ES2721203T3 - Matriz e implante para ingeniería de tejidos - Google Patents

Matriz e implante para ingeniería de tejidos Download PDF

Info

Publication number
ES2721203T3
ES2721203T3 ES14731159T ES14731159T ES2721203T3 ES 2721203 T3 ES2721203 T3 ES 2721203T3 ES 14731159 T ES14731159 T ES 14731159T ES 14731159 T ES14731159 T ES 14731159T ES 2721203 T3 ES2721203 T3 ES 2721203T3
Authority
ES
Spain
Prior art keywords
matrix
implant
tissue engineering
pores
primary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14731159T
Other languages
English (en)
Inventor
Hans U Baer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2721203T3 publication Critical patent/ES2721203T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Abstract

Un implante para ingeniería de tejidos, que comprende - al menos una matriz porosa para ingeniería de tejidos, comprendiendo la matriz un primer componente polimérico biodegradable y biocompatible que forma una estructura primaria tridimensional con poros primarios y que comprende adicionalmente un segundo componente polimérico biodegradable y biocompatible distinto del primer componente polimérico seleccionado del grupo que consiste en colágenos, laminina, fibronectina y sus mezclas, en la que el segundo componente polimérico forma una estructura secundaria tridimensional con poros secundarios, estando contenida la estructura secundaria dentro del espacio interior de al menos una parte de los poros primarios; y - al menos una célula de islotes de Langerhans, en la que la matriz está esencialmente en forma de una lámina con un espesor en el intervalo de 0,1 a 1,0 mm y está provista de células en al menos un lado, y en la que el implante tiene una estructura de bi- o multicapa proporcionada al plegar la matriz o colocando dos o más matrices una encima de la otra.
ES14731159T 2013-06-17 2014-06-16 Matriz e implante para ingeniería de tejidos Active ES2721203T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003086.9A EP2815773B1 (en) 2013-06-17 2013-06-17 Matrix and implant for tissue engineering
PCT/EP2014/001626 WO2014202199A1 (en) 2013-06-17 2014-06-16 Matrix and implant for tissue engineering

Publications (1)

Publication Number Publication Date
ES2721203T3 true ES2721203T3 (es) 2019-07-29

Family

ID=48651875

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13003086.9T Active ES2649616T3 (es) 2013-06-17 2013-06-17 Matriz e implante para ingeniería de tejidos
ES14731159T Active ES2721203T3 (es) 2013-06-17 2014-06-16 Matriz e implante para ingeniería de tejidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES13003086.9T Active ES2649616T3 (es) 2013-06-17 2013-06-17 Matriz e implante para ingeniería de tejidos

Country Status (6)

Country Link
US (1) US20160130558A1 (es)
EP (2) EP2815773B1 (es)
JP (1) JP6382962B2 (es)
CN (1) CN105324136B (es)
ES (2) ES2649616T3 (es)
WO (1) WO2014202199A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG178565A1 (en) 2009-08-28 2012-04-27 Sernova Corp Methods and devices for cellular transplantation
KR102208200B1 (ko) * 2013-08-09 2021-01-27 킴벌리-클라크 월드와이드, 인크. 3차원 인쇄용 중합체 물질
EP3135309A1 (en) * 2015-08-27 2017-03-01 Hans U. Baer Method for preparing a three-dimensional polymer scaffold for tissue engineering
CN108449995B (zh) 2015-11-06 2022-02-01 文塔纳医疗系统公司 代表性诊断
CZ308138B6 (cs) * 2017-05-04 2020-01-22 SCITEG a.s. Nosič pro kultivaci buněk a způsob jeho přípravy
WO2018212792A2 (en) * 2017-05-16 2018-11-22 Embody Llc Biopolymer compositions, scaffolds and devices
AU2018336901A1 (en) * 2017-09-21 2020-04-09 President And Fellows Of Harvard College Tissue construct, methods of producing and using the same
AU2018354277A1 (en) 2017-10-24 2020-04-30 Embody Inc. Biopolymer scaffold implants and methods for their production
JP6854740B2 (ja) * 2017-10-27 2021-04-07 株式会社豊田中央研究所 多孔質細胞足場及びその利用
JP2020081316A (ja) * 2018-11-22 2020-06-04 株式会社日立製作所 細胞デバイス、細胞デバイスの製造方法及び細胞デバイスの移植方法
EP3917756A4 (en) 2019-02-01 2023-05-10 Embody Inc. MICROFLUIDIC EXTRUSION
EP3705142A1 (en) * 2019-03-04 2020-09-09 Hans U. Baer Biodegradable two-layered matrix for preventing post-surgical adhesions, in particular in hernia repair
EP4036221A1 (en) 2021-01-29 2022-08-03 Baer, Hans Ulrich Method for stimulating cell growth and proliferation of cells of interest, and method for preparing a liver or pancreas implant
JP2024507471A (ja) 2021-02-19 2024-02-20 エフ． ホフマン－ラ ロシュ アーゲー 治療用化合物を分泌する細胞を移植するための手段および方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1633807B8 (de) * 2003-06-06 2017-03-15 Human Auto Cell Limited Matrix, zellimplantat, verfahren zu deren herstellung und deren verwendung
ES2401640T3 (es) * 2008-09-22 2013-04-23 University Of Zurich Prorektorat Forschung Placa para gotas en suspensión

