezoelectric shock sensor |
| US12480910B2 (en) | 2019-12-30 | 2025-11-25 | The Regents Of The University Of California | Multi-gas detection with CS-FET arrays for food quality assessment |
| CN115066270A (zh) * | 2020-02-13 | 2022-09-16 | 心脏起搏器股份公司 | 气密密封的可植入式医疗设备及其形成方法 |
| JP2023515475A (ja) * | 2020-02-19 | 2023-04-13 | チャン ザッカーバーグ バイオハブ, インコーポレイテッド | 深部組織超音波埋め込み型発光酸素センサ |
| EP4106863B1 (en) * | 2020-02-19 | 2025-04-09 | Chan Zuckerberg Biohub, Inc. | Anchor loss in millimeter-scale ultrasonic wireless implantable devices |
| CN115443100A (zh) * | 2020-02-20 | 2022-12-06 | 瑞士卡纳里医疗股份公司 | 用于植入骨组织以及表征骨折的医疗装置 |
| FR3107651B1 (fr) * | 2020-03-02 | 2022-03-11 | Carthera | Procede et systeme pour la detection d’un defaut de couplage acoustique entre un dispositif ultrasonore et un tissu a traiter |
| TWI888516B (zh) | 2020-03-25 | 2025-07-01 | 美商感應學公司 | 可植入設備、製造可植入設備之方法、及可植入設備之耦合器 |
| US20210313028A1 (en) * | 2020-04-01 | 2021-10-07 | Medtronic, Inc. | Physiological monitoring system |
| JP7562109B2 (ja) * | 2020-04-13 | 2024-10-07 | 国立大学法人東海国立大学機構 | 神経刺激システムおよび神経刺激方法 |
| US11678112B2 (en) | 2020-04-30 | 2023-06-13 | Massachusetts Institute Of Technology | Underwater transducer for wide-band communication |
| US12453496B2 (en) * | 2020-06-02 | 2025-10-28 | University Of South Florida | Silicon carbide nanoparticles fibrous membrane for implantable glucose sensor integrated with chronoamperometric potentiostat |
| BR112023002278A2 (pt) * | 2020-08-11 | 2023-03-14 | Iota Biosciences Inc | Implante ultrassônico e sistema para medição de pressão intraocular |
| WO2022040102A1 (en) * | 2020-08-17 | 2022-02-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | An implantable miniaturized and soft wireless sensing device to monitor tissue and bone deformation |
| CN111938794B (zh) * | 2020-08-20 | 2022-03-15 | 四川大学华西医院 | 基于应力自适应调节的智能化骨科外支架系统 |
| US20240024032A1 (en) * | 2020-08-24 | 2024-01-25 | Iota Biosciences, Inc. | Tracking an implantable device powered using ultrasonic waves |
| JP2023540055A (ja) | 2020-09-01 | 2023-09-21 | オーフス ウニベルシテット | 高インピーダンスでコンパクトなニューラルセンサフロントエンド |
| ES3036333T3 (en) * | 2020-09-01 | 2025-09-17 | Univ Aarhus | Implantable micro device with high data rate back scattering |
| US20230302300A1 (en) * | 2020-09-14 | 2023-09-28 | Unm Rainforest Innovations | Microfabricated ultrasound transducer array for neural stimulation |
| JP7450929B2 (ja) * | 2020-09-16 | 2024-03-18 | 学校法人東京電機大学 | 圧力測定システム、圧力測定方法、およびプログラム |
| CN112220494B (zh) * | 2020-09-25 | 2023-05-05 | 天津大学 | 一种基于脉冲重复频率的声电神经成像系统 |
| US12274525B2 (en) | 2020-09-29 | 2025-04-15 | Mazor Robotics Ltd. | Systems and methods for tracking anatomical motion |
| US12490908B2 (en) * | 2020-10-20 | 2025-12-09 | The Regents Of The University Of California | Integrated chemical/ultrasonic transducer sensor |
| CN112155597B (zh) * | 2020-10-21 | 2025-06-20 | 北京华科恒生医疗科技有限公司 | 超声同步电极、立体电极、超声传感器及其使用方法 |
| CN112357013B (zh) * | 2020-11-16 | 2021-10-15 | 广东桂荣永磁新材料科技有限公司 | 一种强磁打捞器 |
| IT202000029327A1 (it) * | 2020-12-01 | 2022-06-01 | Imedicals S R L | Metodo per la diagnosi del carcinoma renale mediante analisi di segnali ultrasonici ed immagini ecografiche |
| CN112345116B (zh) * | 2020-12-01 | 2022-10-11 | 山东大学 | 一种基于后向散射能量的超声测温装置与方法 |
| EP4258998A4 (en) * | 2020-12-08 | 2025-01-01 | Geegah LLC | IMAGING AND DETECTION OF A THIN FILM WITH HIGH FREQUENCY ULTRASONIC TRANSDUCERS |
| WO2022120765A1 (zh) * | 2020-12-10 | 2022-06-16 | 中国科学院深圳先进技术研究院 | 一种实时超声刺激电信号记录芯片及其制备方法 |
