ES2699267T3 - Derivados alfa-amino del ácido borónico, inhibidores selectivos del inmunoproteosoma - Google Patents
Derivados alfa-amino del ácido borónico, inhibidores selectivos del inmunoproteosoma Download PDFInfo
- Publication number
- ES2699267T3 ES2699267T3 ES12806491T ES12806491T ES2699267T3 ES 2699267 T3 ES2699267 T3 ES 2699267T3 ES 12806491 T ES12806491 T ES 12806491T ES 12806491 T ES12806491 T ES 12806491T ES 2699267 T3 ES2699267 T3 ES 2699267T3
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- Spain
- Prior art keywords
- hplc
- hal
- acid
- atoms
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CCN[C@](B(O*)O*)C Chemical compound CCN[C@](B(O*)O*)C 0.000 description 3
- XHUQDXLHUWKSRR-UHFFFAOYSA-N CC(NC(B(O)O)Cc1c[o]c2ccccc12)=O Chemical compound CC(NC(B(O)O)Cc1c[o]c2ccccc12)=O XHUQDXLHUWKSRR-UHFFFAOYSA-N 0.000 description 1
- UXZXHWZZOFNCFU-UHFFFAOYSA-N CC(NC(B(O)O)Cc1cc(cccc2)c2cc1)=O Chemical compound CC(NC(B(O)O)Cc1cc(cccc2)c2cc1)=O UXZXHWZZOFNCFU-UHFFFAOYSA-N 0.000 description 1
- GDAFHKTVPJQXRK-DZQSVEARSA-N CCc1cccc(/C=C(\B(O)O)/NC([C@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 Chemical compound CCc1cccc(/C=C(\B(O)O)/NC([C@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 GDAFHKTVPJQXRK-DZQSVEARSA-N 0.000 description 1
- IVXYQPISTRPRQJ-LFQPHHBNSA-N CCc1cccc(CC(B(O)O)NC([C@@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 Chemical compound CCc1cccc(CC(B(O)O)NC([C@@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 IVXYQPISTRPRQJ-LFQPHHBNSA-N 0.000 description 1
- IVXYQPISTRPRQJ-XQZUBTRRSA-N CCc1cccc(CC(B(O)O)NC([C@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 Chemical compound CCc1cccc(CC(B(O)O)NC([C@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 IVXYQPISTRPRQJ-XQZUBTRRSA-N 0.000 description 1
- XSMJJIXXNRFDLW-IBGZPJMESA-N CCc1cccc(C[C@@H](B(O)O)NC(CC[n]2nnc(-c3cccnc3)c2)=O)c1 Chemical compound CCc1cccc(C[C@@H](B(O)O)NC(CC[n]2nnc(-c3cccnc3)c2)=O)c1 XSMJJIXXNRFDLW-IBGZPJMESA-N 0.000 description 1
- IVXYQPISTRPRQJ-ZCYQVOJMSA-N CCc1cccc(C[C@@H](B(O)O)NC([C@@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 Chemical compound CCc1cccc(C[C@@H](B(O)O)NC([C@@H](CC(c2ccccc2)=O)c(cc2)ccc2Cl)=O)c1 IVXYQPISTRPRQJ-ZCYQVOJMSA-N 0.000 description 1
- DECHLHGALUDGHL-UHFFFAOYSA-N CN(CC(NC(B(O)O)Cc1c[o]c2ccccc12)=O)S(C)(=O)=O Chemical compound CN(CC(NC(B(O)O)Cc1c[o]c2ccccc12)=O)S(C)(=O)=O DECHLHGALUDGHL-UHFFFAOYSA-N 0.000 description 1
- RZCYYTBZSZGBAH-BWKNWUBXSA-N COc(cc1)ccc1C(C[C@@H](Cc1ccccc1)C(N[C@H](B(O)O)Cc1cccc(C(F)(F)F)c1)=O)=O Chemical compound COc(cc1)ccc1C(C[C@@H](Cc1ccccc1)C(N[C@H](B(O)O)Cc1cccc(C(F)(F)F)c1)=O)=O RZCYYTBZSZGBAH-BWKNWUBXSA-N 0.000 description 1
- RZCYYTBZSZGBAH-OFVILXPXSA-N COc(cc1)ccc1C(C[C@H](Cc1ccccc1)C(N[C@H](B(O)O)Cc1cc(C(F)(F)F)ccc1)=O)=O Chemical compound COc(cc1)ccc1C(C[C@H](Cc1ccccc1)C(N[C@H](B(O)O)Cc1cc(C(F)(F)F)ccc1)=O)=O RZCYYTBZSZGBAH-OFVILXPXSA-N 0.000 description 1
