CN105764909B - 用于治疗泛酸激酶相关神经变性(pkan)的稳定泛酰巯基乙胺衍生物及用于合成这样的化合物的方法 - Google Patents

用于治疗泛酸激酶相关神经变性(pkan)的稳定泛酰巯基乙胺衍生物及用于合成这样的化合物的方法 Download PDF

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CN105764909B
CN105764909B CN201480060274.8A CN201480060274A CN105764909B CN 105764909 B CN105764909 B CN 105764909B CN 201480060274 A CN201480060274 A CN 201480060274A CN 105764909 B CN105764909 B CN 105764909B
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phosphopantethein
phosphopantetheine
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CN105764909A (zh
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布兰科·延科
格雷格·科塞茨
赫尔沃耶·佩特科维科
艾达·波德戈塞克贝尔克
热尔卡·帕霍尔
阿伦·库萨科
奥达·科妮莉亚·玛丽亚·西邦
巴拉吉·斯里尼瓦桑
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Rijksuniversiteit Groningen
Academisch Ziekenhuis Groningen
Acies Bio doo
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Academisch Ziekenhuis Groningen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480060274.8A 2013-11-04 2014-10-29 用于治疗泛酸激酶相关神经变性(pkan)的稳定泛酰巯基乙胺衍生物及用于合成这样的化合物的方法 Active CN105764909B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13191457.4 2013-11-04
EP20130191457 EP2868662A1 (en) 2013-11-04 2013-11-04 Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds
PCT/EP2014/073258 WO2015063177A1 (en) 2013-11-04 2014-10-29 Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds

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CN105764909B true CN105764909B (zh) 2019-12-06

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AU (1) AU2014343730B2 (enExample)
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DK (1) DK3066106T3 (enExample)
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SI24899A (sl) * 2014-12-23 2016-06-30 Acies Bio D.O.O. Fosfopanteteinske spojine,same ali v kombinaciji z inhibitorji HMG-COA reduktaze za zniževanje serumskega holesterola in serumskih trigliceridov
WO2017099822A1 (en) * 2015-12-08 2017-06-15 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
EP3471828A1 (en) 2016-06-16 2019-04-24 Acies Bio d.o.o. Compositions and methods useful for treating diseases characterized by insufficient pantothenate kinase activity
WO2018022529A1 (en) * 2016-07-25 2018-02-01 Retrophin, Inc. Pantetheine derivatives for the treatment of neurologic disorders
CN106365998A (zh) * 2016-08-19 2017-02-01 陕西思尔生物科技有限公司 一种特戊酸碘甲酯的制备方法
CN107422056B (zh) * 2017-08-17 2020-04-24 山东裕欣药业有限公司 一种特戊酸碘甲酯的气相色谱检测方法及其制备方法
WO2020113209A1 (en) * 2018-11-30 2020-06-04 Comet Therapeutics, Inc. Pantetheine derivatives and uses thereof
CN115919822A (zh) * 2022-10-12 2023-04-07 深圳大学 泛硫乙胺在治疗阿尔茨海默病中的应用

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WO2013163576A1 (en) * 2012-04-27 2013-10-31 Retrophin, Inc. Pantothenate derivatives for the treatment of neurologic disorders

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WO2013163576A1 (en) * 2012-04-27 2013-10-31 Retrophin, Inc. Pantothenate derivatives for the treatment of neurologic disorders

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DK3066106T3 (da) 2019-09-16
CA2929369C (en) 2023-10-17
JP2016536360A (ja) 2016-11-24
CA2929369A1 (en) 2015-05-07
EP3066106B1 (en) 2019-08-14
WO2015063177A1 (en) 2015-05-07
US20160297840A1 (en) 2016-10-13
ES2743921T3 (es) 2020-02-21
JP6568536B2 (ja) 2019-08-28
US9963472B2 (en) 2018-05-08
CN105764909A (zh) 2016-07-13
EP3066106A1 (en) 2016-09-14
EP2868662A1 (en) 2015-05-06
US20180118767A1 (en) 2018-05-03
AU2014343730B2 (en) 2019-08-01

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