ES2692656T3 - Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona - Google Patents

Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona Download PDF

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Publication number
ES2692656T3
ES2692656T3 ES11778981.8T ES11778981T ES2692656T3 ES 2692656 T3 ES2692656 T3 ES 2692656T3 ES 11778981 T ES11778981 T ES 11778981T ES 2692656 T3 ES2692656 T3 ES 2692656T3
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Prior art keywords
formula
compound
equ
solvent
process according
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ES11778981.8T
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English (en)
Spanish (es)
Inventor
Stefan Abele
Jacques-Alexis Funel
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Idorsia Pharmaceuticals Ltd
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Idorsia Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/20—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES11778981.8T 2010-10-20 2011-10-19 Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona Active ES2692656T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2010054743 2010-10-20
WOPCT/IB2010/054743 2010-10-20
PCT/IB2011/054666 WO2012052943A1 (en) 2010-10-20 2011-10-19 Diastereoselective preparation of bicyclo[2.2.2]octan-2-one compounds

Publications (1)

Publication Number Publication Date
ES2692656T3 true ES2692656T3 (es) 2018-12-04

Family

ID=44906287

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11778981.8T Active ES2692656T3 (es) 2010-10-20 2011-10-19 Preparación diastereoselectiva de los compuestos de biciclo[2.2.2]octan-2-ona

Country Status (11)

Country Link
US (1) US8816118B2 (enExample)
EP (1) EP2630120B1 (enExample)
JP (1) JP5909238B2 (enExample)
KR (1) KR101836552B1 (enExample)
CN (1) CN103153947B (enExample)
CA (1) CA2813160C (enExample)
DK (1) DK2630120T3 (enExample)
ES (1) ES2692656T3 (enExample)
IL (1) IL225764A (enExample)
MX (1) MX2013004425A (enExample)
WO (1) WO2012052943A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012052939A2 (en) 2010-10-20 2012-04-26 Actelion Pharmaceuticals Ltd Preparation of bicyclo[2.2.2]octan-2-one compounds
CN103570513A (zh) * 2012-08-07 2014-02-12 中国科学院大连化学物理研究所 一种手性双环[n.3.1]化合物的催化不对称合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001205A1 (es) 2007-04-27 2008-11-14 Actelion Pharmaceuticals Ltd Compuestos derivados de biciclo[2.2.2]octeno; composicion farmaceutica que los contiene; y uso en el tratamiento o prevencion de angina cronica estable, hipertension, isquemia renal y cardiaca, arritmias cardiacas, hipertrofia cardiaca y falla congestiva del corazon.
AU2009239620A1 (en) 2008-04-25 2009-10-29 Actelion Pharmaceuticals Ltd Benzimidazole derivatives as calcium channel blockers
EP2344461B1 (en) * 2008-10-22 2016-12-14 Actelion Pharmaceuticals Ltd. Salts of isobutyric acid (1r*,2r*,4r*)-2-(2-{[3-(4,7-dimethoxy-1 h-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester
WO2012052939A2 (en) 2010-10-20 2012-04-26 Actelion Pharmaceuticals Ltd Preparation of bicyclo[2.2.2]octan-2-one compounds

Also Published As

Publication number Publication date
CN103153947B (zh) 2015-11-25
US20130289295A1 (en) 2013-10-31
CA2813160C (en) 2018-01-02
CN103153947A (zh) 2013-06-12
JP5909238B2 (ja) 2016-04-26
MX2013004425A (es) 2013-07-17
KR101836552B1 (ko) 2018-03-08
DK2630120T3 (en) 2018-10-08
JP2013543841A (ja) 2013-12-09
WO2012052943A1 (en) 2012-04-26
EP2630120B1 (en) 2018-07-25
CA2813160A1 (en) 2012-04-26
US8816118B2 (en) 2014-08-26
KR20130126618A (ko) 2013-11-20
EP2630120A1 (en) 2013-08-28
IL225764A (en) 2016-11-30
IL225764A0 (en) 2013-06-27

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