- JCOVNFKBPKZRGH-UHFFFAOYSA-N OB(C(Cc1cc(C(F)(F)F)ccc1)NC(CCc1n[o]c(-c2ccccc2)n1)=O)O Chemical compound OB(C(Cc1cc(C(F)(F)F)ccc1)NC(CCc1n[o]c(-c2ccccc2)n1)=O)O JCOVNFKBPKZRGH-UHFFFAOYSA-N 0.000 description 1
- HAFRQOMWPPJSQP-FQEVSTJZSA-N OB([C@H](Cc1c[s]cc1)NC(CCC(c1nc(-c2ccccc2)ccc1)=O)=O)O Chemical compound OB([C@H](Cc1c[s]cc1)NC(CCC(c1nc(-c2ccccc2)ccc1)=O)=O)O HAFRQOMWPPJSQP-FQEVSTJZSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579076P | 2011-12-22 | 2011-12-22 | |
| EP11195107 | 2011-12-22 | ||
| PCT/EP2012/076595 WO2013092979A1 (en) | 2011-12-22 | 2012-12-21 | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2699267T3 true ES2699267T3 (es) | 2019-02-08 |
Family
ID=48667763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12806491T Active ES2699267T3 (es) | 2011-12-22 | 2012-12-21 | Derivados alfa-amino del ácido borónico, inhibidores selectivos del inmunoproteosoma |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9688702B2 (enExample) |
| EP (1) | EP2793900B1 (enExample) |
| JP (1) | JP6129203B2 (enExample) |
| KR (1) | KR20140114391A (enExample) |
| CN (1) | CN104321060B (enExample) |
| AU (1) | AU2012356890B2 (enExample) |
| BR (1) | BR112014015363A2 (enExample) |
| CA (1) | CA2860142C (enExample) |
| EA (1) | EA201400735A1 (enExample) |
| ES (1) | ES2699267T3 (enExample) |
| HK (1) | HK1206261A1 (enExample) |
| IL (1) | IL233200A (enExample) |
| MX (1) | MX352652B (enExample) |
| SG (2) | SG11201403254QA (enExample) |
| WO (1) | WO2013092979A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2599791C2 (ru) | 2010-08-10 | 2016-10-20 | Ремпекс Фармасьютикэлз, Инч. | Циклические бороновые кислотно-эфирные производные и их использование в терапии |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| MX2015006715A (es) * | 2012-12-03 | 2015-08-14 | Hoffmann La Roche | Compuestos de acido triazolboronico sustituido. |
| CA2893943C (en) | 2012-12-07 | 2021-03-02 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| JP6324409B2 (ja) * | 2013-01-04 | 2018-05-16 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体及びその治療的使用 |
| AU2014204045B2 (en) * | 2013-01-04 | 2018-10-18 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP6346904B2 (ja) | 2013-01-10 | 2018-06-20 | ベナトルクス ファーマシューティカルズ，インク． | ベータ−ラクタマーゼ阻害剤 |
| WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US9988421B2 (en) | 2014-01-10 | 2018-06-05 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| RS59488B1 (sr) | 2014-05-05 | 2019-12-31 | Rempex Pharmaceuticals Inc | Sinteza boronatnih soli i njihove upotrebe |
| JP6672176B2 (ja) | 2014-05-19 | 2020-03-25 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| EP3882252B1 (en) | 2014-06-11 | 2025-11-19 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| AU2015284307A1 (en) * | 2014-07-01 | 2017-02-02 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US11202817B2 (en) | 2014-08-18 | 2021-12-21 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