| CN112870562B (zh) * | 2021-01-06 | 2022-05-17 | 上海交通大学 | 一种植入式压电mems超声换能器及其制备方法 |
| CN112865116B (zh) * | 2021-01-11 | 2022-04-12 | 广西大学 | 一种平行联邦图神经网络的十三区图无功优化方法 |
| CN112741969A (zh) * | 2021-01-13 | 2021-05-04 | 蔡哲兴 | 可植入颅骨的超声波治疗装置 |
| US11504093B2 (en) * | 2021-01-22 | 2022-11-22 | Exo Imaging, Inc. | Equalization for matrix based line imagers for ultrasound imaging systems |
| EP4266991A4 (en) * | 2021-01-29 | 2025-01-01 | The Regents of University of California | IMPLANTABLE IMAGING DEVICES FOR IN VIVO IMAGING |
| GB202101374D0 (en) * | 2021-02-01 | 2021-03-17 | Sintef Tto As | Object imaging within structures |
| US12465441B2 (en) | 2021-02-01 | 2025-11-11 | Mazor Robotics Ltd. | Multi-arm robotic systems and methods for identifying a target |
| WO2022169850A1 (en) | 2021-02-03 | 2022-08-11 | Bruin Biometrics, Llc | Methods of treating deep and early-stage pressure induced tissue damage |
| CN115078531B (zh) * | 2021-03-15 | 2025-11-14 | 北京信泰智合科技发展有限公司 | 一种高频压电换能振元、高频超声探头和制备方法 |
| EP4340929A4 (en) * | 2021-05-17 | 2024-10-16 | The Trustees Of Columbia University In The City Of New York | DEVICES, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING WIRELESS STENT-BASED INTERFACES TO THE NERVOUS SYSTEM |
| US20220378291A1 (en) * | 2021-06-01 | 2022-12-01 | Twenty Twenty Therapeutics Llc | Ultrasound Intraocular Pressure Sensor in Sclera or in Cornea |
| US12053330B2 (en) | 2021-06-23 | 2024-08-06 | Exo Imaging, Inc. | Systems and methods for testing MEMS arrays and associated ASICs |
| WO2023278612A1 (en) * | 2021-06-29 | 2023-01-05 | Ulink Labs, Inc. | Systems, devices, and methods for establishing a wireless link in a heterogeneous medium |
| CN113676263B (zh) * | 2021-08-10 | 2022-12-16 | 华南理工大学 | 基于超声波反向散射的人体内通信装置及方法 |
| US20250168036A1 (en) * | 2021-08-23 | 2025-05-22 | Industry-Academic Cooperation Foundation, Dankook University | Communication network, and method and device for identifying node connected thereto |
| US12306165B2 (en) * | 2022-03-07 | 2025-05-20 | Hach Company | Probe system with detachable sensor probe that communicates wirelessly |
| MX2024011608A (es) * | 2022-03-23 | 2024-09-30 | Iota Biosciences Inc | Comunicacion de frecuencia modulada. |
| CN116920278A (zh) * | 2022-04-01 | 2023-10-24 | 创领心律管理医疗器械(上海)有限公司 | 植入式心脏起搏器、程控装置以及心脏起搏系统 |
| GB202204823D0 (en) * | 2022-04-01 | 2022-05-18 | Sintef Tto As | Ultrasonic transducer housing |
| EP4514206A1 (en) * | 2022-04-28 | 2025-03-05 | Institut National de la Santé et de la Recherche Médicale | Ultrasound-based wireless battery-free implantable sensors comprising a solutiongated field-effect transistor |
| WO2023223301A1 (en) * | 2022-05-20 | 2023-11-23 | Foundry Innovation & Research 1, Ltd. | Resonant circuit-based vascular monitors and related systems and methods |
| JP2023173685A (ja) * | 2022-05-26 | 2023-12-07 | 上海天馬微電子有限公司 | 超音波センサ装置及びその制御方法 |
| NL1044346B1 (en) | 2022-06-01 | 2023-12-12 | Roodenburg Michael | Reusable Pallet Tent |
| US12179026B2 (en) * | 2022-06-17 | 2024-12-31 | William Marsh Rice University | Systems and methods for wireless communication with implantable devices |
| CN115173581B (zh) * | 2022-06-22 | 2025-12-23 | 深圳大学 | 接收装置、换能系统、充电系统、医疗设备及充电方法 |
| CN115276658B (zh) * | 2022-07-07 | 2025-06-27 | 兰州科近泰基新技术有限责任公司 | 电荷频率转换电路、转换方法及粒子治疗剂量监测装置 |
| WO2024023791A1 (en) | 2022-07-29 | 2024-02-01 | Foundry Innovation & Research 1, Ltd. | Multistranded conductors adapted to dynamic in vivo environments |