Also Published As

Publication number Publication date
EP3010556B1 (en) 2019-01-30
JP2016521614A (ja) 2016-07-25
EP2815773A1 (en) 2014-12-24
EP2815773B1 (en) 2017-08-30
CN105324136B (zh) 2018-11-06
EP3010556A1 (en) 2016-04-27
CN105324136A (zh) 2016-02-10
ES2649616T3 (es) 2018-01-15
WO2014202199A1 (en) 2014-12-24
US20160130558A1 (en) 2016-05-12
JP6382962B2 (ja) 2018-08-29

Similar Documents

Publication Publication Date Title
ES2721203T3 (es) Matriz e implante para ingeniería de tejidos
CL2019001613A1 (es) Hojas absorbentes y suaves que tienen alta absorbencia y alto calibre, así como métodos para elaborar hojas absorbentes y suaves. (solicitud divisional 201801197)
BR112018012191A2 (pt) implante de fusão espinhal poroso
AR105172A1 (es) Implante óseo, implante endoprostético y método para fabricarlos
AR062178A1 (es) Obturador seco de accion rapida y metodos para su uso y fabricacion
ES2723074T3 (es) Materiales porosos, métodos de preparación y usos
BR112017011140A2 (pt) esponja de colágeno
BR112015023515A2 (pt) tecidos do fígado engendrados, suas matrizes e métodos de preparação dos mesmos
BR112018077481A2 (pt) película de polipropileno biaxialmente orientada de mono ou multicamadas, processo para produção de uma película de polipropileno biaxialmente orientada de mono ou multicamadas, usos de pelo menos um carbonato de cálcio natural e de uma película de polipropileno biaxialmente orientada de mono ou multicamadas, e, artigo.
BR112017007305A2 (pt) estruturas fibrosas com aberturas e métodos para a produção das mesmas
CL2008003219A1 (es) Uso de una biomatriz de colageno biofuncional, multicapas y no porosa, que dirige el crecimiento celular dentro de los intersticios de la biomatriz de colageno, para tratar un defecto de una membrana visceral o parietal; y biomatriz utilizada.
BR112015028193B8 (pt) Suporte para cicatrização de feridas
BR112012029540A2 (pt) método para a fabricação de um cartucho de filtro que tem um compartimento de parede lateral à base de cilindro
WO2013148834A3 (en) Tissue thickness compensator comprising tissue ingrowth features
AR085397A1 (es) Combinacion de inhibidores de quinasa y sus usos
CL2016002837A1 (es) Capa exterior de puerta, placa de gofrado para formar un patrón de veta de madera en una capa exterior de puerta que incluye marcas y porciones tonales dispuestas para parecer un patrón de veta de madera natural; y método para grabar dicho patrón en una placa de gofrado.
BR112012000327B8 (pt) Método de fabricação de uma prótese de osso sintética e prótese de osso sintética
BR112013032169A2 (pt) materiais microporosos com estrutura fibrilar de malha de rede e métodos de fabricação e uso dos mesmos
BR112015028937A2 (pt) painel, placa de gesso cartonado, e, método para fabricação de uma placa de gesso cartonado
BR112014032151A2 (pt) métodos de artigos de armazenamento térmico de baixa fração de espaço vazio
JP2016103422A5 (es)
BR112014029782A8 (pt) Defletor parcialmente preenchido
BR112018073413A2 (pt) estabilizador de carga fluida
AR109612A1 (es) Proceso y catalizador para preparar 1,4-butanodiol
CL2012003244A1 (es) Proceso para la produccion de parches o apositos de piel autologa mediante cultivo de queratinocitos y fibroblastos autologos con suero autologo para generacion; parche o apósito que comprende un sustrato de malla sobre la cual se ha colocado colágeno, encima queratinocitos y encima fibroblastos.