ES2834333T3 - Inhibidores pirimidinil de tirosina quinasa - Google Patents

Inhibidores pirimidinil de tirosina quinasa Download PDF

Info

Publication number
ES2834333T3
ES2834333T3 ES18171833T ES18171833T ES2834333T3 ES 2834333 T3 ES2834333 T3 ES 2834333T3 ES 18171833 T ES18171833 T ES 18171833T ES 18171833 T ES18171833 T ES 18171833T ES 2834333 T3 ES2834333 T3 ES 2834333T3
Authority
ES
Spain
Prior art keywords
amino
compound
chloro
oxo
bipiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18171833T
Other languages
English (en)
Spanish (es)
Inventor
Brian T Hopkins
Patrick Conlon
Timothy R Chan
Tracy J Jenkins
Xiongwei Cai
Michael Humora
Xianglin Shi
Ross A Miller
Andrew Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen MA Inc
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Biogen MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc, Biogen MA Inc filed Critical Sunesis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2834333T3 publication Critical patent/ES2834333T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ES18171833T 2012-06-08 2013-06-07 Inhibidores pirimidinil de tirosina quinasa Active ES2834333T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261657360P 2012-06-08 2012-06-08

Publications (1)

Publication Number Publication Date
ES2834333T3 true ES2834333T3 (es) 2021-06-17

Family

ID=49712704

Family Applications (2)

Application Number Title Priority Date Filing Date
ES18171833T Active ES2834333T3 (es) 2012-06-08 2013-06-07 Inhibidores pirimidinil de tirosina quinasa
ES13800042.7T Active ES2684268T3 (es) 2012-06-08 2013-06-07 Inhibidores de pirimidinil tirosina quinasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13800042.7T Active ES2684268T3 (es) 2012-06-08 2013-06-07 Inhibidores de pirimidinil tirosina quinasa

Country Status (30)

Country Link
US (6) US9394277B2 (cg-RX-API-DMAC7.html)
EP (3) EP2858499B1 (cg-RX-API-DMAC7.html)
JP (6) JP6214643B2 (cg-RX-API-DMAC7.html)
KR (4) KR20220154850A (cg-RX-API-DMAC7.html)
CN (3) CN109305959B (cg-RX-API-DMAC7.html)
AR (1) AR091273A1 (cg-RX-API-DMAC7.html)
AU (5) AU2013271407B2 (cg-RX-API-DMAC7.html)
BR (2) BR122021002178B1 (cg-RX-API-DMAC7.html)
CA (2) CA3108186A1 (cg-RX-API-DMAC7.html)
CY (1) CY1120638T1 (cg-RX-API-DMAC7.html)
DK (1) DK2858499T3 (cg-RX-API-DMAC7.html)
EA (2) EA027823B1 (cg-RX-API-DMAC7.html)
ES (2) ES2834333T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20181294T1 (cg-RX-API-DMAC7.html)
HU (1) HUE039897T2 (cg-RX-API-DMAC7.html)
IL (2) IL235938B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN10576A (cg-RX-API-DMAC7.html)