| US11886668B1 (en) * | 2022-10-07 | 2024-01-30 | Infineon Technologies Ag | Ultrasonic touch sensor with active feedback |
| WO2024097917A1 (en) * | 2022-11-04 | 2024-05-10 | Secondwave Systems, Inc. | Implantable neurostimulator device |
| DE102022129889B3 (de) * | 2022-11-11 | 2023-12-21 | Tdk Electronics Ag | Elektro-akustisches Multifunktionsmodul und elektro-akustisches Kommunikationssystem |
| EP4639820A2 (en) * | 2022-12-23 | 2025-10-29 | Ulink Labs, Inc. | Systems, devices, and methods for exchanging wireless signals |
| CN116140174B (zh) * | 2023-01-03 | 2024-11-29 | 深圳高性能医疗器械国家研究院有限公司 | 微纳超声发生器件以及声穿孔基因转染系统 |
| CN116251016B (zh) * | 2023-05-10 | 2023-08-01 | 四川大学华西医院 | 一种用于治疗骨质疏松的治疗头装置 |
| WO2024263992A1 (en) * | 2023-06-21 | 2024-12-26 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, devices, and methods for using focused ultrasonic energy to inhibit communication of peripheral sensory nerves |
| CN116541896B (zh) * | 2023-07-06 | 2023-09-12 | 北京领创医谷科技发展有限责任公司 | 一种植入设备识别电路、植入设备及读取设备 |
| WO2025038973A1 (en) * | 2023-08-16 | 2025-02-20 | Nidus Holdings, Llc | Implantable energy devices and methods |
| TWI880418B (zh) * | 2023-10-30 | 2025-04-11 | 佳世達科技股份有限公司 | 超音波收發裝置及其控制方法 |
| TWI879220B (zh) * | 2023-11-09 | 2025-04-01 | 佳世達科技股份有限公司 | 超音波傳感器及其控制方法 |
| GB2639636A (en) * | 2024-03-20 | 2025-10-01 | Univ Newcastle | Ultrasound apparatus |
| CN118236624B (zh) * | 2024-04-16 | 2025-09-02 | 华中科技大学 | 一种基于超声驱动的无源植入式双相脑刺激器件 |
| DE102024115784A1 (de) | 2024-06-06 | 2025-12-11 | Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts | System zum Überwachen eines körperlichen Zustands einer Person im häuslichen Umfeld und/oder für Fitnessaufzeichnungsanwendungen |
| TWI889557B (zh) * | 2024-09-27 | 2025-07-01 | 大陸商慶鼎精密電子(淮安)有限公司 | 生物可植入裝置及其製造方法 |
Family Cites Families (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1178612A (en) | 1914-01-26 | 1916-04-11 | Yawman & Erbe Mfg Co | Metallic-furniture casing. |
| US2830274A (en) | 1954-01-04 | 1958-04-08 | Gen Electric | Electromechanical transducer |
| JPS5149826Y2 (enExample) | 1971-05-28 | 1976-12-01 | ||
| US5662109A (en) | 1990-12-14 | 1997-09-02 | Hutson; William H. | Method and system for multi-dimensional imaging and analysis for early detection of diseased tissue |
| DE4104359A1 (de) | 1991-02-13 | 1992-08-20 | Implex Gmbh | Ladesystem fuer implantierbare hoerhilfen und tinnitus-maskierer |
| US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
| US5749909A (en) | 1996-11-07 | 1998-05-12 | Sulzer Intermedics Inc. | Transcutaneous energy coupling using piezoelectric device |
| US6185452B1 (en) | 1997-02-26 | 2001-02-06 | Joseph H. Schulman | Battery-powered patient implantable device |
| US6050943A (en) | 1997-10-14 | 2000-04-18 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
| US6239724B1 (en) | 1997-12-30 | 2001-05-29 | Remon Medical Technologies, Ltd. | System and method for telemetrically providing intrabody spatial position |
| US6402689B1 (en) | 1998-09-30 | 2002-06-11 | Sicel Technologies, Inc. | Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors |
| US7575550B1 (en) | 1999-03-11 | 2009-08-18 | Biosense, Inc. | Position sensing based on ultrasound emission |
| US6170488B1 (en) | 1999-03-24 | 2001-01-09 | The B. F. Goodrich Company | Acoustic-based remotely interrogated diagnostic implant device and system |
| US6200265B1 (en) | 1999-04-16 | 2001-03-13 | Medtronic, Inc. | Peripheral memory patch and access method for use with an implantable medical device |
