ES2745525T3 - Compuestos de aminopiridina sustituida con heteroarilo - Google Patents
Compuestos de aminopiridina sustituida con heteroarilo Download PDFInfo
- Publication number
- ES2745525T3 ES2745525T3 ES16734538T ES16734538T ES2745525T3 ES 2745525 T3 ES2745525 T3 ES 2745525T3 ES 16734538 T ES16734538 T ES 16734538T ES 16734538 T ES16734538 T ES 16734538T ES 2745525 T3 ES2745525 T3 ES 2745525T3
- Authority
- ES
- Spain
- Prior art keywords
- pyridin
- pyrazolo
- carbonitrile
- triazol
- isopropylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CN(C1N=C2*)C=NC1C=C2[Rh] Chemical compound CN(C1N=C2*)C=NC1C=C2[Rh] 0.000 description 8
- SGTGXXLTWWAIDL-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1c[n](CC(F)(F)F)nc1 Chemical compound CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1c[n](CC(F)(F)F)nc1 SGTGXXLTWWAIDL-UHFFFAOYSA-N 0.000 description 1
- WRWNPDTZJNLWHL-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1cc(C2CNC2)n[o]1 Chemical compound CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1cc(C2CNC2)n[o]1 WRWNPDTZJNLWHL-UHFFFAOYSA-N 0.000 description 1
- SWRKUPLIPIEAOS-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCN(CC(F)F)CC2)c1 Chemical compound CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCN(CC(F)F)CC2)c1 SWRKUPLIPIEAOS-UHFFFAOYSA-N 0.000 description 1
- CPLQNQBMMGLAAJ-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCNCC2)c1 Chemical compound CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCNCC2)c1 CPLQNQBMMGLAAJ-UHFFFAOYSA-N 0.000 description 1
- GVPHIPBSKCVWBA-DLBZAZTESA-N CC(C)Nc(cc(nc1)Cl)c1-c1c[n]([C@@H](CCN(C2)C(OC(C)(C)C)=O)[C@@H]2O)nn1 Chemical compound CC(C)Nc(cc(nc1)Cl)c1-c1c[n]([C@@H](CCN(C2)C(OC(C)(C)C)=O)[C@@H]2O)nn1 GVPHIPBSKCVWBA-DLBZAZTESA-N 0.000 description 1
- CNAUUJIWAQALDJ-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(C)C)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(C)C)nn1 CNAUUJIWAQALDJ-UHFFFAOYSA-N 0.000 description 1
- HIUCJCFXTWGEIE-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(CC2CC2)=O)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(CC2CC2)=O)nn1 HIUCJCFXTWGEIE-UHFFFAOYSA-N 0.000 description 1
- JMLWLLVDDWTHOR-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1cc(C(C2)CN2C(C)=O)n[o]1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1cc(C(C2)CN2C(C)=O)n[o]1 JMLWLLVDDWTHOR-UHFFFAOYSA-N 0.000 description 1
- BFKKIDHWWRDAPL-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3cc(C#N)cnc23)ncc1-c1c[n](C(C2)CN2c2nnc(C)[o]2)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3cc(C#N)cnc23)ncc1-c1c[n](C(C2)CN2c2nnc(C)[o]2)nn1 BFKKIDHWWRDAPL-UHFFFAOYSA-N 0.000 description 1
- ZRJCNMYMCUBLAI-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1c[nH]nc1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[nH]nc1 ZRJCNMYMCUBLAI-UHFFFAOYSA-N 0.000 description 1
- QGSSQOPZQYGFHL-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1c[n](CC(C)F)nn1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[n](CC(C)F)nn1 QGSSQOPZQYGFHL-UHFFFAOYSA-N 0.000 description 1
- UMBXYHRYEHEXSL-SFHVURJKSA-N CC(C)Nc1cc(Cl)ncc1-c1c[n](C[C@H](Cc2ccccc2)NC(OC(C)(C)C)=O)nn1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[n](C[C@H](Cc2ccccc2)NC(OC(C)(C)C)=O)nn1 UMBXYHRYEHEXSL-SFHVURJKSA-N 0.000 description 1
