ES2743232T3 - Métodos para la activación o eliminación controlada de células terapéuticas - Google Patents

Métodos para la activación o eliminación controlada de células terapéuticas Download PDF

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ES2743232T3
ES2743232T3 ES15823866T ES15823866T ES2743232T3 ES 2743232 T3 ES2743232 T3 ES 2743232T3 ES 15823866 T ES15823866 T ES 15823866T ES 15823866 T ES15823866 T ES 15823866T ES 2743232 T3 ES2743232 T3 ES 2743232T3
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region
multimerization region
chimeric polypeptide
multimerization
polypeptide comprises
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David Spencer
Joseph Bayle
Aaron Foster
Kevin Slawin
Annemarie Moseley
Matthew Collinson-Pautz
Mylinh Duong
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Bellicum Pharmaceuticals Inc
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Bellicum Pharmaceuticals Inc
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Un ácido nucleico que comprende un promotor, unido operativamente a a) un primer polinucleótido que codifica un primer polipéptido quimérico, en donde el primer polipéptido quimérico comprende (i) una primera región de multimerización o una segunda región de multimerización; y (ii) una región de polipéptido MyD88 o una región de polipéptido MyD88 truncada que carece del dominio TIR; y b) un segundo polinucleótido que codifica un segundo polipéptido quimérico, en donde el segundo polipéptido quimérico comprende (i) una región de polipéptido proapoptótico y (ii) la primera región de multimerización o la segunda región de multimerización, en donde la segunda región de multimerización tiene una secuencia de aminoácidos diferente a la primera región de multimerización; el primer polipéptido quimérico comprende la primera región de multimerización y el segundo polipéptido quimérico comprende la segunda región de multimerización o el primer polipéptido quimérico comprende la segunda región de multimerización y el segundo polipéptido quimérico comprende la primera región de multimerización; la primera región de multimerización y la segunda región de multimerización se unen a un primer ligando; la primera región de multimerización se une a un segundo ligando; y el segundo ligando no se une significativamente a la segunda región de multimerización.
ES15823866T 2014-12-15 2015-12-14 Métodos para la activación o eliminación controlada de células terapéuticas Active ES2743232T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462092149P 2014-12-15 2014-12-15
US201562148386P 2015-04-16 2015-04-16
PCT/US2015/065646 WO2016100241A2 (en) 2014-12-15 2015-12-14 Methods for controlled activation or elimination of therapeutic cells

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ES2743232T3 true ES2743232T3 (es) 2020-02-18

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ES15823866T Active ES2743232T3 (es) 2014-12-15 2015-12-14 Métodos para la activación o eliminación controlada de células terapéuticas

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US (2) US20160175359A1 (es)
EP (2) EP3234145B1 (es)
JP (2) JP6720176B2 (es)
AU (2) AU2015362753A1 (es)
CA (1) CA2966241A1 (es)
DK (1) DK3234145T3 (es)
ES (1) ES2743232T3 (es)
HK (1) HK1245827B (es)
WO (1) WO2016100241A2 (es)

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