ES2743921T3 - Derivados de panteteína estables para el tratamiento de la neurodegeneración asociada a pantotenato quinasa (PKAN) y métodos para la síntesis de tales compuestos - Google Patents
Derivados de panteteína estables para el tratamiento de la neurodegeneración asociada a pantotenato quinasa (PKAN) y métodos para la síntesis de tales compuestos Download PDFInfo
- Publication number
- ES2743921T3 ES2743921T3 ES14790616T ES14790616T ES2743921T3 ES 2743921 T3 ES2743921 T3 ES 2743921T3 ES 14790616 T ES14790616 T ES 14790616T ES 14790616 T ES14790616 T ES 14790616T ES 2743921 T3 ES2743921 T3 ES 2743921T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- methyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- MTAAFLMZZIYJHI-UHFFFAOYSA-N CC(Oc1ccccc1CCC(O)=O)=O Chemical compound CC(Oc1ccccc1CCC(O)=O)=O MTAAFLMZZIYJHI-UHFFFAOYSA-N 0.000 description 1
- ANMYMLIUCWWISO-UHFFFAOYSA-N CCc(cc1)ccc1OC(C)=O Chemical compound CCc(cc1)ccc1OC(C)=O ANMYMLIUCWWISO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20130191457 EP2868662A1 (en) | 2013-11-04 | 2013-11-04 | Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds |
| PCT/EP2014/073258 WO2015063177A1 (en) | 2013-11-04 | 2014-10-29 | Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2743921T3 true ES2743921T3 (es) | 2020-02-21 |
Family
ID=49518786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14790616T Active ES2743921T3 (es) | 2013-11-04 | 2014-10-29 | Derivados de panteteína estables para el tratamiento de la neurodegeneración asociada a pantotenato quinasa (PKAN) y métodos para la síntesis de tales compuestos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9963472B2 (enExample) |
| EP (2) | EP2868662A1 (enExample) |
| JP (1) | JP6568536B2 (enExample) |
| CN (1) | CN105764909B (enExample) |
| AU (1) | AU2014343730B2 (enExample) |
| CA (1) | CA2929369C (enExample) |
| DK (1) | DK3066106T3 (enExample) |
| ES (1) | ES2743921T3 (enExample) |
| WO (1) | WO2015063177A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI24899A (sl) * | 2014-12-23 | 2016-06-30 | Acies Bio D.O.O. | Fosfopanteteinske spojine,same ali v kombinaciji z inhibitorji HMG-COA reduktaze za zniževanje serumskega holesterola in serumskih trigliceridov |
| EP3386995A1 (en) * | 2015-12-08 | 2018-10-17 | Retrophin, Inc. | Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders |
| EP3471828A1 (en) | 2016-06-16 | 2019-04-24 | Acies Bio d.o.o. | Compositions and methods useful for treating diseases characterized by insufficient pantothenate kinase activity |
| JP2019523259A (ja) * | 2016-07-25 | 2019-08-22 | レトロフィン， インコーポレイテッド | 神経性障害の処置のためのパンテテイン誘導体 |
| CN106365998A (zh) * | 2016-08-19 | 2017-02-01 | 陕西思尔生物科技有限公司 | 一种特戊酸碘甲酯的制备方法 |
| CN107422056B (zh) * | 2017-08-17 | 2020-04-24 | 山东裕欣药业有限公司 | 一种特戊酸碘甲酯的气相色谱检测方法及其制备方法 |
| AU2019389168A1 (en) * | 2018-11-30 | 2021-06-24 | Comet Therapeutics, Inc. | Pantetheine derivatives and uses thereof |
| CN115919822A (zh) * | 2022-10-12 | 2023-04-07 | 深圳大学 | 泛硫乙胺在治疗阿尔茨海默病中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE532299A (enExample) * | 1953-10-07 | |||
| AU2002326412A1 (en) | 2001-07-20 | 2003-03-03 | Oregon Health And Science University | Novel human nucleic acids encoding a pantothenate kinase and methods of use |
| WO2012017400A1 (en) | 2010-08-03 | 2012-02-09 | North-West University | Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives |
| SI3112372T1 (sl) * | 2012-04-27 | 2019-04-30 | Retrophin, Inc. | Derivati pantotenata za zdravljenje nevroloških motenj |
-
2013
- 2013-11-04 EP EP20130191457 patent/EP2868662A1/en not_active Withdrawn
-
2014
- 2014-10-29 US US15/034,244 patent/US9963472B2/en not_active Expired - Fee Related
- 2014-10-29 CN CN201480060274.8A patent/CN105764909B/zh active Active
- 2014-10-29 EP EP14790616.8A patent/EP3066106B1/en active Active
- 2014-10-29 CA CA2929369A patent/CA2929369C/en active Active
- 2014-10-29 DK DK14790616.8T patent/DK3066106T3/da active
- 2014-10-29 ES ES14790616T patent/ES2743921T3/es active Active
- 2014-10-29 AU AU2014343730A patent/AU2014343730B2/en not_active Ceased
- 2014-10-29 WO PCT/EP2014/073258 patent/WO2015063177A1/en not_active Ceased
- 2014-10-29 JP JP2016550994A patent/JP6568536B2/ja not_active Expired - Fee Related
-
2017
- 2017-12-21 US US15/850,252 patent/US20180118767A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK3066106T3 (da) | 2019-09-16 |
| CN105764909A (zh) | 2016-07-13 |
| US20160297840A1 (en) | 2016-10-13 |
| JP2016536360A (ja) | 2016-11-24 |
| AU2014343730B2 (en) | 2019-08-01 |
| EP3066106B1 (en) | 2019-08-14 |
| US9963472B2 (en) | 2018-05-08 |
| CN105764909B (zh) | 2019-12-06 |
| WO2015063177A1 (en) | 2015-05-07 |
| CA2929369C (en) | 2023-10-17 |
| CA2929369A1 (en) | 2015-05-07 |
| JP6568536B2 (ja) | 2019-08-28 |
| EP3066106A1 (en) | 2016-09-14 |
| US20180118767A1 (en) | 2018-05-03 |
| EP2868662A1 (en) | 2015-05-06 |
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