| US6725073B1 (en) | 1999-08-17 | 2004-04-20 | Board Of Regents, The University Of Texas System | Methods for noninvasive analyte sensing |
| US6216022B1 (en) | 2000-06-22 | 2001-04-10 | Biosafe Laboratories, Inc. | Implantable optical measurement device and method for using same |
| US6654638B1 (en) | 2000-04-06 | 2003-11-25 | Cardiac Pacemakers, Inc. | Ultrasonically activated electrodes |
| US7283874B2 (en) | 2000-10-16 | 2007-10-16 | Remon Medical Technologies Ltd. | Acoustically powered implantable stimulating device |
| US6628989B1 (en) | 2000-10-16 | 2003-09-30 | Remon Medical Technologies, Ltd. | Acoustic switch and apparatus and methods for using acoustic switches within a body |
| US7024248B2 (en) | 2000-10-16 | 2006-04-04 | Remon Medical Technologies Ltd | Systems and methods for communicating with implantable devices |
| US7198603B2 (en) * | 2003-04-14 | 2007-04-03 | Remon Medical Technologies, Inc. | Apparatus and methods using acoustic telemetry for intrabody communications |
| ATE282358T1 (de) | 2001-07-28 | 2004-12-15 | Aesculap Ag & Co Kg | Medizinisches implantatsystem |
| US7479112B2 (en) | 2003-08-26 | 2009-01-20 | Cardiac Pacemakers, Inc. | Acoustic physiological sensor |
| US7418292B2 (en) | 2003-10-01 | 2008-08-26 | Medtronic, Inc. | Device and method for attenuating an immune response |
| US20050075702A1 (en) | 2003-10-01 | 2005-04-07 | Medtronic, Inc. | Device and method for inhibiting release of pro-inflammatory mediator |
| WO2005051871A2 (en) | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
| US20050215764A1 (en) | 2004-03-24 | 2005-09-29 | Tuszynski Jack A | Biological polymer with differently charged portions |
| US20050249667A1 (en) | 2004-03-24 | 2005-11-10 | Tuszynski Jack A | Process for treating a biological organism |
| WO2005103873A2 (en) | 2004-04-14 | 2005-11-03 | Tyco Electronics Corporation | Acoustic touch sensor |
| JP5153343B2 (ja) | 2004-12-21 | 2013-02-27 | イービーアール システムズ, インコーポレイテッド | 埋め込み可能な変換器デバイス |
| US8165696B2 (en) | 2005-02-25 | 2012-04-24 | Boston Scientific Neuromodulation Corporation | Multiple-pronged implantable stimulator and methods of making and using such a stimulator |
| US7542800B2 (en) | 2005-04-05 | 2009-06-02 | Cardiac Pacemakers, Inc. | Method and apparatus for synchronizing neural stimulation to cardiac cycles |
| US8634908B2 (en) | 2005-08-01 | 2014-01-21 | Ebr Systems, Inc. | Efficiently delivering acoustic stimulation energy to tissue |
| US8649876B2 (en) * | 2005-09-10 | 2014-02-11 | Artann Laboratories Inc. | Leadless system for deep brain stimulation using time reversal acoustics |
| US7616990B2 (en) * | 2005-10-24 | 2009-11-10 | Cardiac Pacemakers, Inc. | Implantable and rechargeable neural stimulator |
| WO2007090159A1 (en) | 2006-01-31 | 2007-08-09 | Medtronic, Inc. | Implantable sensor |
| JP5098214B2 (ja) | 2006-04-28 | 2012-12-12 | 日産自動車株式会社 | 半導体装置およびその製造方法 |
| US7894904B2 (en) | 2006-06-20 | 2011-02-22 | Ebr Systems, Inc. | Systems and methods for implantable leadless brain stimulation |
| US8078283B2 (en) | 2006-06-20 | 2011-12-13 | Ebr Systems, Inc. | Systems and methods for implantable leadless bone stimulation |
| US7894907B2 (en) | 2006-06-20 | 2011-02-22 | Ebr Systems, Inc. | Systems and methods for implantable leadless nerve stimulation |
| US7899541B2 (en) | 2006-06-20 | 2011-03-01 | Ebr Systems, Inc. | Systems and methods for implantable leadless gastrointestinal tissue stimulation |
| US7899542B2 (en) | 2006-06-20 | 2011-03-01 | Ebr Systems, Inc. | Systems and methods for implantable leadless spine stimulation |