LT (1) LT2858499T (cg-RX-API-DMAC7.html)
MX (2) MX363672B (cg-RX-API-DMAC7.html)
NZ (1) NZ702715A (cg-RX-API-DMAC7.html)
PH (2) PH12018501463B1 (cg-RX-API-DMAC7.html)
PL (1) PL2858499T3 (cg-RX-API-DMAC7.html)
PT (1) PT2858499T (cg-RX-API-DMAC7.html)
RS (1) RS57978B1 (cg-RX-API-DMAC7.html)
SG (2) SG10201708535UA (cg-RX-API-DMAC7.html)
SI (1) SI2858499T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800442T1 (cg-RX-API-DMAC7.html)
TW (3) TWI792158B (cg-RX-API-DMAC7.html)
WO (1) WO2013185084A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201409255B (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI557127B (zh) 2009-09-04 2016-11-11 百健Ma公司 布魯頓氏酪胺酸激酶抑制劑
US9273028B2 (en) 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
US9353087B2 (en) * 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
MY179781A (en) * 2013-12-11 2020-11-13 Biogen Ma Inc Biaryl inhibitors of bruton's tyrosine kinase
WO2015151006A1 (en) 2014-03-29 2015-10-08 Lupin Limited Substituted purine compounds as btk inhibitors
WO2015170266A1 (en) 2014-05-07 2015-11-12 Lupin Limited Substituted pyrimidine compounds as btk inhibitors
HUE050706T2 (hu) * 2014-10-24 2020-12-28 Bristol Myers Squibb Co Indol karboxamid vegyületek, amelyek hasznosak kináz inhibitorokként
CN110049976A (zh) 2016-07-21 2019-07-23 比奥根Ma公司 布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物
JP7331843B2 (ja) 2018-04-27 2023-08-23 小野薬品工業株式会社 Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
WO2023081709A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Vecabrutinib for the treatment of graft-versus-host disease
WO2023081715A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Combination of car t-cell therapy with btk inhibitors and methods of use thereof
KR20240157639A (ko) 2021-12-14 2024-11-01 크로스파이어 온콜로지 홀딩 비.브이. 거대고리 btk 억제제
WO2024245577A1 (en) 2023-06-02 2024-12-05 Netherlands Translational Research Center Holding B.V. Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor
WO2024246287A1 (en) 2023-06-02 2024-12-05 Crossfire Oncology Holding B.V. Medical use of a macrocyclic reversible btk inhibitor
WO2024245578A1 (en) 2023-06-02 2024-12-05 Netherlands Translational Research Center Holding B.V. Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor
WO2024256568A1 (en) 2023-06-13 2024-12-19 Crossfire Oncology Holding B.V. Salt and crystal forms of a macrocyclic btk inhibitor
WO2024256574A1 (en) 2023-06-13 2024-12-19 Crossfire Oncology Holding B.V. Process for preparing macrocyclic btk inhibitors

