ES2720483T3 - Sistemas y procedimientos de anticuerpos anti p40 - Google Patents
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
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| US201361770956P | 2013-02-28 | 2013-02-28 | |
| PCT/US2014/019705 WO2014134587A1 (en) | 2013-02-28 | 2014-02-28 | Anti-p40 antibodies systems and methods |
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| ES2720483T3 true ES2720483T3 (es) | 2019-07-22 |
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| EP (1) | EP2962113B1 (enExample) |
| JP (1) | JP6445467B2 (enExample) |
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| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
| EP3166974A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Anti-pd-l1 antibodies and diagnostic uses thereof |
| TWI794761B (zh) | 2015-08-28 | 2023-03-01 | 德商英麥提克生物技術股份有限公司 | 用於多種癌症之免疫治療的新穎胜肽、胜肽的組合物及支架 |
| CN108467433B (zh) * | 2018-05-30 | 2021-05-07 | 福州迈新生物技术开发有限公司 | 抗Napsin A蛋白的单克隆抗体及其细胞株、制备方法和应用 |
| WO2020243733A1 (en) * | 2019-05-30 | 2020-12-03 | Sakura Finetek Usa, Inc. | Detection of antigens in a biological specimen using antibody reagents |
| US11976282B2 (en) | 2020-06-23 | 2024-05-07 | Qatar University | GATA3 inhibitors for the promotion of subcutaneous fat deposition |
| CA3192627A1 (en) * | 2020-08-26 | 2022-03-03 | Agilent Technologies, Inc. | Antibodies for use in immunohistochemistry (ihc) protocols to diagnose cancer |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145406A (en) | 1977-04-11 | 1979-03-20 | Miles Laboratories, Inc. | Specific binding - adsorbent assay method and test means |
| US4254082A (en) | 1978-06-12 | 1981-03-03 | Miles Laboratories, Inc. | Specific binding-adsorbent assay test means |
| CA1247538A (en) | 1982-05-21 | 1988-12-28 | Mark C. Glassy | Human-human hybridomas for solid tumors |
| US4687732A (en) | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
| US4690890A (en) | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
| JPS60248618A (ja) | 1984-05-24 | 1985-12-09 | Nippon Zoki Pharmaceut Co Ltd | ジペプチドを含有する潰瘍治療剤 |
| US4792521A (en) | 1985-08-15 | 1988-12-20 | Immunomedics, Inc. | Non-enzymatic immunohistochemical staining system and reagents |
| US4863875A (en) | 1985-08-26 | 1989-09-05 | Gia Research Company, L.P. | Dye labelled antibodies as reagents for use in immunoassay systems |
| GB8607101D0 (en) | 1986-03-21 | 1986-04-30 | Serono Diagnostics Ltd | Immunoassay |
| US5089423A (en) | 1987-05-06 | 1992-02-18 | Cyberfluor Inc. | Immunoassay methods and reagents and methods for producing the latter |
| US5620845A (en) | 1988-06-06 | 1997-04-15 | Ampcor, Inc. | Immunoassay diagnostic kit |
| US5252487A (en) | 1989-05-19 | 1993-10-12 | Cell Analysis Systems, Inc. | Method and apparatus for determining the amount of oncogene protein product in a cell sample |
| US6008057A (en) | 1989-08-25 | 1999-12-28 | Roche Diagnostics Corporation | Immunoassay system |
| US5719063A (en) | 1989-08-25 | 1998-02-17 | Boehringer Mannheim Corporation | Multiplex immunoassay system |
| US5492821A (en) | 1990-11-14 | 1996-02-20 | Cargill, Inc. | Stabilized polyacrylic saccharide protein conjugates |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5280108A (en) * | 1991-09-27 | 1994-01-18 | United States Of America | Antibodies to p40 |
| EP0669836B1 (en) | 1992-11-13 | 1996-07-03 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
| US5482698A (en) | 1993-04-22 | 1996-01-09 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin polymer conjugates |
| US5487975A (en) | 1993-11-15 | 1996-01-30 | Ventana Medical Systems, Inc. | Biotin/avidin formulation |
| AU689214B2 (en) | 1994-02-01 | 1998-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Fusion proteins that include antibody and nonantibody portions |
| US5869274A (en) | 1995-08-09 | 1999-02-09 | Zymed Laboratories, Inc. | Immuno-histochemical method that reduces background staining |
| US5891658A (en) | 1996-06-27 | 1999-04-06 | FCI--FiberChem, Inc. | Single-step, solid-state competitive immunoassay |
| ES2327440T3 (es) | 1996-08-23 | 2009-10-29 | Vegenics Limited | Factor recombinante de crecimiento de las celulas endoteliales vasculares-d (vegf-d). |
| US7196164B2 (en) | 1997-07-08 | 2007-03-27 | Human Genome Sciences, Inc. | Secreted protein HHTLF25 |
| CA2303165C (en) | 1997-09-22 | 2006-07-11 | Chiron Corporation | Buffers for stabilizing antigens |
| US7294459B1 (en) | 1997-10-15 | 2007-11-13 | President And Fellows Of Harvard College | Cell regulatory genes, encoded products, and uses related thereto |
| US6476206B1 (en) * | 1998-03-27 | 2002-11-05 | The Johns Hopkins University | p40 protein acts as an oncogene |
| JP3524401B2 (ja) | 1998-09-16 | 2004-05-10 | 株式会社ニチレイ | 酵素抗体複合体およびその製造方法 |
| WO2000069473A2 (en) | 1999-05-14 | 2000-11-23 | The Regents Of The University Of California | Macromolecular carrier for drug and diagnostic agent delivery |
