ES2720779T3 - Preparación de muestras lipémicas de plasma o de suero para el establecimiento de una interferencia de lípidos - Google Patents
Preparación de muestras lipémicas de plasma o de suero para el establecimiento de una interferencia de lípidos Download PDFInfo
- Publication number
- ES2720779T3 ES2720779T3 ES16187839T ES16187839T ES2720779T3 ES 2720779 T3 ES2720779 T3 ES 2720779T3 ES 16187839 T ES16187839 T ES 16187839T ES 16187839 T ES16187839 T ES 16187839T ES 2720779 T3 ES2720779 T3 ES 2720779T3
- Authority
- ES
- Spain
- Prior art keywords
- plasma
- sample
- lipemic
- serum
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000002632 lipids Chemical class 0.000 title claims abstract description 114
- 230000001000 lipidemic effect Effects 0.000 title claims abstract description 90
- 210000002966 serum Anatomy 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 60
- 230000036961 partial effect Effects 0.000 claims abstract description 28
- 239000006228 supernatant Substances 0.000 claims abstract description 26
- 238000005119 centrifugation Methods 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 5
- 238000000926 separation method Methods 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims description 89
- 239000012491 analyte Substances 0.000 claims description 53
- 230000000694 effects Effects 0.000 claims description 26
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 238000005259 measurement Methods 0.000 claims description 23
- 238000002156 mixing Methods 0.000 claims description 19
- 238000011895 specific detection Methods 0.000 claims description 17
- 239000007858 starting material Substances 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 2
- 230000002829 reductive effect Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 84
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 30
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- 150000003626 triacylglycerols Chemical class 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
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- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 101710117545 C protein Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
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- 230000000712 assembly Effects 0.000 description 1
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- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
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- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 229940088598 enzyme Drugs 0.000 description 1
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- 229950003499 fibrin Drugs 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
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- 230000001771 impaired effect Effects 0.000 description 1
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- 239000002960 lipid emulsion Substances 0.000 description 1
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- 206010025135 lupus erythematosus Diseases 0.000 description 1
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- 229940127234 oral contraceptive Drugs 0.000 description 1
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- 238000009210 therapy by ultrasound Methods 0.000 description 1
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- 238000004879 turbidimetry Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4083—Concentrating samples by other techniques involving separation of suspended solids sedimentation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16187839.2A EP3293521B1 (de) | 2016-09-08 | 2016-09-08 | Herstellung lipämischer plasma- oder serumproben für die bestimmung einer lipidinterferenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2720779T3 true ES2720779T3 (es) | 2019-07-24 |
Family
ID=56936286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16187839T Active ES2720779T3 (es) | 2016-09-08 | 2016-09-08 | Preparación de muestras lipémicas de plasma o de suero para el establecimiento de una interferencia de lípidos |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10488308B2 (enExample) |
| EP (1) | EP3293521B1 (enExample) |
| JP (1) | JP7022538B2 (enExample) |
| CN (1) | CN107807024B (enExample) |
| CA (1) | CA2978476C (enExample) |
| ES (1) | ES2720779T3 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7097514B2 (ja) * | 2019-01-29 | 2022-07-07 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | ヘモグロビンＡ１ｃアッセイにおける濁度正規化アルゴリズム及びイントラリピッド／脂肪血症干渉を低減する方法 |
| CN111929449A (zh) * | 2020-08-28 | 2020-11-13 | 保定天岳生物工程有限公司 | 一种aptt检测试剂盒 |
| CN116422481A (zh) * | 2022-01-11 | 2023-07-14 | 汾沃有限公司 | 基于脂质浓度对离心机中的目标界面位置进行调整 |
| CN119901692B (zh) * | 2023-10-28 | 2025-12-02 | 柏荣诊断产品（上海）有限公司 | 一种减弱脂血对透散射融合增强免疫比浊检测影响的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4977685A (enExample) * | 1972-11-29 | 1974-07-26 | ||
| DE4223355A1 (de) * | 1992-07-16 | 1994-01-20 | Boehringer Mannheim Gmbh | Verfahren und Reagenz zur spezifischen Bestimmung von LDL in Serumproben |
| JP4273311B2 (ja) * | 2002-04-26 | 2009-06-03 | 株式会社シノテスト | 試料中の測定対象物質の測定方法及び測定試薬 |
| CN101398422B (zh) * | 2008-10-28 | 2012-09-05 | 四川大学华西医院 | 高甘油三脂对血红蛋白浓度测定干扰的消除方法 |
| US20130084592A1 (en) * | 2011-10-04 | 2013-04-04 | Siemens Healthcare Diagnostics Inc. | Methods for correcting assay measurements |
-
2016
- 2016-09-08 EP EP16187839.2A patent/EP3293521B1/de active Active
- 2016-09-08 ES ES16187839T patent/ES2720779T3/es active Active
-
2017
- 2017-09-05 CN CN201710789597.6A patent/CN107807024B/zh active Active
- 2017-09-06 CA CA2978476A patent/CA2978476C/en active Active
- 2017-09-07 US US15/698,618 patent/US10488308B2/en active Active
- 2017-09-07 JP JP2017171651A patent/JP7022538B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107807024A (zh) | 2018-03-16 |
| CA2978476A1 (en) | 2018-03-08 |
| US20180067022A1 (en) | 2018-03-08 |
| JP7022538B2 (ja) | 2022-02-18 |
| EP3293521A1 (de) | 2018-03-14 |
| JP2018040799A (ja) | 2018-03-15 |
| US10488308B2 (en) | 2019-11-26 |
| CA2978476C (en) | 2024-06-18 |
| CN107807024B (zh) | 2021-11-23 |
| EP3293521B1 (de) | 2019-01-02 |
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