CN112121008A - 用于预防和治疗眼痛的氨基次膦酸衍生物 - Google Patents

用于预防和治疗眼痛的氨基次膦酸衍生物 Download PDF

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Publication number
CN112121008A
CN112121008A CN202010893476.8A CN202010893476A CN112121008A CN 112121008 A CN112121008 A CN 112121008A CN 202010893476 A CN202010893476 A CN 202010893476A CN 112121008 A CN112121008 A CN 112121008A
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CN
China
Prior art keywords
compound
formula
group
ethyl
propionylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010893476.8A
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English (en)
Chinese (zh)
Inventor
H.波雷斯
M.沃姆
S.梅利克帕萨达尼安兹
A.雷奥克斯-勒戈亚齐戈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaleads SA
Original Assignee
Pharmaleads SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaleads SA filed Critical Pharmaleads SA
Publication of CN112121008A publication Critical patent/CN112121008A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202010893476.8A 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物 Pending CN112121008A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1561598 2015-11-30
FR1561598A FR3044227B1 (fr) 2015-11-30 2015-11-30 Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
CN201680070092.8A CN108289901B (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680070092.8A Division CN108289901B (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物

Publications (1)

Publication Number Publication Date
CN112121008A true CN112121008A (zh) 2020-12-25

Family

ID=55346018

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010893476.8A Pending CN112121008A (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物
CN201680070092.8A Active CN108289901B (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680070092.8A Active CN108289901B (zh) 2015-11-30 2016-11-30 用于预防和治疗眼痛的氨基次膦酸衍生物

Country Status (15)

Country Link
US (2) US20180344753A1 (https=)
EP (1) EP3383403B1 (https=)
JP (1) JP6889176B2 (https=)
KR (1) KR102657652B1 (https=)
CN (2) CN112121008A (https=)
BR (1) BR112018010007A2 (https=)
CA (1) CA3006365A1 (https=)
DK (1) DK3383403T3 (https=)
ES (1) ES2773148T3 (https=)
FR (1) FR3044227B1 (https=)
IL (1) IL259562B (https=)
MX (1) MX382921B (https=)
TW (1) TWI729039B (https=)
WO (1) WO2017093322A1 (https=)
ZA (1) ZA201804037B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
BR112019016458A2 (pt) 2017-03-09 2020-04-07 Pharmaleads derivados aminofosfínicos para a prevenção e tratamento de inflamação no olho
FR3063635B1 (fr) * 2017-03-09 2019-06-07 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR3104581B1 (fr) * 2019-12-11 2021-11-26 Pharmaleads Procédé de préparation industrielle du sel disodique de ((2S)-3-([1,1'-biphenyl]-4-yl)-2-((hydroxy((1R)-1-(((1-(isobutyryloxy)ethoxy)carbonyl)amino)ethyl)phosphoryl) methyl)propanoyl)-L-alanine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0987291A (ja) * 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
ES2174337T3 (es) * 1996-12-16 2002-11-01 Alcon Lab Inc Uso topico de los agonistas opioides kappa para el tratamiento del dolor ocular.
FR2777780B1 (fr) * 1998-04-22 2001-05-04 Inst Nat Sante Rech Med Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2934627B1 (fr) 2008-07-29 2010-08-13 Paul Marie Bernard Dispositif de positionnement et de calage d'un garde corps escamotable sur plateforme support de banches
CN104994839A (zh) * 2013-02-13 2015-10-21 诺华股份有限公司 局部眼用镇痛剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERNARD P. ROQUES ET AL.: "Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain", 《NATURE REVIEW DRUG DISCOVERY》 *

Also Published As

Publication number Publication date
ZA201804037B (en) 2020-07-29
US10688113B2 (en) 2020-06-23
HK1259181A1 (zh) 2019-11-29
MX382921B (es) 2025-03-13
FR3044227B1 (fr) 2017-11-24
FR3044227A1 (fr) 2017-06-02
TWI729039B (zh) 2021-06-01
CN108289901B (zh) 2021-05-04
BR112018010007A2 (pt) 2018-11-21
CN108289901A (zh) 2018-07-17
TW201726146A (zh) 2017-08-01
MX2018006580A (es) 2018-08-01
DK3383403T3 (da) 2020-03-16
KR102657652B1 (ko) 2024-04-15
US20190167701A1 (en) 2019-06-06
WO2017093322A1 (fr) 2017-06-08
KR20180095555A (ko) 2018-08-27
JP6889176B2 (ja) 2021-06-18
IL259562A (en) 2018-07-31
US20180344753A1 (en) 2018-12-06
CA3006365A1 (fr) 2017-06-08
JP2018536714A (ja) 2018-12-13
EP3383403B1 (fr) 2019-12-25
ES2773148T3 (es) 2020-07-09
IL259562B (en) 2020-08-31
EP3383403A1 (fr) 2018-10-10

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