ES2688743T3 - Láser para terapia fotodinámica - Google Patents
Láser para terapia fotodinámica Download PDFInfo
- Publication number
- ES2688743T3 ES2688743T3 ES13763985.2T ES13763985T ES2688743T3 ES 2688743 T3 ES2688743 T3 ES 2688743T3 ES 13763985 T ES13763985 T ES 13763985T ES 2688743 T3 ES2688743 T3 ES 2688743T3
- Authority
- ES
- Spain
- Prior art keywords
- laser
- laser beams
- optical
- beams
- fiber optic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002428 photodynamic therapy Methods 0.000 title description 46
- 230000003287 optical effect Effects 0.000 claims abstract description 66
- 239000000835 fiber Substances 0.000 claims abstract description 46
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 16
- 239000000906 photoactive agent Substances 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims description 17
- 229960003895 verteporfin Drugs 0.000 claims description 7
- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 67
- 238000000034 method Methods 0.000 description 34
- 230000008569 process Effects 0.000 description 18
- 239000003814 drug Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 12
- 206010064930 age-related macular degeneration Diseases 0.000 description 8
- 208000002780 macular degeneration Diseases 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229940061392 visudyne Drugs 0.000 description 6
- 208000003569 Central serous chorioretinopathy Diseases 0.000 description 5
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 5
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 230000017525 heat dissipation Effects 0.000 description 5
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 3
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010038848 Retinal detachment Diseases 0.000 description 2
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- 201000004569 Blindness Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
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- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 230000003416 augmentation Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
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- 210000003161 choroid Anatomy 0.000 description 1
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- 239000002826 coolant Substances 0.000 description 1
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- 231100000433 cytotoxic Toxicity 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
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- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000018769 loss of vision Diseases 0.000 description 1
- 231100000864 loss of vision Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000011022 opal Substances 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000002186 photoactivation Effects 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
- 238000000015 thermotherapy Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00821—Methods or devices for eye surgery using laser for coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20361—Beam shaping or redirecting; Optical components therefor with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2065—Multiwave; Wavelength mixing, e.g. using four or more wavelengths
- A61B2018/207—Multiwave; Wavelength mixing, e.g. using four or more wavelengths mixing two wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00863—Retina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00821—Methods or devices for eye surgery using laser for coagulation
- A61F9/00823—Laser features or special beam parameters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
- A61N2005/0667—Filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201213426470 | 2012-03-21 | ||
