ES410933A1 - 15alpha,16alpha-methylene-delta4-oestren-17beta-ols - Google Patents

15alpha,16alpha-methylene-delta4-oestren-17beta-ols

Info

Publication number
ES410933A1
ES410933A1 ES410933A ES410933A ES410933A1 ES 410933 A1 ES410933 A1 ES 410933A1 ES 410933 A ES410933 A ES 410933A ES 410933 A ES410933 A ES 410933A ES 410933 A1 ES410933 A1 ES 410933A1
Authority
ES
Spain
Prior art keywords
methylene
hydrogen
estren
general formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES410933A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES410933A1 publication Critical patent/ES410933A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Procedure for the preparation of 15α, 16α-methylene-4-estren-17β-ol of the general formula **(See formula)** wherein R1 signifies a lower alcohol radical, R2 signifies a hydrogen atom or an acyl radical; R means a hydrogen atom or a saturated or unsaturated, substituted or unsubstituted lower alcohol radical; X means an oxygen atom or the group H, OR4, in which R4 represents a hydrogen atom or an acyl radical, characterized in that a 15α, 16α-methylene-17-oxo-5 (6) - or - is reduced 5 (10) - premiere of the general formula **(See formula)** where R1 has the meanings indicated above and Y means a keto group, preferably protected in ketal form, with hydrogen or hydrogen donating agents, to form a 15α, 16α-methylene-5 (6) - or 5 (10) - estren-17β-ol (R3 = H) or with an organ-metal compound R3-metal to form a 15α, 16α-methylene-5 (6) - or 5 (10) -estren-17β-ol (R3 = saturated alcohol or unsaturated) of the general formula **(See formula)** where R1, R3 and Y have the meanings indicated above, if desired, a protective group introduced at the beginning is removed, with formation of a 15α, 16α-methylene-4-estren-17β-ol-3-one of the general formula **(See formula)** wherein R1 and R3 have the meanings indicated above, and, depending on the ultimately intended meanings of X, R2, and R4, eventually the 17-hydroxy group is esterified and/or the 3-keto group is reduced with hydrogen or hydrogen donors, and free hydroxy groups present in the molecule are esterified. (Machine-translation by Google Translate, not legally binding)
ES410933A 1972-02-11 1973-01-24 15alpha,16alpha-methylene-delta4-oestren-17beta-ols Expired ES410933A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2207421A DE2207421C3 (en) 1972-02-11 1972-02-11 15?, 16? -Methylene-4-oestrene-17? -ols or acylates, processes for their production and medicaments containing them

Publications (1)

Publication Number Publication Date
ES410933A1 true ES410933A1 (en) 1976-03-01

Family

ID=5836211

Family Applications (1)

Application Number Title Priority Date Filing Date
ES410933A Expired ES410933A1 (en) 1972-02-11 1973-01-24 15alpha,16alpha-methylene-delta4-oestren-17beta-ols

Country Status (29)

Country Link
JP (1) JPS5829317B2 (en)
KR (1) KR780000156B1 (en)
AT (1) AT327413B (en)
AU (1) AU467306B2 (en)
BE (1) BE795241A (en)
CA (1) CA997753A (en)
CH (2) CH593995A5 (en)
CS (1) CS193019B2 (en)
DD (1) DD102379A5 (en)
DE (1) DE2207421C3 (en)
DK (1) DK131037B (en)
EG (1) EG10914A (en)
ES (1) ES410933A1 (en)
FI (1) FI52225C (en)
FR (1) FR2181719B1 (en)
GB (1) GB1425636A (en)
GR (1) GR63160B (en)
HU (1) HU165253B (en)
IE (1) IE37266B1 (en)
IL (1) IL41506A (en)
NL (1) NL177217C (en)
NO (2) NO140304C (en)
PH (1) PH9370A (en)
PL (1) PL81084B1 (en)
RO (1) RO73527A (en)
SE (3) SE403781B (en)
SU (1) SU513628A3 (en)
YU (1) YU35035B (en)
ZA (1) ZA73944B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007027636A1 (en) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17β-Cyano-18α-homo-19-nor-androst-4-ene derivative, its use and the derivative-containing drug
DE102007027637A1 (en) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17β-cyano-19-nor-androst-4-ene derivative, its use and the derivative-containing drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT274653B (en) * 1966-11-10 1969-09-25 Alexander Schoeller & Co Kg Stackable, rectangular, closed plastic transport container for fine-grained bulk goods and liquids

Also Published As

Publication number Publication date
SE7514513L (en) 1975-12-22
EG10914A (en) 1976-09-30
DD102379A5 (en) 1973-12-12
AU5207673A (en) 1974-08-15
NL177217C (en) 1985-08-16
NO140304C (en) 1979-08-08
SE403781B (en) 1978-09-04
FR2181719B1 (en) 1975-11-21
SU513628A3 (en) 1976-05-05
SE409329B (en) 1979-08-13
FI52225C (en) 1977-07-11
FR2181719A1 (en) 1973-12-07
SE426834B (en) 1983-02-14
YU24373A (en) 1979-12-31
AU467306B2 (en) 1975-11-27
CH593995A5 (en) 1977-12-30
RO73527A (en) 1982-02-01
IL41506A (en) 1976-07-30
BE795241A (en) 1973-08-09
NO143065B (en) 1980-09-01
IE37266L (en) 1973-08-11
YU35035B (en) 1980-06-30
PL81084B1 (en) 1975-08-30
NO782754L (en) 1973-08-14
DE2207421A1 (en) 1973-08-16
DK131037B (en) 1975-05-20
IL41506A0 (en) 1973-04-30
JPS4886856A (en) 1973-11-15
HU165253B (en) 1974-07-27
FI52225B (en) 1977-03-31
AT327413B (en) 1976-01-26
DE2207421C3 (en) 1981-05-07
GB1425636A (en) 1976-02-18
ATA112473A (en) 1975-04-15
KR780000156B1 (en) 1978-05-02
DE2207421B2 (en) 1980-07-24
PH9370A (en) 1975-10-22
ZA73944B (en) 1973-11-28
NL177217B (en) 1985-03-18
DK131037C (en) 1975-10-20
GR63160B (en) 1979-09-25
NO143065C (en) 1980-12-10
SE7713896L (en) 1977-12-07
IE37266B1 (en) 1977-06-08
CH590883A5 (en) 1977-08-31
NL7301974A (en) 1973-08-14
NO140304B (en) 1979-04-30
CA997753A (en) 1976-09-28
CS193019B2 (en) 1979-09-17
JPS5829317B2 (en) 1983-06-22

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