KR102657652B1 - 눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체 - Google Patents

눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체 Download PDF

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Publication number
KR102657652B1
KR102657652B1 KR1020187018504A KR20187018504A KR102657652B1 KR 102657652 B1 KR102657652 B1 KR 102657652B1 KR 1020187018504 A KR1020187018504 A KR 1020187018504A KR 20187018504 A KR20187018504 A KR 20187018504A KR 102657652 B1 KR102657652 B1 KR 102657652B1
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South Korea
Prior art keywords
ethyl
phosphinoyl
propionylamino
hydroxy
benzyl
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KR1020187018504A
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English (en)
Korean (ko)
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KR20180095555A (ko
Inventor
에르베 포라스
미셸 부름
파르사다니안츠 스테빤 멜릭
과지고 아나벨 로-르
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파마리드스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020187018504A 2015-11-30 2016-11-30 눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체 Active KR102657652B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1561598 2015-11-30
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
PCT/EP2016/079285 WO2017093322A1 (fr) 2015-11-30 2016-11-30 Dérivés aminophosphiniques pour la prévention et le traitement des douleurs oculaires

Publications (2)

Publication Number Publication Date
KR20180095555A KR20180095555A (ko) 2018-08-27
KR102657652B1 true KR102657652B1 (ko) 2024-04-15

Family

ID=55346018

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187018504A Active KR102657652B1 (ko) 2015-11-30 2016-11-30 눈 통증의 예방 및 치료를 위한 아미노포스핀산 유도체

Country Status (15)

Country Link
US (2) US20180344753A1 (https=)
EP (1) EP3383403B1 (https=)
JP (1) JP6889176B2 (https=)
KR (1) KR102657652B1 (https=)
CN (2) CN108289901B (https=)
BR (1) BR112018010007A2 (https=)
CA (1) CA3006365A1 (https=)
DK (1) DK3383403T3 (https=)
ES (1) ES2773148T3 (https=)
FR (1) FR3044227B1 (https=)
IL (1) IL259562B (https=)
MX (1) MX382921B (https=)
TW (1) TWI729039B (https=)
WO (1) WO2017093322A1 (https=)
ZA (1) ZA201804037B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
TWI771386B (zh) * 2017-03-09 2022-07-21 法商領先藥物公司 用於預防及治療眼發炎的氨基膦衍生物
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110124601A1 (en) * 2008-07-23 2011-05-26 Pharmaleads Aminophosphinic derivatives that can be used in the treatment of pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
ES2174337T3 (es) * 1996-12-16 2002-11-01 Alcon Lab Inc Uso topico de los agonistas opioides kappa para el tratamiento del dolor ocular.
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
JP2016511246A (ja) * 2013-02-13 2016-04-14 ノバルティス アーゲー 局所眼用鎮痛薬

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110124601A1 (en) * 2008-07-23 2011-05-26 Pharmaleads Aminophosphinic derivatives that can be used in the treatment of pain

Also Published As

Publication number Publication date
US10688113B2 (en) 2020-06-23
HK1259181A1 (zh) 2019-11-29
FR3044227B1 (fr) 2017-11-24
US20180344753A1 (en) 2018-12-06
JP6889176B2 (ja) 2021-06-18
CA3006365A1 (fr) 2017-06-08
TW201726146A (zh) 2017-08-01
ZA201804037B (en) 2020-07-29
ES2773148T3 (es) 2020-07-09
BR112018010007A2 (pt) 2018-11-21
CN108289901B (zh) 2021-05-04
MX382921B (es) 2025-03-13
EP3383403A1 (fr) 2018-10-10
US20190167701A1 (en) 2019-06-06
EP3383403B1 (fr) 2019-12-25
MX2018006580A (es) 2018-08-01
IL259562B (en) 2020-08-31
DK3383403T3 (da) 2020-03-16
WO2017093322A1 (fr) 2017-06-08
CN108289901A (zh) 2018-07-17
KR20180095555A (ko) 2018-08-27
TWI729039B (zh) 2021-06-01
CN112121008A (zh) 2020-12-25
FR3044227A1 (fr) 2017-06-02
JP2018536714A (ja) 2018-12-13
IL259562A (en) 2018-07-31

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