| US13/426,470 US9211214B2 (en) | 2012-03-21 | 2012-03-21 | Photodynamic therapy laser |
| PCT/US2013/033309 WO2013142693A1 (en) | 2012-03-21 | 2013-03-21 | Photodynamic therapy laser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2688743T3 true ES2688743T3 (es) | 2018-11-06 |
Family
ID=49212461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13763985.2T Active ES2688743T3 (es) | 2012-03-21 | 2013-03-21 | Láser para terapia fotodinámica |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9211214B2 (enExample) |
| EP (1) | EP2827818B1 (enExample) |
| JP (1) | JP6242024B2 (enExample) |
| KR (1) | KR102056103B1 (enExample) |
| CN (1) | CN104540481B (enExample) |
| AU (1) | AU2013235019B2 (enExample) |
| CA (1) | CA2867021C (enExample) |
| ES (1) | ES2688743T3 (enExample) |
| MX (1) | MX344249B (enExample) |
| WO (1) | WO2013142693A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10589120B1 (en) | 2012-12-31 | 2020-03-17 | Gary John Bellinger | High-intensity laser therapy method and apparatus |
| WO2016086183A1 (en) | 2014-11-26 | 2016-06-02 | Convergent Dental, Inc. | Systems and methods for supplying power to and cooling dental laser systems |
| DE102015100878B4 (de) * | 2015-01-21 | 2021-12-02 | HELBO Medizintechnik GmbH | Vorrichtung zur flächigen Bestrahlung einer Behandlungsstelle |
| CN106389004B (zh) * | 2015-07-29 | 2018-12-07 | 广东福地新视野光电技术有限公司 | 一种光斑连续可调的激光适配器及眼底激光治疗仪 |
| ITUB20159634A1 (it) * | 2015-12-22 | 2017-06-22 | Quanta System Spa | Dispositivo laser per il trattamento selettivo dell'acne con ridotto incremento della tempertura cutanea |
| CN110234301B (zh) * | 2017-01-28 | 2022-10-18 | 爱尔康公司 | 飞秒激光器的单阶段对接 |
| US12396890B2 (en) | 2017-02-09 | 2025-08-26 | Norlase Aps | Apparatus for photothermal ophthalmic treatment |
| WO2018146070A2 (en) | 2017-02-09 | 2018-08-16 | Norlase Aps | Apparatus for photothermal ophthalmic treatment |
| US11400308B2 (en) | 2017-11-21 | 2022-08-02 | Cutera, Inc. | Dermatological picosecond laser treatment systems and methods using optical parametric oscillator |
| EP4265212B1 (en) | 2017-12-12 | 2025-03-19 | Alcon Inc. | Multiple-input-coupled illuminated multi-spot laser probe |
| WO2019116283A1 (en) | 2017-12-12 | 2019-06-20 | Novartis Ag | Surgical probe with shape-memory material |
| US11213426B2 (en) | 2017-12-12 | 2022-01-04 | Alcon Inc. | Thermally robust multi-spot laser probe |
| AU2018385649B2 (en) | 2017-12-12 | 2024-05-02 | Alcon Inc. | Multiple-input-coupled illuminated multi-spot laser probe |
| EP3810265A4 (en) * | 2018-06-22 | 2022-02-23 | Avava, Inc. | APPARATUS FOR THE SELECTIVE TREATMENT OF TISSUE |
| US20200038677A1 (en) * | 2018-08-02 | 2020-02-06 | Candela Corporation | Laser System For Skin Treatment |
| CN112739414B (zh) * | 2018-08-09 | 2022-10-04 | 麻省总医院 | 将剂量分布和/或注量分布传送到目标区域的系统 |
| EP3843642A4 (en) * | 2018-08-31 | 2022-06-08 | Iridex Corporation | METHODS AND SYSTEMS FOR LARGE SPOT LASER TREATMENT OF THE RETINA |
| US11684514B2 (en) * | 2018-09-26 | 2023-06-27 | Norlase Aps | Direct diode laser module for delivering pulsed visible green laser energy |
| US10864380B1 (en) | 2020-02-29 | 2020-12-15 | Cutera, Inc. | Systems and methods for controlling therapeutic laser pulse duration |
| US11253720B2 (en) | 2020-02-29 | 2022-02-22 | Cutera, Inc. | Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing |
| US12642985B2 (en) | 2020-02-29 | 2026-06-02 | Cutera, Inc. | Dermatological laser systems and methods with pressure sensing handpiece |
| CN115734995B (zh) | 2020-04-27 | 2024-10-11 | 株式会社寺冈制作所 | 粘合带 |
| KR102547764B1 (ko) | 2021-01-15 | 2023-06-26 | 주식회사 인코아 | 광역학적 광 조사장치 |
| CN113040902B (zh) * | 2021-03-23 | 2022-03-04 | 哈尔滨医科大学 | 激光消蚀导管 |
| CN216096959U (zh) * | 2021-11-02 | 2022-03-22 | 东莞市昂图智能科技有限公司 | 一种可收折防丢失快速对焦的激光装置 |
