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Merck KGaA
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E Merck AG
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Application filed by E Merck AGfiledCriticalE Merck AG
Publication of ES274241A1publicationCriticalpatent/ES274241A1/en
Process for the preparation of alkylthio steroids of the general formula I ** (See formula) ** in which R = alfaR2, betaOR1 R1 = H or acyl R2 = H, CH3 = -C = CH R3 = alkyl with 5 carbon atoms at most X = H, H o H, CH o =0 Y = H o F Z = H,H o CH2 and R2, X, Y and Z can mean, not simultaneously, hydrogen, as well as its 1-dehydro derivatives, characterized in that a 4,6-dien-3-keto-steroid of the general formula II is reacted ** (See formula) ** in which R, X, Y and Z, have the meaning already expressed, with an alkylmercaptan having at most 5 carbon atoms, dehydrogenated optionally in position 1,2, in a known manner and by chemical or microbiological means, the 7alpha-alkylthio steroid of the formula I, and optionally the ester groups are saponified and/or the hydrophilic groups existing in the intermediate or final products obtained are esterified. (Machine-translation by Google Translate, not legally binding)
ES0274241A1961-02-021962-02-01Procedure for the preparation of alkylite-steroids (Machine-translation by Google Translate, not legally binding)
ExpiredES274241A1
(en)
A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)
Procedure of 11, b 13 b-di alkiloon - 4 - eno - 3,17 b - dicle, replaced with unsaturated hydrocarbons in position 17 and their steres. (Machine-translation by Google Translate, not legally binding)