| US7757565B2 (en) | 2006-08-24 | 2010-07-20 | Board Of Trustees Operating Michigan State University | Self-powered sensor |
| US9135686B2 (en) | 2006-10-25 | 2015-09-15 | The Invention Science Fund I Llc | Distorting feature compensating |
| US11389171B2 (en) | 2006-11-21 | 2022-07-19 | David S. Goldsmith | Integrated system for the infixion and retrieval of implants |
| US11320588B1 (en) | 2012-04-16 | 2022-05-03 | Mohammad A. Mazed | Super system on chip |
| US8718773B2 (en) | 2007-05-23 | 2014-05-06 | Ebr Systems, Inc. | Optimizing energy transmission in a leadless tissue stimulation system |
| WO2008156981A2 (en) | 2007-06-14 | 2008-12-24 | Cardiac Pacemakers, Inc. | Multi-element acoustic recharging system |
| US8082041B1 (en) | 2007-06-15 | 2011-12-20 | Piezo Energy Technologies, LLC | Bio-implantable ultrasound energy capture and storage assembly including transmitter and receiver cooling |
| US20090018403A1 (en) | 2007-07-12 | 2009-01-15 | Sicel Technologies, Inc. | Trackable implantable sensor devices, systems, and related methods of operation |
| US20110288615A1 (en) * | 2007-11-26 | 2011-11-24 | The Board Of Regents, The University Of Texas System | Implantable Therapeutic Systems Including Neurostimulation Circuits, Devices, Systems and Methods |
| AU2008336077B2 (en) | 2007-12-12 | 2013-03-07 | Cardiac Pacemakers, Inc. | System for delivering neurostimulation from pulmonary artery |
| US7953493B2 (en) | 2007-12-27 | 2011-05-31 | Ebr Systems, Inc. | Optimizing size of implantable medical devices by isolating the power source |
| US20090275997A1 (en) | 2008-05-01 | 2009-11-05 | Michael Allen Faltys | Vagus nerve stimulation electrodes and methods of use |
| US9364362B2 (en) | 2008-10-21 | 2016-06-14 | General Electric Company | Implantable device system |
| ES2452484T3 (es) | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| JP5581333B2 (ja) | 2008-12-18 | 2014-08-27 | サザン イノヴェーション インターナショナル プロプライアトリー リミテッド | 数学的変換を使用することによってパイルアップされたパルスを分離する方法および装置 |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US20110054569A1 (en) | 2009-09-01 | 2011-03-03 | Zitnik Ralph J | Prescription pad for treatment of inflammatory disorders |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| RU2573184C2 (ru) * | 2009-05-15 | 2016-01-20 | Конинклейке Филипс Электроникс Н.В. | Имплантируемое устройство со средствами связи |
| EP2440284B1 (en) | 2009-06-09 | 2018-09-12 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
| US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| US20160331952A1 (en) | 2009-11-17 | 2016-11-17 | Michael A. Faltys | External programmer |
| EP3636314B1 (en) | 2009-12-23 | 2021-09-08 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| CA2797302C (en) | 2010-04-28 | 2019-01-15 | Ryerson University | System and methods for intraoperative guidance feedback |
| US9095284B2 (en) | 2010-10-28 | 2015-08-04 | Medtronic, Inc. | Distance measurement using implantable acoustic transducers |
| US8849412B2 (en) | 2011-01-28 | 2014-09-30 | Micron Devices Llc | Microwave field stimulator |
| WO2012103519A2 (en) | 2011-01-28 | 2012-08-02 | Stimwave Technologies Incorporated | Neural stimulator system |
| US9220897B2 (en) | 2011-04-04 | 2015-12-29 | Micron Devices Llc | Implantable lead |
| CN103492022A (zh) | 2011-04-04 | 2014-01-01 | 斯蒂维科技公司 | 可植入式导入治疗装置 |
| CA2834786A1 (en) | 2011-05-06 | 2012-11-15 | Ndsu Research Foundation | Intelligent self-organizing electrode stimulation delivery system |