| CN117323579A (zh) * | 2023-10-27 | 2024-01-02 | 上海交通大学医学院附属第九人民医院 | 激光光动力的口腔治疗设备、控制方法及治疗药物的应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0075860A3 (en) | 1981-09-24 | 1984-12-27 | James Robert Morris | Microsurgical laser |
| US5171749A (en) | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5095030A (en) | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| EP0280414A1 (en) | 1987-02-02 | 1988-08-31 | Taunton Technologies, Inc. | Sculpture apparatus for correcting curvature of the cornea |
| EP0293126A1 (en) * | 1987-05-20 | 1988-11-30 | Keeler Limited | Photocoagulation apparatus |
| US5098426A (en) | 1989-02-06 | 1992-03-24 | Phoenix Laser Systems, Inc. | Method and apparatus for precision laser surgery |
| EP0402017A3 (en) | 1989-06-09 | 1991-03-06 | Premier Laser Systems, Inc. | Fiber optic apparatus for use with medical lasers |
| JP2980938B2 (ja) * | 1990-04-12 | 1999-11-22 | 株式会社ニデック | 半導体レーザー光を集光するためのレンズ系 |
| US5305759A (en) * | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
| JP3164236B2 (ja) * | 1991-10-04 | 2001-05-08 | 株式会社ニデック | 光治療装置 |
| DE69221806T2 (de) * | 1991-10-10 | 1998-03-26 | Coherent Inc | Vorrichtung zum Abgeben eines defokussierten Laserstrahls mit scharfkantigem Querschnitt |
| CA2087902C (en) | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
| PT680365E (pt) | 1992-11-20 | 2000-07-31 | Univ British Columbia | Activacao de agentes fotossensibilizadores |
| US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
| US5707608A (en) | 1995-08-02 | 1998-01-13 | Qlt Phototherapeutics, Inc. | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
| US5756541A (en) | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US5843070A (en) | 1996-05-13 | 1998-12-01 | Partech, Inc. | Simulating corneal laser surgery |
| AU3147200A (en) * | 1999-03-08 | 2000-09-28 | Asah Medico A/S | An apparatus for tissue treatment and having a monitor for display of tissue features |
| US6932807B1 (en) * | 1999-09-01 | 2005-08-23 | Nidek Co., Ltd. | Laser treatment apparatus |
| JP3881508B2 (ja) * | 2000-12-04 | 2007-02-14 | 株式会社ニデック | レーザ治療装置 |
| FR2842413B1 (fr) * | 2002-07-18 | 2005-06-03 | Univ Lille Sciences Tech | Appareil pour le traitement de la degenerescence maculaire liee a l'age (dmla) |
| US6868236B2 (en) | 2002-07-18 | 2005-03-15 | Terabeam Corporation | Apparatus and method for combining multiple optical beams in a free-space optical communications system |
| JP2005008614A (ja) | 2003-03-28 | 2005-01-13 | Nano Career Kk | 高分子ミセルを用いた眼科用ドラッグデリバリーシステム |
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2012
- 2012-03-21 US US13/426,470 patent/US9211214B2/en active Active
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2013
- 2013-03-21 WO PCT/US2013/033309 patent/WO2013142693A1/en not_active Ceased
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- 2013-03-21 ES ES13763985.2T patent/ES2688743T3/es active Active
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| CN104540481A (zh) | 2015-04-22 |
| JP2015513947A (ja) | 2015-05-18 |
| US9949877B2 (en) | 2018-04-24 |
| WO2013142693A1 (en) | 2013-09-26 |
| EP2827818B1 (en) | 2018-08-08 |
| AU2013235019A1 (en) | 2014-10-09 |
| US20130253411A1 (en) | 2013-09-26 |
| JP6242024B2 (ja) | 2017-12-06 |
| CN104540481B (zh) | 2017-06-09 |
| MX2014011271A (es) | 2015-08-14 |
| KR20150056499A (ko) | 2015-05-26 |
| MX344249B (es) | 2016-12-09 |
| EP2827818A4 (en) | 2015-12-16 |
| US20160074222A1 (en) | 2016-03-17 |
| US9211214B2 (en) | 2015-12-15 |
| WO2013142693A8 (en) | 2014-10-23 |
| CA2867021C (en) | 2021-01-19 |
| CA2867021A1 (en) | 2013-09-26 |
| AU2013235019B2 (en) | 2016-06-16 |
| EP2827818A1 (en) | 2015-01-28 |
| KR102056103B1 (ko) | 2019-12-16 |
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