- JNDCZWRSJRYUDD-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)CCN2C(OC(C)(C)C)=O)=O)[o]1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)CCN2C(OC(C)(C)C)=O)=O)[o]1 JNDCZWRSJRYUDD-UHFFFAOYSA-N 0.000 description 1
- IMFLIGANAFVVEX-UHFFFAOYSA-O CC(C)Nc1cc(Cl)ncc1C(N=N)=C[NH2+]CC(C)F Chemical compound CC(C)Nc1cc(Cl)ncc1C(N=N)=C[NH2+]CC(C)F IMFLIGANAFVVEX-UHFFFAOYSA-O 0.000 description 1
- GTVJTOUCOLLRGC-UHFFFAOYSA-N CC(C)[n]1ncc(O)c1 Chemical compound CC(C)[n]1ncc(O)c1 GTVJTOUCOLLRGC-UHFFFAOYSA-N 0.000 description 1
- JANHZYJACYIJQP-UHFFFAOYSA-N CCCN1C=NC2C=NC([Rh])=NC12 Chemical compound CCCN1C=NC2C=NC([Rh])=NC12 JANHZYJACYIJQP-UHFFFAOYSA-N 0.000 description 1
- NOEFIUWJGDCTGB-UHFFFAOYSA-N CCOC(c(c(NC(C)C)c1)cnc1-[n](cc1)c2c1cncn2)=O Chemical compound CCOC(c(c(NC(C)C)c1)cnc1-[n](cc1)c2c1cncn2)=O NOEFIUWJGDCTGB-UHFFFAOYSA-N 0.000 description 1
- BLHTXORQJNCSII-UHFFFAOYSA-N Cc1c[n](C)cn1 Chemical compound Cc1c[n](C)cn1 BLHTXORQJNCSII-UHFFFAOYSA-N 0.000 description 1
- SZQCPPRPWDXLMM-UHFFFAOYSA-N Cc1c[n](C)nc1 Chemical compound Cc1c[n](C)nc1 SZQCPPRPWDXLMM-UHFFFAOYSA-N 0.000 description 1
- FICAQKBMCKEFDI-UHFFFAOYSA-N Cc1n[o]c(C)c1 Chemical compound Cc1n[o]c(C)c1 FICAQKBMCKEFDI-UHFFFAOYSA-N 0.000 description 1
- ZOEPGDLOKCFSAJ-WOJBJXKFSA-N N#Cc1cc(cn[n]2-c(nc3)cc(NC4CC4)c3-c3c[n]([C@H](CNCC4)[C@@H]4O)nn3)c2nc1 Chemical compound N#Cc1cc(cn[n]2-c(nc3)cc(NC4CC4)c3-c3c[n]([C@H](CNCC4)[C@@H]4O)nn3)c2nc1 ZOEPGDLOKCFSAJ-WOJBJXKFSA-N 0.000 description 1
- DEJUUKULVAIMNF-UHFFFAOYSA-N Nc1cc(Cl)ncc1I Chemical compound Nc1cc(Cl)ncc1I DEJUUKULVAIMNF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1877DE2015 | 2015-06-24 | ||
| PCT/US2016/038858 WO2016210034A1 (en) | 2015-06-24 | 2016-06-23 | Heteroaryl substituted aminopyridine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2745525T3 true ES2745525T3 (es) | 2020-03-02 |
Family
ID=56322320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16734538T Active ES2745525T3 (es) | 2015-06-24 | 2016-06-23 | Compuestos de aminopiridina sustituida con heteroarilo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10294229B2 (OSRAM) |
| EP (1) | EP3313840B1 (OSRAM) |
| JP (1) | JP6843775B2 (OSRAM) |
| CN (1) | CN107849039B (OSRAM) |
| AR (1) | AR105113A1 (OSRAM) |
| ES (1) | ES2745525T3 (OSRAM) |
| TW (1) | TW201718571A (OSRAM) |
| UY (1) | UY36748A (OSRAM) |
| WO (1) | WO2016210034A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108026099B (zh) * | 2015-06-24 | 2020-07-10 | 百时美施贵宝公司 | 经杂芳基取代的氨基吡啶化合物 |
| TWI825663B (zh) * | 2016-10-14 | 2023-12-11 | 美商林伯士拉克許米公司 | Tyk2抑制劑及其用途 |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| EA039189B1 (ru) | 2017-05-11 | 2021-12-15 | Бристол-Маерс Сквибб Компани | Тиенопиридины и бензотиофены в качестве ингибиторов irak4 |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| IL322809A (en) | 2017-09-22 | 2025-10-01 | Kymera Therapeutics Inc | Protein Decomposers and Their Uses |
| TWI876442B (zh) * | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| TWI797366B (zh) | 2018-08-13 | 2023-04-01 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒衍生物 |
| TWI727392B (zh) * | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| CN112533924B (zh) * | 2018-08-13 | 2023-11-28 | 吉利德科学公司 | 作为IRAK4抑制剂的吡咯并[1,2-b]哒嗪衍生物 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CN109836376B (zh) * | 2019-04-10 | 2022-03-22 | 江苏汉阔生物有限公司 | 一种以2，3-吡啶二羧酸为原料制备2-氯代烟酸的方法 |