| EP2726930A4 (en) | 2011-06-28 | 2015-03-04 | Pelican Imaging Corp | OPTICAL ARRANGEMENTS FOR USE WITH AN ARRAY CAMERA |
| US9492678B2 (en) | 2011-07-14 | 2016-11-15 | Cyberonics, Inc. | Far field radiative powering of implantable medical therapy delivery devices |
| JP2014524279A (ja) | 2011-07-29 | 2014-09-22 | スティムウェイブ テクノロジーズ インコーポレイテッド | 神経刺激器のための電力又は極性選択の遠隔制御 |
| US8787526B2 (en) | 2011-09-08 | 2014-07-22 | Elwha Llc | Systems, devices, and methods including implants for managing cumulative X-ray radiation dosage including X-ray radiation direction determination devices |
| US8693633B2 (en) | 2011-09-08 | 2014-04-08 | Elwha Llc | Systems, devices, and methods including implants for managing cumulative x-ray radiation dosage |
| TR201802844T4 (tr) | 2011-09-15 | 2018-03-21 | Andresen Chad | İmplant için röle modülü. |
| US9446255B2 (en) | 2011-11-13 | 2016-09-20 | Arizona Board of Regents on Behalf Arizona State University | Controlled stimulation delivery from neurostimulator |
| US20130178915A1 (en) | 2012-01-10 | 2013-07-11 | Piezo Energy Technologies, LLC | High power ultrasound wireless transcutaneous energy transfer (us-tet) source |
| US9974593B2 (en) | 2012-03-08 | 2018-05-22 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation and associated systems and methods for the treatment of sexual dysfunction |
| WO2013134479A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Neuromodulation and associated systems and methods for the management of pain |
| KR101914618B1 (ko) | 2012-05-21 | 2018-11-05 | 센시메드 에스아 | 관성 센서를 포함하는 안압 측정 또는 모니터링 시스템 |
| US10252085B2 (en) | 2012-05-22 | 2019-04-09 | Arizona Board Of Regents On Behalf Of Arizona State University | Apparatus, system and method for neurostimulation by high frequency ultrasound |
| WO2014153228A1 (en) | 2013-03-14 | 2014-09-25 | Perryman Laura Tyler | Miniature implantable device and methods |
| WO2014153223A1 (en) | 2013-03-14 | 2014-09-25 | Perryman Laura Tyler | Treating inflammation, chronic pain and other disorders with neuromodulation |
| US9623253B2 (en) | 2012-07-17 | 2017-04-18 | Micron Devices, LLC | Devices and methods for treating urological disorders |
| US10245436B2 (en) | 2012-07-17 | 2019-04-02 | Stimwave Technologies Incorporated | Miniature implantable device and methods |
| WO2014153219A1 (en) | 2013-03-14 | 2014-09-25 | Perryman Laura Tyler | Devices and methods for treating urological disorders |
| US9717921B2 (en) | 2012-07-17 | 2017-08-01 | Micron Devices, LLC | Treating inflammation, chronic pain and other disorders with neuromodulation |
| US10463858B2 (en) | 2012-07-17 | 2019-11-05 | Stimwave Technologies Incorporated | Devices and methods for treating craniofacial pain |
| WO2014153218A1 (en) | 2013-03-14 | 2014-09-25 | Tyler Perryman Laura | Devices and methods for treating craniofacial pain |
| US9820669B2 (en) * | 2012-08-07 | 2017-11-21 | The General Hospital Corporation | System and method for electrical impedance spectroscopy |
| BR112015013077B1 (pt) | 2012-12-05 | 2022-02-08 | Micron Devices Llc | Dispositivo para fornecer uma sonda implantável com energia sem fio e sistema e método para modular tecido excitável em um corpo de um paciente |
| WO2014122467A1 (en) * | 2013-02-06 | 2014-08-14 | Loxbridge Research Llp | Systems and methods for early disease detection and real-time disease monitoring |
| CN105229995B (zh) | 2013-02-22 | 2019-05-21 | 赛威医疗公司 | 用于一组个体的联网的神经调节的方法和装置 |