| BR112017006349A2 (pt) | 2014-10-01 | 2017-12-12 | Merck Patent Gmbh | derivados de ácido borônico |
| ES2873000T3 (es) * | 2014-10-01 | 2021-11-03 | Merck Patent Gmbh | Derivados del ácido borónico. |
| CN107001391B (zh) * | 2014-10-01 | 2020-11-27 | 默克专利股份公司 | 硼酸衍生物 |
| ES2811273T3 (es) * | 2014-10-01 | 2021-03-11 | Merck Patent Gmbh | Derivados del ácido borónico |
| US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2017044828A1 (en) | 2015-09-11 | 2017-03-16 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| KR102764027B1 (ko) | 2015-10-15 | 2025-02-07 | 코넬 유니버시티 | 프로테아좀 억제제 및 이의 용도 |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN107151255A (zh) * | 2016-03-06 | 2017-09-12 | 复旦大学 | 硼酸类化合物及其制备方法和用途 |
| JP7060245B2 (ja) | 2016-06-30 | 2022-04-26 | キューペックス バイオファーマ， インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
| ES2927283T3 (es) | 2017-08-24 | 2022-11-03 | Merck Patent Gmbh | Derivados del ácido borónico |
| US11203613B2 (en) | 2017-10-11 | 2021-12-21 | Cornell University | Peptidomimetic proteasome inhibitors |
| CA3078627A1 (en) | 2017-10-11 | 2019-04-18 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
| CN107556336A (zh) * | 2017-10-16 | 2018-01-09 | 康化（上海）新药研发有限公司 | 一种呋喃‑2‑甲烷基硼酸频哪醇酯的合成方法 |
| EP3710457B1 (en) | 2017-11-16 | 2022-08-03 | Principia Biopharma Inc. | Immunoproteasome inhibitors |
| CN111491938B (zh) | 2017-11-16 | 2024-05-24 | 普林斯匹亚生物制药公司 | 免疫蛋白酶体抑制剂 |
| CN108130370B (zh) * | 2018-01-05 | 2020-11-17 | 武汉惠康达科技有限公司 | Psmb8及其抑制剂在制备治疗脂肪肝及其相关疾病药物中的应用 |
| EP3781576B1 (en) | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| WO2019226931A1 (en) | 2018-05-25 | 2019-11-28 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| KR20210038590A (ko) | 2018-07-26 | 2021-04-07 | 메르크 파텐트 게엠베하 | 보론산 유도체 |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN114075227B (zh) * | 2020-08-19 | 2023-07-04 | 北京嵩润医药科技有限责任公司 | 吡唑硼酸类化合物、包含其的药物组合物及它们的用途 |
| US20250340577A1 (en) * | 2021-03-02 | 2025-11-06 | Case Western Reserve University | Beta-lactomase inhibitors and uses thereof |
| CN116940580A (zh) * | 2021-03-05 | 2023-10-24 | Ａｇｃ株式会社 | 化合物、化合物的制造方法及表面处理剂的制造方法 |
| CA3227452A1 (en) | 2021-07-29 | 2023-02-02 | Merck Patent Gmbh | Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| WO2023061445A1 (zh) * | 2021-10-14 | 2023-04-20 | 首药控股(北京)股份有限公司 | 硼酸衍生物 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| US7332343B2 (en) | 2004-01-16 | 2008-02-19 | Board Of Regents, The University Of Texas System | Determining enantiomeric excess using indicator-displacement assays |
| NZ550522A (en) * | 2004-03-30 | 2010-08-27 | Millennium Pharm Inc | Synthesis of boronic ester and acid compounds |
| JP5232160B2 (ja) | 2006-11-14 | 2013-07-10 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖインヒビターとしての三環式芳香族複素環化合物 |