| US6723506B2 (en) | 2000-01-20 | 2004-04-20 | Brigham And Women's Hospital | Method of identifying PAX8-PPAR gamma-nucleic acid molecules |
| US20030017491A1 (en) | 2000-09-14 | 2003-01-23 | Zuo-Rong Shi | Chromogenic in situ hybridization methods, kits, and compositions |
| DE10063179A1 (de) | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20020173053A1 (en) | 2001-04-27 | 2002-11-21 | Bassam Damaj | Multiple simultaneous antigen detection by immunohistochemistry |
| US20040076955A1 (en) | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
| US6580056B1 (en) | 2001-09-21 | 2003-06-17 | Biocare Medical | Biological specimen heating device and quality control method for immunohistochemistry heat retrieval procedures |
| EP1480520A4 (en) | 2002-02-12 | 2006-02-15 | Raven Biotechnologies Inc | EPITHELIAL CELLS FROM THE HUMAN FOLDS BUBBLE |
| CN102659946A (zh) | 2002-03-13 | 2012-09-12 | 拜奥根Idec马萨诸塞公司 | 抗αvβ6抗体 |
| US7850912B2 (en) * | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
| KR20110094361A (ko) | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| WO2005007809A2 (en) | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
| CA2544577C (en) | 2003-12-01 | 2013-01-08 | Dako Denmark A/S | Methods and compositions for immuno-histochemical detection |
| WO2005076005A2 (en) | 2004-01-30 | 2005-08-18 | Medizinische Universität Wien | A method for classifying a tumor cell sample based upon differential expression of at least two genes |
| US20050186642A1 (en) | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| ES2351057T3 (es) | 2005-07-08 | 2011-01-31 | Pfizer Limited | Anticuerpos contra madcam. |
| JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| BRPI0619249A2 (pt) * | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
| HUE043255T2 (hu) * | 2006-06-07 | 2019-08-28 | Bioalliance Cv | Antitestek, amelyek felismernek ráksejteken expresszált CD43-on és CEA-n jelenlévõ, szénhidrátot tartalmazó epitópot, és eljárások alkalmazásukra |
| US20100092457A1 (en) | 2006-08-14 | 2010-04-15 | Forerunner Pharma Research Co., Ltd. | Diagnosis and Treatment of Cancer Using Anti-Desmoglein-3 Antibodies |
| CN101855241B (zh) | 2006-12-08 | 2013-11-06 | 莱克康制药公司 | 针对angptl3的单克隆抗体 |
| WO2008127642A1 (en) | 2007-04-11 | 2008-10-23 | Enteron Limited Partnership | Myelin specific ige unencumbered by corresponding blocking antibodies as a causative factor in multiple sclerosis |
| JP5117765B2 (ja) | 2007-05-28 | 2013-01-16 | 国立大学法人 東京大学 | 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤 |
| MX2010003325A (es) | 2007-09-26 | 2010-04-09 | Genentech Inc | Anticuepos novedosos. |
| RU2540146C2 (ru) | 2008-08-29 | 2015-02-10 | Симфоген А/С | Композиции рекомбинантных антител против рецептора эпидермального фактора роста |
| EP2342229A1 (en) | 2008-09-12 | 2011-07-13 | ISIS Innovation Limited | Pd-1 specific antibodies and uses thereof |
| US7846762B2 (en) | 2008-09-22 | 2010-12-07 | Applied Materials, Inc. | Integrated emitter formation and passivation |
| CA2760569C (en) | 2009-05-01 | 2018-01-02 | Dako Denmark A/S | New antibody cocktail |
| CN102666584A (zh) * | 2009-05-12 | 2012-09-12 | 辉瑞公司 | 封闭性抗dkk-1抗体及其用途 |
| US20120245051A1 (en) | 2009-10-13 | 2012-09-27 | Rimm David L | Objective, quantitative method to predict histological subtype in non-small cell lung cancer |
| US20120321557A1 (en) | 2010-02-26 | 2012-12-20 | Forerunner Pharma Research Co., Ltd. | Anti-icam3 antibody and use thereof |
| EP2402370A1 (en) * | 2010-06-29 | 2012-01-04 | Pierre Fabre Médicament | Novel antibody for the diagnosis and/or prognosis of cancer |
| NZ608814A (en) | 2010-09-03 | 2015-06-26 | Stem Centrx Inc | Novel modulators and methods of use |
| CA2851101C (en) | 2010-10-06 | 2017-02-14 | Biocare Medical, Llc | Methods and systems for efficient processing of biological samples |
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| US10429390B2 (en) * | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
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2014
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- 2014-02-28 ES ES14756627T patent/ES2720483T3/es active Active
- 2014-02-28 JP JP2015560386A patent/JP6445467B2/ja active Active
- 2014-02-28 EP EP14756627.7A patent/EP2962113B1/en active Active
- 2014-02-28 WO PCT/US2014/019705 patent/WO2014134587A1/en not_active Ceased
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2015
- 2015-08-28 US US14/839,744 patent/US9428576B2/en active Active
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2962113A4 (en) | 2016-11-09 |
| US20160009795A1 (en) | 2016-01-14 |
| DK2962113T3 (da) | 2019-07-01 |
| JP6445467B2 (ja) | 2019-01-09 |
| EP2962113B1 (en) | 2019-04-03 |
| US9708395B2 (en) | 2017-07-18 |
| US9428576B2 (en) | 2016-08-30 |
| WO2014134587A1 (en) | 2014-09-04 |
| JP2016516008A (ja) | 2016-06-02 |
| US20160333085A1 (en) | 2016-11-17 |
| EP2962113A1 (en) | 2016-01-06 |
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