| US8874233B2 (en) | 2013-03-05 | 2014-10-28 | The Charles Stark Draper Laboratory, Inc. | Distributed neuro-modulation system with auxiliary stimulation-recording control units |
| US9323397B2 (en) * | 2013-03-11 | 2016-04-26 | The Regents Of The University Of California | In-air ultrasonic rangefinding and angle estimation |
| JP6450328B2 (ja) * | 2013-03-15 | 2019-01-09 | コナヴィ メディカル インコーポレーテッド | 超音波を用いる低侵襲デバイスの能動的位置特定及び視覚化 |
| US9544068B2 (en) * | 2013-05-13 | 2017-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Hybrid communication system for implantable devices and ultra-low power sensors |
| US10014570B2 (en) | 2013-05-13 | 2018-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Single transducer for data and power in wirelessly powered devices |
| CA2919780A1 (en) * | 2013-08-09 | 2015-02-12 | Yoram Palti | Passive data transmission |
| JP6050206B2 (ja) | 2013-09-17 | 2016-12-21 | 富士フイルム株式会社 | 放射線撮影システム及び通信環境制御装置 |
| WO2015127476A1 (en) | 2014-02-24 | 2015-08-27 | Setpoint Medial Corporation | Vagus nerve stimulation screening test |
| WO2015142842A2 (en) | 2014-03-17 | 2015-09-24 | Towe Bruce C | Methods and systems for measuring tissue impedance and monitoring pvd treatment using neuro-implants with improved ultrasound powering |
| US20160000590A1 (en) * | 2014-04-07 | 2016-01-07 | Washington University | Intravascular Device |
| JP2015211801A (ja) | 2014-05-07 | 2015-11-26 | セイコーエプソン株式会社 | 生体情報検出装置、生体情報提示システム及び電子機器 |
| WO2016007093A1 (en) | 2014-07-09 | 2016-01-14 | Dexing Pang | Device, system and method for nerve stimulation |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| JP6043030B2 (ja) | 2014-12-17 | 2016-12-14 | オリンパス株式会社 | 管腔通過確認剤 |
| US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
| MA41950A (fr) | 2015-04-24 | 2018-02-28 | Acad Medisch Ct | Dispositif de neuromodulation |
| US20170100588A1 (en) | 2015-05-15 | 2017-04-13 | Ohio State Innovation Foundation | Systems and methods of improving cancer symptoms by neuromodulation of immune function |
| US20160331962A1 (en) | 2015-05-15 | 2016-11-17 | Ohio State Innovation Foundation | Methods for improving a patient's immune response |
| US20170100604A1 (en) | 2015-05-15 | 2017-04-13 | Ohio State Innovation Foundation | Systems and methods of improving metabolic syndrome |
| US10201706B2 (en) | 2015-05-15 | 2019-02-12 | Ohio State Innovation Foundation | Systems and methods of improving an inflammatory disorder |
| US20170100589A1 (en) | 2015-05-15 | 2017-04-13 | Ohio State Innovation Foundation | Systems and methods of improving infections by neuromodulation of immune function |
| US20170100605A1 (en) | 2015-05-15 | 2017-04-13 | Ohio State Innovation Foundation | Systems and methods of improving an immune disorder |
| WO2017030900A1 (en) | 2015-08-14 | 2017-02-23 | The Regents Of The University Of California | Quantitative tool using impedance spectroscopy to monitor fracture healing |
| US10177606B2 (en) | 2015-10-21 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Dynamic reconfiguration for maximizing the overall link efficiency of energy receivers in a reliable implantable system |
| WO2017149526A2 (en) * | 2016-03-04 | 2017-09-08 | May Patents Ltd. | A method and apparatus for cooperative usage of multiple distance meters |
| EP4395124A3 (en) | 2016-03-21 | 2024-07-31 | Nalu Medical, Inc. | Devices and methods for positioning external devices in relation to implanted devices |
| WO2017173352A1 (en) | 2016-03-31 | 2017-10-05 | Thomas Jefferson University | Tumor bed implant for multimodality treatment of at risk tissue surrounding a resection cavity |