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1624A (en) * 1840-06-10 Cooking-stove
US4528138A (en) 1984-06-20 1985-07-09 E. R. Squibb & Sons, Inc. 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
JP2003528072A (ja) 2000-03-17 2003-09-24 ブリストル−マイヤーズ スクイブ ファーマ カンパニー マトリックスメタロプロテアーゼおよびTNF−αの阻害剤としての環状β−アミノ酸誘導体
MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
CN100351253C (zh) 2000-06-26 2007-11-28 辉瑞产品公司 作为免疫抑制剂的吡咯并[2,3-d]嘧啶化合物
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2002363236A1 (en) * 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
EP1442039A1 (en) 2001-10-31 2004-08-04 Bayer HealthCare AG Pyrimido (4,5-b) indole derivatives
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
CA2542076C (en) 2003-10-14 2013-02-26 Arizona Board Of Regents On Behalf Of The University Of Arizona Substituted tricyclic compounds as protein kinase inhibitors
EP1778298A4 (en) * 2004-04-01 2010-03-31 Univ Pennsylvania LIPOPROTEIN-NANO PLATFORMS
JP5213229B2 (ja) 2004-04-23 2013-06-19 エグゼリクシス, インコーポレイテッド キナーゼ調節因子および使用方法
FR2870541B1 (fr) 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
TW200621760A (en) 2004-09-09 2006-07-01 Mitsubishi Pharma Corp 2-morpholino-4-pyrimidone compound
AU2005304784B2 (en) * 2004-11-04 2011-03-24 Vertex Pharmaceuticals Incorporated Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
EP1819684B1 (en) 2004-12-03 2013-08-07 Intervet International B.V. Substituted piperazines as cb1 antagonists
CA2590961C (en) 2004-12-28 2013-11-26 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
WO2006071875A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
US7423043B2 (en) * 2005-02-18 2008-09-09 Lexicon Pharmaceuticals, Inc. 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
US20060281700A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
US20060281764A1 (en) 2005-06-10 2006-12-14 Gaul Michael D Aminopyrimidines as kinase modulators
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
JP5191391B2 (ja) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
AU2006331994A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Combination of an H3 antagonist/inverse agonist and an appetite suppressant
WO2008005368A2 (en) 2006-06-30 2008-01-10 Abbott Laboratories Piperazines as p2x7 antagonists
WO2008012635A2 (en) 2006-07-26 2008-01-31 Pfizer Products Inc. Amine derivatives useful as anticancer agents
CA2659605A1 (en) 2006-07-26 2008-01-31 Novartis Ag Inhibitors of undecaprenyl pyrophosphate synthase
US20100160292A1 (en) 2006-09-11 2010-06-24 Cgi Pharmaceuticals, Inc Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors
ES2616789T3 (es) 2006-09-22 2017-06-14 Pharmacyclics, Inc. Inhibidores de tirosina cinasa de Bruton
TW200840571A (en) * 2007-03-02 2008-10-16 Schering Corp Piperidine derivatives and methods of use thereof
US8188272B2 (en) 2007-03-21 2012-05-29 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
WO2008144253A1 (en) 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
JP5291095B2 (ja) 2007-06-01 2013-09-18 グラクソスミスクライン エルエルシー イミダゾピリジンキナーゼ阻害剤
WO2009098144A1 (en) * 2008-02-05 2009-08-13 F. Hoffmann-La Roche Ag Novel pyridinones and pyridazinones
MX343525B (es) 2008-04-29 2016-11-09 Immunexcite Inc Composiciones inmunomoduladoras y metodos de uso de las mismas.
CN102159214A (zh) 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
WO2010068788A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Heterocyclic amides as btk inhibitors
CN102325753B (zh) * 2008-12-19 2014-09-10 百时美施贵宝公司 用作激酶抑制剂的咔唑甲酰胺化合物
EP3828185B1 (en) * 2009-01-06 2024-11-20 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
ES2565952T3 (es) 2009-05-25 2016-04-07 Sandoz Ag Método para la producción de ceftobiprol medocaril
WO2011029043A1 (en) 2009-09-04 2011-03-10 Biogen Idec Ma Inc. Heteroaryl btk inhibitors
TWI557127B (zh) * 2009-09-04 2016-11-11 百健Ma公司 布魯頓氏酪胺酸激酶抑制劑
US8685880B2 (en) 2010-06-30 2014-04-01 Chevron U.S.A. Inc. On-site drying of aqueous salt for ionic liquid make-up
US9273028B2 (en) 2010-10-29 2016-03-01 Biogen Ma Inc. Heterocyclic tyrosine kinase inhibitors
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
MY179781A (en) 2013-12-11 2020-11-13 Biogen Ma Inc Biaryl inhibitors of bruton's tyrosine kinase
WO2015089327A1 (en) 2013-12-11 2015-06-18 Biogen Idec Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
WO2016054627A1 (en) 2014-10-03 2016-04-07 Ohio State Innovation Foundation Biomarkers of bruton tyrosine kinase inhibitor resistance
CN110049976A (zh) * 2016-07-21 2019-07-23 比奥根Ma公司 布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物

