ES2759507T3 - Método para predecir una respuesta de tratamiento a un antagonista de V1B en un paciente con síntomas depresivos y/o de ansiedad - Google Patents

Método para predecir una respuesta de tratamiento a un antagonista de V1B en un paciente con síntomas depresivos y/o de ansiedad Download PDF

Info

Publication number
ES2759507T3
ES2759507T3 ES14736319T ES14736319T ES2759507T3 ES 2759507 T3 ES2759507 T3 ES 2759507T3 ES 14736319 T ES14736319 T ES 14736319T ES 14736319 T ES14736319 T ES 14736319T ES 2759507 T3 ES2759507 T3 ES 2759507T3
Authority
ES
Spain
Prior art keywords
snp
nucleotide
seq
represented
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14736319T
Other languages
English (en)
Spanish (es)
Inventor
Florian Holsboer
Bertram Müller-Myhsok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Application granted granted Critical
Publication of ES2759507T3 publication Critical patent/ES2759507T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES14736319T 2013-06-17 2014-06-16 Método para predecir una respuesta de tratamiento a un antagonista de V1B en un paciente con síntomas depresivos y/o de ansiedad Active ES2759507T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1310782.6A GB201310782D0 (en) 2013-06-17 2013-06-17 Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
PCT/EP2014/062592 WO2014202541A1 (en) 2013-06-17 2014-06-16 Method for predicting a treatment response to a crhr1 antagonist and/or a v1b antagonist in a patient with depressive and/or anxiety symptoms

Publications (1)

Publication Number Publication Date
ES2759507T3 true ES2759507T3 (es) 2020-05-11

Family

ID=48914695

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14736319T Active ES2759507T3 (es) 2013-06-17 2014-06-16 Método para predecir una respuesta de tratamiento a un antagonista de V1B en un paciente con síntomas depresivos y/o de ansiedad

Country Status (8)

Country Link
US (2) US10190168B2 (enExample)
EP (2) EP3623483A1 (enExample)
JP (1) JP6689743B2 (enExample)
CA (1) CA2914866C (enExample)
DK (1) DK3011048T3 (enExample)
ES (1) ES2759507T3 (enExample)
GB (1) GB201310782D0 (enExample)
WO (1) WO2014202541A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201210686D0 (en) 2012-06-15 2012-08-01 Holsboermaschmeyer Neurochemie Gmbh V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en) 2013-06-17 2013-07-31 Max Planck Innovation Gmbh Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
AU2016240213B2 (en) * 2015-04-02 2022-01-27 HMNC Holding GmbH Method of treatment using genetic predictors of a response to treatment with CRHR1 antagonists
AU2016240212B2 (en) * 2015-04-02 2022-01-27 HMNC Holding GmbH Genetic predictors of a response to treatment with CRHR1 antagonists
WO2017035528A1 (en) * 2015-08-27 2017-03-02 Nantneuro, Llc Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau
CN113632174B (zh) 2019-01-23 2025-03-25 密歇根大学董事会 用于nmda、甘氨酸和ampa受体的调节剂的药物基因组学决策支持
WO2022200966A1 (en) * 2021-03-23 2022-09-29 Iluria Ltd. Diagnosis and monitoring medical treatment effectivness for anxiety and depression disorders