| US9802055B2 (en) | 2016-04-04 | 2017-10-31 | Medtronic, Inc. | Ultrasound powered pulse delivery device |
| US11524161B2 (en) | 2016-06-10 | 2022-12-13 | Purdue Research Foundation | System for wireless recording and stimulating bioelectric events |
| US10232168B2 (en) | 2016-06-27 | 2019-03-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for active skull replacement for brain interface and method of using the same |
| EP3481285B1 (en) | 2016-07-07 | 2020-09-30 | The Regents of The University of California | Implants using ultrasonic waves for stimulating tissue |
| US11577092B2 (en) | 2016-08-01 | 2023-02-14 | Immunolight, Llc | Phosphor-containing drug activator activatable by a monte carlo derived X-ray exposure, system containing the activator, and methods for use |
| AU2017348440C1 (en) | 2016-10-31 | 2023-07-20 | GE Precision Healthcare LLC | Techniques for neuromodulation |
| EP3538209A1 (en) | 2016-11-08 | 2019-09-18 | Galvani Bioelectronics Limited | Treatment of inflammatory disorders |
| US20190275330A1 (en) | 2016-11-14 | 2019-09-12 | Galvani Bioelectronics Limited | Modular Neuromodulation Systems, Methods of Manufacture, and Methods of Treating Rheumatoid Arthritis |
| WO2018098158A1 (en) | 2016-11-22 | 2018-05-31 | Immunolight, Llc | Drug activator and system activatable by a monte carlo derived x-ray exposure |
| WO2018118861A1 (en) | 2016-12-19 | 2018-06-28 | Ohio State Innovation Foundation | Systems and methods of improving cancer symptoms by neuromodulation of immune function |
| WO2018118857A1 (en) | 2016-12-19 | 2018-06-28 | Ohio State Innovation Foundation | Systems and methods of improving an immune disorder |
| WO2018118860A1 (en) | 2016-12-19 | 2018-06-28 | Ohio State Innovation Foundation | Systems and methods of improving an inflammatory disorder |
| US10456600B2 (en) | 2017-07-26 | 2019-10-29 | Reflexion Medical, Inc. | Graphical representation of radiation therapy |
| BR112020021286A2 (pt) | 2018-04-19 | 2021-01-26 | Iota Biosciences, Inc. | implantes usando comunicação ultrassônica para modular a atividade do nervo esplênico |
| WO2019204773A1 (en) | 2018-04-19 | 2019-10-24 | Iota Biosciences, Inc. | Implants using ultrasonic communication for neural sensing and stimulation |
| US11857316B2 (en) | 2018-05-07 | 2024-01-02 | Hi Llc | Non-invasive optical detection system and method |
| KR20210053915A (ko) | 2018-08-29 | 2021-05-12 | 아이오타 바이오사이언시즈 인코퍼레이티드 | 이식 가능한 폐회로 뉴로모듈레이션 장치, 시스템 및 사용 방법 |
| CA3120288A1 (en) | 2018-12-06 | 2020-06-11 | Jose M. Carmena | Device networks for modulating neural activity |
| BR112021013075A2 (pt) | 2019-01-04 | 2021-09-21 | Iota Biosciences, Inc. | Controles de potência para um dispositivo implantável alimentado com o uso de ondas ultrassônicas |
| CN113226455A (zh) * | 2019-01-04 | 2021-08-06 | 艾奧塔生物科技公司 | 用于操作可植入设备的基于超声的协议 |
| US20200410189A1 (en) * | 2019-06-27 | 2020-12-31 | Qualcomm Incorporated | Biometric fingerprint photoacoustic tomographic imaging |
| JP2023515475A (ja) | 2020-02-19 | 2023-04-13 | チャン ザッカーバーグ バイオハブ, インコーポレイテッド | 深部組織超音波埋め込み型発光酸素センサ |
| EP4106863B1 (en) | 2020-02-19 | 2025-04-09 | Chan Zuckerberg Biohub, Inc. | Anchor loss in millimeter-scale ultrasonic wireless implantable devices |
| US11963683B2 (en) | 2020-10-02 | 2024-04-23 | Cilag Gmbh International | Method for operating tiered operation modes in a surgical system |
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