Also Published As

Publication number Publication date
CN109305959A (zh) 2019-02-05
JP2021073299A (ja) 2021-05-13
EP3385263A1 (en) 2018-10-10
MX363672B (es) 2019-03-29
PH12018501463A1 (en) 2019-03-04
US20240417389A1 (en) 2024-12-19
MX2019003618A (es) 2019-07-18
US20160304494A1 (en) 2016-10-20
TW201805279A (zh) 2018-02-16
JP2021073298A (ja) 2021-05-13
TWI592406B (zh) 2017-07-21
NZ702715A (en) 2016-11-25
ZA201409255B (en) 2015-12-23
ES2684268T3 (es) 2018-10-02
KR20220154850A (ko) 2022-11-22
EA201790418A1 (ru) 2017-11-30
CN104540385A (zh) 2015-04-22
SG10201708535UA (en) 2017-11-29
PT2858499T (pt) 2018-10-24
TW201410668A (zh) 2014-03-16
EP2858499A4 (en) 2016-01-20
CN113549055A (zh) 2021-10-26
RS57978B1 (sr) 2019-01-31
US20210017155A1 (en) 2021-01-21
EA201492056A1 (ru) 2015-05-29
AU2017201536B2 (en) 2019-03-07
AU2019203476A1 (en) 2019-06-06
HUE039897T2 (hu) 2019-02-28
BR112014030655B1 (pt) 2021-04-20
AU2019203476B2 (en) 2021-01-28
BR112014030655A8 (pt) 2018-01-02
CA2875799A1 (en) 2013-12-12
EP2858499B1 (en) 2018-05-16
SI2858499T1 (sl) 2018-10-30
KR20150036020A (ko) 2015-04-07
PL2858499T3 (pl) 2019-03-29
TWI719209B (zh) 2021-02-21
BR112014030655A2 (pt) 2017-06-27
AR091273A1 (es) 2015-01-21
US10618887B2 (en) 2020-04-14
CA2875799C (en) 2021-03-23
IL235938B (en) 2020-10-29
JP2019077728A (ja) 2019-05-23
PH12018501463B1 (en) 2024-03-27
US9394277B2 (en) 2016-07-19
AU2021202412A1 (en) 2021-05-20
IL235938A0 (en) 2015-02-01
SG11201408173WA (en) 2015-01-29
IN2014DN10576A (cg-RX-API-DMAC7.html) 2015-08-28
AU2013271407A1 (en) 2015-01-22
AU2017201536A1 (en) 2017-03-23
AU2013271407B2 (en) 2016-12-08
US20190047986A1 (en) 2019-02-14
JP2023052415A (ja) 2023-04-11
EP3753934A1 (en) 2020-12-23
CN104540385B (zh) 2018-06-05
KR20210072139A (ko) 2021-06-16
CA3108186A1 (en) 2013-12-12
JP2015518903A (ja) 2015-07-06
HRP20181294T1 (hr) 2018-10-05
JP6214643B2 (ja) 2017-10-18
KR102468430B1 (ko) 2022-11-21
KR102102587B1 (ko) 2020-04-22
TWI792158B (zh) 2023-02-11
CN109305959B (zh) 2022-02-08
PH12014502699B1 (en) 2015-02-02
JP2017193583A (ja) 2017-10-26
US20150158843A1 (en) 2015-06-11
EP2858499A1 (en) 2015-04-15
LT2858499T (lt) 2018-09-10
EP3385263B1 (en) 2020-07-22
BR122021002178B1 (pt) 2022-03-22
US9944622B2 (en) 2018-04-17
HK1209284A1 (en) 2016-04-01
IL277951A (en) 2020-11-30
KR20200043497A (ko) 2020-04-27
PH12014502699A1 (en) 2015-02-02
EA027823B1 (ru) 2017-09-29
MX2014015044A (es) 2015-09-22
DK2858499T3 (en) 2018-08-20
MX385593B (es) 2025-03-18
SMT201800442T1 (it) 2018-09-13
AU2022275504A1 (en) 2023-01-05
WO2013185084A1 (en) 2013-12-12
US20230174511A1 (en) 2023-06-08
CY1120638T1 (el) 2019-12-11
TW202142535A (zh) 2021-11-16

Similar Documents

Publication Publication Date Title
ES2834333T3 (es) Inhibidores pirimidinil de tirosina quinasa
HK40043767A (en) Pyrimidinyl derivatives useful as tyrosine kinase inhibitors
HK1262106B (en) Pyrimidinyl tyrosine kinase inhibitors
HK1262106A1 (en) Pyrimidinyl tyrosine kinase inhibitors
HK1209284B (zh) 嘧啶基酪氨酸激酶抑制劑