ES2831865T3 - Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP - Google Patents

Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP Download PDF

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Publication number
ES2831865T3
ES2831865T3 ES18153676T ES18153676T ES2831865T3 ES 2831865 T3 ES2831865 T3 ES 2831865T3 ES 18153676 T ES18153676 T ES 18153676T ES 18153676 T ES18153676 T ES 18153676T ES 2831865 T3 ES2831865 T3 ES 2831865T3
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Prior art keywords
vwf
polypeptide
human
ttp
days
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ES18153676T
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English (en)
Spanish (es)
Inventor
Christian Duby
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Ablynx NV
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Ablynx NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES18153676T 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP Active ES2831865T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2013007A NL2013007B1 (en) 2014-06-16 2014-06-16 Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
US201462030817P 2014-07-30 2014-07-30

Publications (1)

Publication Number Publication Date
ES2831865T3 true ES2831865T3 (es) 2021-06-09

Family

ID=51541255

Family Applications (5)

Application Number Title Priority Date Filing Date
ES18153676T Active ES2831865T3 (es) 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP
ES18153674T Active ES2924199T3 (es) 2014-06-16 2015-06-16 Dominios variables individuales de inmunoglobulina para el uso en métodos para tratar TTP
ES15729829T Active ES2881331T3 (es) 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en el tratamiento de TTP
ES18153673T Active ES2915473T3 (es) 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP
ES18153671T Active ES2843642T3 (es) 2014-06-16 2015-06-16 Métodos de tratamiento de TTP con dominios variables únicos de inmunoglobulina y usos de los mismos

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES18153674T Active ES2924199T3 (es) 2014-06-16 2015-06-16 Dominios variables individuales de inmunoglobulina para el uso en métodos para tratar TTP
ES15729829T Active ES2881331T3 (es) 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en el tratamiento de TTP
ES18153673T Active ES2915473T3 (es) 2014-06-16 2015-06-16 Dominios variables únicos de inmunoglobulina para su uso en métodos de tratamiento de TTP
ES18153671T Active ES2843642T3 (es) 2014-06-16 2015-06-16 Métodos de tratamiento de TTP con dominios variables únicos de inmunoglobulina y usos de los mismos

Country Status (15)

Country Link
US (5) US10858445B2 (enExample)
EP (6) EP3366305B1 (enExample)
JP (3) JP6688746B2 (enExample)
KR (2) KR102403388B1 (enExample)
CN (1) CN106559985A (enExample)
AU (2) AU2015276237B2 (enExample)
CA (1) CA2952103A1 (enExample)
ES (5) ES2831865T3 (enExample)
IL (1) IL249540B (enExample)
NL (1) NL2013007B1 (enExample)
PL (5) PL3366305T3 (enExample)
PT (5) PT3154569T (enExample)
RU (1) RU2704444C2 (enExample)
SG (2) SG11201610488QA (enExample)
WO (1) WO2015193326A1 (enExample)

Families Citing this family (6)

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NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
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CN111670202A (zh) * 2018-02-06 2020-09-15 埃博灵克斯股份有限公司 以免疫球蛋白单可变结构域治疗ttp初次发作的方法
US20230405096A1 (en) * 2020-11-18 2023-12-21 Green Cross Corporation Adamts13 variant having increased escaping rate or activity against autoantibody
JP2024535249A (ja) 2021-09-17 2024-09-30 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 合成ヒト化ラマナノボディライブラリーおよびｓａｒｓ－ｃｏｖ－２中和抗体を同定するためのその使用
CN118715246A (zh) * 2021-12-10 2024-09-27 李人浩 结合血管性血友病因子(vwf)a1结构域或自动抑制模块的多肽、变体及其用途

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Also Published As

Publication number Publication date
KR102568585B1 (ko) 2023-08-18
EP3332800A1 (en) 2018-06-13
RU2017100077A3 (enExample) 2018-12-25
US12269893B2 (en) 2025-04-08
IL249540B (en) 2021-09-30
JP6688746B2 (ja) 2020-04-28
SG10201811109PA (en) 2019-01-30
KR20170015513A (ko) 2017-02-08
US20180155440A1 (en) 2018-06-07
EP3335724B1 (en) 2022-06-22
US20180155443A1 (en) 2018-06-07
EP4059513A1 (en) 2022-09-21
AU2015276237B2 (en) 2021-02-25
ES2915473T3 (es) 2022-06-22
CN106559985A (zh) 2017-04-05
PT3335723T (pt) 2022-05-20
HK1256731A1 (en) 2019-10-04
PL3335724T3 (pl) 2022-09-19
PT3332800T (pt) 2020-11-19
RU2704444C2 (ru) 2019-10-28
HK1258508A1 (en) 2019-11-15
US20170210822A1 (en) 2017-07-27
RU2017100077A (ru) 2018-07-12
AU2021202747B2 (en) 2024-02-15
EP3154569B1 (en) 2021-04-21
IL249540A0 (en) 2017-02-28
WO2015193326A1 (en) 2015-12-23
EP3335723A1 (en) 2018-06-20
JP2022160431A (ja) 2022-10-19
KR20220053040A (ko) 2022-04-28
NL2013007B1 (en) 2016-07-05
PL3366305T3 (pl) 2021-06-14
PT3366305T (pt) 2020-12-21
KR102403388B1 (ko) 2022-06-03
US20180155442A1 (en) 2018-06-07
SG11201610488QA (en) 2017-01-27
EP3366305B1 (en) 2020-11-18
US10858445B2 (en) 2020-12-08
JP7105260B2 (ja) 2022-07-22
HK1256730A1 (en) 2019-10-04
AU2015276237A1 (en) 2017-01-19
CA2952103A1 (en) 2015-12-23
PT3335724T (pt) 2022-08-02
US10919980B2 (en) 2021-02-16
JP2017519762A (ja) 2017-07-20
EP3154569A1 (en) 2017-04-19
RU2019131713A (ru) 2019-11-11
PL3332800T3 (pl) 2021-04-19
ES2881331T3 (es) 2021-11-29
ES2924199T3 (es) 2022-10-05
EP3335724A1 (en) 2018-06-20
PL3335723T3 (pl) 2022-07-18
JP2020097600A (ja) 2020-06-25
EP3366305A1 (en) 2018-08-29
EP3335723B1 (en) 2022-03-30
PL3154569T3 (pl) 2021-11-02
PT3154569T (pt) 2021-06-22
US20180155441A1 (en) 2018-06-07
ES2843642T3 (es) 2021-07-19
AU2021202747A1 (en) 2021-05-27
EP3332800B1 (en) 2020-08-26

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