| US12304914B2 (en) | 2019-07-18 | 2025-05-20 | Bristol-Myers Squibb Company | Pyrazolo[3,4-d]pyrrolo[1,2-b]pyridazinyl compounds useful as IRAK4 inhibitors |
| US12286428B2 (en) | 2019-07-18 | 2025-04-29 | Bristol-Myers Squibb Company | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors |
| ES3036306T3 (en) * | 2019-07-23 | 2025-09-17 | Bristol Myers Squibb Co | Thienopyridinyl and thiazolopyridinyl compounds useful as irak4 inhibitors |
| ES2983263T3 (es) | 2019-08-06 | 2024-10-22 | Bristol Myers Squibb Co | Compuestos heterocíclicos bicíclicos útiles como inhibidores de IRAK4 |
| US11578071B2 (en) | 2019-10-04 | 2023-02-14 | University Of Kentucky Research Foundation | Preparation of pyrazolo[3,4-B]pyridines as antimalarials |
| JP2023509366A (ja) | 2019-12-17 | 2023-03-08 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| MX2022007455A (es) | 2019-12-18 | 2022-08-15 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como plaguicidas. |
| WO2021158495A1 (en) | 2020-02-03 | 2021-08-12 | Bristol-Myers Squibb Company | Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as irak4 inhibitors |
| EP4107158A1 (en) * | 2020-02-19 | 2022-12-28 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| MX2023007852A (es) | 2020-12-30 | 2023-07-07 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
| EP4291187A4 (en) | 2021-02-15 | 2025-01-15 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| CN117715904A (zh) | 2021-05-07 | 2024-03-15 | 凯麦拉医疗公司 | Cdk2降解剂和其用途 |
| EP4367118B1 (en) | 2021-08-18 | 2025-01-29 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
| EP4422635A4 (en) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS |
| AU2023214044A1 (en) | 2022-01-31 | 2024-08-08 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1399440B1 (en) | 2001-06-15 | 2009-06-03 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl)benzisoxazoles as protein kinase inhibitors |
| AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
| GB0211019D0 (en) | 2002-05-14 | 2002-06-26 | Syngenta Ltd | Novel compounds |
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| MXPA05007503A (es) | 2003-01-17 | 2005-09-21 | Warner Lambert Co | Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular. |
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-
2016
- 2016-06-23 WO PCT/US2016/038858 patent/WO2016210034A1/en not_active Ceased
- 2016-06-23 UY UY0001036748A patent/UY36748A/es not_active Application Discontinuation
- 2016-06-23 US US15/738,362 patent/US10294229B2/en active Active
- 2016-06-23 AR ARP160101892A patent/AR105113A1/es unknown
- 2016-06-23 ES ES16734538T patent/ES2745525T3/es active Active
- 2016-06-23 CN CN201680040987.7A patent/CN107849039B/zh active Active
- 2016-06-23 TW TW105119777A patent/TW201718571A/zh unknown
- 2016-06-23 JP JP2017566643A patent/JP6843775B2/ja active Active
- 2016-06-23 EP EP16734538.8A patent/EP3313840B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| UY36748A (es) | 2016-12-30 |
| JP2018522859A (ja) | 2018-08-16 |
| AR105113A1 (es) | 2017-09-06 |
| JP6843775B2 (ja) | 2021-03-17 |
| CN107849039B (zh) | 2020-07-03 |
| EP3313840B1 (en) | 2019-07-24 |
| US20180186799A1 (en) | 2018-07-05 |
| TW201718571A (zh) | 2017-06-01 |
| WO2016210034A1 (en) | 2016-12-29 |
| US10294229B2 (en) | 2019-05-21 |
| EP3313840A1 (en) | 2018-05-02 |
| CN107849039A (zh) | 2018-03-27 |
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