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0674641B1 (en) 1992-12-17 1999-03-03 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
HUT74464A (en) 1993-10-12 1996-12-30 Du Pont Merck Pharma 1n-alkyl-n-arylpyrimidinamines and derivatives thereof, and pharmaceutical compositions containing them
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US5591588A (en) 1994-09-20 1997-01-07 Gideon Goldstein Method for the diagnosis of depression based on monitoring blood levels of arginine vasopressin and/or thymopoietin
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
PL191271B1 (pl) 1996-02-07 2006-04-28 Neurocrine Biosciences Inc Pochodna pirazolopirymidyny i jej zastosowanie oraz kompozycja farmaceutyczna
EA006626B1 (ru) 1996-07-24 2006-02-24 Дюпон Фармасьютикалз Компани Азолопиримидины, фармацевтическая композиция и способ лечения
US6060478A (en) 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
FR2796380B3 (fr) 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
US20030092019A1 (en) * 2001-01-09 2003-05-15 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
ATE355102T1 (de) 2001-03-13 2006-03-15 Bristol Myers Squibb Pharma Co 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6- methoxypyrid-3-yl) pyrazolo- 1,5-aö-1,3,5-triazin,seine enantiomeren und pharmazeutisch annehmbare salze als corticotropin-releasing-factor-rezeptor-ligande
EP1514946A4 (en) 2002-05-17 2006-06-07 Riken METHOD FOR DETECTING GENE POLYMORPHISM
GR1004664B (en) 2002-11-26 2004-09-02 Bionature E A Ltd The charakteristics and advantages of our invention are illustrated by the following description, methods and results of our research, attached figures and supporting references
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
EP1659121A4 (en) 2003-08-28 2008-11-26 Taisho Pharmaceutical Co Ltd 1,3-dihydro-2H-indol-2-one derivative
US20050069936A1 (en) 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US20080118918A1 (en) 2004-08-13 2008-05-22 The Regents Of The University Of California Compositions and Methods For Determining and Predicting Treatment Responses For Depression and Anxiety
EP1628136A1 (en) 2004-08-19 2006-02-22 B.R.A.H.M.S. Aktiengesellschaft Method of diagnosis of disease using copeptin
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
JP2008526702A (ja) * 2004-12-31 2008-07-24 アボット ゲーエムベーハー ウント カンパニー カーゲー 置換オキシインドール誘導体、該誘導体を含んでいる薬物及びそれらの使用
JP5125501B2 (ja) 2005-01-28 2013-01-23 大正製薬株式会社 １，３−ジヒドロ−２ｈ−インドール−２−オン化合物、及び芳香族複素環が縮合したピロリジン−２−オン化合物
BRPI0711872A2 (pt) 2006-05-22 2011-12-06 Vanda Pharmaceuticals Inc tratamento para distúrbios depressivos
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
WO2009113985A1 (en) 2008-03-13 2009-09-17 Maria Athanasiou Genetic markers associated with response to antidepressants
WO2009130232A1 (en) 2008-04-24 2009-10-29 Glaxo Group Limited Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors
US9644240B2 (en) * 2009-10-22 2017-05-09 Leiden University Disease susceptibility
US20150278438A1 (en) 2012-04-23 2015-10-01 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Genetic predictors of response to treatment with crhr1 antagonists
EP2841068B8 (en) 2012-04-23 2019-03-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Crhr1 antagonists for use in the treatment of patients having crh overactivity
GB201210686D0 (en) * 2012-06-15 2012-08-01 Holsboermaschmeyer Neurochemie Gmbh V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en) 2013-06-17 2013-07-31 Max Planck Innovation Gmbh Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms

Also Published As

Publication number Publication date
CA2914866A1 (en) 2014-12-24
JP2016521987A (ja) 2016-07-28
US10190168B2 (en) 2019-01-29
US10837062B2 (en) 2020-11-17
WO2014202541A1 (en) 2014-12-24
EP3011048B1 (en) 2019-08-07
CA2914866C (en) 2024-09-10
US20160153043A1 (en) 2016-06-02
EP3011048A1 (en) 2016-04-27
US20190194752A1 (en) 2019-06-27
JP6689743B2 (ja) 2020-04-28
GB201310782D0 (en) 2013-07-31
EP3623483A1 (en) 2020-03-18
DK3011048T3 (da) 2019-11-04

Similar Documents

Publication Publication Date Title
ES2759507T3 (es) Método para predecir una respuesta de tratamiento a un antagonista de V1B en un paciente con síntomas depresivos y/o de ansiedad
Montag et al. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case–control study
Wendland et al. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
Li et al. Genes associated with autism spectrum disorder
Adriani et al. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity
Kirby et al. Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis
Nymberg et al. Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype
Gui et al. Evidence for polymerase gamma, POLG1 variation in reduced mitochondrial DNA copy number in Parkinson's disease
US20150278438A1 (en) Genetic predictors of response to treatment with crhr1 antagonists
Kumar et al. Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia
EP2841068B1 (en) Crhr1 antagonists for use in the treatment of patients having crh overactivity
Nöthen et al. New findings in the genetics of major psychoses
Tsai et al. Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation
Holt et al. Links between genetics and pathophysiology in the autism spectrum disorders
ES2873926T3 (es) Método para predecir una respuesta al tratamiento con un antagonista del receptor V1B en un paciente con síntomas depresivos y/o síntomas de ansiedad
Pehlivan et al. The role of combined SNV and CNV burden in patients with distal symmetric polyneuropathy
Iamjan et al. Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis
JP2018516231A (ja) Ｃｒｈｒ１拮抗薬を用いた治療に対する反応の遺伝子予測因子を用いた治療の方法
Kim et al. LAMB1 polymorphism is associated with autism symptom severity in Korean autism spectrum disorder patients
ES2724100T3 (es) Factores de predicción genéticos de una respuesta al tratamiento con antagonistas de CRHR1
Oh et al. Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke
MacIntyre et al. Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population
KR102158673B1 (ko) 양극성장애 환자의 계절성 또는 일주기 변화 진단을 위한 단일염기다형성 마커를 이용한 정보 제공 방법
Huang et al. Silencer variants are key drivers of gene upregulation in Alzheimer’s disease
Krohn et al. Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies