ES2674526T3 - Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer - Google Patents

Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer Download PDF

Info

Publication number
ES2674526T3
ES2674526T3 ES14726887.4T ES14726887T ES2674526T3 ES 2674526 T3 ES2674526 T3 ES 2674526T3 ES 14726887 T ES14726887 T ES 14726887T ES 2674526 T3 ES2674526 T3 ES 2674526T3
Authority
ES
Spain
Prior art keywords
alpha
complement
afamin
protein
apolipoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14726887.4T
Other languages
English (en)
Spanish (es)
Inventor
Peter Fitzgerald
Ivan McConnell
John Lamont
Ciaran RICHARDSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Randox Teoranta
Original Assignee
Randox Teoranta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randox Teoranta filed Critical Randox Teoranta
Application granted granted Critical
Publication of ES2674526T3 publication Critical patent/ES2674526T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4716Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775Apolipopeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121Serpins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Computation (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
ES14726887.4T 2013-03-05 2014-03-04 Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer Active ES2674526T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201303936 2013-03-05
GB1303936.7A GB2511525A (en) 2013-03-05 2013-03-05 Methods and Compositions for the Diagnosis of Alzheimer's Disease
PCT/EP2014/054185 WO2014135546A1 (en) 2013-03-05 2014-03-04 Methods and compositions for the diagnosis of alzheimer's disease

Publications (1)

Publication Number Publication Date
ES2674526T3 true ES2674526T3 (es) 2018-07-02

Family

ID=48142456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14726887.4T Active ES2674526T3 (es) 2013-03-05 2014-03-04 Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer

Country Status (9)

Country Link
US (1) US20160097780A1 (https=)
EP (1) EP2965090B1 (https=)
JP (1) JP6430413B2 (https=)
CN (1) CN105164536B (https=)
AU (1) AU2014224727B2 (https=)
CA (1) CA2900002C (https=)
ES (1) ES2674526T3 (https=)
GB (1) GB2511525A (https=)
WO (1) WO2014135546A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201504432D0 (en) 2015-03-17 2015-04-29 Electrophoretics Ltd Materials and methods for diagnosis and treatment of alzheimers disease
JP6702836B2 (ja) * 2016-09-28 2020-06-03 ハルメク・ベンチャーズ株式会社 認知症判定得点算出装置及びそのプログラム
EP3309550A1 (en) * 2016-10-12 2018-04-18 sphingotec GmbH Method for the detection of apolipoprotein e4
AU2018359624A1 (en) * 2017-10-31 2020-04-30 Ge Healthcare Limited Medical system for diagnosing cognitive disease pathology and/or outcome
JP6950952B2 (ja) * 2017-12-20 2021-10-13 国立大学法人三重大学 脳アミロイド血管症の末梢血バイオマーカー
CN108681748A (zh) * 2018-05-18 2018-10-19 宝枫生物科技(北京)有限公司 判别轻度认知障碍的模型选择处理方法及装置
CN112703402A (zh) * 2018-07-19 2021-04-23 吉宁特有限公司 基于标志物分子将个体鉴定为具有淀粉样蛋白阳性痴呆症或处于发展淀粉样蛋白阳性痴呆症的风险中的方法和相关用途
CN110464833A (zh) * 2019-09-04 2019-11-19 北京豪思生物科技有限公司 铜蓝蛋白的应用
KR102567081B1 (ko) * 2019-10-07 2023-08-16 연세대학교 산학협력단 퇴행성 신경질환의 진단용 바이오마커
JP7109499B2 (ja) * 2020-05-07 2022-07-29 一般社団法人脳と心の健康科学研究所 認知症判定得点算出装置及びそのプログラム
CN115066615A (zh) * 2020-12-28 2022-09-16 株式会社Mcbi 判定辅助信息生成方法、判定辅助信息生成系统以及信息处理装置
ES2924776A1 (es) * 2021-03-25 2022-10-10 Univ Castilla La Mancha Metodos para el diagnostico y pronostico de la enfermedad de alzheimer
CN112858697B (zh) * 2021-03-29 2024-03-01 鲁东大学 ALG-2-interacting protein X在制备分子标志物中的应用
CN114634970A (zh) * 2022-03-29 2022-06-17 南通惠皓医疗科技有限公司 遗传性阿尔兹海默症致病基因panel检测方法
CN116990395A (zh) * 2022-04-26 2023-11-03 中国科学院深圳先进技术研究院 一种基于粪便的阿尔兹海默症生物标志物及其应用
EP4549945A1 (en) * 2022-06-28 2025-05-07 Mcbi Inc. Assessment-supporting information generating method, assessment-supporting information generating system, and information processing device
CN116063447B (zh) * 2022-09-13 2023-11-03 北京湃德智健科技有限公司 用于检测adap自身抗体的抗原多肽及其应用
CN119495355B (zh) * 2024-10-31 2026-04-24 山东大学 一种阿尔兹海默症诊断标志物的筛选方法和系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH067191A (ja) * 1991-09-26 1994-01-18 Konica Corp モノクローナル抗体、それを産生するハイブリド−マ、その対応抗原及びそれを用いた測定方法
US5652352A (en) * 1994-03-31 1997-07-29 Amgen Inc. Afamin: a human serum albumin-like gene
AT411014B (de) * 2001-04-30 2003-09-25 Vitateq Biotechnology Gmbh Präparationen von vitamin e in kombination mit afamin
EP1434053B1 (en) * 2001-10-04 2008-03-26 Immuno-Biological Laboratories Co., Ltd. Reagent for detecting risk factor for alzheimer's disease, detection kit therefor and method of detecting risk factor for alzheimer's disease using the same
WO2005107760A1 (en) * 2004-04-30 2005-11-17 Irm Llc Compounds and compositions as inducers of keratinocyte differentiation
WO2006108051A2 (en) * 2005-04-05 2006-10-12 Neurodx, Llc Compositions and methods relating to alzheimer's disease
GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method
US7575876B2 (en) * 2005-10-27 2009-08-18 The University Of Washington Biomarkers for neurodegenerative disorders
AT505727B1 (de) * 2007-09-04 2009-06-15 Univ Innsbruck Verfahren zur diagnose des metabolischen syndroms
GB0921447D0 (en) * 2009-12-04 2010-01-20 Randox Lab Ltd Assay
EP2569451A4 (en) * 2010-05-14 2013-09-11 Rules Based Medicine Inc METHOD AND DEVICES FOR DIAGNOSING MORBUS ALZHEIMER
CN104204807B (zh) * 2012-01-20 2016-11-09 阿德莱德研究及创新控股有限公司 用于胃癌的生物标志物及其应用
ITMI20120865A1 (it) * 2012-05-18 2013-11-19 Antonio Bertolotto Biomarcatori per patologie del sistema nervoso centrale

Also Published As

Publication number Publication date
AU2014224727B2 (en) 2020-09-03
EP2965090B1 (en) 2018-04-25
EP2965090A1 (en) 2016-01-13
JP6430413B2 (ja) 2018-11-28
JP2016511406A (ja) 2016-04-14
WO2014135546A1 (en) 2014-09-12
CA2900002C (en) 2022-01-25
CA2900002A1 (en) 2014-09-12
AU2014224727A1 (en) 2015-08-13
GB201303936D0 (en) 2013-04-17
US20160097780A1 (en) 2016-04-07
CN105164536B (zh) 2018-02-06
GB2511525A (en) 2014-09-10
CN105164536A (zh) 2015-12-16

Similar Documents

Publication Publication Date Title
ES2674526T3 (es) Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer
Hu et al. Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays
RU2675370C2 (ru) Способ выявления присутствия или отсутствия агрессивного рака предстательной железы
Chahine et al. Blood-based biomarkers for Parkinson's disease
Shaw et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
ES2612197T3 (es) Marcadores en la orina para la detección del cáncer de vejiga
ES3041639T3 (en) Biomarkers and methods for assessing psoriatic arthritis disease activity
ES2694409T3 (es) Método de pronóstico para individuos con cáncer de próstata
JP5878875B2 (ja) アルツハイマー病の診断法
ES2706534T3 (es) Método para ayudar al diagnóstico diferencial del accidente cerebrovascular
BRPI0709374A2 (pt) técnica de obtenção de impressão digital de apolipoproteìna e métodos relacionados á mesma
Li et al. UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis
HK1248316A1 (en) Methods of assessing colorectal health of an individual
TWI868698B (zh) 用於快速診斷川崎病的分子生物標誌物和分析方法
ES2361808B1 (es) Método de obtención de datos útiles para el diagnóstico o el pronóstico del c�?ncer colorrectal.
US10078089B2 (en) Compositions and methods for treating steroid resistant nephrotic syndrome and/or steroid sensitive nephrotic syndrome
ES2975228T3 (es) Derivados de GFAP para el diagnóstico de accidente cerebrovascular
Everest et al. Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers
US20230133776A1 (en) Methods for diagnosing cancer
CN113699235A (zh) 免疫原性细胞死亡相关基因在头颈鳞癌生存预后及放疗应答性中的应用
KR102136747B1 (ko) 장형 위암의 예후 진단 마커
Seyhan Biomarkers in drug discovery and development
CA2959408A1 (en) Biomarkers for detection of breast cancer
KR20250097696A (ko) Reg3a를 포함하는 ctnnb1 돌연변이 간암 진단용 바이오마커 조성물
ES2686736T3 (es) Combinaciones de biomarcadores para su uso en la detección del cáncer de páncreas