ES2773148T3 - Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares - Google Patents

Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares Download PDF

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Publication number
ES2773148T3
ES2773148T3 ES16809676T ES16809676T ES2773148T3 ES 2773148 T3 ES2773148 T3 ES 2773148T3 ES 16809676 T ES16809676 T ES 16809676T ES 16809676 T ES16809676 T ES 16809676T ES 2773148 T3 ES2773148 T3 ES 2773148T3
Authority
ES
Spain
Prior art keywords
group
compound
ethyl
atoms
phosphinoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16809676T
Other languages
English (en)
Spanish (es)
Inventor
Hervé Poras
Michel Wurm
Parsadaniantz Stéphane Melik
Goazigo Annabelle Reaux-Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaleads SA
Original Assignee
Pharmaleads SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaleads SA filed Critical Pharmaleads SA
Application granted granted Critical
Publication of ES2773148T3 publication Critical patent/ES2773148T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES16809676T 2015-11-30 2016-11-30 Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares Active ES2773148T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
PCT/EP2016/079285 WO2017093322A1 (fr) 2015-11-30 2016-11-30 Dérivés aminophosphiniques pour la prévention et le traitement des douleurs oculaires

Publications (1)

Publication Number Publication Date
ES2773148T3 true ES2773148T3 (es) 2020-07-09

Family

ID=55346018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16809676T Active ES2773148T3 (es) 2015-11-30 2016-11-30 Derivados aminofosfínicos para la prevención y el tratamiento de los dolores oculares

Country Status (15)

Country Link
US (2) US20180344753A1 (https=)
EP (1) EP3383403B1 (https=)
JP (1) JP6889176B2 (https=)
KR (1) KR102657652B1 (https=)
CN (2) CN108289901B (https=)
BR (1) BR112018010007A2 (https=)
CA (1) CA3006365A1 (https=)
DK (1) DK3383403T3 (https=)
ES (1) ES2773148T3 (https=)
FR (1) FR3044227B1 (https=)
IL (1) IL259562B (https=)
MX (1) MX382921B (https=)
TW (1) TWI729039B (https=)
WO (1) WO2017093322A1 (https=)
ZA (1) ZA201804037B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
TWI771386B (zh) * 2017-03-09 2022-07-21 法商領先藥物公司 用於預防及治療眼發炎的氨基膦衍生物
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
ES2174337T3 (es) * 1996-12-16 2002-11-01 Alcon Lab Inc Uso topico de los agonistas opioides kappa para el tratamiento del dolor ocular.
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
JP2016511246A (ja) * 2013-02-13 2016-04-14 ノバルティス アーゲー 局所眼用鎮痛薬

Also Published As

Publication number Publication date
US10688113B2 (en) 2020-06-23
KR102657652B1 (ko) 2024-04-15
HK1259181A1 (zh) 2019-11-29
FR3044227B1 (fr) 2017-11-24
US20180344753A1 (en) 2018-12-06
JP6889176B2 (ja) 2021-06-18
CA3006365A1 (fr) 2017-06-08
TW201726146A (zh) 2017-08-01
ZA201804037B (en) 2020-07-29
BR112018010007A2 (pt) 2018-11-21
CN108289901B (zh) 2021-05-04
MX382921B (es) 2025-03-13
EP3383403A1 (fr) 2018-10-10
US20190167701A1 (en) 2019-06-06
EP3383403B1 (fr) 2019-12-25
MX2018006580A (es) 2018-08-01
IL259562B (en) 2020-08-31
DK3383403T3 (da) 2020-03-16
WO2017093322A1 (fr) 2017-06-08
CN108289901A (zh) 2018-07-17
KR20180095555A (ko) 2018-08-27
TWI729039B (zh) 2021-06-01
CN112121008A (zh) 2020-12-25
FR3044227A1 (fr) 2017-06-02
JP2018536714A (ja) 2018-12-13
IL259562A (en) 2018-07-31

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