ES2734743T3 - Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario - Google Patents

Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario Download PDF

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Publication number
ES2734743T3
ES2734743T3 ES16155285T ES16155285T ES2734743T3 ES 2734743 T3 ES2734743 T3 ES 2734743T3 ES 16155285 T ES16155285 T ES 16155285T ES 16155285 T ES16155285 T ES 16155285T ES 2734743 T3 ES2734743 T3 ES 2734743T3
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chain
seq
rna
catenin
dsrna
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Spanish (es)
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Bob Dale Brown
Henryk T Dudek
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Dicerna Pharmaceuticals Inc
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Dicerna Pharmaceuticals Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/343Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES16155285T 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario Active ES2734743T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36177610P 2010-07-06 2010-07-06

Publications (1)

Publication Number Publication Date
ES2734743T3 true ES2734743T3 (es) 2019-12-11

Family

ID=45441761

Family Applications (3)

Application Number Title Priority Date Filing Date
ES16155285T Active ES2734743T3 (es) 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario
ES11804230.8T Active ES2635388T3 (es) 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario
ES19171689T Active ES2873893T3 (es) 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES11804230.8T Active ES2635388T3 (es) 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario
ES19171689T Active ES2873893T3 (es) 2010-07-06 2011-07-01 Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario

Country Status (9)

Country Link
US (5) US8815825B2 (OSRAM)
EP (4) EP3587579B1 (OSRAM)
JP (1) JP5976643B2 (OSRAM)
AU (1) AU2011276365B2 (OSRAM)
CA (2) CA2804214C (OSRAM)
DK (3) DK2591105T3 (OSRAM)
ES (3) ES2734743T3 (OSRAM)
PT (1) PT3587579T (OSRAM)
WO (1) WO2012006243A2 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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CA2860676A1 (en) 2012-01-09 2013-07-18 Novartis Ag Organic compositions to treat beta-catenin-related diseases
EP3265179A4 (en) * 2015-03-04 2018-07-18 The University of Chicago Beta-catenin inhibitors in cancer immunotherapy
US10821112B2 (en) 2016-03-16 2020-11-03 Dicerna Pharmaceuticals, Inc. Compositions and methods for the treatment of a beta-catenin-associated disease or disorder
MA45469A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Acides nucléiques de bêta-caténine et leurs utilisations
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
NZ757538A (en) * 2017-03-28 2023-07-28 Dicerna Pharmaceuticals Inc Reducing beta-catenin expression to potentiate immunotherapy
US10407681B2 (en) * 2017-03-28 2019-09-10 The United States Of America, As Represented By The Secretary Of Agriculture Plant-mediated silencing of a fatty acid and retinoid binding protein in Pratylenchus penetrans
CN111225922B (zh) * 2017-10-18 2023-07-18 迪克纳制药公司 β连环蛋白核酸抑制剂分子
EP3714054A1 (en) * 2017-11-20 2020-09-30 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
AU2019205904A1 (en) * 2018-01-05 2020-06-18 Dicerna Pharmaceuticals, Inc. Reducing beta-catenin and IDO expression to potentiate immunotherapy
EP3740248A4 (en) * 2018-03-02 2022-01-26 Dicerna Pharmaceuticals, Inc. Methods and compositions for treating bile duct paucity-associated conditions
US10961534B2 (en) 2018-07-13 2021-03-30 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating porphyria
AU2022316139A1 (en) * 2021-07-23 2024-01-18 Alnylam Pharmaceuticals, Inc. Beta-catenin (ctnnb1) irna compositions and methods of use thereof

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US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
WO1992007065A1 (en) 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Modified ribozymes
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
US6248878B1 (en) 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
US7829693B2 (en) * 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US8273866B2 (en) 2002-02-20 2012-09-25 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US20030064384A1 (en) * 2001-04-02 2003-04-03 Mien-Chie Hung Beta-catenin is a strong and independent prognostic factor for cancer
US20060019917A1 (en) * 2001-05-18 2006-01-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
JP4912873B2 (ja) * 2003-04-09 2012-04-11 アルナイラム ファーマシューティカルズ, インコーポレイテッド iRNA複合体
CA2521464C (en) 2003-04-09 2013-02-05 Alnylam Pharmaceuticals, Inc. Irna conjugates
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
WO2005089287A2 (en) 2004-03-15 2005-09-29 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
EP1752536A4 (en) * 2004-05-11 2008-04-16 Alphagen Co Ltd POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
US20080213891A1 (en) 2004-07-21 2008-09-04 Alnylam Pharmaceuticals, Inc. RNAi Agents Comprising Universal Nucleobases
WO2006031977A2 (en) * 2004-09-13 2006-03-23 The Regents Of The University Of California Inhibition of pancreatic cancer cell growth
US20090176725A1 (en) * 2005-08-17 2009-07-09 Sirna Therapeutics Inc. Chemically modified short interfering nucleic acid molecules that mediate rna interference
US20090018097A1 (en) 2005-09-02 2009-01-15 Mdrna, Inc Modification of double-stranded ribonucleic acid molecules
WO2007031091A2 (en) * 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
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TWI455944B (zh) * 2008-07-01 2014-10-11 Daiichi Sankyo Co Ltd 雙股多核苷酸
JP2012005734A (ja) 2010-06-28 2012-01-12 Panasonic Corp 電気掃除機用吸込具及びそれを備えた電気掃除機
JP6043285B2 (ja) 2010-08-02 2016-12-14 サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害

Also Published As

Publication number Publication date
AU2011276365A1 (en) 2013-01-10
US9243244B2 (en) 2016-01-26
JP2013534425A (ja) 2013-09-05
DK2591105T3 (en) 2017-07-31
US9428752B2 (en) 2016-08-30
EP3587579A1 (en) 2020-01-01
WO2012006243A3 (en) 2012-06-14
HK1227054A1 (en) 2017-10-13
US20140288292A1 (en) 2014-09-25
US20190002879A1 (en) 2019-01-03
EP3587579B1 (en) 2021-03-03
EP2591105B1 (en) 2017-05-31
DK3037538T3 (da) 2019-06-24
EP2591105A4 (en) 2014-09-10
US10612023B2 (en) 2020-04-07
EP3037538B1 (en) 2019-05-01
EP3037538A1 (en) 2016-06-29
US20160053263A1 (en) 2016-02-25
US20160186176A1 (en) 2016-06-30
AU2011276365B2 (en) 2017-05-11
CA3146952A1 (en) 2012-01-12
US10072263B2 (en) 2018-09-11
DK3587579T3 (da) 2021-04-26
CA2804214A1 (en) 2012-01-12
PT3587579T (pt) 2021-05-24
US20130109740A1 (en) 2013-05-02
US8815825B2 (en) 2014-08-26
ES2635388T3 (es) 2017-10-03
CA2804214C (en) 2022-04-12
EP3854874A1 (en) 2021-07-28
WO2012006243A2 (en) 2012-01-12
EP2591105A2 (en) 2013-05-15
ES2873893T3 (es) 2021-11-04
JP5976643B2 (ja) 2016-08-24

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