ES2674526T3 - Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer - Google Patents

Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer Download PDF

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Publication number
ES2674526T3
ES2674526T3 ES14726887.4T ES14726887T ES2674526T3 ES 2674526 T3 ES2674526 T3 ES 2674526T3 ES 14726887 T ES14726887 T ES 14726887T ES 2674526 T3 ES2674526 T3 ES 2674526T3
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Prior art keywords
alpha
complement
afamin
protein
apolipoprotein
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ES14726887.4T
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English (en)
Spanish (es)
Inventor
Peter Fitzgerald
Ivan McConnell
John Lamont
Ciaran RICHARDSON
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Randox Teoranta
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Randox Teoranta
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Epidemiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Biology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
ES14726887.4T 2013-03-05 2014-03-04 Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer Active ES2674526T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1303936.7A GB2511525A (en) 2013-03-05 2013-03-05 Methods and Compositions for the Diagnosis of Alzheimer's Disease
GB201303936 2013-03-05
PCT/EP2014/054185 WO2014135546A1 (en) 2013-03-05 2014-03-04 Methods and compositions for the diagnosis of alzheimer's disease

Publications (1)

Publication Number Publication Date
ES2674526T3 true ES2674526T3 (es) 2018-07-02

Family

ID=48142456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14726887.4T Active ES2674526T3 (es) 2013-03-05 2014-03-04 Métodos y composiciones para el diagnóstico de la enfermedad de Alzheimer

Country Status (9)

Country Link
US (1) US20160097780A1 (cg-RX-API-DMAC10.html)
EP (1) EP2965090B1 (cg-RX-API-DMAC10.html)
JP (1) JP6430413B2 (cg-RX-API-DMAC10.html)
CN (1) CN105164536B (cg-RX-API-DMAC10.html)
AU (1) AU2014224727B2 (cg-RX-API-DMAC10.html)
CA (1) CA2900002C (cg-RX-API-DMAC10.html)
ES (1) ES2674526T3 (cg-RX-API-DMAC10.html)
GB (1) GB2511525A (cg-RX-API-DMAC10.html)
WO (1) WO2014135546A1 (cg-RX-API-DMAC10.html)

Families Citing this family (19)

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GB201504432D0 (en) * 2015-03-17 2015-04-29 Electrophoretics Ltd Materials and methods for diagnosis and treatment of alzheimers disease
JP6702836B2 (ja) * 2016-09-28 2020-06-03 ハルメク・ベンチャーズ株式会社 認知症判定得点算出装置及びそのプログラム
EP3309550A1 (en) * 2016-10-12 2018-04-18 sphingotec GmbH Method for the detection of apolipoprotein e4
CN118866316A (zh) * 2017-10-31 2024-10-29 通用电气健康护理有限公司 用于诊断认知疾病病理和/或结果的医疗系统
JP6950952B2 (ja) * 2017-12-20 2021-10-13 国立大学法人三重大学 脳アミロイド血管症の末梢血バイオマーカー
CN108681748A (zh) * 2018-05-18 2018-10-19 宝枫生物科技(北京)有限公司 判别轻度认知障碍的模型选择处理方法及装置
JP7437376B2 (ja) * 2018-07-19 2024-02-22 ジェネンテック,インコーポレーテッド マーカー分子に基づいて、アミロイド陽性認知症を罹患していると、または発症するリスクがあると個体を同定する方法、および関連する使用
CN110464833A (zh) * 2019-09-04 2019-11-19 北京豪思生物科技有限公司 铜蓝蛋白的应用
WO2021071219A1 (ko) * 2019-10-07 2021-04-15 조한나 퇴행성 신경질환의 진단용 바이오마커
JP7109499B2 (ja) * 2020-05-07 2022-07-29 一般社団法人脳と心の健康科学研究所 認知症判定得点算出装置及びそのプログラム
CN115066615A (zh) * 2020-12-28 2022-09-16 株式会社Mcbi 判定辅助信息生成方法、判定辅助信息生成系统以及信息处理装置
ES2924776A1 (es) * 2021-03-25 2022-10-10 Univ Castilla La Mancha Metodos para el diagnostico y pronostico de la enfermedad de alzheimer
CN112858697B (zh) * 2021-03-29 2024-03-01 鲁东大学 ALG-2-interacting protein X在制备分子标志物中的应用
CN114634970A (zh) * 2022-03-29 2022-06-17 南通惠皓医疗科技有限公司 遗传性阿尔兹海默症致病基因panel检测方法
CN116990395A (zh) * 2022-04-26 2023-11-03 中国科学院深圳先进技术研究院 一种基于粪便的阿尔兹海默症生物标志物及其应用
WO2024004944A1 (ja) * 2022-06-28 2024-01-04 株式会社Mcbi 判定支援情報生成方法、判定支援情報生成システム、及び情報処理装置
CN116063447B (zh) * 2022-09-13 2023-11-03 北京湃德智健科技有限公司 用于检测adap自身抗体的抗原多肽及其应用
US20240138749A1 (en) * 2022-10-31 2024-05-02 Movalytix, Inc. Method for screening of movement disorders
CN119495355B (zh) * 2024-10-31 2026-04-24 山东大学 一种阿尔兹海默症诊断标志物的筛选方法和系统

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JPH067191A (ja) * 1991-09-26 1994-01-18 Konica Corp モノクローナル抗体、それを産生するハイブリド−マ、その対応抗原及びそれを用いた測定方法
US5652352A (en) * 1994-03-31 1997-07-29 Amgen Inc. Afamin: a human serum albumin-like gene
AT411014B (de) * 2001-04-30 2003-09-25 Vitateq Biotechnology Gmbh Präparationen von vitamin e in kombination mit afamin
DE60225821T2 (de) * 2001-10-04 2009-04-30 Immuno-Biological Laboratories Co., Ltd., Takasaki Reagens zum Nachweis eines Risikofaktors der Alzheimer-Krankheit, Nachweiskit dafür und Verfahren zum Nachweis eines Risikofaktors der Alzheimer-Krankheit unter ihrer Verwendung
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GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method
US7575876B2 (en) * 2005-10-27 2009-08-18 The University Of Washington Biomarkers for neurodegenerative disorders
AT505727B1 (de) * 2007-09-04 2009-06-15 Univ Innsbruck Verfahren zur diagnose des metabolischen syndroms
GB0921447D0 (en) * 2009-12-04 2010-01-20 Randox Lab Ltd Assay
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JP6198752B2 (ja) * 2012-01-20 2017-09-20 アデレード リサーチ アンド イノベイション ピーティーワイ エルティーディーAdelaide Research & Innovation Pty Ltd 胃癌のバイオマーカー及びその使用
ITMI20120865A1 (it) * 2012-05-18 2013-11-19 Antonio Bertolotto Biomarcatori per patologie del sistema nervoso centrale

Also Published As

Publication number Publication date
EP2965090B1 (en) 2018-04-25
JP2016511406A (ja) 2016-04-14
CN105164536A (zh) 2015-12-16
AU2014224727B2 (en) 2020-09-03
EP2965090A1 (en) 2016-01-13
GB201303936D0 (en) 2013-04-17
AU2014224727A1 (en) 2015-08-13
JP6430413B2 (ja) 2018-11-28
CA2900002C (en) 2022-01-25
US20160097780A1 (en) 2016-04-07
GB2511525A (en) 2014-09-10
CA2900002A1 (en) 2014-09-12
WO2014135546A1 (en) 2014-09-12
CN105164536B (zh) 2018-02-06

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