| ES2390606T3 (es) * | 2007-08-06 | 2012-11-14 | Millennium Pharmaceuticals, Inc. | Inhibidores de proteasomas |
| WO2009051581A1 (en) * | 2007-10-16 | 2009-04-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| BRPI0820532A2 (pt) * | 2007-11-13 | 2012-07-10 | Protez Pharmaceuticals Inc | inibidores de beta-lactamase |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| EA029521B1 (ru) * | 2010-03-31 | 2018-04-30 | Милленниум Фармасьютикалз, Инк. | Производные 1-амино-2-циклопропилэтилбороновой кислоты |
| WO2011137049A1 (en) | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived m1 receptor positive allosteric modulators |
-
2012
- 2012-12-21 JP JP2014548061A patent/JP6129203B2/ja not_active Expired - Fee Related
- 2012-12-21 BR BR112014015363A patent/BR112014015363A2/pt not_active Application Discontinuation
- 2012-12-21 ES ES12806491T patent/ES2699267T3/es active Active
- 2012-12-21 US US14/366,949 patent/US9688702B2/en not_active Expired - Fee Related
- 2012-12-21 MX MX2014007362A patent/MX352652B/es active IP Right Grant
- 2012-12-21 WO PCT/EP2012/076595 patent/WO2013092979A1/en not_active Ceased
- 2012-12-21 EA EA201400735A patent/EA201400735A1/ru unknown
- 2012-12-21 CN CN201280063440.0A patent/CN104321060B/zh not_active Expired - Fee Related
- 2012-12-21 SG SG11201403254QA patent/SG11201403254QA/en unknown
- 2012-12-21 CA CA2860142A patent/CA2860142C/en active Active
- 2012-12-21 SG SG10201605152SA patent/SG10201605152SA/en unknown
- 2012-12-21 AU AU2012356890A patent/AU2012356890B2/en not_active Ceased
- 2012-12-21 EP EP12806491.2A patent/EP2793900B1/en active Active
- 2012-12-21 KR KR1020147020413A patent/KR20140114391A/ko not_active Ceased
- 2012-12-21 HK HK15106906.3A patent/HK1206261A1/xx unknown
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2014
- 2014-06-17 IL IL233200A patent/IL233200A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HK1206261A1 (en) | 2016-01-08 |
| WO2013092979A1 (en) | 2013-06-27 |
| BR112014015363A8 (pt) | 2017-06-13 |
| CN104321060A (zh) | 2015-01-28 |
| IL233200A0 (en) | 2014-07-31 |
| CN104321060B (zh) | 2018-08-07 |
| MX352652B (es) | 2017-12-04 |
| US20140364396A1 (en) | 2014-12-11 |
| MX2014007362A (es) | 2014-08-01 |
| US9688702B2 (en) | 2017-06-27 |
| CA2860142A1 (en) | 2013-06-27 |
| JP2015502387A (ja) | 2015-01-22 |
| IL233200A (en) | 2017-08-31 |
| SG10201605152SA (en) | 2016-08-30 |
| AU2012356890B2 (en) | 2017-06-08 |
| EA201400735A1 (ru) | 2015-04-30 |
| AU2012356890A1 (en) | 2014-08-07 |
| EP2793900A1 (en) | 2014-10-29 |
| EP2793900B1 (en) | 2018-08-22 |
| CA2860142C (en) | 2020-10-27 |
| SG11201403254QA (en) | 2014-07-30 |
| JP6129203B2 (ja) | 2017-05-17 |
| BR112014015363A2 (pt) | 2017-06-13 |
| KR20140114391A (ko) | 2014-09-26 |
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